scholarly journals The BDNF Val66Met polymorphism moderates the relationship between cognitive reserve and executive function

2015 ◽  
Vol 5 (6) ◽  
pp. e590-e590 ◽  
Author(s):  
D D Ward ◽  
M J Summers ◽  
N L Saunders ◽  
K Ritchie ◽  
J J Summers ◽  
...  
Keyword(s):  
Executive Function ◽  
Cognitive Reserve ◽  
Val66met Polymorphism ◽  
Bdnf Val66met Polymorphism ◽  
The Relationship

The BDNF Val66Met Polymorphism, Regular Exercise, and Cognition: A Systematic Review

2020 ◽  
Vol 42 (8) ◽  
pp. 660-673
Author(s):  
Tingting Liu ◽  
Hongjin Li ◽  
Joseph P. Colton ◽  
Song Ge ◽  
Changwei Li
Keyword(s):  
English Language ◽  
Research Evidence ◽  
Human Subjects ◽  
Regular Exercise ◽  
Journal Articles ◽  
Information Processing Speed ◽  
Val66met Polymorphism ◽  
Bdnf Val66met Polymorphism ◽  
Global Cognition ◽  
The Relationship

The purpose of this study was to synthesize research evidence from studies on the relationships among the BDNF Val66Met polymorphism, regular exercise, and cognition in human subjects. PubMed, CINAHL, and Web of Science were searched systematically. Search limiters applied in these databases included humans, English language, time limits from 2009 to 2019, and peer-reviewed journal articles. Eight studies were included in the current review. While there was some evidence to tentatively suggest that greater levels of exercise were associated with certain forms of memory in Val/Val homozygotes than Met carriers, more research is needed to corroborate these findings. Regarding attention/information processing speed, executive function as well as global cognition, the evidence is either inconsistent or sparse and does not allow for tentative conclusions. Compelling evidence from high-quality clinical trials is needed to re-examine the relationship between the BDNF Val66Met polymorphism, exercise, and cognition.

364. The BDNF Val66Met Polymorphism Moderates the Relationship between PTSD and Fear Extinction Learning

2017 ◽  
Vol 81 (10) ◽  
pp. S149 ◽  
Author(s):  
Kim Felmingham ◽  
Daniel Zuj ◽  
Ken Chia Ming Hsu ◽  
Emma Nicholson ◽  
Matthew Palmer ◽  
...  
Keyword(s):  
Fear Extinction ◽  
Extinction Learning ◽  
Val66met Polymorphism ◽  
Bdnf Val66met Polymorphism ◽  
The Relationship

BDNF Val66Met polymorphism is associated with aggressive behavior in schizophrenia

2010 ◽  
Vol 25 (6) ◽  
pp. 311-313 ◽  
Author(s):  
G. Spalletta ◽  
D.W. Morris ◽  
F. Angelucci ◽  
I.A. Rubino ◽  
I. Spoletini ◽  
...  
Keyword(s):  
Aggressive Behavior ◽  
Neurotrophic Factor ◽  
Aggressive Behaviour ◽  
Brain Derived Neurotrophic Factor ◽  
Gene Variants ◽  
Bdnf Gene ◽  
Val66met Polymorphism ◽  
Schizophrenic Patients ◽  
Bdnf Val66met Polymorphism ◽  
The Relationship

AbstractBrain-derived neurotrophic factor (BDNF) gene variants may potentially influence behaviour. In order to test this hypothesis, we investigated the relationship between BDNF Val66Met polymorphism and aggressive behaviour in a population of schizophrenic patients. Our results showed that increased number of BDNF Met alleles was associated with increased aggressive behaviour.

scholarly journals LANGUAGE AND DEMENTIA: NEUROPSYCHOLOGICAL ASPECTS

2008 ◽  
Vol 28 ◽  
pp. 73-90 ◽  
Author(s):  
Daniel Kempler ◽  
Mira Goral
Keyword(s):  
Alzheimer’S Disease ◽  
Executive Function ◽  
Cognitive Reserve ◽  
Language Ability ◽  
Semantic Dementia ◽  
Language Abilities ◽  
Nonfluent Aphasia ◽  
Conceptual Organization ◽  
The Relationship ◽  
Progressive Nonfluent Aphasia

This article reviews recent evidence for the relationship between extralinguistic cognitive and language abilities in dementia. A survey of data from investigations of three dementia syndromes (Alzheimer's disease, semantic dementia and progressive nonfluent aphasia) reveals that, more often than not, deterioration of conceptual organization appears associated with lexical impairments, whereas impairments in executive function are associated with sentence- and discourse-level deficits. These connections between extralinguistic functions and language ability also emerge from the literature on cognitive reserve and bilingualism that investigates factors that delay the onset and possibly the progression of neuropsychological manifestation of dementia.

scholarly journals Cognitive Reserve, Executive Function, and Memory in Parkinson’s Disease

2021 ◽  
Vol 11 (8) ◽  
pp. 992
Author(s):  
Andrea M. Loftus ◽  
Natalie Gasson ◽  
Nicole Lopez ◽  
Michelle Sellner ◽  
Carly Reid ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Executive Function ◽  
Verbal Memory ◽  
Verbal Fluency ◽  
Cognitive Reserve ◽  
Cognitive Domain ◽  
Delayed Recall ◽  
Immediate Recall ◽  
The Relationship

Cognitive impairment is acknowledged as a feature of Parkinson’s disease (PD), and the most common cognitive declines are in executive function (EF) and memory. Cognitive reserve (CR) may offer some protection against cognitive dysfunction in PD. The present study used two proxies of CR (years of education, premorbid IQ) to examine the relationship between CR and (i) EF (ii) memory in a large PD sample (n = 334). Two aspects of EF were examined, including verbal fluency and planning skills. Two aspects of verbal memory were examined, including immediate recall and delayed recall. For EF, both CR proxies significantly predicted verbal fluency, but only years of education predicted planning skills. Years of education significantly predicted immediate recall, but premorbid IQ did not. Neither CR proxy predicted delayed recall. These findings suggest that CR, in particular years of education, may contribute to EF and memory function in those with PD. A key finding of this study is the varying contribution of CR proxies to different aspects of the same cognitive domain. The findings indicate that using only one proxy has the potential to be misleading and suggest that when testing the relationship between CR and cognition, studies should include tasks that measure different aspects of the cognitive domain(s) of interest.

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