scholarly journals Dengue detection: Advances and challenges in diagnostic technology

2021 ◽  
pp. 100100
Author(s):  
Shreeganesh Subraya Hegde ◽  
Badekai Ramachandra Bhat
Keyword(s):  
Diagnostic Technology

Solid-phase structures of cerebrospinal fluid in diagnosis of early asymptomatic neurosyphilis

2018 ◽  
pp. 56-61
Author(s):  
С.Н. Шатохина ◽  
Н.А. Кузнецова ◽  
В.Н. Шабалин
Keyword(s):  
Cerebrospinal Fluid ◽  
Visual Analysis ◽  
Solid Phase ◽  
Biological Fluids ◽  
Laboratory Methods ◽  
Phase Structures ◽  
Morphological Picture ◽  
Diagnostic Technology

Цель проведённого исследования состояла в оценке эффективности визуального анализа твёрдофазных структур спинномозговой жидкости для диагностики ранних форм нейросифилиса. Методы. Использован метод краевой дегидратации биологических жидкостей, входящий в состав авторской диагностической технологии «Литос-система». Диагностика раннего асимптомного нейросифилиса заключается в выявлении деструктивных образований в форме овалов в морфологической картине твёрдой фазы спинномозговой жидкости. Результаты. Проведён сравнительный анализ результатов исследования спинномозговой жидкости у 19 больных с подтверждённым диагнозом «ранний асимптомный нейросифилис», полученных традиционными лабораторными методами и методом краевой дегидратации. Выявлено, что локализация овалов внутри сферолитов указывает на длительность заболевания нейросифилисом менее трёх лет, а вне сферолитов - от трех до пяти лет. Заключение. Метод краевой дегидратации позволяет диагностировать ранний асимптомный нейросифилис по наличию деструктивных образований в форме овалов в морфологической картине твёрдой фазы спинномозговой жидкости. The aim of this study was to evaluate effectiveness of visual analysis of solid-phase structures in cerebrospinal fluid to diagnose early forms of neurosyphilis. Methods. We used a method of marginal dehydration of biological fluids as a part of the author’s diagnostic technology, Litos-System. Early asymptomatic neurosyphilis is diagnosed based on detection of destructive, oval-shaped formations in the morphological picture of cerebrospinal fluid solid phase. Results. Data from analyses of cerebrospinal fluid performed with traditional laboratory methods and the method of marginal dehydration were compared for 19 patients with documented diagnosis of early asymptomatic neurosyphilis. A localization of ovals within spherulites indicated a less than a three-year duration of neurosyphilis while a localization outside spherulites indicated a duration of three to five years. Conclusion. The method of marginal dehydration allows detecting early asymptomatic neurosyphilis based on the presence of destructive, oval-shaped formations in the morphological picture of cerebrospinal fluid solid phase.

Intel® Component Diagnostic Technology: Tools and Education for Intel Component Defect Reduction

2004 ◽  
Author(s):  
Julie S. Doll
Keyword(s):  
User Interface ◽  
Data Management ◽  
Contract Manufacturing ◽  
Defect Reduction ◽  
Web Based ◽  
Technology Tools ◽  
Diagnostic Capability ◽  
Diagnostic Technology

Abstract To enable efficient, accurate debug of Intel architecture components to take place within contract manufacturing sites, and to provide alternatives for the removal of Intel components from, Intel is deploying a diagnostic capability and attendant educational collateral known as to achieve these objectives Intel® Component Diagnostic Technology. This paper will describe details of Intel® Component Diagnostic Technology, including the diagnostic fixture and user interface, diagnostic scripts and analytical coverage, data management and reporting, and on-site and Web-based educational offerings.

scholarly journals MPT64 assays for the rapid detection of Mycobacterium tuberculosis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xun-Jie Cao ◽  
Ya-Ping Li ◽  
Jia-Ying Wang ◽  
Jie Zhou ◽  
Xu-Guang Guo
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Rapid Detection ◽  
Web Of Science ◽  
Mortality Rates ◽  
Cochrane Library ◽  
Diagnostic Efficiency ◽  
Funnel Plot ◽  
High Infection ◽  
Diagnostic Technology ◽  
Commercial Kits

Abstract Background Tuberculosis (TB) is a serious infectious disease caused by Mycobacterium tuberculosis (MTB). An estimated 1.7 billion people worldwide are infected with Mycobacterium tuberculosis (LTBI) during the incubation period without any obvious symptoms. Because of MTB’s high infection and mortality rates, there is an urgent need to develop a fast, portable, and sensitive diagnostic technology for its detection. Methods We included research from PubMed, Cochrane Library, Web of Science, and Embase and extracted the data. MetaDisc and STATA were used to build forest plots, Deek’s funnel plot, Fagan plot, and bivariate boxplot for analysis. Results Forty-six articles were analyzed, the results of which are as follows: sensitivity and specificity were 0.92 (0.91–0.93) and 0.95 (0.94–0.95) respectively. The NLR and PLR were 0.04 (95% CI 0.03–0.07) and 25.32 (95% CI 12.38–51.78) respectively. DOR was 639.60 (243.04–1683.18). The area under the SROC curve (AUC) was 0.99. Conclusions MPT64 exhibits good diagnostic efficiency for MTB. There is no obvious heterogeneity between the three commercial kits.

scholarly journals Laboratory diagnosis of pneumonia in the molecular age

2016 ◽  
Vol 48 (6) ◽  
pp. 1764-1778 ◽  
Author(s):  
Antoni Torres ◽  
Nelson Lee ◽  
Catia Cilloniz ◽  
Jordi Vila ◽  
Menno Van der Eerden
Keyword(s):  
Laboratory Diagnosis ◽  
High Rate ◽  
Microbial Pathogens ◽  
Molecular Diagnostic ◽  
Respiratory Pathogens ◽  
Major Advance ◽  
Lung Microbiome ◽  
Microbiological Methods ◽  
New Knowledge ◽  
Diagnostic Technology

Pneumonia remains a worldwide health problem with a high rate of morbidity and mortality. Identification of microbial pathogens which cause pneumonia is an important area for optimum clinical management of pneumonia patients and is a big challenge for conventional microbiological methods. The development and implementation of molecular diagnostic tests for pneumonia has been a major advance in the microbiological diagnosis of respiratory pathogens in recent years. However, with new knowledge regarding the microbiome, together with the recognition that the lungs are a dynamic microbiological ecosystem, our current concept of pneumonia is not totally realistic as this new concept of pneumonia involves a dysbiosis or alteration of the lung microbiome. A new challenge for microbiologists and clinicians has therefore arisen. There is much to learn regarding the information provided by this new diagnostic technology, which will lead to improvements in the time to antibiotic therapy, targeted antibiotic selection and more effective de-escalation and improved stewardship for pneumonia patients. This article provides an overview of current methods of laboratory diagnosis of pneumonia in the molecular age.

Study on Equipment Diagnostic Technology Utilizing Tribology

2011 ◽  
Vol 2011 (18) ◽  
pp. 524-535
Author(s):  
Masahiro Ito ◽  
Ryohei Sakane ◽  
Makoto Tanokura
Keyword(s):  
Diagnostic Technology

Diagnostic technology and an expert system for photovoltaic systems using the learning method

2003 ◽  
Vol 75 (3-4) ◽  
pp. 655-663 ◽  
Author(s):  
Yasuhiro Yagi ◽  
Hitoshi Kishi ◽  
Ryuzou Hagihara ◽  
Toshiya Tanaka ◽  
Shinichi Kozuma ◽  
...  
Keyword(s):  
Expert System ◽  
Photovoltaic Systems ◽  
Learning Method ◽  
Diagnostic Technology

Remaining service life diagnostic technology of insulators for power distribution equipment

2009 ◽  
Vol 167 (2) ◽  
pp. 1-9
Author(s):  
Shinsuke Miki ◽  
Hiroshi Okazawa ◽  
Taketoshi Hasegawa ◽  
Sei Tsunoda ◽  
Hiroshi Inujima
Keyword(s):  
Service Life ◽  
Power Distribution ◽  
Remaining Service Life ◽  
Diagnostic Technology

Use of Circulating Cell-Free DNA to Guide Precision Medicine in Patients with Colorectal Cancer

2021 ◽  
Vol 72 (1) ◽  
pp. 399-413
Author(s):  
Van K. Morris ◽  
John H. Strickler
Keyword(s):  
Colorectal Cancer ◽  
Precision Medicine ◽  
Residual Disease ◽  
Cost Effective ◽  
Patient Specific ◽  
Blood Draw ◽  
Cell Free Dna ◽  
Free Dna ◽  
Metastatic Setting ◽  
Diagnostic Technology

Patient-specific biomarkers form the foundation of precision medicine strategies. To realize the promise of precision medicine in patients with colorectal cancer (CRC), access to cost-effective, convenient, and safe assays is critical. Improvements in diagnostic technology have enabled ultrasensitive and specific assays to identify cell-free DNA (cfDNA) from a routine blood draw. Clinicians are already employing these minimally invasive assays to identify drivers of therapeutic resistance and measure genomic heterogeneity, particularly when tumor tissue is difficult to access or serial sampling is necessary. As cfDNA diagnostic technology continues to improve, more innovative applications are anticipated. In this review, we focus on four clinical applications for cfDNA analysis in the management of CRC: detecting minimal residual disease, monitoring treatment response in the metastatic setting, identifying drivers of treatment sensitivity and resistance, and guiding therapeutic strategies to overcome resistance.

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