Comorbid Illness Profiles Predict Greater Costs: An Analysis of 417,477 Heart Failure Admissions

2012 ◽  
Vol 18 (8) ◽  
pp. S76
Author(s):  
Christopher S. Lee ◽  
Julie T. Bidwell ◽  
Quin E. Denfeld ◽  
Ruth Masterson Creber ◽  
Jill M. Gelow ◽  
...  
2021 ◽  
Vol 14 (4) ◽  
pp. e241914
Author(s):  
Uzair Akbar Ali ◽  
Muhammad Sajjad Sadiq ◽  
Muhammad Jawad Yunus

SARS-CoV-2 preferentially targets the human’s lungs, but it can affect multiple organ systems. We report a case of cardiorenal syndrome in a 37-year-old man who had symptoms of fever, myalgia and cough. He tested positive for COVID-19 and presented 5 days later with acute heart failure. Work up was done including echocardiography showing reduced ejection fraction. Later in the hospital course he developed acute renal failure and was treated with intermittent renal replacement therapy. No other definite cause of cardiorenal complications was identified during the course of the disease. A possible link with COVID-19 was considered with underlying mechanisms still needed to be explored. This case highlights the potential of SARS-CoV-2 affecting heart and kidneys. The disease not only involves the organs directly but can exacerbate the underlying comorbid illness.


Author(s):  
Nurul Azwanti ◽  
Erlin Elisa

There are approximately 95% of cases of unknown cause of hypertension, while the rest caused by other diseases such as coronary heart disease, impaired kidney function, and impaired cognitive function or stroke. RSUD Embung Fatimah is an Indonesian hospital located in Batam Island Riau Province. In 2015, the total number of inpatients for hospitalization reaches 10,317 inhabitants. With the large number of patients per year it causes patient data is increasing. To overcome the problem in tackling people with hypertension disease, it is necessary to analyze the existing disease data, to predict the patient's illness which must be handled based on the pattern of the disease. In data mining there is a model that can be used to predict a pattern in a condition that is predictive or prediction model. One of the algorithms that can be used to create a decision tree (decission tree) is the C4.5 algorithm. The C4.5 algorithm is a method used for predictive classification. Using C4.5 algorithm method, the researcher can classify the pattern of hypertension as a comorbid illness of heart failure, kidney failure, diabetes, stroke and hypoglycemia. In this study, researchers used WEKA (Waikato Environment for Knowledge Analysis) software as tools or tools used to perform testing in order to obtain the pattern of disease from hypertension. From the research findings in the find that in the prediction of hypertension disease as a disease, the attributes that are very influential to hypertension are heart failure.


Author(s):  
George Hug ◽  
William K. Schubert

A white boy six months of age was hospitalized with respiratory distress and congestive heart failure. Control of the heart failure was achieved but marked cardiomegaly, moderate hepatomegaly, and minimal muscular weakness persisted.At birth a chest x-ray had been taken because of rapid breathing and jaundice and showed the heart to be of normal size. Clinical studies included: EKG which showed biventricular hypertrophy, needle liver biopsy which showed toxic hepatitis, and cardiac catheterization which showed no obstruction to left ventricular outflow. Liver and muscle biopsies revealed no biochemical or histological evidence of type II glycogexiosis (Pompe's disease). At thoracotomy, 14 milligrams of left ventricular muscle were removed. Total phosphorylase activity in the biopsy specimen was normal by biochemical analysis as was the degree of phosphorylase activation. By light microscopy, vacuoles and fine granules were seen in practically all myocardial fibers. The fibers were not hypertrophic. The endocardium was not thickened excluding endocardial fibroelastosis. Based on these findings, the diagnosis of idiopathic non-obstructive cardiomyopathy was made.


Author(s):  
Chi-Ming Wei ◽  
Margarita Bracamonte ◽  
Shi-Wen Jiang ◽  
Richard C. Daly ◽  
Christopher G.A. McGregor ◽  
...  

Nitric oxide (NO) is a potent endothelium-derived relaxing factor which also may modulate cardiomyocyte inotropism and growth via increasing cGMP. While endothelial nitric oxide synthase (eNOS) isoforms have been detected in non-human mammalian tissues, expression and localization of eNOS in the normal and failing human myocardium are poorly defined. Therefore, the present study was designed to investigate eNOS in human cardiac tissues in the presence and absence of congestive heart failure (CHF).Normal and failing atrial tissue were obtained from six cardiac donors and six end-stage heart failure patients undergoing primary cardiac transplantation. ENOS protein expression and localization was investigated utilizing Western blot analysis and immunohistochemical staining with the polyclonal rabbit antibody to eNOS (Transduction Laboratories, Lexington, Kentucky).


2020 ◽  
Vol 134 (1) ◽  
pp. 71-72
Author(s):  
Naseer Ahmed ◽  
Masooma Naseem ◽  
Javeria Farooq

Abstract Recently, we have read with great interest the article published by Ibarrola et al. (Clin. Sci. (Lond.) (2018) 132, 1471–1485), which used proteomics and immunodetection methods to show that Galectin-3 (Gal-3) down-regulated the antioxidant peroxiredoxin-4 (Prx-4) in cardiac fibroblasts. Authors concluded that ‘antioxidant activity of Prx-4 had been identified as a protein down-regulated by Gal-3. Moreover, Gal-3 induced a decrease in total antioxidant capacity which resulted in a consequent increase in peroxide levels and oxidative stress markers in cardiac fibroblasts.’ We would like to point out some results stated in the article that need further investigation and more detailed discussion to clarify certain factors involved in the protective role of Prx-4 in heart failure.


Ob Gyn News ◽  
2005 ◽  
Vol 40 (3) ◽  
pp. 10
Author(s):  
BRUCE JANCIN
Keyword(s):  

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