Benign and Malignant Male Breast Diseases: Radiologic and Pathologic Correlation

2015 ◽  
Vol 66 (3) ◽  
pp. 198-207 ◽  
Author(s):  
Peggy P.W. Yen ◽  
Namita Sinha ◽  
Penny J. Barnes ◽  
Robinette Butt ◽  
Sian Iles
Keyword(s):  
Wide Spectrum ◽  
Breast Disease ◽  
Male Breast ◽  
Breast Diseases ◽  
Pathological Characteristic ◽  
The Past ◽  
Pathologic Correlation ◽  
Ductal Carcinomas ◽  
Histologic Subtypes ◽  
Breast Malignancies

Male breast disease comprises a wide spectrum of benign and malignant processes. We present the spectrum of diseases encountered at our institution over the past 7 years (2007-2013) and correlate their radiological and histopathological appearances. Gynaecomastia is the most frequently encountered disease due to its association with a variety of causes. Male breast malignancies, though rare, must be considered. The most frequently encountered pathological characteristic is invasive and the predominant histologic subtypes are infiltrating ductal carcinomas.

scholarly journals Male Breast Disease: Pictorial Review with Radiologic-Pathologic Correlation

Radiographics ◽  
2013 ◽  
Vol 33 (3) ◽  
pp. 763-779 ◽  
Author(s):  
Cheri Nguyen ◽  
Mark D. Kettler ◽  
Michael E. Swirsky ◽  
Vivian I. Miller ◽  
Caleb Scott ◽  
...  
Keyword(s):  
Breast Disease ◽  
Male Breast ◽  
Pathologic Correlation ◽  
Pictorial Review

scholarly journals Breast Evaluation Findings in Calabar, Nigeria

2014 ◽  
Vol 2 (4) ◽  
pp. 650-654
Author(s):  
Anthonia Ikpeme ◽  
Akintunde Akintomide ◽  
Grace Inah ◽  
Afiong Oku
Keyword(s):  
Breast Disease ◽  
Breast Diseases ◽  
Outer Quadrant ◽  
Tertiary Institutions ◽  
X Ray ◽  
The Past ◽  
Significant Difference ◽  
Malignant Breast ◽  
Developed World ◽  
Do So

BACKGROUND:  X-ray and sonomammography constitute a significant option in the early detection and management of breast diseases in the developed world. Unfortunately these modalities became available in Nigeria, only in the past few decades.AIM: The aim of this audit is therefore to document the imaging findings, in the past three years in a developing facility in Nigeria relating them with the demograghic features.METHODS: We prospectively studied the x-ray and sonomammography in all patients, presenting over a three year period, for breast evaluation with the hope of discerning the epidemiologic pattern of breast lesions in this environment.RESULTS: One hundred and forty-five females and four males. Median was 38 years (IQR=30-48). The commonest reason for evaluation was screening. Patients that were below 38 years showed no significant difference in frequency and type of lesion compared with patients over 38 years. The commonest breast pattern was fatty replaced. The upper outer quadrant was the commonest site.CONCLUSION: Patients presenting for breast evaluation in Calabar do so for screening mainly. Patients below 38 are nearly equally affected by malignant breast disease as their older counterparts. The commonest breast pattern was fatty replaced. Digital mammography should be available in all tertiary institutions.

Sonographic Appearances of Benign and Malignant Male Breast Disease With Mammographic and Pathologic Correlation

2010 ◽  
Vol 29 (6) ◽  
pp. 931-947 ◽  
Author(s):  
Silaja Yitta ◽  
Cory I. Singer ◽  
Hildegard B. Toth ◽  
Cecilia L. Mercado
Keyword(s):  
Breast Disease ◽  
Male Breast ◽  
Pathologic Correlation

Impact of microRNAs on molecular epidemiology

2011 ◽  
Vol 152 (16) ◽  
pp. 633-641 ◽  
Author(s):  
Katalin Gőcze ◽  
Katalin Gombos ◽  
Gábor Pajkos ◽  
Ingrid Magda ◽  
Ágoston Ember ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Cancer Research ◽  
Molecular Epidemiology ◽  
Wide Spectrum ◽  
Translation Regulation ◽  
Rna Sequences ◽  
Serum Mirna ◽  
The Past ◽  
Non Coding Rna ◽  
Free Serum

Cancer research concerning short non-coding RNA sequences and functionally linked to RNA interference (RNAi) have reached explosive breakthrough in the past decade. Molecular technology applies microRNA in extremely wide spectrum from molecular tumor prediction, diagnostics, progression monitoring and prevention. Functional analysis of tissue miRNA and cell-free serum miRNA in posttranscription and translation regulation innovated and restructured the knowledge on the field. This review focuses on molecular epidemiology and primary prevention aspects of the small non-coding RNA sequences. Orv. Hetil., 2011, 152, 633–641.

Recent Advances in Therapeutic Applications of Bisbenzimidazoles

2020 ◽  
Vol 16 (4) ◽  
pp. 454-486 ◽  
Author(s):  
Smita Verma ◽  
Vishnuvardh Ravichandiran ◽  
Nihar Ranjan ◽  
Swaran J.S. Flora
Keyword(s):  
Heterocyclic Compounds ◽  
Wide Spectrum ◽  
Dna Recognition ◽  
Present Review ◽  
Pharmacological Activities ◽  
Structural Motifs ◽  
Therapeutic Applications ◽  
The Past ◽  
Recent Advances

Nitrogen-containing heterocycles are one of the most common structural motifs in approximately 80% of the marketed drugs. Of these, benzimidazoles analogues are known to elicit a wide spectrum of pharmaceutical activities such as anticancer, antibacterial, antiparasitic, antiviral, antifungal as well as chemosensor effect. Based on the benzimidazole core fused heterocyclic compounds, crescent-shaped bisbenzimidazoles were developed which provided an early breakthrough in the sequence-specific DNA recognition. Over the years, a number of functional variations in the bisbenzimidazole core have led to the emergence of their unique properties and established them as versatile ligands against several classes of pathogens. The present review provides an overview of diverse pharmacological activities of the bisbenzimidazole analogues in the past decade with a brief account of its development through the years.

Cucurbitacins as Anticancer Agents: A Patent Review

2019 ◽  
Vol 14 (2) ◽  
pp. 133-143 ◽  
Author(s):  
Hidayat Hussain ◽  
Ivan R. Green ◽  
Muhammad Saleem ◽  
Khanzadi F. Khattak ◽  
Muhammad Irshad ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Wide Spectrum ◽  
Biological Effects ◽  
Therapeutic Effects ◽  
Cytotoxic Effects ◽  
Natural Sources ◽  
Oh Groups ◽  
Drug Candidates ◽  
The Past ◽  
Wide Range

Background: Cucurbitacins belong to a group of tetracyclic triterpenoids that display a wide range of biological effects. In the past, numerous cucurbitacins have been isolated from natural sources and many active compounds have been synthesized using the privileged scaffold in order to enhance its cytotoxic effects. Objective: his review covers patents on the therapeutic effects of natural cucurbitacins and their synthetic analogs published during the past decade. By far, the majority of patents published are related to cancer and Structure-Activity Relationships (SAR) of these compounds are included to lend gravitas to this important class of natural products. Methods: The date about the published patents was downloaded via online open access patent databases. Results: Cucurbitacins display significant cytotoxic properties, in particular cucurbitacins B and D which possess very potent effects towards a number of cancer cells. Numerous cucurbitacins isolated from natural sources have been derivatized through chemical modification at the C(2)-OH and C(25)- OH groups. Most importantly, an acyl ester of the C(25)-OH and, iso-propyl, n-propyl and ethyl ether groups of the C(2)-OH demonstrated the most increased cytotoxic activity. Conclusion: The significant cytotoxic effects of natural and semi-synthetic cucurbitacins make them attractive as new drug candidates. Moreover, cucurbitacins have the capability to form conjugates with other anticancer drugs which will synergistically enhance their anticancer effects. The authors believe that in order to get lead compounds, there should be a greater focus on the synthesis of homodimers, heterodimers, and halo derivatives of cucurbitacins. In the opinion of the authors the analysis of the published patents on the cucurbitacins indicates that these compounds can be developed into a regimen to treat a wide spectrum of cancers.

Toward Unity among Environmentalists

1995 ◽  
Author(s):  
Bryan G. Norton
Keyword(s):  
Resource Use ◽  
Wide Spectrum ◽  
Strong Support ◽  
Environmental Issues ◽  
Value Systems ◽  
Special Interests ◽  
Unified Approach ◽  
Policy Makers ◽  
The Past ◽  
Control Growth

Today, six out of ten Americans describe themselves as "active" environmentalists or as "sympathetic" to the movement's concerns. The movement, in turn, reflects this millions-strong support in its diversity, encompassing a wide spectrum of causes, groups, and sometimes conflicting special interests. For far-sighted activists and policy makers, the question is how this diversity affects the ability to achieve key goals in the battle against pollution, erosion, and out-of-control growth. This insightful book offers an overview of the movement -- its past as well as its present -- and issues the most persuasive call yet for a unified approach to solving environmental problems. Focusing on examples from resource use, pollution control, protection of species and habitats, and land use, the author shows how the dynamics of diversity have actually hindered environmentalists in the past, but also how a convergence of these interests around forward-looking policies can be effected, despite variance in value systems espoused. The book is thus not only an assessment of today's movement, but a blueprint for action that can help pull together many different concerns under a common banner. Anyone interested in environmental issues and active approaches to their solution will find the author's observations both astute and creative.

scholarly journals Imaging Evaluation of Male Breast Masses with Histopathologic Correlation: A Case Series

2021 ◽  
Author(s):  
Tanvi P. Vaidya ◽  
Subhash K. Ramani
Keyword(s):  
Magnetic Resonance Imaging ◽  
Wide Spectrum ◽  
Case Series ◽  
Male Breast ◽  
Radiological Evaluation ◽  
Resonance Imaging ◽  
Imaging Evaluation ◽  
Breast Masses ◽  
Female Breast

AbstractThe male breast can be afflicted with a wide spectrum of benign and malignant masses, similar to the female breast. A systematic radiological evaluation using mammography, ultrasonography, and when appropriate, magnetic resonance imaging, could aid this differentiation and provide clues to the diagnosis. In this article, we present six cases of male breast masses with an emphasis on the role of imaging in characterization and diagnosis.

Twisted oxide lateral homostructures with conjunction tunability

2021 ◽  
Author(s):  
Jan-Chi Yang ◽  
Ping-Chun Wu ◽  
Chia-Chun Wei ◽  
Qilan Zhong ◽  
Sheng-Zhu Ho ◽  
...  
Keyword(s):  
Wide Spectrum ◽  
Strain Engineering ◽  
Epitaxial Films ◽  
Modern Technology ◽  
Specific Substrate ◽  
Lattice Structures ◽  
High Quality ◽  
The Past ◽  
Sharp Interfaces ◽  
Selection Of

Abstract Epitaxial growth is of significant importance over the past decades, given it has been the key process of modern technology for delivering high-quality thin films. For conventional heteroepitaxy, the selection of proper single crystal substrates not only facilitates the integration of different materials but also fulfills interface and strain engineering upon a wide spectrum of functionalities. Nevertheless, the lattice structures, regularity and crystalline orientation are determined once a specific substrate is chosen. In this work, we reveal the growth of twisted oxide lateral homostructures with multiple conjunction degree of freedom. The twisted lateral homostructures with atomically sharp interfaces can be composed of epitaxial “blocks” with different crystalline orientations, ferroic orders and phases. We further demonstrate that this approach is universal for fabricating various complex systems. Our results establish an efficient pathway towards twisted lateral homostructures, allowing epitaxial films to be arbitrarily tailored at designated positions with unbounded in-plane conjunction tunability.

scholarly journals A Comparison of Mammography and Ultrasonography in the Evaluation of Breast Masses in Early Stage

2018 ◽  
Vol 2 (2) ◽  
pp. 209-220
Author(s):  
Salwa Sadoon ◽  
Muhammed Naseer ◽  
Sameerah Saadoon ◽  
Hadeel Ahmed
Keyword(s):  
Early Stage ◽  
Phyllodes Tumor ◽  
Breast Disease ◽  
Breast Diseases ◽  
Prospective Clinical Study ◽  
Simple Cyst ◽  
Secondary Sexual Characteristics ◽  
Breast Examination ◽  
Sexual Characteristics ◽  
Palpable Breast

Breasts are one of the secondary sexual characteristics in females. They are the rout for of nutrition & growing of infant till 4-6 months of age. Breast diseases are one of the most common diseases in the females of any society. Multiple types of benign breast lesions like fibroadenomas, simple cyst, breast abscess, lymph nodes enlargement and different malignancies are common pathologies of the breast. Up to 30% of women suffer from benign breast disease at any time of their life and this compels them to take the treatment. The prospective clinical study was achieved for 283 women ( age was ranged between 20 60 years) had palpable breast lesion referred by their managing surgeons to the radiological department at Azadi Teaching Hospital, for a period of 8 months (from January 2018 to August of the same year). The study depended firstly in all women on clinical examination/self-breast examination. Results:- 283 patients were included in this study with age between 20 _ 60 ys, most of the patients were diagnosed as fibroadenoma which is most common around 54.9% of the total cases studied, Fibrocystic diseases (Duct ectasia, cysts, and galactocele ) 19.3 %.Followed by infection as mastitis 15.4%, and phyllodes tumor less than 1% approximately and finally carcinoma 9.5%.

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