Iodinated chlorin p 6 copper complex induces anti-proliferative effect in oral cancer cells through elevation of intracellular reactive oxygen species

2017 ◽  
Vol 277 ◽  
pp. 137-144 ◽  
Author(s):  
Paromita Sarbadhikary ◽  
Alok Dube
Keyword(s):  
Reactive Oxygen Species ◽  
Oral Cancer ◽  
Cancer Cells ◽  
Copper Complex ◽  
Reactive Oxygen ◽  
Intracellular Reactive Oxygen Species ◽  
Oxygen Species ◽  
Proliferative Effect ◽  
Oral Cancer Cells

scholarly journals Costunolide Induces Apoptosis via the Reactive Oxygen Species and Protein Kinase B Pathway in Oral Cancer Cells

2021 ◽  
Vol 22 (14) ◽  
pp. 7509
Author(s):  
Hai Huang ◽  
Jun-Koo Yi ◽  
Su-Geun Lim ◽  
Sijun Park ◽  
Haibo Zhang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Cycle ◽  
Flow Cytometry ◽  
Oral Cancer ◽  
Cancer Cells ◽  
Reactive Oxygen ◽  
Migration And Invasion ◽  
Oxygen Species ◽  
Oral Cancer Cells

Oral cancer (OC) has been attracted research attention in recent years as result of its high morbidity and mortality. Costunolide (CTD) possesses potential anticancer and bioactive abilities that have been confirmed in several types of cancers. However, its effects on oral cancer remain unclear. This study investigated the potential anticancer ability and underlying mechanisms of CTD in OC in vivo and in vitro. Cell viability and anchorage-independent colony formation assays were performed to examine the antigrowth effects of CTD on OC cells; assessments for migration and invasion of OC cells were conducted by transwell; Cell cycle and apoptosis were investigated by flow cytometry and verified by immunoblotting. The results revealed that CTD suppressed the proliferation, migration and invasion of oral cancer cells effectively and induced cell cycle arrest and apoptosis; regarding the mechanism, CTD bound to AKT directly by binding assay and repressed AKT activities through kinase assay, which thereby downregulating the downstream of AKT. Furthermore, CTD remarkably promotes the generation of reactive oxygen species by flow cytometry assay, leading to cell apoptosis. Notably, CTD strongly suppresses cell-derived xenograft OC tumor growth in an in vivo mouse model. In conclusion, our results suggested that costunolide might prevent progression of OC and promise to be a novel AKT inhibitor.

scholarly journals RelA-Mediated BECN1 Expression Is Required for Reactive Oxygen Species-Induced Autophagy in Oral Cancer Cells Exposed to Low-Power Laser Irradiation

PLoS ONE ◽  
2016 ◽  
Vol 11 (9) ◽  
pp. e0160586 ◽  
Author(s):  
Chih-Wen Shu ◽  
Hong-Tai Chang ◽  
Chieh-Shan Wu ◽  
Chien-Hsun Chen ◽  
Sam Wu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Oral Cancer ◽  
Low Power ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Power Laser ◽  
Oral Cancer Cells

scholarly journals Reactive oxygen species mediate soft corals-derived sinuleptolide-induced antiproliferation and DNA damage in oral cancer cells

2017 ◽  
Vol Volume 10 ◽  
pp. 3289-3297 ◽  
Author(s):  
Yung-Ting Chang ◽  
Chiung-Yao Huang ◽  
Jen-Yang Tang ◽  
Chih-Chuang Liaw ◽  
Ruei-Nian Li ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Dna Damage ◽  
Oral Cancer ◽  
Cancer Cells ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Soft Corals ◽  
Oral Cancer Cells

A new biosafe reactive oxygen species (ROS)-responsive nanoplatform for drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (45) ◽  
pp. 38984-38989 ◽  
Author(s):  
Qing Li ◽  
Yong Wen ◽  
Jie Wen ◽  
Yun-Peng Zhang ◽  
Xiao-Ding Xu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Oral Cancer ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Rapid Release ◽  
Oral Cancer Cells

.A new ROS-responsive nanoplatform was deleveloped to load anticancer drug for oral cancer therapy. The ROS in cytoplasm can efficiently destroy the nanoplatform, leading to a rapid release of loaded drug and apoptosis of oral cancer cells.

Sign in / Sign up

Export Citation Format

Share Document