Adipokines as novel biomarkers of cardio-metabolic disorders

2020 ◽  
Vol 507 ◽  
pp. 31-38 ◽  
Author(s):  
Xin Su ◽  
Daoquan Peng
Keyword(s):  
Metabolic Disorders ◽  
Novel Biomarkers

Structural elucidation of novel biomarkers of known metabolic disorders based on multistage fragmentation mass spectra

2017 ◽  
Vol 41 (3) ◽  
pp. 407-414 ◽  
Author(s):  
Jan Václavík ◽  
Karlien L. M. Coene ◽  
Ivo Vrobel ◽  
Lukáš Najdekr ◽  
David Friedecký ◽  
...  
Keyword(s):  
Mass Spectra ◽  
Metabolic Disorders ◽  
Structural Elucidation ◽  
Novel Biomarkers

scholarly journals Which Role Plays 2-Hydroxybutyric Acid on Insulin Resistance?

Metabolites ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 835
Author(s):  
André P. Sousa ◽  
Diogo M. Cunha ◽  
Carolina Franco ◽  
Catarina Teixeira ◽  
Frantz Gojon ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Protein Metabolism ◽  
Metabolic Pathways ◽  
Chronic Condition ◽  
Metabolic Disorders ◽  
Cell Loss ◽  
Hydroxybutyric Acid ◽  
Novel Biomarkers

Type 2 Diabetes Mellitus (T2D) is defined as a chronic condition caused by beta cell loss and/or dysfunction and insulin resistance (IR). (1) Background: The discovering of novel biomarkers capable of identifying T2D and other metabolic disorders associated with IR in a timely and accurate way is critical. In this review, 2-hydroxybutyric acid (2HB) is presented as that upheaval biomarker with an unexplored potential ahead. Due to the activation of other metabolic pathways during IR, 2HB is synthesized as a coproduct of protein metabolism, being the progression of IR intrinsically related to the increasing of 2HB levels. Hence, the focus of this review will be on the 2HB metabolite and its involvement in glucose homeostasis. (2) Methods: A literature review was conducted, which comprised an examination of publications from different databases that had been published over the previous ten years. (3) Results: A total of 19 articles fulfilled the intended set of criteria. The use of 2HB as an early indicator of IR was separated into subjects based on the number of analytes examined simultaneously. In terms of the association between 2HB and IR, it has been established that increasing 2HB levels can predict the development of IR. (4) Conclusions: Thus, 2HB has demonstrated considerable promise as a clinical monitoring molecule, not only as an IR biomarker, but also for disease follow-up throughout IR treatment.

scholarly journals Hyocholic acid species as novel biomarkers for metabolic disorders

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Xiaojiao Zheng ◽  
Tianlu Chen ◽  
Aihua Zhao ◽  
Zhangchi Ning ◽  
Junliang Kuang ◽  
...  
Keyword(s):  
Metabolic Disorders ◽  
Gastric Bypass Surgery ◽  
Lower Serum ◽  
Obesity And Diabetes ◽  
Remission Of Diabetes ◽  
Novel Biomarkers ◽  
Prospective Cohorts ◽  
Human Blood And Urine ◽  
Hyocholic Acid ◽  
Separate Cohort

AbstractHyocholic acid (HCA) is a major bile acid (BA) species in the BA pool of pigs, a species known for its exceptional resistance to spontaneous development of diabetic phenotypes. HCA and its derivatives are also present in human blood and urine. We investigate whether human HCA profiles can predict the development of metabolic disorders. We find in the first cohort (n = 1107) that both obesity and diabetes are associated with lower serum concentrations of HCA species. A separate cohort study (n = 91) validates this finding and further reveals that individuals with pre-diabetes are associated with lower levels of HCA species in feces. Serum HCA levels increase in the patients after gastric bypass surgery (n = 38) and can predict the remission of diabetes two years after surgery. The results are replicated in two independent, prospective cohorts (n = 132 and n = 207), where serum HCA species are found to be strong predictors for metabolic disorders in 5 and 10 years, respectively. These findings underscore the association of HCA species with diabetes, and demonstrate the feasibility of using HCA profiles to assess the future risk of developing metabolic abnormalities.

Author response for "Serum exosomal microRNAs as novel biomarkers for multiple myeloma"

2019 ◽  
Author(s):  
Zhi‐yao Zhang ◽  
Yanchen Li ◽  
Chuan‐ying Geng ◽  
Huixing Zhou ◽  
Wen Gao ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Author Response ◽  
Novel Biomarkers

Plasminogen Activation in Diabetes Mellitus: Normalization of Blood Sugar Levels Improves Impaired Enzyme Kinetics In Vitro

1985 ◽  
Vol 54 (02) ◽  
pp. 413-414 ◽  
Author(s):  
Margarethe Geiger ◽  
Bernd R Binder
Keyword(s):  
Plasminogen Activator ◽  
Blood Sugar ◽  
Metabolic Disorders ◽  
Normal Values ◽  
Diabetic Patients ◽  
Type I ◽  
Plasminogen Activation ◽  
Lag Period ◽  
Sugar Levels

SummaryWe have demonstrated previously that fibrin enhanced plasmin formation by the vascular plasminogen activator was significantly impaired, when components isolated from the plasma of three uncontrolled diabetic patients (type I) were used to study plasminogen activation in vitro. In the present study it can be demonstrated that functional properties of the vascular plasminogen activators as well as of the plasminogens from the same three diabetic patients are significantly improved after normalization of blood sugar levels and improvement of HbAlc values. Most pronounced the Km of diabetic vascular plasminogen activator in the presence of fibrin returned to normal values, and for diabetic plasminogen the prolonged lag period until maximal plasmin formation occurred was shortened to almost control values. From these data we conclude that the observed abnormalities of in vitro fibrinolysis are not primarily associated with the diabetic disease, but might be secondary to metabolic disorders caused by diabetes.

Clinical, morphological and biochemical signs of polymycotoxicosis in highly productive cows

2020 ◽  
pp. 14-17
Author(s):  
Irina A. Shkuratova ◽  
◽  
Lyudmila I. Drozdova ◽  
Aleksander I. Belousov ◽  
Keyword(s):  
Metabolic Disorders ◽  
Hepatorenal Syndrome ◽  
Morphological Changes ◽  
Clinical Manifestations ◽  
The Body ◽  
Feed Mixture ◽  
Milk Productivity ◽  
Structural Disorders ◽  
Increased Sensitivity ◽  
Penicillium Spp

Mycotoxicological monitoring of forages shows that the problem of mycotoxicosis has been relevant for several decades. Minimal doses of mycotoxins in feed lead to a decrease in milk productivity, increased sensitivity to infectious and non-infectious diseases. When several mycotoxins enter the body simultaneously, a synergistic effect develops, causing a significant increase in toxicity. Feed contaminated with several types of fungi and their toxins is dangerous for dairy cattle. It was found that the feed mixture contained the types of associations of Aspergillus spp. fungi + Fusarium; Aspergillus spp. + Penicillium spp. + Mucor spp; Fusarium + Penicillium; Mucor spp. + Fusarium + Ustilaginales. Pathogenetic features of metabolic and morphological changes in highly productive cows with polymycotoxicosis were studied. Feeding food contaminated with various metabolites of mold fungi leads to the development of signs of chronic toxemia in animals. Clinical manifestations are the development of diarrhea and dehydration, with a decrease in milk productivity. Metabolic disorders feature the development of an inflammatory process, metabolic acidosis, hyperfermentonemia, with an increase in the amount of creatinine and urea in the blood serum. Metabolic signs indicate the development of hepatorenal syndrome due to structural disorders of the liver and kidneys. Histological signs of polymicotoxicosis are intracapillary and hemorrhagic glomerulonephritis, hepatocyte micronecrosis, and proliferation of connective tissue stroma cells, which leads to the development of atrophic cirrhosis in the interstitial and circular phases.

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