Recent progress in sensor arrays using nucleic acid as sensing elements

2022 ◽  
Vol 456 ◽  
pp. 214379
Author(s):  
Fang Pu ◽  
Jinsong Ren ◽  
Xiaogang Qu
Keyword(s):  
Nucleic Acid ◽  
Recent Progress ◽  
Sensor Arrays

Recent progress in flexible pressure sensor arrays: from design to applications

2018 ◽  
Vol 6 (44) ◽  
pp. 11878-11892 ◽  
Author(s):  
Jing Li ◽  
Rongrong Bao ◽  
Juan Tao ◽  
Yiyao Peng ◽  
Caofeng Pan
Keyword(s):  
Pressure Sensor ◽  
Recent Progress ◽  
Sensor Arrays ◽  
Device Applications ◽  
Flexible Pressure Sensor

This review summarizes the progress in flexible pressure sensor arrays from their fundamental designs to device applications.

scholarly journals Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy

Molecules ◽  
2019 ◽  
Vol 24 (3) ◽  
pp. 429 ◽  
Author(s):  
Sefan Asamitsu ◽  
Shunsuke Obata ◽  
Zutao Yu ◽  
Toshikazu Bando ◽  
Hiroshi Sugiyama
Keyword(s):  
Nucleic Acid ◽  
Secondary Structure ◽  
Recent Progress ◽  
Development Process ◽  
Protein Targeting ◽  
Molecular Probe ◽  
Drug Development Process ◽  
Quadruplex Structure ◽  
G4 Dna ◽  
G Quadruplex

A G-quadruplex (G4) is a well-known nucleic acid secondary structure comprising guanine-rich sequences, and has profound implications for various pharmacological and biological events, including cancers. Therefore, ligands interacting with G4s have attracted great attention as potential anticancer therapies or in molecular probe applications. To date, a large variety of DNA/RNA G4 ligands have been developed by a number of laboratories. As protein-targeting drugs face similar situations, G-quadruplex-interacting drugs displayed low selectivity to the targeted G-quadruplex structure. This low selectivity could cause unexpected effects that are usually reasons to halt the drug development process. In this review, we address the recent research on synthetic G4 DNA-interacting ligands that allow targeting of selected G4s as an approach toward the discovery of highly effective anticancer drugs.

Structural Mechanisms for Replicating DNA in Eukaryotes

2021 ◽  
Vol 90 (1) ◽  
Author(s):  
Ilan Attali ◽  
Michael R. Botchan ◽  
James M. Berger
Keyword(s):  
Nucleic Acid ◽  
Online Publication ◽  
Recent Progress ◽  
Molecular Machines ◽  
Cellular Process ◽  
Annual Review ◽  
Publication Date ◽  
Working Together ◽  
Protein Nucleic Acid ◽  
Structural Mechanisms

The faithful and timely copying of DNA by molecular machines known as replisomes depends on a disparate suite of enzymes and scaffolding factors working together in a highly orchestrated manner. Large, dynamic protein–nucleic acid assemblies that selectively morph between distinct conformations and compositional states underpin this critical cellular process. In this article, we discuss recent progress outlining the physical basis of replisome construction and progression in eukaryotes. Expected final online publication date for the Annual Review of Biochemistry, Volume 90 is June 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Surface-Enhanced Resonance Raman Scattering Spectral Probe Based on Functional Nucleic Acid and Nanoparticle

2013 ◽  
Vol 680 ◽  
pp. 145-148
Author(s):  
Qing Ye Liu ◽  
Gui Qing Wen ◽  
Fang Gui Ye ◽  
Ai Hui Liang
Keyword(s):  
Nucleic Acid ◽  
Raman Scattering ◽  
Recent Progress ◽  
Resonance Raman ◽  
Detection Technique ◽  
Resonance Raman Scattering ◽  
Highly Sensitive ◽  
Gold Silver ◽  
Surface Enhanced ◽  
Spectral Detection

Highly sensitive and selective surface-enhanced resonance Raman scattering (SERRS) spectral detection technique are developed by combining the functional nucleic acid (FNA) including aptamer and DNAzyme, and nanoparticle such as gold/silver (NG/NS) aggregation. The recent progress of SERRS was reviewed in this paper.

Nanoparticle-based optical sensor arrays

Nanoscale ◽  
2017 ◽  
Vol 9 (43) ◽  
pp. 16546-16563 ◽  
Author(s):  
Arafeh Bigdeli ◽  
Forough Ghasemi ◽  
Hamed Golmohammadi ◽  
Samira Abbasi-Moayed ◽  
M. Amin Farahmand Nejad ◽  
...  
Keyword(s):  
Optical Sensor ◽  
Recent Progress ◽  
Sensor Arrays ◽  
Wide Range

Recent progress in nanoparticle-based optical sensor arrays toward the detection and discrimination of a wide range of analytes.

Recent progress in microfluidic devices for nucleic acid and antibody assays

2003 ◽  
Vol 91 (6) ◽  
pp. 954-975 ◽  
Author(s):  
P.R. Selvaganapathy ◽  
E.T. Carlen ◽  
C.H. Mastrangelo
Keyword(s):  
Nucleic Acid ◽  
Recent Progress ◽  
Microfluidic Devices ◽  
Antibody Assays

scholarly journals Recent progress in non-native nucleic acid modifications

2021 ◽  
Vol 50 (8) ◽  
pp. 5126-5164 ◽  
Author(s):  
Luke K. McKenzie ◽  
Roberto El-Khoury ◽  
James D. Thorpe ◽  
Masad J. Damha ◽  
Marcel Hollenstein
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Genetic Information ◽  
Recent Progress ◽  
Vast Array ◽  
Synthetic Accessibility ◽  
Rna And Dna

While Nature harnesses RNA and DNA to store, read and write genetic information, the inherent programmability, synthetic accessibility and wide functionality of these nucleic acids make them attractive tools for use in a vast array of applications.

scholarly journals Application of Nucleic Acid Frameworks in the Construction of Nanostructures and Cascade Biocatalysts: Recent Progress and Perspective

2022 ◽  
Vol 9 ◽  
Author(s):  
Gan Zhu ◽  
Ping Song ◽  
Jing Wu ◽  
Minglan Luo ◽  
Zhipeng Chen ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Recent Progress ◽  
Cascade Reactions ◽  
Molecular Structures ◽  
Potential Contribution ◽  
Enzyme Systems ◽  
Structures And Properties ◽  
Living Organisms ◽  
Future Direction

Nucleic acids underlie the storage and retrieval of genetic information literally in all living organisms, and also provide us excellent materials for making artificial nanostructures and scaffolds for constructing multi-enzyme systems with outstanding performance in catalyzing various cascade reactions, due to their highly diverse and yet controllable structures, which are well determined by their sequences. The introduction of unnatural moieties into nucleic acids dramatically increased the diversity of sequences, structures, and properties of the nucleic acids, which undoubtedly expanded the toolbox for making nanomaterials and scaffolds of multi-enzyme systems. In this article, we first introduce the molecular structures and properties of nucleic acids and their unnatural derivatives. Then we summarized representative artificial nanomaterials made of nucleic acids, as well as their properties, functions, and application. We next review recent progress on constructing multi-enzyme systems with nucleic acid structures as scaffolds for cascade biocatalyst. Finally, we discuss the future direction of applying nucleic acid frameworks in the construction of nanomaterials and multi-enzyme molecular machines, with the potential contribution that unnatural nucleic acids may make to this field highlighted.

Recent progress of nucleic acid probes based on small molecules

2012 ◽  
Vol 42 (12) ◽  
pp. 1700-1716
Author(s):  
XiaoCheng WENG ◽  
Xiang ZHOU ◽  
Heng XIAO ◽  
Tian TIAN ◽  
ShaoRu WANG
Keyword(s):  
Nucleic Acid ◽  
Small Molecules ◽  
Recent Progress ◽  
Nucleic Acid Probes

Recent Progress in Self‐healing Materials for Sensor Arrays

ChemNanoMat ◽  
2020 ◽  
Vol 6 (11) ◽  
pp. 1522-1538
Author(s):  
Van‐Phu Vu ◽  
Le Hoang Sinh ◽  
Sung‐Hoon Choa
Keyword(s):  
Recent Progress ◽  
Sensor Arrays ◽  
Self Healing
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