Optimisation of takeaway delivery routes considering the mutual satisfactions of merchants and customers

2021 ◽  
Vol 162 ◽  
pp. 107728
Author(s):  
Ren Teng ◽  
Xu Hong-bo ◽  
Jin Kang-ning ◽  
Luo Tian-yu ◽  
Wang Ling ◽  
...  
Keyword(s):  
Delivery Routes

scholarly journals The Ocular Gene Delivery Landscape

Biomolecules ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1135
Author(s):  
Bhubanananda Sahu ◽  
Isha Chug ◽  
Hemant Khanna
Keyword(s):  
Gene Therapy ◽  
Genetic Diseases ◽  
Gene Therapies ◽  
Advantages And Disadvantages ◽  
Fda Approval ◽  
New Information ◽  
Efficient Delivery ◽  
Delivery Routes ◽  
History Of ◽  
Different Parts

The eye is at the forefront of developing therapies for genetic diseases. With the FDA approval of the first gene-therapy drug for a form of congenital blindness, numerous studies have been initiated to develop gene therapies for other forms of eye diseases. These examinations have revealed new information about the benefits as well as restrictions to using drug-delivery routes to the different parts of the eye. In this article, we will discuss a brief history of gene therapy and its importance to the eye and ocular delivery landscape that is currently being investigated, and provide insights into their advantages and disadvantages. Efficient delivery routes and vehicle are crucial for an effective, safe, and longer-lasting therapy.

Intraspinal drug delivery routes for treatment of chronic pain and spasticity

2003 ◽  
Vol 1 (4) ◽  
pp. 254-259 ◽  
Author(s):  
Leonardo Kapural ◽  
Alexandra Szabova ◽  
Nagy A Mekhail
Keyword(s):  
Drug Delivery ◽  
Chronic Pain ◽  
Delivery Routes

scholarly journals Transconjunctival versus Transcutaneous Injection of Botulinum Toxin into the Lacrimal Gland to Reduce Lacrimal Production: A Randomized Controlled Trial

Toxins ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 77
Author(s):  
Andrew G. Lee ◽  
Shin-Hyo Lee ◽  
Minsu Jang ◽  
Sang Jae Lee ◽  
Hyun Jin Shin
Keyword(s):  
Botulinum Toxin ◽  
Lacrimal Gland ◽  
Botulinum Toxin A ◽  
Controlled Trial ◽  
Clinical Effectiveness ◽  
Controlled Study ◽  
Randomized Controlled ◽  
Delivery Routes ◽  
Tear Meniscus Height

The purpose of this study was to determine and compare the effects between injecting botulinum toxin A (BTX-A) transconjunctivally into the palpebral lobe and transcutaneously into the orbital lobe of the lacrimal gland in patients with epiphora due to lacrimal outflow obstruction. This randomized controlled study included 53 eyes of 31 patients with unilateral or bilateral epiphora. Patients were randomly allocated to receive an injection of BTX-A (3 units) either transconjunctivally (n = 15, 25 eyes) or transcutaneously (n = 16, 28 eyes). For objective assessments, the tear meniscus height and Schirmer’s I test with topical anesthesia were measured at baseline and after 2, 6, 12, and 24 weeks of follow-up. Subjective evaluations were performed using the Munk score. After BTX-A injection, patients in both groups experienced significant objective and subjective reductions in tearing at all follow-up times compared to pre-injection (success rate 86.8%), and the effect lasted for a mean duration of 5.63 months. The two delivery routes showed similar clinical effectiveness for a single injected dose of BTX-A. In conclusion, injecting BTX-A via either a transconjunctival or transcutaneous route helps to reduce normal tear production and results in significant improvements in the symptoms in patients with epiphora.

Neo-Adjuvant chemotherapy for inoperable gastric cancer via local and general delivery routes (FLEP Therapy)

1994 ◽  
pp. 411-413 ◽  
Author(s):  
T. Nakajima ◽  
S. Ishihara ◽  
H. Motohashi ◽  
Y. Kitamura ◽  
Y. Nakajima ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Adjuvant Chemotherapy ◽  
Delivery Routes ◽  
Neo Adjuvant Chemotherapy

A Digital Twin for Decision Making on Livestock Feeding

2021 ◽  
Author(s):  
David Raba ◽  
Rafael D. Tordecilla ◽  
Pedro Copado ◽  
Angel A. Juan ◽  
Daniel Mount
Keyword(s):  
Decision Making ◽  
Cost Effective ◽  
Effective Solution ◽  
Digital Twin ◽  
Delivery Routes ◽  
Livestock Feeding

Looking for an accurate and cost-effective solution to measure feed inventories, forecast the feed demand and allow feed suppliers to optimize inventories, production batches, and delivery routes.

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