Two Cases of Meningitis Caused by Aggregatibacter Aphrophilus (Haemophilus Aphrophilus)

2012 ◽  
Vol 34 (22) ◽  
pp. 180-183
Author(s):  
Y.S. Schreiber ◽  
M. Gupta ◽  
P. Jessamine
Keyword(s):  
Aggregatibacter Aphrophilus ◽  
Haemophilus Aphrophilus

scholarly journals Reclassification of Actinobacillus actinomycetemcomitans, Haemophilus aphrophilus, Haemophilus paraphrophilus and Haemophilus segnis as Aggregatibacter actinomycetemcomitans gen. nov., comb. nov., Aggregatibacter aphrophilus comb. nov. and Aggregatibacter segnis comb. nov., and emended description of Aggregatibacter aphrophilus to include V factor-dependent and V factor-independent isolates

2006 ◽  
Vol 56 (9) ◽  
pp. 2135-2146 ◽  
Author(s):  
Niels Nørskov-Lauritsen ◽  
Mogens Kilian
Keyword(s):  
Type Strain ◽  
Aggregatibacter Actinomycetemcomitans ◽  
Actinobacillus Actinomycetemcomitans ◽  
Strain Atcc ◽  
Nicotinamide Phosphoribosyltransferase ◽  
Aggregatibacter Aphrophilus ◽  
The Family ◽  
Haemophilus Aphrophilus ◽  
Species Type

The aim of this study was to reinvestigate the relationships and the generic affiliations of the species Actinobacillus actinomycetemcomitans, Haemophilus aphrophilus, Haemophilus paraphrophilus and Haemophilus segnis. The nicotinamide phosphoribosyltransferase gene (nadV) conferring V factor-independent growth was identified in Haemophilus aphrophilus. The gene encodes a polypeptide of 462 amino acids that shows 74.5 % amino acid sequence identity to the corresponding enzyme from Actinobacillus actinomycetemcomitans. Ten isolates of Haemophilus paraphrophilus all carried a nadV pseudogene. DNA from Haemophilus aphrophilus was able to transform Haemophilus paraphrophilus into the NAD-independent phenotype. The transformants carried a full-length nadV inserted in the former locus of the pseudogene. The DNA–DNA relatedness between the type strains of Haemophilus aphrophilus and Haemophilus paraphrophilus was 77 %. We conclude that the division into two species Haemophilus aphrophilus and Haemophilus paraphrophilus is not justified and that Haemophilus paraphrophilus should be considered a later heterotypic synonym of Haemophilus aphrophilus. Forty strains of Actinobacillus actinomycetemcomitans, Haemophilus aphrophilus and Haemophilus segnis were investigated by multilocus sequence analysis. The 40 strains form a monophyletic group clearly separate from other evolutionary lineages of the family Pasteurellaceae. We propose the transfer of Actinobacillus actinomycetemcomitans, Haemophilus aphrophilus and Haemophilus segnis to a new genus Aggregatibacter gen. nov. as Aggregatibacter actinomycetemcomitans comb. nov. (the type species; type strain ATCC 33384T=CCUG 13227T=CIP 52.106T=DSM 8324T=NCTC 9710T), Aggregatibacter aphrophilus comb. nov. (type strain ATCC 33389T=CCUG 3715T=CIP 70.73T=NCTC 5906T) and Aggregatibacter segnis comb. nov. (type strain HK316T=ATCC 33393T=CCUG 10787T=CCUG 12838T=CIP 103292T=NCTC 10977T). The species of the genus Aggregatibacter are independent of X factor and variably dependent on V factor for growth in vitro.

scholarly journals An unusual case of multiple hepatic and pulmonary abscesses caused by Aggregatibacter aphrophilus in a young man: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Johannes Sumer ◽  
Sabine Haller ◽  
Mikael Sawatzki ◽  
Jan Kellner ◽  
Katia Boggian
Keyword(s):  
Unusual Case ◽  
Liver Enzymes ◽  
Hematogenous Spread ◽  
Chain Reaction ◽  
Case Presentation ◽  
Doxycycline Treatment ◽  
Aggregatibacter Aphrophilus ◽  
Haemophilus Aphrophilus ◽  
Polymerase Chain ◽  
Diagnostic Importance

Abstract Background Aggregatibacter aphrophilus, formerly known as Haemophilus aphrophilus, belongs to the HACEK organisms, a group of pathogens classically associated with infectious endocarditis. A. aphrophilus is a rarely found pathogen, though abscess formation in various organs has been described, typically due to spread from an infected heart valve. Here we describe the unusual case of multiple hepatic abscesses caused by A. aphrophilus. Case presentation A 33-year-old Caucasian man presented at our hospital with fever and malaise, elevated inflammatory markers, and liver enzymes. Imaging was compatible with multiple liver and pulmonary abscesses, without evidence of endocarditis. Cultures of blood and liver abscess material remained without growth. Polymerase chain reaction finally revealed Aggregatibacter aphrophilus in the liver tissue. The patient recovered fully within 6 weeks of doxycycline treatment. Conclusions There are only a few case descriptions of liver abscesses caused by A. aphrophilus. As a ubiquitous organism in the gastrointestinal tract, A. aphrophilus may reach the liver via the portal venous system, as well as through hematogenous spread from the oropharynx. HACEK organisms are notoriously difficult to grow on culture, which highlights the diagnostic importance of eubacterial PCR.

scholarly journals Complete Genome Sequence of Aggregatibacter (Haemophilus) aphrophilus NJ8700

2009 ◽  
Vol 191 (14) ◽  
pp. 4693-4694 ◽  
Author(s):  
Maria Pia Di Bonaventura ◽  
Rob DeSalle ◽  
Mihai Pop ◽  
Niranjan Nagarajan ◽  
David H. Figurski ◽  
...  
Keyword(s):  
Genome Sequence ◽  
Secretion System ◽  
Type Vi Secretion System ◽  
Dual Roles ◽  
Oral Flora ◽  
Aggregatibacter Aphrophilus ◽  
Type Vi Secretion ◽  
Genes Encoding ◽  
Health And Disease ◽  
Haemophilus Aphrophilus

ABSTRACT We report the finished and annotated genome sequence of Aggregatibacter aphrophilus strain NJ8700, a strain isolated from the oral flora of a healthy individual, and discuss characteristics that may affect its dual roles in human health and disease. This strain has a rough appearance, and its genome contains genes encoding a type VI secretion system and several factors that may participate in host colonization.

Severe Pulmonary Infection by Haemophilus aphrophilus in a Non-compromised Child

1985 ◽  
Vol 17 (3) ◽  
pp. 327-329
Author(s):  
Per Arneborn ◽  
Bo Lindquist ◽  
Lennart Sjöberg
Keyword(s):  
Pulmonary Infection ◽  
Haemophilus Aphrophilus

Aggregatibacter aphrophilus spinal epidural abscess

2020 ◽  
Vol 13 (7) ◽  
pp. e235320
Author(s):  
Antoine Altdorfer ◽  
Pierre Gavage ◽  
Filip Moerman
Keyword(s):  
Risk Factors ◽  
Lower Limb ◽  
Rare Case ◽  
Epidural Abscess ◽  
Spinal Epidural Abscess ◽  
Surgical Drainage ◽  
Eikenella Corrodens ◽  
Aggregatibacter Aphrophilus ◽  
Progressive Neurological Deficit ◽  
Spinal Epidural

A 76-year-old woman with a rare case of spinal epidural abscess (SEA) that had no risk factors for such type of infection, presented symptoms of back pain, progressive neurological deficit of the lower limb and loss of sphincter control. A gadolinium-enhanced MRI confirmed the diagnosis of an SEA. The patient underwent laminectomy with surgical drainage, where cultures showed the presence of Aggregatibacter aphrophilus, a bacterium of the HACEK group (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species), rarely involved in SEA. Following surgery, the patient was treated with intravenous ceftriaxone for 6 weeks, and this gave excellent results.

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