Effects of early nutritional support treatment before hospitalization on clinical outcomes in patients with solid organ tumors

2021 ◽  
Vol 46 ◽  
pp. S777
Author(s):  
C. Hu ◽  
H. Shi
Keyword(s):  
Clinical Outcomes ◽  
Nutritional Support ◽  
Solid Organ ◽  
Support Treatment

Effects of nutritional support on the clinical outcomes of well-nourished patients with cancer: a meta-analysis

2020 ◽  
Vol 74 (10) ◽  
pp. 1389-1400
Author(s):  
Xingxia Zhang ◽  
Xinrong Chen ◽  
Jie Yang ◽  
Yanjie Hu ◽  
Ka Li
Keyword(s):  
Clinical Outcomes ◽  
Nutritional Support ◽  
Meta Analysis ◽  
Patients With Cancer

The Impact of Health Literacy and Numeracy on Post-Transplantation Outcomes in Organ Transplant Recipients

2018 ◽  
Author(s):  
Mary Zhu
Keyword(s):  
Health Literacy ◽  
Clinical Outcomes ◽  
Self Efficacy ◽  
Organ Transplant ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Limited Health Literacy ◽  
Health Numeracy ◽  
Post Transplant ◽  
Limited Health

Background: Patients referred for solid organ transplant with limited health literacy have been shown to be less likely to have access to transplantation. We examined the association between health literacy, health numeracy and post-transplant clinical outcomes (i.e. graft failure, non-adherence, readmissions, self-efficacy, or mortality). Methods: A search of Medline for publications during the period January 1946 to July 2016 that examined health literacy, numeracy, and outcomes of transplant recipients. Titles and abstracts were independently examined by three reviewers for exclusion, and the full-text was then reviewed for inclusion. Results: Of 247 citations, 12 met inclusion criteria including one review article and five randomized control trials (RCTs). Health literacy of recipients was measured using Newest Vital Sign (NVS) (n=2),  Short Test of Functional Health Literacy in Adults (STOHFLA) (n=2), Rapid Estimate of Adult Literacy in Medicine (REALM-T) (n=1), and other knowledge questionnaires (n=5). Level of formal education was also examined as an assay of health literacy (n=3). Post-transplant outcomes were assessed through medication adherence (n=4), skin cancer incidence (n=2), graft loss (n=1), recipient mortality (n=1), kidney function (n=1), health-related quality of life (n=1), and self-efficacy (n=1). Eleven citations found limited health literacy to be associated with adverse post-transplant clinical outcomes, and one citation found no association between health literacy and non-adherence. Health numeracy was not studied in any of the citations. Conclusion: Health literacy is negatively associated with adverse post-transplant clinical outcomes. Future studies should analyze the association between health numeracy and clinical outcomes after transplant.

Effects of prognostic nutrition index on side effects and prognosis of radiotherapy and chemotherapy after radical gastrectomy.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e16002-e16002
Author(s):  
Jiyu Liu ◽  
Hongmin Dong ◽  
Wenling Wang ◽  
Gang Wang ◽  
Huan Pan ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Overall Survival ◽  
Side Effects ◽  
Nutritional Support ◽  
Gastrointestinal Surgery ◽  
Prognostic Nutritional Index ◽  
Survival Prognosis ◽  
The Impact ◽  
Prognostic Nutrition Index ◽  
Support Treatment

e16002 Background: To investigate the impact of preoperative prognostic nutritional index (PNI) on the severity of radiotherapy and chemotherapy toxicity and survival prognosis in patients with gastric cancer through retrospective analysis and research in order to guide clinical nutritional support treatment for patients with gastric cancer. Methods: Through a retrospective cohort study，we analyzed the data of 191 patients with gastric cancer in the Department of Gastrointestinal Surgery of the Affiliated Hospital of Guizhou Medical University and Guizhou Cancer Hospital from January 2008 to December 2018. According to the cut-off value, the patients were divided into high PNI group (PNI≥47.7) and low PNI group (PNI < 47.7). We Compared the incidences of severe radiotherapy and chemotherapy toxicities and overall survival in high PNI group and low PNI group. and make Analysis of prognostic factors. Results: The low PNI group was more prone to severe radiochemotherapy hematological side effects than the high PNI group, and the postoperative survival time was shorter. Multivariate analysis showed that: TNM stage (P = 0.000) and PNI (P = 0.001) were Independent risk factors in predicting overall survival rate. Conclusions: The preoperative prognostic nutrition index is a useful factor for predicting the incidence of radiotherapy and chemotherapy toxicities in patients after gastric cancer surgery.It is one of the important factors affecting the prognosis of gastric cancer and helps to guide the nutritional support treatment of gastric cancer patients.

Effect of malnutrition-driven nutritional support protocol on clinical outcomes in autologous stem cell transplantation patients

2020 ◽  
Vol 29 (2) ◽  
pp. 997-1003
Author(s):  
Heather Lazarow ◽  
Ryan Singer ◽  
Charlene Compher ◽  
Cheryl Gilmar ◽  
Colleen R. Kucharczuk ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Clinical Outcomes ◽  
Cell Transplantation ◽  
Autologous Stem Cell Transplantation ◽  
Nutritional Support

scholarly journals Screening of Nutritional Risk and Nutritional Support in General Surgery Patients: A Survey from Shanghai, China

2015 ◽  
Vol 100 (5) ◽  
pp. 841-848 ◽  
Author(s):  
Zhen-Yi Jia ◽  
Jun Yang ◽  
Da-Nian Tong ◽  
Jia-Yuan Peng ◽  
Zhong-Wei Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
At Risk ◽  
Clinical Outcomes ◽  
Support Group ◽  
Complication Rate ◽  
Nutritional Support ◽  
Nutritional Risk ◽  
Complication Rates ◽  
Lower Complication ◽  
Risk Patients

To determine the prevalence of nutritional risk in surgical departments and to evaluate the impact of nutritional support on clinical outcomes. The nutritional risk in different surgical diseases and the different way of nutritional support on clinical outcomes in patients at nutritional risk remain unclear. Hospitalized patients from general surgical departments were screened using the Nutritional Risk Screening (NRS) 2002 questionnaire on admission. Data were collected on nutritional risk, complications, and length of stay (LOS). Overall, 5034 patients were recruited; the overall prevalence of nutritional risk on admission were 19.2%. The highest prevalence was found among patients with gastric cancer. At-risk patients had more complications and longer LOS than nonrisk patients. Of the at-risk patients, the complication rate was significantly lower and LOS was significantly shorter in the nutritional-support group than in the no-support group (20.9 versus 30.0%, P &lt; 0.05). Subgroup analysis showed reduced complication rates and LOS only in patients with gastric cancer, colorectal cancer, and hepato-pancreato-biliary (HPB) cancer. Significantly lower complication rates relative to nonsupported patients were found among patients who received enteral nutrition or who received support for 5 to 7 days, or daily support entailing 16 to 25 kcal/kg of nonprotein energy. Different surgical diseases have different levels of nutritional risk. The provision of nutritional support was associated with a lower complication rate and a shorter LOS for gastric, colorectal, and HPB cancer patients at nutritional risk. The improper use of nutritional support may not improve outcomes for at-risk patients.

The impact of immune status on clinical outcomes in patients with Merkel cell carcinoma.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 8590-8590
Author(s):  
Sean Donovan ◽  
Amy Weaver ◽  
Clark Otley ◽  
Richard Wayne Joseph
Keyword(s):  
Cell Carcinoma ◽  
Clinical Outcomes ◽  
Merkel Cell Carcinoma ◽  
Clinical Characteristics ◽  
Immune Status ◽  
Cox Regression ◽  
Solid Organ ◽  
Merkel Cell ◽  
Stage 1 ◽  
The Impact

8590 Background: Merkel Cell Carcinoma (MCC) is an aggressive cutaneous malignancy of neuroendocrine origin associated with immunosuppression presumably through infection with Merkel Cell Polyomavirus present in >80% of patients (pts). The impact of immune status on clinical outcomes in pts with MCC is unknown. The primary objective of this study was to compare clinical characteristics and outcomes of pts with MCC who are immunosuppressed (ISP) versus non-immunosuppressed (non-ISP). Methods: We performed a retrospective chart review on pts with MCC diagnosed at the Mayo Clinic between 1981 and 2009. A dermatopathologist confirmed all cases. ISP was defined as pts diagnosed with chronic lymphocytic leukemia, HIV, solid organ transplant recipients, or chronic immunosuppressive medication. The association between ISP status and overall survival was summarized using the hazard ratio (HR) and 95% confidence interval (CI) estimated from a Cox regression model. Results: Of the 268 pts identified and included in the study, 38 (14%) were ISP. We found no differences in age, tumor size, tumor location, stage of disease, or recurrence rate in ISP vs Non-ISP. Among pts who had Stage 3-4 disease, there was no difference in the size of the primary between groups. Among pts with Stage 1-2 disease, ISP status was not significantly associated with poorer survival (HR 1.5, 95% CI 0.7-3.3). However, among pts with Stage 3-4 disease, ISP pts had significantly poorer survival compared to non-ISP pts (HR 2.7, 95% CI 1.2 - 6.2). Conclusions: Baseline clinical characteristics of pts with MCC do not differ based on immunosuppression, and outcomes do not differ in pts in regards to immunosuppression in early stage MCC (Stage 1-2). However, in pts with Stage III-IV MCC, ISP pts have a worse clinical outcome suggesting that metastatic MCC either behaves more aggressively in ISP pts either through intrinsic differences in the biology of the tumor or improved immune evasion in ISP pts. These results should be cautiously interpreted given the small number (n=12) of immunosuppressed pts with advanced stage MCC. The authors will update their data with an additional 58 patients by the date of presentation.

scholarly journals Effect of Early Nutritional Assessment and Nutritional Support on Immune Function and Clinical Prognosis of Critically Ill Children

2022 ◽  
Vol 2022 ◽  
pp. 1-7
Author(s):  
Jie Guo ◽  
Zixuan Jin ◽  
Yibing Cheng ◽  
Jun Su ◽  
Zheng Li ◽  
...  
Keyword(s):  
Immune Function ◽  
Clinical Outcomes ◽  
Critically Ill ◽  
Nutritional Support ◽  
Nutritional Assessment ◽  
Nutritional Risk ◽  
Critically Ill Children ◽  
Control Group ◽  
Clinical Prognosis ◽  
Experimental Group

The aim of this study was to study the effect of early nutritional assessment and nutritional support on immune function and clinical prognosis of critically ill children. 90 critically ill children at the same level of severity admitted to the pediatric intensive care unit (PICU) of our hospital (June 2019–June 2020) were chosen as the research objects and were equally separated into the experimental group and the control group by the random number table method. The children in the control group were admitted to the PICU according to the routine process, and the nutritional support was provided to the malnourished ones. After admission to the PICU, the children in the experimental group were given nutritional assessment, nutritional risk screening, and nutritional support according to the screening results. The PICU stay time and total hospitalization time of the experimental group were obviously shorter than those of the control group ( P < 0.05 ), the hospitalization expenses of the experimental group were obviously lower than those of the control group ( P < 0.05 ), the clinical outcomes and immune function of the experimental group were obviously better than those of the control group ( P < 0.05 ), and the nutrition indicators of the experimental group were obviously higher than those of the control group ( P < 0.05 ). Early nutritional assessment and nutritional support can effectively improve the immune function and reduce the incidence of adverse clinical outcomes of critically ill children, which are worthy of clinical application and promotion.

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