Novel nanotube/poly(ethylene-co-methacrylic acid)/epoxy composite adhesive possessing in-situ electrical-heating activated crack healing function

We present a facile method to measure Fickian diffusion coefficients of paramagnetic species in materials, using electron spin resonance (ESR) spectroscopy. The method requires no postannealing sample preparation, is adaptable to in situ measurement, and requires only that the spectrum of the paramagnetic species change monotonically with its local concentration. We illustrated this method with poly(ethylene-co-methacrylic acid) ionomers, using laminates prepared from the same copolymer neutralized with either paramagnetic Mn2+ or diamagnetic Zn2+. For Mn2+, the exchange interaction between neighboring Mn2+ caused the six-line hyperfine pattern to transform to a single broad signal, providing the measurement of local concentration. Diffusion coefficients of Mn2+ in this ionomer pair measured by ESR were compared with those for Zn2+ measured by conventional electron probe microanalysis and found to be in satisfactory agreement.

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In situ monitoring of specific adsorption processes of poly(ethylene glycol) at monolayers of poly(methacrylic acid)-based amphiphiles deposited on a quartz crystal microbalance

Journal of the Chemical Society Chemical Communications ◽

10.1039/c39950000637 ◽

1995 ◽

pp. 637 ◽

Cited By ~ 2

Author(s):

Masazo Niwa ◽

Katsuhiko Yokoyama ◽

Ai Fuchino ◽

Nobuyuki Higashi

Keyword(s):

Ethylene Glycol ◽

Quartz Crystal Microbalance ◽

Methacrylic Acid ◽

Quartz Crystal ◽

Specific Adsorption ◽

In Situ Monitoring ◽

Poly Ethylene Glycol ◽

Adsorption Processes ◽

Poly Ethylene

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Poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) Copolymers for the Formulation of In Situ Forming Depot Long-Acting Injectables

Pharmaceutics ◽

10.3390/pharmaceutics13050605 ◽

2021 ◽

Vol 13 (5) ◽

pp. 605

Author(s):

Marie-Emérentienne Cagnon ◽

Silvio Curia ◽

Juliette Serindoux ◽

Jean-Manuel Cros ◽

Feifei Ng ◽

...

Keyword(s):

Ethylene Glycol ◽

Surface Erosion ◽

Sustained Delivery ◽

Trimethylene Carbonate ◽

Poly Ethylene Glycol ◽

In Situ Forming ◽

Poly Ethylene ◽

Long Acting

This article describes the utilization of (methoxy)poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) ((m)PEG–PTMC) diblock and triblock copolymers for the formulation of in situ forming depot long-acting injectables by solvent exchange. The results shown in this manuscript demonstrate that it is possible to achieve long-term drug deliveries from suspension formulations prepared with these copolymers, with release durations up to several months in vitro. The utilization of copolymers with different PEG and PTMC molecular weights affords to modulate the release profile and duration. A pharmacokinetic study in rats with meloxicam confirmed the feasibility of achieving at least 28 days of sustained delivery by using this technology while showing good local tolerability in the subcutaneous environment. The characterization of the depots at the end of the in vivo study suggests that the rapid phase exchange upon administration and the surface erosion of the resulting depots are driving the delivery kinetics from suspension formulations. Due to the widely accepted utilization of meloxicam as an analgesic drug for animal care, the results shown in this article are of special interest for the development of veterinary products aiming at a very long-term sustained delivery of this therapeutic molecule.

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The Impact of Nano CaCO3 Modified in situ with Methacrylic Acid on the Structure and Properties of Natural Rubber

Journal of Wuhan University of Technology-Mater Sci Ed ◽

10.1007/s11595-020-2369-3 ◽

2020 ◽

Vol 35 (6) ◽

pp. 1169-1176

Author(s):

Zongqiang Zeng ◽

Yongzhen Li ◽

Chao Wang ◽

Pengfei Zhao

Keyword(s):

Natural Rubber ◽

Methacrylic Acid ◽

Structure And Properties ◽

The Impact

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Synthesis of Poly(methacrylic acid-co-butyl acrylate) Grafted onto Functionalized Carbon Nanotube Nanocomposites for Drug Delivery

Polymers ◽

10.3390/polym13040533 ◽

2021 ◽

Vol 13 (4) ◽

pp. 533 ◽

Cited By ~ 1

Author(s):

Josué A. Torres-Ávalos ◽

Leonardo R. Cajero-Zul ◽

Milton Vázquez-Lepe ◽

Fernando A. López-Dellamary ◽

Antonio Martínez-Richa ◽

...

Keyword(s):

Carbon Nanotubes ◽

Drug Delivery ◽

Methacrylic Acid ◽

Butyl Acrylate ◽

Chemical Vapor ◽

Vis Spectroscopy ◽

Ir And Raman Spectroscopies ◽

Ft Ir

Design of a smart drug delivery system is a topic of current interest. Under this perspective, polymer nanocomposites (PNs) of butyl acrylate (BA), methacrylic acid (MAA), and functionalized carbon nanotubes (CNTsf) were synthesized by in situ emulsion polymerization (IEP). Carbon nanotubes were synthesized by chemical vapor deposition (CVD) and purified with steam. Purified CNTs were analyzed by FE-SEM and HR-TEM. CNTsf contain acyl chloride groups attached to their surface. Purified and functionalized CNTs were studied by FT-IR and Raman spectroscopies. The synthesized nanocomposites were studied by XPS, 13C-NMR, and DSC. Anhydride groups link CNTsf to MAA–BA polymeric chains. The potentiality of the prepared nanocomposites, and of their pure polymer matrices to deliver hydrocortisone, was evaluated in vitro by UV–VIS spectroscopy. The relationship between the chemical structure of the synthesized nanocomposites, or their pure polymeric matrices, and their ability to release hydrocortisone was studied by FT-IR spectroscopy. The hydrocortisone release profile of some of the studied nanocomposites is driven by a change in the inter-associated to self-associated hydrogen bonds balance. The CNTsf used to prepare the studied nanocomposites act as hydrocortisone reservoirs.

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Bio-based polyurethane nanocomposite thin coatings from two comparable POSS with eight same vertex groups for controlled release urea

Scientific Reports ◽

10.1038/s41598-021-89254-9 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Lixia Li ◽

Meng Wang ◽

Xiandong Wu ◽

Wenping Yi ◽

Qiang Xiao

Keyword(s):

In Situ Polymerization ◽

Polyhedral Oligomeric Silsesquioxanes ◽

Poly Ethylene Glycol ◽

Thin Coatings ◽

Polyurethane Coatings ◽

Coated Urea ◽

Poly Ethylene ◽

Coated Fertilizer ◽

Polyurethane Matrix

AbstractNanocomposite modification has attracted much attention in improving properties of bio-based polymer coating material for coated fertilizer. Herein two comparable polyhedral oligomeric silsesquioxanes (POSS), with eight poly(ethylene glycol) (PEG) and octaphenyl groups attached to the cage, respectively, were successfully incorporated into thin castor oil-based polyurethane coatings via in-situ polymerization on the urea surface. The nanostructure coatings are environmentally friendly, easy to prepare, and property-tunable. The results show that the vertex group of POSS had a pronounced influence on dispersion level and interaction between polyurethane and POSS that well-tuned the release pattern and period of coated urea, even at the coating rate as low as of 2 wt%. The liquid POSS with long and flexible PEG groups had better compatibility and dispersibility in polyurethane matrix than the solid POSS with rigid octaphenyl groups, as evidenced by SEM/EDS. The unique properties were resulted from the different extents of physical crosslinkings. This modification of bio-based polyurethane coating with POSS provided an alternative method of regulating and controlling the properties of coated fertilizer.

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