New denture adhesive containing miconazole nitrate polymeric microparticles: Antifungal, adhesive force and toxicity properties

2017 ◽  
Vol 33 (2) ◽  
pp. e53-e61 ◽  
Author(s):  
Andrés Felipe Cartagena ◽  
Luís Antonio Esmerino ◽  
Rogerio Polak-Junior ◽  
Sibelli Olivieri Parreiras ◽  
Milton Domingos Michél ◽  
...  
Author(s):  
Jay Mamtora ◽  
Tripty Rahangdale ◽  
Prabha Shakya Newaskar ◽  
Nikita Agrawal ◽  
Saurabh Shrivastava ◽  
...  

Aims: The aim of current study is to evaluate adhesive force and qualitative mycological culture analysis of Denture adhesive (DA) after incorporating antifungal agent in various concentrations. Study Design: Experimental study. Place and Duration of Study: The current study was conducted at the Department of   Prosthodontics, Mansarovar Dental College and Hospital, Bhopal (M. P.) from September 2017 to October 2018. Methodology: A total of 80 specimens were prepared with heat cured acrylic resin, out of which 40 were used for qualitative anti-microbiological test, and 40 were used for Adhesive force measurement test. Both test had four groups: Group A (Control group DA without MN); Group B (DA+MN 10%); Group C (DA+MN 20%); and Group D (DA+MN 30%). Results: The mean zone of inhibition was 8.85 ± 0.28 mm for 10% w/w Miconazole Nitrate (MN), 12.95±0.30 mm for 20% w/w MN, and 22.25 ± 0.38 mm for 30% w/w MN. There was a statistically highly significant (P< .001) difference between the groups, with an F value of 1077.8. Conclusion: Within the limitation of the study qualitative anti-microbial property for favorable laboratory performance can be achieved only after the addition of 20% w/w Miconazole Nitrate to denture adhesive paste.


2020 ◽  
Author(s):  
Debayan Dasgupta ◽  
Dharma Pally ◽  
Deepak K. Saini ◽  
Ramray Bhat ◽  
Ambarish Ghosh

The dissemination of cancer is brought about by continuous interaction of malignant cells with their surrounding tissue microenvironment. Understanding and quantifying the remodeling of local extracellular matrix (ECM) by invading cells can therefore provide fundamental insights into the dynamics of cancer dissemination. In this paper, we use an active and untethered nanomechanical tool, realized as magnetically driven nanorobots, to locally probe a 3D tissue culture microenvironment consisting of cancerous and non-cancerous epithelia, embedded within reconstituted basement membrane (rBM) matrix. Our assay is designed to mimic the in vivo histopathological milieu of a malignant breast tumor. We find that nanorobots preferentially adhere to the ECM near cancer cells: this is due to the distinct charge conditions of the cancer-remodeled ECM. Surprisingly, quantitative measurements estimate that the adhesive force increases with the metastatic ability of cancer cell lines, while the spatial extent of the remodeled ECM was measured to be approximately 40 μm for all cancer cell lines studied here. We hypothesized and experimentally confirmed that specific sialic acid linkages specific to cancer-secreted ECM may be a major contributing factor in determining this adhesive behavior. The findings reported here can lead to promising applications in cancer diagnosis, quantification of cancer aggression, in vivo drug delivery applications, and establishes the tremendous potential of magnetic nanorobots for fundamental studies of cancer biomechanics.


2017 ◽  
Vol 14 (8) ◽  
Author(s):  
Andres Felipe Cartagena ◽  
Amanda Martinez Lyra ◽  
Aline Cristina Kapuchczinski ◽  
Amanda Migliorini Urban ◽  
Luis Antonio Esmerino ◽  
...  

Metals ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1021
Author(s):  
Mauro Andres Cerra Florez ◽  
Gemma Fargas Ribas ◽  
Jorge Luiz Cardoso ◽  
Antonio Manuel Mateo García ◽  
Joan Josep Roa Rovira ◽  
...  

Aging heat treatments in maraging steels are fundamental to achieve the excellent mechanical properties required in several industries, i.e., nuclear, automotive, etc. In this research, samples of maraging 300 alloy were aged using a novel procedure that combines different steps with two atmospheres (nitrogen and water vapor) for several hours. The oxidized surface layer was chemical, microstructural and micromechanically characterized. Due to the thermodynamic and kinetic conditions, these gases reacted and change the surface chemistry of this steel producing a thin iron-based oxide layer of a homogeneous thickness of around 500 nm. Within the aforementioned information, porosity and other microstructural defects showed a non-homogeneous oxide, mainly constituted by magnetite, nickel ferrite, cobalt ferrite, and a small amount of hematite in the more external parts of the oxide layer. In this sense, from a chemical point of view, the heat treatment under specific atmosphere allows to induce a thin magnetic layer in a mixture of iron, nickel, and cobalt spinel ferrites. On the other hand, the oxide layer presents an adhesive force 99 mN value that shows the capability for being used for tribological applications under sliding contact tests.


Materials ◽  
2021 ◽  
Vol 14 (4) ◽  
pp. 745 ◽  
Author(s):  
Weronika Prus-Walendziak ◽  
Justyna Kozlowska

This study aimed at designing emulsion films based on sodium alginate, gelatin, and glycerol, and their modification by the addition of lipids (cottonseed oil and beeswax). Film composition with the most promising properties was further modified by the incorporation of polylactide (PLA) microparticles with Calendula officinalis flower extract. PLA microspheres were obtained by the emulsion/solvent evaporation method. The size distribution of oily particles in emulsions was investigated. Mechanical properties, moisture content, UV-Vis spectra, and the color of films were analyzed, while biophysical skin parameters were assessed after their application to the skin. Moreover, the contact angles were measured, and the surface free energy of polymeric films was determined. An investigation of the amount of Calendula officinalis flower extract which can be incorporated into PLA microparticles was performed. The modification of the composition of films significantly influenced their physicochemical properties. The selected active ingredient in the form of plant extract was successfully incorporated into polymeric microparticles that were further added into the developed emulsion film. The condition of the skin after the application of obtained emulsion films improved. The prepared materials, especially containing microparticles with plant extract, can be considered for designing new cosmetic forms, such as cosmetic masks, as well as new topical formulations for pharmaceutical delivery.


2021 ◽  
Author(s):  
Amit K. Tripathi ◽  
John G. Tsavalas

Herein, we demonstrate a facile approach to fully transform spherical polymeric microparticles to elongated spherocylinders containing an internal cavity under ambient and mild stirring conditions. Critical to the process is...


2020 ◽  
Vol 982 ◽  
pp. 195-200
Author(s):  
Abdullah Al Mamun ◽  
Okan Sirin

Nanotechnology has contributed significantly to different subfields of the construction industry, including asphalt pavement engineering. The improved properties and new functionalities of the nanomaterials have provided different desired properties of asphalt. In this study, the effectiveness of multi-walled carbon nanotubes (MWCNT) in resisting the oxidation of polymer-modified asphalt was measured. A total of three different percentages (0.5%, 1%, and 1.5%) of MWCNT were used to modify the Styrene-Butadiene (SB) and styrene–butadiene–styrene (SBS) modified asphalt (4% and 5%). The laboratory oxidized asphalt samples were evaluated by an atomic force microscopy machine. The oxidation of the polymer-MWCNT modified asphalt is measured by simulating the existing functional group of the asphalt and as a function of the adhesive force. It is observed that the use of MWCNT in SB and SBS can increase the resistance to oxidation.


Sign in / Sign up

Export Citation Format

Share Document