Laboratory data on long-term sealing behaviors of two water-swelling materials for shield tunnel gasket

Lung hepatoid adenocarcinoma (HAC) is a rare primary lung carcinoma pathologically characterized by hepatocellular carcinoma-like tumor cells, the majority of which produce alpha-fetoprotein (AFP). The clinical prognosis of lung HAC is generally poor, and effective therapeutic regimens for inoperable or recurrent cases have not been established. Here, we report a case of AFP-producing lung HAC with brain metastasis with long-term disease control, treated with the 5-fluorouracil-derived regimen S-1. The patient was a 66-year-old male admitted to the hospital with alexia. Chest X-ray revealed a massive tumor in the left upper lobe, and a head CT scan revealed a metastasis in the left parietal lobe. The laboratory data showed a remarkably elevated AFP level (97,561 ng/mL). Pathological assessment of the resected brain tumor revealed HAC, which was compatible with the lung biopsies. Together with the absence of other metastatic lesions, a final diagnosis of primary lung HAC, stage IV T4N3M1b, was given. The patient first underwent non-small cell lung cancer chemotherapy regimens (carboplatin and paclitaxel as the first line, and pemetrexed as the second line), but had clinical progression. After third-line oral S-1 (tegafur/gimeracil/oteracil) administration, the serum AFP level significantly dropped and the patient achieved long-term disease control without relapse, surviving more than 19 months after disease presentation. The autopsy result was consistent with the diagnosis of primary lung HAC, and immunohistochemical staining was AFP+, glypican 3+, and spalt-like transcription factor 4+. Here, we report the case of a rare primary lung HAC with apparent disease control on S-1 therapy, together with a literature review.

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THALIDOMIDE FOR PATIENTS WITH THALASSEMIA INTERMEDIA: A RETROSPECTIVE MULTICENTER CLINICAL STUDY

Mediterranean Journal of Hematology and Infectious Diseases ◽

10.4084/mjhid.2020.021 ◽

2020 ◽

Vol 12 (1) ◽

pp. e2020021

Author(s):

Kun Yang ◽

Yi Wu ◽

Yali Zhou ◽

Tianhong Zhou ◽

Li Wang ◽

...

Keyword(s):

Blood Transfusion ◽

Laboratory Data ◽

Drug Discontinuation ◽

Therapeutic Effects ◽

Efficacy And Safety ◽

Thalassemia Intermedia ◽

Short Term ◽

Long Term Follow Up

Objective: This study focused on the efficacy and safety of thalidomide for patients with thalassemia intermedia (TI) in a multicenter trial. Methods：Clinical and laboratory data of 62 patients subjected to thalidomide therapy in four centers were retrospectively analyzed. We evaluated the efficacy and safety of thalidomide in the short-term (three months) and long-term follow-up (12 and 24 months). Response to thalidomide was defined as follows: Main Responder (MaR) showing an increase in Hb level of >2.0 g/dl or removal from blood transfusion and Minor Responder (MiR) achieving elevated hemoglobin (Hb) level of 1.0-2.0 g/dl or ≥50% reduction in blood transfusion frequency. Results：The overall response rate (ORR) of 62 patients with TI was 93.5% (58/62), with MaR and MiR rates accounting for 62.9% (39/62) and 30.6% (19/62) in short-term follow-up and 66.1% (41/62) and 27.4% (17/62) in long-term follow-up, respectively. The clinical response during long-term follow-up was maintained and the Hb level remained stable during the observation period. The response was still observed in patients with dose reduction despite a slight decrease in Hb level. However, Hb decreased rapidly to the baseline level after drug discontinuation. No effect of thalidomide on spleen size in nonsplenectomized patients was evident. Minimal side-effects were documented throughout, except peripheral neurotoxicity in one patient. Nevertheless, the mean serum ferritin (SF) level was significantly increased after treatment. Conclusion: Thalidomide had significant therapeutic effects on patients with TI, and the response was sustained with acceptable short-term and long-term adverse reactions. While these preliminary results support the potential long-term efficacy and safety of thalidomide as a therapeutic agent for TI, several issues need to be addressed before its application in the clinic.

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Impact of first-wave COronaVIrus disease 2019 infection in patients on haemoDIALysis in Alsace: the observational COVIDIAL study

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfaa170 ◽

2020 ◽

Vol 35 (8) ◽

pp. 1338-1411 ◽

Cited By ~ 3

Author(s):

Nicolas Keller ◽

François Chantrel ◽

Thierry Krummel ◽

Dorothée Bazin-Kara ◽

Anne Laure Faller ◽

...

Keyword(s):

Laboratory Data ◽

Case Fatality ◽

Patient Characteristics ◽

Complete Recovery ◽

High Rate ◽

Atypical Symptoms ◽

Reactive Protein ◽

Risk Of Death ◽

Included Patient

Abstract Background There are only scarce data regarding the presentation, incidence, severity and outcomes of coronavirus disease 2019 (COVID-19) in patients undergoing long-term haemodialysis (HD). A prospective observational study was conducted in eight HD facilities in Alsace, France, to identify clinical characteristics of HD patients with COVID-19 and to assess the determinants of the risk of death. Methods All HD patients tested positive for COVID-19 from 5 March to 28 April 2020 were included. Collected data included patient characteristics, clinical features at diagnosis, laboratory data, treatments and outcomes. Results Among 1346 HD patients, 123 tested positive for COVID-19. Patients had a median age of 77 years (interquartile range 66–83), with a high number of comorbidities (3.2 ± 1.6 per patient). Symptoms were compatible in 63% of patients. Asthenia (77%), diarrhoea (34%) and anorexia (32%) were frequent at diagnosis. The delay between the onset of symptoms and diagnosis, death or complete recovery was 2 (0–5), 7 (4–11) and 32 (26.5–35) days, respectively. Treatment, including lopinavir/ritonavir, hydroxychloroquine and corticosteroids, was administered in 23% of patients. The median C-reactive protein (CRP) and lymphocyte count at diagnosis was 55 mg/L (IQR 25–106) and 690 Ly/µL (IQR 450–960), respectively. The case fatality rate was 24% and determinants associated with the risk of death were body temperature {hazard ratio [HR] 1.96 [95% confidence interval (CI) 1.11–3.44]; P = 0.02} and CRP at diagnosis [HR 1.01 (95% CI 1.005–1.017); P < 0.0001]. Conclusions HD patients were found to be at high risk of developing COVID-19 and exhibited a high rate of mortality. While patients presented severe forms of the disease, they often displayed atypical symptoms, with the CRP level being highly associated with the risk of death.

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Modeling of Production Decline Caused by Fines Migration in Deepwater Reservoirs

SPE Journal ◽

10.2118/187263-pa ◽

2019 ◽

Vol 25 (01) ◽

pp. 391-405

Author(s):

Yunhui Tan ◽

Yan Li ◽

Margaretha C. M. Rijken ◽

Karim Zaki ◽

Bin Wang ◽

...

Keyword(s):

Flow Velocity ◽

Critical Velocity ◽

Laboratory Data ◽

Permeability Reduction ◽

Fines Migration ◽

The Core ◽

Decline Rate ◽

Reduction Function ◽

Reservoir Simulator

Summary Many deepwater wells experience steep productivity declines. Some field observations indicate that this decline is partly attributable to fines-migration effects. In this paper, we present a numerical workflow to simulate the effect (over time) of flow-induced fines migration on production decline in deepwater reservoirs. A permeability-reduction function was extracted from long-term coreflood tests and implemented into a reservoir simulator. Using the permeability-reduction function, production degradation caused by fines migration was simulated in a detailed single-well model. From previous research, it was understood that fines migration does not start until the flow velocity is greater than the critical velocity. After many long-term coreflood tests, or extended fines-migration (EFM) tests, we concluded that the permeability damage induced by fines migration is a function of the pore-volume (PV) throughput (fluid volume flowing through the core divided by the PV of the core). To address these observations, the numerical model was updated such that the interstitial flow velocity was tracked in each individual cell. When the interstitial velocity is greater than the critical velocity, the cell's permeability follows the permeability-reduction trend obtained from laboratory data. Validation of the workflow is performed using a cylinder model to match the laboratory test core-plug data. A detailed 3D model was constructed to study the fines-migration effect in each part of the near-wellbore (e.g., perforation, fracture) region and the reservoir. As expected, fines migration started near the perforation where the flow velocity was the highest. Depending on the permeability-decline rate, the production asymptotes eventually reached a constant value after a certain period. Both the decline rate and the ultimate residual permeability had a strong effect on the final production. Sensitivities were run to study the effect of fines migration in different completions. To the authors’ understanding, this is the first time that laboratory-based fines-migration data were incorporated into a reservoir simulator to predict the production decline using experiment-based fines-migration functions. This workflow will help reservoir engineers predict the damage caused by fines migration, predict production decline, and plan for remediation.

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Natural Analogues: Alamosa River Monzonite Intrusive into Tuffaceous and Andesitic Rocks

MRS Proceedings ◽

10.1557/proc-15-299 ◽

1982 ◽

Vol 15 ◽

Author(s):

D. G. Brookins ◽

M. S. Abashian ◽

L. H. Cohen ◽

A. E. Williams ◽

H. A. Wollenberg ◽

...

Keyword(s):

Fission Product ◽

Conceptual Models ◽

Laboratory Data ◽

Hydrothermal Systems ◽

Rock Matrix ◽

Natural Processes ◽

Natural Analogues ◽

Time Periods ◽

Over Time

This project encompasses investigations of selected natural analogues of minerals and rocks containing radioelements and fission-product elements, to ascertain how radionuclides and their daughter elements may migrate from sites of origin in response to long-term natural processes such as heating due to an igneous intrusion, circulating hydrothermal systems, diffusion through the rock matrix, weathering and erosion. Comparison of natural occurrences with conceptual models based on laboratory data will furnish a test of such models over time periods comparable to or longer than those expected for a repository.

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Chlamydia retesting and retest positivity rates: results from a state-wide laboratory data linkage study in Tasmania, 2012–13

Sexual Health ◽

10.1071/sh16137 ◽

2017 ◽

Vol 14 (3) ◽

pp. 261 ◽

Cited By ~ 1

Author(s):

Nicola Stephens ◽

David Coleman ◽

Kelly Shaw ◽

Maree O'Sullivan ◽

Alistair McGregor ◽

...

Keyword(s):

Data Linkage ◽

Safer Sex ◽

Laboratory Data ◽

Partner Notification ◽

Linkage Study ◽

Chlamydia Infection ◽

Socioeconomic Indicators ◽

Safer Sex Practices ◽

Positive Results

Background Chlamydia re-infection increases the likelihood of adverse long-term sequelae. Clinical guidelines recommend retesting at 3–12 months for individuals with positive results, to detect re-infections. Retesting and test positivity levels were measured in young people who previously tested positive for chlamydia infection. Methods: All chlamydia tests conducted during 2012–13 in Tasmanian residents aged 15–29 years were linked. Retesting and retest positivity rates were calculated by sex, age, socioeconomic indicators and test timeframe. Results: Retesting rates were higher in females than males at 3 months (14.5%, n = 242/1673 vs 10%, n = 71/721) (P < 0.01) and 12 months (27%, 265/968 vs 24%, 98/410) (P = 0.24). The retesting rate was higher in females living in areas of most disadvantage (35.5%, 154/434) compared with areas of middle and least disadvantage (26% 139/534) (P < 0.01). Males were more likely than females to retest positive at 3 months (35%, 25/71 vs 23%, 55/242) (P < 0.01); retest positivity at 12 months was 32% in both sexes (males 98/140; females 265/968). Retest positivity was higher in males living in areas of least disadvantage (43%, 3/7) compared with middle (24%, 16/67) (P = 0.27) and most (27%, 10/37) (P = 0.09); and higher in females living in areas of least disadvantage (39%, 7/18) compared with middle (24%, 29/121) (P < 0.01) and most (31%, 48/154) (P = 0.02). Conclusions: Retesting rates are low in Tasmania and retest positivity is high, reinforcing the importance of promoting safer sex practices, partner notification and treatment, and retesting.

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Natural Analogues: Their Application to the Prediction of the Long-Term Behavior of Nuclear Waste Forms

MRS Proceedings ◽

10.1557/proc-84-67 ◽

1986 ◽

Vol 84 ◽

Cited By ~ 22

Author(s):

Rodney C. Ewing ◽

Michael J. Jercinovic

Keyword(s):

Nuclear Waste ◽

Borosilicate Glass ◽

Large Scale ◽

Laboratory Data ◽

Waste Form ◽

Long Time ◽

Natural Analogues ◽

Long Term Behavior ◽

Nuclear Waste Forms

AbstractOne of the unique and scientifically most difficult aspects of nuclear waste isolation is the extrapolation ofshot-term laboratory data (hours to years) to the long time periods (103-105 years) required by regulatory agencies for performance assessment. The direct verification of these extrapolations is not possible, but methods must be developed to demonstrate compliance with government regulations and to satisfy the lay public that there is a demonstrable and reasonable basis for accepting the long-term extrapolations. Natural analogues of both the repository environment (e.g. radionuclide migration at Oklo) and nuclear waste form behavior (e.g. alteration of basaltic glasses and radiation damage in minerals) have been used to demonstrate the long-term behavior of large scale geologic systems and, on a smaller scale, waste form durability. This paper reviews the use of natural analogues to predict the long-term behavior of nuclear waste form glasses. Particular emphasis is placed on the inherent limitations of any conclusions that are based on “proof” by analogy. An example -- corrosion of borosilicate glass -- is discussed in detail with specific attention to the proper and successful use of natural analogues (basaltic glass) in understanding the long-term corrosion behavior of borosilicate glass.

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The Role of Ischemia-modified Albumin as a Biomarker in Preeclampsia

Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics ◽

10.1055/s-0040-1709662 ◽

2020 ◽

Vol 42 (03) ◽

pp. 133-139

Author(s):

Süleyman Serkan Karaşin ◽

Tayfur Çift

Keyword(s):

Pregnant Women ◽

Laboratory Data ◽

Cross Sectional Study ◽

Enzyme Linked Immunosorbent Assay ◽

Cross Sectional ◽

Ischemia Modified Albumin ◽

Significant Difference ◽

Gestational Week ◽

Severity Of The Disease

Abstract Objective Ischemia-modified albumin (IMA)is a modified type of albumin protein that is formed under oxidative stress. This study aims to compare the levels of serum IMA between normotensive and preeclamptic pregnancies and to evaluate the relationship between the severity of the disease. Methods A total of 90 pregnant women aged between 18 and 45 years participated in this cross-sectional study. The levels of serum IMA were measured by enzyme-linked immunosorbent assay in 30 preeclamptic pregnant women with the severe signs of the disease, 30 preeclamptic pregnant women, and 30 normotensive pregnant women.. The study was designed as a cross-sectional clinical study. Results When the demographic characteristics were examined, statistically significant differences were found between the groups in terms of age, gestational week at birth and blood pressure. Age was higher in the preeclampsia with signs of severity group than in the normotensive group (p = 0.033). Pregnancy week was significantly the lowest in the preeclampsia with the severity signs group (p = 0.004). In normotensive patients, IMA levels were lower than in the preeclampsia groups (p < 0.001) but there was no significant difference in terms of severity of disease (p = 0.191). According to laboratory data; only the creatinine level was significantly different between the groups. Conclusion The levels of serum IMA were higher in patients with preeclampsia than in healthy pregnancies. However, there was no significant correlation in terms of preeclampsia severity; more extensive, prospective and long-term studies are needed.

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A model of dislocation-controlled rheology for the mantle

Philosophical Transactions of the Royal Society of London. Series A, Mathematical and Physical Sciences ◽

10.1098/rsta.1981.0025 ◽

1981 ◽

Vol 299 (1449) ◽

pp. 319-356 ◽

Cited By ~ 154

Keyword(s):

Steady State ◽

Absorption Band ◽

Laboratory Data ◽

Tectonic Stress ◽

Seismic Attenuation ◽

Steady State Creep ◽

Dominant Factor ◽

Total Strength ◽

Self Diffusion

The dislocation microstructure of mantle materials can account simultaneously for long-term steady-state creep, and for stress wave attenuation at seismic frequencies. The hypothesis that a single microstructural model explains therheology for characteristic times ranging from 1 to 1010 seconds can be used to restrict the class of permissible rheological models for the mantle. W e review steady-state dislocation dam ping models in order of increasing complexity, and reject those which do not satisfy laboratory data or geophysical constraints. This elimination procedure leads us to consider an organized microstructure, in which most dislocations are found inside subgrain walls. The cells contain relatively few dislocation links. These are free to bow under small, i.e. seismic, stresses. The time constant of this mechanism is controlled either by the diffusion of kinks or of point defects bound to the dislocation line. The glide of intragrain dislocations explains the m agnitude and frequency range of seismic attenuation. Steady-state creep is governed by recovery through climb and annihilation in cell walls. Under conditions of jog undersaturation, climb is controlled by jog formation in addition to self-diffusion, and the model requires a higher creep activation energy than for self-diffusion, in agreement w th observations on olivine. Quantitative agreement with laboratory data is achieved if the density of cell-wall dislocations is one to two orders of magnitude higher than the density of intracell dislocations. Self-diffusion is probably controlled by silicon diffusion at low pressure and by oxygen diffusion at high pressure. T he long-term tectonic stress is the dominant factor determining scale lengths; as a result, the total strength of the relaxation associated with bowing of intracell dislocation links is fixed by the geometry and is of the order of 10 % . This limits the width of the seismic absorption band to 2 -3 decades in frequency for each mantle mineral. T he actual position of the seismic absorption band is determined primarily as a result of a trade-off between temperature, pressure and tectonic stress. This model provides a physical framework within which the quality factor and viscosity are related via the dislocation microstructure.

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