Loss of naive T lymphocytes is associated with advanced liver fibrosis in alcohol use disorder

2020 ◽  
Vol 213 ◽  
pp. 108046 ◽  
Author(s):  
Paola Zuluaga ◽  
Arantza Sanvisens ◽  
Aina Teniente-Serra ◽  
Oumaima El Ars ◽  
Daniel Fuster ◽  
...  
Keyword(s):  
Alcohol Use ◽  
T Lymphocytes ◽  
Liver Fibrosis ◽  
Alcohol Use Disorder ◽  
Advanced Liver Fibrosis ◽  
Naive T Lymphocytes

Do serum markers of liver fibrosis vary by HCV infection in patients with alcohol use disorder?

2018 ◽  
Vol 188 ◽  
pp. 180-186 ◽  
Author(s):  
Arantza Sanvisens ◽  
Alvaro Muñoz ◽  
Ferran Bolao ◽  
Paola Zuluaga ◽  
Magí Farré ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Liver Fibrosis ◽  
Alcohol Use Disorder ◽  
Serum Markers ◽  
Hcv Infection

scholarly journals Zinc deficiency and advanced liver fibrosis among HIV and hepatitis C co-infected anti-retroviral naïve persons with alcohol use in Russia

PLoS ONE ◽  
2019 ◽  
Vol 14 (6) ◽  
pp. e0218852 ◽  
Author(s):  
Joshua A. Barocas ◽  
Kaku So-Armah ◽  
Debbie M. Cheng ◽  
Dmitry Lioznov ◽  
Marianna Baum ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Alcohol Use ◽  
Liver Fibrosis ◽  
Zinc Deficiency ◽  
Advanced Liver Fibrosis

Alcohol use disorder and liver fibrosis - cases are missed through failure to test

2020 ◽  
Vol 73 ◽  
pp. S176-S177
Author(s):  
Freya Rhodes ◽  
Sara Cococcia ◽  
Declan Connoley ◽  
Preya Patel ◽  
William Rosenberg
Keyword(s):  
Alcohol Use ◽  
Liver Fibrosis ◽  
Alcohol Use Disorder

scholarly journals Markers of Monocyte Activation, Inflammation, and Microbial Translocation Are Associated with Liver Fibrosis in Alcohol Use Disorder

2021 ◽  
Vol 10 (16) ◽  
pp. 3496
Author(s):  
Daniel Fuster ◽  
Xavier Garcia-Calvo ◽  
Oriol Farré ◽  
Paola Zuluaga ◽  
Ferran Bolao ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Liver Fibrosis ◽  
Alcohol Use Disorder ◽  
Binding Protein ◽  
Correlation Coefficients ◽  
Microbial Translocation ◽  
Monocyte Activation ◽  
Protein Levels ◽  
Markers Of Inflammation ◽  
Lps Binding

Background: The association between markers of inflammation (interleukin (IL)-6 and IL-10), monocyte activation (sCD163 and sCD14), and microbial translocation (lipopolysaccharide (LPS) and LPS binding protein) and liver fibrosis in patients with alcohol use disorder (AUD) and no overt liver disease is not well established. Methods: We studied patients admitted for treatment of AUD at two hospitals in Barcelona. Advanced liver fibrosis (ALF) was defined as FIB-4 > 3.25. Results: A total of 353 participants (76.3% male) were included and 94 (26.5%) had ALF. In adjusted correlation analyses, sCD163, sCD14, IL-6, IL-10, and LPS binding protein levels directly correlated with FIB-4 values (adjusted correlation coefficients 0.214, 0.452, 0.317, 0.204, and 0.171, respectively). However, LPS levels were inversely associated with FIB-4 (−0.283). All plasma marker levels in the highest quartile, except LPS, were associated with ALF (sCD163, sCD14, IL-6, IL-10, and LPS binding protein: adjusted odds ratio (aOR) 11.49 (95% confidence interval 6.42–20.56), 1.87 (1.11–3.16), 2.99 (1.79–5.01), 1.84 (1.11–3.16), and 2.13 (1.30–3.50), respectively). Conversely, LPS levels in the lowest quartile were associated with ALF (aOR 2.58 (1.48–4.58), p < 0.01). Conclusion: In AUD patients, plasma levels of the markers of inflammation, monocyte activation, and microbial translocation are associated with ALF.

scholarly journals Association of hyperuricemia and gamma glutamyl transferase as a marker of metabolic risk in alcohol use disorder

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Anna Hernández-Rubio ◽  
Arantza Sanvisens ◽  
Ferran Bolao ◽  
Clara Pérez-Mañá ◽  
Nuria García-Marchena ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Age Of Onset ◽  
Critical Role ◽  
Gamma Glutamyl Transferase ◽  
Metabolic Risk ◽  
Excessive Alcohol Consumption ◽  
Advanced Liver Fibrosis ◽  
Glutamyl Transferase

AbstractExcessive alcohol consumption leads to overproduction of urates and renal function plays a critical role in serum uric acid levels. We aimed to assess associations of hyperuricemia in patients with alcohol use disorder (AUD) and comparable Glomerular Filtration Rate (GFR). A total of 686 patients undergoing treatment for AUD between 2013 and 2017 were eligible (77% men); age at admission was 47 years [interquartile range (IQR), 40–53 years], age of onset of alcohol consumption was 16 years [IQR, 16–18 years] and the amount of alcohol consumed was 160 g/day [IQR, 120–240 g/day]. Body Mass Index was 24.7 kg/m2 [IQR, 21.9–28.4 kg/m2], eGFR was 105 mL/min/1.73 m2 [IQR, 95.7–113.0 mL], 9.7% had metabolic syndrome and 23% had advanced liver fibrosis (FIB-4 > 3.25). Prevalence of hyperuricemia was 12.5%. The eGFR-adjusted multivariate analysis showed that relative to patients with GGT ≤ 50, those with GGT between 51 and 300 U/L and those with GGT > 300 U/L were 4.31 (95% CI 1.62–11.46) and 10.3 (95% CI 3.50–29.90) times more likely to have hyperuricemia, respectively. Our data shows that hyperuricemia in the context of AUD is strongly associated with serum GGT levels and suggest an increased cardio-metabolic risk in this population.

Tu1625 NON-INVASIVE TECHNIQUES FOR SCREENING OF SIGNIFICANT LIVER FIBROSIS AND STEATOSIS IN PATIENTS WITH ALCOHOL USE DISORDER

2020 ◽  
Vol 158 (6) ◽  
pp. S-1437
Author(s):  
Camelia G. Foncea ◽  
Alina Popescu ◽  
Raluca Lupusoru ◽  
Tudor V. Moga ◽  
Mirela Danila ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Liver Fibrosis ◽  
Alcohol Use Disorder ◽  
Non Invasive ◽  
Invasive Techniques ◽  
Significant Liver Fibrosis

DSM-5 alcohol use disorder features among treatment-seeking older adults

2018 ◽  
Vol 64 (4) ◽  
pp. 185-196 ◽  
Author(s):  
Silke Behrendt ◽  
Barbara Braun ◽  
Randi Bilberg ◽  
Gerhard Bühringer ◽  
Michael Bogenschutz ◽  
...  
Keyword(s):  
Older Adults ◽  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
The Elderly ◽  
Treatment Seeking ◽  
Controlled Clinical Trial ◽  
Dsm 5 ◽  
Wide Range ◽  
And Gender ◽  
International Multicenter

Abstract. Background: The number of older adults with alcohol use disorder (AUD) is expected to rise. Adapted treatments for this group are lacking and information on AUD features in treatment seeking older adults is scarce. The international multicenter randomized-controlled clinical trial “ELDERLY-Study” with few exclusion criteria was conducted to investigate two outpatient AUD-treatments for adults aged 60+ with DSM-5 AUD. Aims: To add to 1) basic methodological information on the ELDERLY-Study by providing information on AUD features in ELDERLY-participants taking into account country and gender, and 2) knowledge on AUD features in older adults seeking outpatient treatment. Methods: baseline data from the German and Danish ELDERLY-sites (n=544) were used. AUD diagnoses were obtained with the Mini International Neuropsychiatric Interview, alcohol use information with Form 90. Results: Lost control, desired control, mental/physical problem, and craving were the most prevalent (> 70 %) AUD-symptoms. 54.9 % reported severe DSM-5 AUD (moderate: 28.2 %, mild: 16.9 %). Mean daily alcohol use was 6.3 drinks at 12 grams ethanol each. 93.9 % reported binging. More intense alcohol use was associated with greater AUD-severity and male gender. Country effects showed for alcohol use and AUD-severity. Conclusion: European ELDERLY-participants presented typical dependence symptoms, a wide range of severity, and intense alcohol use. This may underline the clinical significance of AUD in treatment-seeking seniors.

Persönliche vs. computerbasierte Alkoholintervention für Krankenhauspatienten: Studiendesign

2015 ◽  
Vol 61 (6) ◽  
pp. 347-355 ◽  
Author(s):  
Jennis Freyer-Adam ◽  
Sophie Baumann ◽  
Inga Schnuerer ◽  
Katja Haberecht ◽  
Ulrich John ◽  
...  
Keyword(s):  
Public Health ◽  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Identification Test ◽  
Disorder Identification

Zusammenfassung. Ziel: Persönliche Beratungen können bei stationären Krankenhauspatienten Alkoholkonsum und Mortalität reduzieren. Sie sind jedoch mit hohen Kosten verbunden, wenn aus Public-Health-Erfordernis viele Menschen einer Bevölkerung erreicht werden müssen. Computerbasierte Interventionen stellen eine Alternative dar. Jedoch ist ihre Wirksamkeit im Vergleich zu persönlichen Beratungen und im Allgemeinkrankenhaus noch unklar. Eine quasi-randomisierte Kontrollgruppenstudie „Die Bedeutung der Vermittlungsform für Alkoholinterventionen bei Allgemeinkrankenhauspatienten: Persönlich vs. Computerisiert“ soll dies untersuchen. Design und Methoden werden beschrieben. Methode: Über 18 Monate sind alle 18- bis 64-jährigen Patienten auf Stationen der Universitätsmedizin Greifswald mittels Alcohol Use Disorder Identification Test (AUDIT) zu screenen. Frauen/Männer mit AUDIT-Consumption ≥ 4/5 und AUDIT < 20 werden einer von drei Gruppen zugeordnet: persönliche Intervention (Beratungen zur Konsumreduktion), computerbasierte Intervention (individualisierte Rückmeldebriefe und Broschüren) und Kontrollgruppe. Beide Interventionen erfolgen im Krankenhaus sowie telefonisch bzw. postalisch nach 1 und 3 Monaten. In computergestützten Telefoninterviews nach 6, 12, 18 und 24 Monaten wird Alkoholkonsum erfragt. Schlussfolgerung: Das Studienvorhaben, sofern erfolgreich umgesetzt, ist geeignet die längerfristige Wirksamkeit einer persönlichen und computerbasierten Intervention im Vergleich zu untersuchen.

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