MON-161 ASSESSMENT OF CIRCULATING OXIDATIVE STRESS MARKERS, INFLAMMATORY MARKERS AND THEIR CORRELATION WITH QUALITY OF LIFE IN PATIENTS ON MAINTENANCE HEMODIALYSIS

IntroductionDecreased insulin sensitivity occurs early in type 2 diabetes (T2D). T2D is highly prevalent in the Middle East and North Africa regions. This study assessed the variations in insulin sensitivity in normal apparently healthy subjects and the levels of adiponectin, adipsin and inflammatory markers.Research design and methodsA total of 60 participants (aged 18–45, body mass index <28) with a normal oral glucose tolerance test (OGTT) completed hyperinsulinemic-euglycemic clamp (40 mU/m2/min) and body composition test by dual-energy X-ray absorptiometry scan. Blood samples were assayed for glucose, insulin, C peptide, inflammatory markers, oxidative stress markers, adiponectin and adipsin.ResultsThe subjects showed wide variations in the whole-body glucose disposal rate (M value) from 2 to 20 mg/kg/min and were divided into three groups: most responsive (M>12 mg/kg/min, n=17), least responsive (M≤6 mg/kg/min, n=14) and intermediate responsive (M=6.1–12 mg/kg/min, n=29). Insulin and C peptide responses to OGTT were highest among the least insulin sensitive group. Triglycerides, cholesterol, alanine transaminase (ALT) and albumin levels were higher in the least responsive group compared with the other groups. Among the inflammatory markers, C reactive protein (CRP) was highest in the least sensitivity group compared with the other groups; however, there were no differences in the level of soluble receptor for advanced glycation end products and Tumor Necrosis Factor Receptor Superfamily 1B (TNFRS1B). Plasma levels of insulin sensitivity markers, adiponectin and adipsin, and oxidative stress markers, oxidized low-density lipoprotein, total antioxidant capacity and glutathione peroxidase 1, were similar between the groups.ConclusionsA wide range in insulin sensitivity and significant differences in triglycerides, cholesterol, ALT and CRP concentrations were observed despite the fact that the study subjects were homogenous in terms of age, gender and ethnic background, and all had normal screening comprehensive chemistry and normal glucose response to OGTT. The striking differences in insulin sensitivity reflect differences in genetic predisposition and/or environmental exposure. The low insulin sensitivity status associated with increased insulin level may represent an early stage of metabolic abnormality.

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Oxidative Stress Parameters after Abdominal Hysterectomy and Their Relationships with Quality of Recovery

Serbian Journal of Experimental and Clinical Research ◽

10.1515/sjecr-2017-0046 ◽

2019 ◽

Vol 20 (2) ◽

pp. 27-36 ◽

Cited By ~ 3

Author(s):

Danijela Jovanovic ◽

Dragan R. Milovanovic ◽

Nevena Jeremic ◽

Tamara Nikolic ◽

Isidora Stojic ◽

...

Keyword(s):

Oxidative Stress ◽

Stress Response ◽

Smoking Status ◽

Abdominal Hysterectomy ◽

Oxidative Stress Response ◽

Oxidative Stress Markers ◽

Quality Of Recovery ◽

Stress Markers ◽

Duration Of Surgery

Abstract Study aimed to investigate relationship between oxidative stress markers and postoperative recovery in woman after abdominal hysterectomy, as well as to test the hypothesis that different analgesics differently influence redox status. The quality of recovery was evaluated with a QoR-40 questionnaire in fifty-one patients who underwent abdominal hysterectomy, preoperatively and on the 1st, 2nd, 3rd postoperative days (POD1,2,3). Blood samples were collected at baseline (T0), 3 (T1), 24 (T2), 48 (T3) and 72 (T4) hours after surgery. Oxidative stress markers concentrations (TBARS, NO2−, H2O2, O2− ) as well as antioxidative enzymes (SOD, CAT, and GSH) were analyzed. QoR-40 total score significantly declined on POD1 and POD2 and returned to baseline levels on POD3 (p<0.001). H2O2 levels significantly decreased from T0 to T3 and then, increased at T4 (p=0,011). Changes of TBARS and H2O2 from T0 to T3 showed significant and negative correlation (r=−0.303, p=0.046). There was no significant correlation between QoR-40 total score and any parameter of oxidative stress response (p>0.05). Changes in TBARS levels from T0 to T3 were statistically significant between the study subgroups primarily due to increase of the concentrations in patients receiving paracetamol (p=0.031). Patients age, duration of surgery and cigarette smoking status showed significant influcences on and association with some oxidative stress response markers (TBARS, O2−, CAT) (p<0.05). Women who underwent hysterectomy had significant changes of H2O2 and TBARS activity however, those changes were not associated with changes of QoR-40 total scores during recovery.

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Effect of Yoga intervention on biochemical, oxidative stress markers, inflammatory markers and sleep quality among subjects with type 2 diabetes in South India: Results from the SATYAM project

Diabetes Research and Clinical Practice ◽

10.1016/j.diabres.2020.108644 ◽

2020 ◽

pp. 108644

Author(s):

Vijay Viswanathan ◽

S. Sumathi ◽

A. Sai Prathiba ◽

D. Arutselvi ◽

G. Leema ◽

...

Keyword(s):

Oxidative Stress ◽

Type 2 Diabetes ◽

Sleep Quality ◽

Inflammatory Markers ◽

South India ◽

Oxidative Stress Markers ◽

Yoga Intervention ◽

Stress Markers

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Cottonseed feeding changes oxidative stress markers in ewes during the peripartum period and increases the quality of colostrum

The Veterinary Journal ◽

10.1016/j.tvjl.2019.02.009 ◽

2019 ◽

Vol 247 ◽

pp. 32-37 ◽

Cited By ~ 1

Author(s):

Debora B. Moretti ◽

Carolina R. Jimenez ◽

Heloisa M. Trinca ◽

Raul Machado-Neto ◽

Helder Louvandini

Keyword(s):

Oxidative Stress ◽

Oxidative Stress Markers ◽

Stress Markers ◽

Peripartum Period

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Oxidative Stress Markers Are Associated with Persistent Atrial Fibrillation

Clinical Chemistry ◽

10.1373/clinchem.2006.083923 ◽

2007 ◽

Vol 53 (9) ◽

pp. 1652-1657 ◽

Cited By ~ 139

Author(s):

Robert B Neuman ◽

Heather L Bloom ◽

Irfan Shukrullah ◽

Lyndsey A Darrow ◽

David Kleinbaum ◽

...

Keyword(s):

Oxidative Stress ◽

Atrial Fibrillation ◽

Inflammatory Markers ◽

Smoking Status ◽

Serum Markers ◽

Oxidative Stress Markers ◽

Cross Sectional ◽

Stress Markers ◽

Myocardial Oxidative Stress ◽

Antioxidant Agents

Abstract Background: Atrial fibrillation (AF) has been associated with myocardial oxidative stress, and antioxidant agents have demonstrated antiarrhythmic benefit in humans. We compared serum markers of oxidation and associated inflammation in individuals with or without AF. Methods: Serum markers of oxidative stress and inflammation were compared in a cross-sectional, case-control design study of 40 male individuals, with or without persistent or permanent AF, who were matched for age, sex, diabetes, and smoking status, known confounding variables for the measurement of oxidative stress. We used derivatives of reactive oxidative metabolites (DROMs) and ratios of oxidized to reduced glutathione (Eh GSH) and cysteine (Eh CySH) to quantify oxidative stress. We also measured inflammatory markers, including high-sensitivity C-reactive protein, interleukins 1β and 6, and tumor necrosis factor α. Results: Univariate, conditional logistical regression analysis showed that oxidative stress but not inflammatory markers were statistically associated with AF (P <0.05). The increase in the odds ratios for AF for Eh GSH, Eh CySH, and DROMs were 6.1 (95% CI, 1.3–28.3; P = 0.02), 13.6 (95% CI, 2.5–74.1; P = 0.01), and 15.9 (95% CI, 1.7–153.9; P = 0.02), respectively. There was a stronger correlation between Eh GSH and Eh CySH (r = 0.66) than between Eh GSH and DROMs (r = 0.41). In multivariate analysis corrected for statins and other AF risk factors differing between the groups, the association of AF and oxidative stress remained significant. Conclusions: These data suggest that oxidative stress markers may have predictive value in AF management.

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Effect of Acute Thermal Injury in Status of Serum Vitamins, Inflammatory Markers, and Oxidative Stress Markers

Journal of Burn Care & Research ◽

10.1097/bcr.0b013e31826fc506 ◽

2013 ◽

Vol 34 (2) ◽

pp. e87-e91 ◽

Cited By ~ 11

Author(s):

Paula Pileggi Vinha ◽

Edson Zangiacomi Martinez ◽

Helio Vannucchi ◽

Julio Sergio Marchini ◽

Jayme Adriano Farina ◽

...

Keyword(s):

Oxidative Stress ◽

Inflammatory Markers ◽

Thermal Injury ◽

Oxidative Stress Markers ◽

Stress Markers ◽

And Oxidative Stress

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Neurotrophins, cytokines, oxidative stress mediators and mood state in bipolar disorder: systematic review and meta-analyses

The British Journal of Psychiatry ◽

10.1192/bjp.2018.144 ◽

2018 ◽

Vol 213 (3) ◽

pp. 514-525 ◽

Cited By ~ 36

Author(s):

Tobias Rowland ◽

Benjamin I. Perry ◽

Rachel Upthegrove ◽

Nicholas Barnes ◽

Jayanta Chatterjee ◽

...

Keyword(s):

Oxidative Stress ◽

Systematic Review ◽

Bipolar Disorder ◽

Inflammatory Markers ◽

Healthy Controls ◽

Oxidative Stress Markers ◽

Stress Markers ◽

Tnf Α ◽

Meta Analyses ◽

And Oxidative Stress

BackgroundA reliable biomarker signature for bipolar disorder sensitive to illness phase would be of considerable clinical benefit. Among circulating blood-derived markers there has been a significant amount of research into inflammatory markers, neurotrophins and oxidative stress markers.AimsTo synthesise and interpret existing evidence of inflammatory markers, neurotrophins and oxidative stress markers in bipolar disorder focusing on the mood phase of illness.MethodFollowing PRISMA (Preferred Reporting Items for Systematic reviews and Meta-analyses) guidelines, a systematic review was conducted for studies investigating peripheral biomarkers in bipolar disorder compared with healthy controls. We searched Medline, Embase, PsycINFO, SciELO and Web of Science, and separated studies by bipolar mood phase (mania, depression and euthymia). Extracted data on each biomarker in separate mood phases were synthesised using random-effects model meta-analyses.ResultsIn total, 53 studies were included, comprising 2467 cases and 2360 controls. Fourteen biomarkers were identified from meta-analyses of three or more studies. No biomarker differentiated mood phase in bipolar disorder individually. Biomarker meta-analyses suggest a combination of high-sensitivity C-reactive protein/interleukin-6, brain derived neurotrophic factor/tumour necrosis factor (TNF)-α and soluble TNF-α receptor 1 can differentiate specific mood phase in bipolar disorder. Several other biomarkers of interest were identified.ConclusionsCombining biomarker results could differentiate individuals with bipolar disorder from healthy controls and indicate a specific mood-phase signature. Future research should seek to test these combinations of biomarkers in longitudinal studies.Declaration of interestNone.

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