scholarly journals Moxa smoke: Is it a beneficial or hazardous factor for infertility? A preclinical study on sperm parameters and sex hormones in male rats

2016 ◽  
Vol 8 (1) ◽  
pp. 28-35 ◽  
Author(s):  
Lei Wang ◽  
Li Han ◽  
Ping Liu ◽  
Jia Yang ◽  
Yingxue Cui ◽  
...  
Keyword(s):  
Sex Hormones ◽  
Preclinical Study ◽  
Sperm Parameters ◽  
Male Rats

scholarly journals Effects of phosalone plant pesticide on sperm parameters and sexual hormone levels in Wistar rats: An experimental study

2020 ◽  
Author(s):  
Fahime Mazaheri ◽  
Kazem Kamali Aliabad ◽  
Seyed Mehdi Kalantar ◽  
Noosha Ziya ◽  
Arezoo Khoradmehr ◽  
...  
Keyword(s):  
Experimental Study ◽  
Sex Hormones ◽  
Sperm Motility ◽  
Enzyme Inhibitor ◽  
Food Group ◽  
Sperm Parameters ◽  
Male Rats ◽  
Dependent Manner ◽  
Organophosphate Insecticide ◽  
Negative Effects

Background: Phosalone is an organophosphate insecticide, applied to control of plant pests. This compound has various side effects because it acts as an acetyl cholinesterase enzyme inhibitor. Objective: To investigate the effects of phosalone on the sperm parameters of and levels of sex hormones in adult male rats. Materials and Methods: In this experimental study, 16 adult (8-12 wk) male Wister rates (weighing 220-280 gr) were randomly assigned into 4 groups (n = 4/each). Group 1 (control) received only routine adequate water and food; Group 2, 3, and 4 received different low doses of phosalone (60, 90, and 120 mg/kg respectively). The rats were weighed and anesthetized after 48 days. Sperm parameters including number, motility, and viability as well as sex hormones (such as Luteinizing Hormone, Follicle Stimulating Hormone, and testosterone) were evaluated and compared after removing the epididymis tail. Results: Our results showed that phosalone decreased sperm motility, viability, and number in a dose-dependent manner. The level of FSH and LH was increased, and testosterone was decreased. Also, depending on the dose, phosalone decrease sperm motility and viability (p ≤ 0.001), while the level of FSH and LH was increased and testosterone was decreased (p = 0.861). Conclusion: Phosalone has negative effects on reproductive indices in male rats and can cause serious damage and decrease the number and sperms motility. It can also cause infertility due to changing the concentration of hormones. Key words: Organophosphate, Pesticides, Phosalone, Sperm, Sex hormones.

Differential regulation of insulin resistance and hypertension by sex hormones in fructose-fed male rats

2005 ◽  
Vol 289 (4) ◽  
pp. H1335-H1342 ◽  
Author(s):  
Harish Vasudevan ◽  
Hong Xiang ◽  
John H. McNeill
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Insulin Sensitivity ◽  
Sex Hormones ◽  
Threshold Value ◽  
Relative Increase ◽  
Estrogen Treatment ◽  
Male Rats ◽  
Normal Chow

Differences in gender are in part responsible for the development of insulin resistance (IR) and associated hypertension. Currently, it is unclear whether these differences are dictated by gender itself or by the relative changes in plasma estrogen and/or testosterone. We investigated the interrelationships between testosterone and estrogen in the progression of IR and hypertension in vivo in intact and gonadectomized fructose-fed male rats. Treatment with estrogen significantly reduced the testosterone levels in both normal chow-fed and fructose-fed rats. Interestingly, fructose feeding induced a relative increase in estradiol levels, which did not affect IR in both intact and gonadectomized fructose-fed rats. However, increasing the estrogen levels improved insulin sensitivity in both intact and gonadectomized fructose-fed rats. In intact males, fructose feeding increased the blood pressure (140 ± 2 mmHg), which was prevented by estrogen treatment. However, the blood pressure in the fructose-fed estrogen rats (125 ± 1 mmHg) was significantly higher than that of normal chow-fed (113 ± 1 mmHg) and fructose-fed gonadectomized rats. Estrogen treatment did not affect the blood pressure in gonadectomized fructose-fed rats (105 ± 2 mmHg). These data suggest the existence of a threshold value for estrogen below which insulin sensitivity is unaffected. The development of hypertension in this model is dictated solely by the presence or absence of testosterone. In summary, the development of IR and hypertension is governed not by gender per se but by the interactions of specific sex hormones such as estrogen and testosterone.

scholarly journals Curcumin Along With Fe3O4 Nanoparticles Improved Sperm Parameters In Rats With Testicular Ischemia

2021 ◽  
Vol 10 ◽  
pp. e2034
Author(s):  
Shabnam Zarei Moradi ◽  
Seyed Abdolhamid Angaji ◽  
Mitra Salehi ◽  
Mehrdad Hashemi
Keyword(s):  
Fe3o4 Nanoparticles ◽  
Sperm Concentration ◽  
Concomitant Administration ◽  
Testicular Tissue ◽  
Sperm Parameters ◽  
Male Rats ◽  
Semen Parameters ◽  
Control Group ◽  
Fe3o4 Nps ◽  
Testicular Ischemia

Background: Ischemic/reperfusion (I/R) in testicular tissue is one reason for the worldwide increase in male infertility. In the present study, we assessed the effects of curcumin and Fe3O4 nanoparticles (NPs) on sperm parameters in rats with I/R damage. Materials and Methods: Forty-eight adult male rats were divided into two groups (n=24 per group): control and torsion/detorsion. The control and torsion/detorsion groups were divided into four subgroups include sham, Fe3O4 NPs, curcumin, and Fe3O4 NPs+curcumin. After the rats were sacrificed, semen was collected from their epididymal tissues to assess sperm viability, motility, concentration, and morphology. Results: Curcumin significantly improved viability, motility, and normal sperm morphology in rats with I/R damage compared to the control group; however, it did not have a significant effect on sperm concentration (P<0.001). Fe3O4 NPs alone decreased all sperm parameters in the control and I/R rats (P<0.001). However, concomitant administration of Fe3O4 nanoparticles with curcumin significantly improved sperm parameters in rats with I/R damage (P<0.001). Conclusion: The increase in all semen parameters in the experimental groups with concomitant use of Fe3O4 NPs plus curcumin indicated that green synthesis of NPs could be recommended for future clinical studies.

scholarly journals Silver Nanoparticles Stimulates Spermatogenesis Impairments and Hematological Alterations in Testis and Epididymis of Male Rats

Molecules ◽  
2020 ◽  
Vol 25 (5) ◽  
pp. 1063 ◽  
Author(s):  
Janet Olayemi Olugbodi ◽  
Oladipupo David ◽  
Ene Naomi Oketa ◽  
Bashir Lawal ◽  
Bamidele Joseph Okoli ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Hematological Parameters ◽  
Silver Ions ◽  
Thiol Group ◽  
Sperm Parameters ◽  
Male Rats ◽  
Ag Nps ◽  
Hematological Indices ◽  
Electron Microscopies ◽  
Pharmaceutical Application

The potential pharmaceutical application of nanoparticles has led to the toxicity within the male reproductive system. In the present study, the effects of silver nanoparticles (Ag-NPs) on hematological parameters, free radical generation, antioxidant system, sperm parameters, and organ histo-morphometry in male rats were investigated. Ag-NPs were produced by the reduction of silver ions, while the formation of which was monitored by UV–visible spectrophotometry. Zeta potential, transmission, and scanning electron microscopies were applied for the characterization of AgNPs. A total of 30 rats were divided into 6 groups and were sub-dermally exposed to Ag-NPs at the dosage of 0 (control), 10, and 50 mg/kg bodyweight (bw) doses for either 7 or 28 days. Ag-NP administration altered hematological indices and caused dose-dependent decreases in sperm motility, velocity, kinematic parameters, concentrations of luteinizing hormone, follicle-stimulating hormone, and testosterone. In the epididymis and testis, the concentrations of malondialdehyde and peroxide increases while superoxide dismutase, catalase, reduced glutathione, and total thiol group decreases. These findings suggest that Ag-NP triggered hormonal imbalance and induce oxidative stress in testis and epididymis; which negatively affect sperm parameters of male rats.

The effect of sex and sex hormones on the infection of rats by Trichinella spiralis

1972 ◽  
Vol 50 (5) ◽  
pp. 597-602 ◽  
Author(s):  
Sarojam K. Mankau ◽  
Raymond Hamilton
Keyword(s):  
Sex Hormones ◽  
Worm Burden ◽  
Testosterone Propionate ◽  
Marked Decrease ◽  
Trichinella Spiralis ◽  
Male Rats ◽  
Normal Male ◽  
Normal Males

Male hooded rats infected with Trichinella spiralis larvae had three times more larvae in the muscles than females. Gonadectomized males injected with stilbestrol had a lower worm burden than normal males. Gonadectomized females injected with testosterone propionate harbored far more worms than normal females. Stilbestrol administered to normal male rats caused a marked decrease in T. spiralis, while testosterone administered to normal females resulted in a significant increase in the number of parasites.

The Effect of Leptin on Sex Hormones and Antioxidant Enzyme Levels in Obese and Normal Male Rats

2018 ◽  
Vol 25 (3) ◽  
pp. 1105-1111 ◽  
Author(s):  
Hossein Cheraghi ◽  
Morteza Zendehdel ◽  
Jamshid GhiasiGhalehkandi ◽  
Parviz Tajik ◽  
Negar Panahi
Keyword(s):  
Antioxidant Enzyme ◽  
Sex Hormones ◽  
Male Rats ◽  
Normal Male

scholarly journals Male gender increases sensitivity to proteinuria induced by mild NOS inhibition in rats: role of sex hormones

2000 ◽  
Vol 279 (4) ◽  
pp. F664-F670 ◽  
Author(s):  
A. Marjan G. Verhagen ◽  
Diana M. A. Attia ◽  
Hein A. Koomans ◽  
Jaap A. Joles
Keyword(s):  
Nitric Oxide ◽  
Sex Hormones ◽  
Oxide System ◽  
Female Rats ◽  
Male Rats ◽  
Time Control ◽  
Ovx Rats ◽  
Increased Sensitivity ◽  
Dose Dependent Increase

Men are at greater risk for renal injury than women. We studied whether male rats are more sensitive to the hypertensive and proteinuric effects of chronic nitric oxide sythase (NOS) inhibition than female rats. In addition, we studied whether androgens or estrogens are responsible for differences in sensitivity to proteinuria induced by chronic NOS inhibition. Females and males were treated with 10, 20, 30, and 100 mg/l N ω-nitro-l-arginine (l-NNA) during 24 wk. Systolic blood pressure (SBP) and proteinuria were measured regularly and compared with time-control measurements in control females and males. In females and males treatment with 10 mg/l l-NNA had no effect on SBP or proteinuria. Treatment with 20, 30, and 100 mg/l l-NNA resulted in a dose-dependent increase in SBP that was similar in males and females. However, females treated with 20 and 30 mg/ll-NNA were resistant to the development of proteinuria: maximum values were 16 ± 7 and 46 ± 21, respectively, vs. 16 ± 3 mg/day in controls, whereas males treated with those doses showed an increase in proteinuria [139 ± 35 ( P< 0.05) and 318 ± 82 ( P < 0.01), respectively, vs. 55 ± 11 mg/day in controls]. Treatment with 100 mg/ll-NNA increased proteinuria similarly in both females and males. To study the role of sex hormones in differences in sensitivity to proteinuria induced by mild chronic NOS inhibition, treatment with 20 mg/l l-NNA was repeated in ovariectomized (Ovx) and orchidectomized rats. Ovariectomy did not affect the increase in SBP caused by 20 mg/l l-NNA, but, in contrast to intact females, this dose of l-NNA did cause Ovx rats to develop proteinuria (51 ± 16 vs. 16 ± 7 mg/day in control Ovx rats; P < 0.05). Orchidectomy completely prevented the increased SBP as well as proteinuria induced by 20 mg/ll-NNA in male rats. In conclusion, male rats are more sensitive than female rats to develop proteinuria induced by mild chronic NOS inhibition. Estrogens provide some protection in females, whereas androgens are responsible for the increased sensitivity of male rats to proteinuria induced by mild chronic NOS inhibition. Risk factors associated with a compromised nitric oxide system may be more detrimental to the kidney in men than in women.

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