P.0662 The beneficial effects of tart cherry on neuroinflammation in a diet-induced obesity model

2021 ◽  
Vol 53 ◽  
pp. S485
Author(s):  
L. Botticelli ◽  
M.V. Micioni Di Bonaventura ◽  
I. Martinelli ◽  
M. Moruzzi ◽  
E. Micioni Di Bonaventura ◽  
...  
Keyword(s):  
Tart Cherry ◽  
Beneficial Effects ◽  
Diet Induced Obesity

scholarly journals Tart Cherry (Fruit of Prunus cerasus) Concentrated Powder (TCcp) Ameliorates Glucocorticoid-Induced Muscular Atrophy in Mice

Medicina ◽  
2021 ◽  
Vol 57 (5) ◽  
pp. 485
Author(s):  
Sae-Kwang Ku ◽  
Jong-Min Lim ◽  
Hyung-Rae Cho ◽  
Khawaja Muhammad Imran Bashir ◽  
Young Suk Kim ◽  
...  
Keyword(s):  
Gastrocnemius Muscle ◽  
Muscular Atrophy ◽  
Muscle Protein ◽  
Oral Treatment ◽  
Calf Muscle ◽  
Prunus Cerasus ◽  
Tart Cherry ◽  
Muscle Weight ◽  
Beneficial Effects ◽  
Antioxidant Defense Systems

Background and Objectives: The present study investigated the beneficial effects of tart cherry (fruit of Prunus cerasus) concentrated powder (TCcp) on glucocorticoid (GLU)-induced catabolic muscular atrophy in the skeletal muscle of mice. Furthermore, its potential mechanism was also studied. Materials and Methods: Changes in calf thickness, calf muscle weight, calf muscle strength, body weight, gastrocnemius muscle histology, immunohistochemistry, serum creatinine, creatine kinase, lactate dehydrogenase, and antioxidant defense systems were measured. Malondialdehyde, reactive oxygen species, glutathione content, catalase, and superoxide dismutase activities in the gastrocnemius muscle, and muscle-specific mRNA expressions were evaluated. Results: After 24 days, GLU control mice showed muscular atrophy at all criteria of indexes. The muscular atrophy symptoms were significantly inhibited by oral treatment with 250 mg/kg and 500 mg/kg of TCcp through antioxidative and anti-inflammatory modulated expression of genes involved in muscle protein degradation (myostatin, atrogin-1, SIRT1, and MuRF1) and synthesis (A1R, Akt1, TRPV4, and PI3K). Conclusions: This study shows that the TCcp (500 mg/kg and 250 mg/kg) could improve muscular atrophies caused by various etiologies.

scholarly journals Effect of Supplementation with Hydroethanolic Extract of Campomanesia xanthocarpa (Berg.) Leaves and Two Isolated Substances from the Extract on Metabolic Parameters of Mice Fed a High-Fat Diet

Molecules ◽  
2020 ◽  
Vol 25 (11) ◽  
pp. 2693 ◽  
Author(s):  
Carla Maiara Lopes Cardozo ◽  
Aline Carla Inada ◽  
Claudia Andrea Lima Cardoso ◽  
Wander Fernando de Oliveira Filiú ◽  
Bernardo Barcelar de Farias ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Metabolic Disorders ◽  
Brazilian Cerrado ◽  
American Institute ◽  
High Fat ◽  
Beneficial Effects ◽  
Diet Induced Obesity ◽  
Protein Expressions ◽  
Hydroethanolic Extract ◽  
Lipid Parameters

There are still controversies regarding the correlation between the beneficial effects for health and the administration of isolated compounds or crude extracts in therapeutic applications. Campomanesia xanthocarpa, found in the Brazilian Cerrado, demonstrated beneficial effects in metabolic disorders associated with obesity. We investigated the effects of Campomanesia xanthocarpa hydroethanolic extract and two isolated substances from the extract (S1 and S2) in a diet-induced obesity (DIO) model. Male Swiss mice were divided into five groups: (1) American Institute of Nutrition (AIN-93M) diet, (2) high-fat diet (HF), (3) HF supplemented with C. xanthocarpa hydroethanolic leaf extract at 100 mg/kg (HFE), (4) HF supplemented with S1 at 1 mg/kg (HFS1) and (5) HF supplemented with S2 at 1 mg/kg (HFS2). The HFS1, HFS2 and HFE groups did not present decreasing body weight or visceral adiposity gain. No differences in glycemic and lipid parameters, or in the expression of protein content in two cytokines, interleukin-6 (IL-6) and anti-inflammatory (IL-10), were observed. Only the HFS1 group displayed decreased food intake. Even though substantial effects such as an improvement in obesity features or the metabolic and histological parameters promoted by S1, S2 and the extract were not observed, further investigations are necessary to evaluate the principal genes and protein expressions involved in regulating food behavior promoted by S1.

scholarly journals The Beneficial Effects of n-3 Polyunsaturated Fatty Acids on Diet Induced Obesity and Impaired Glucose Control Do Not Require Gpr120

PLoS ONE ◽  
2014 ◽  
Vol 9 (12) ◽  
pp. e114942 ◽  
Author(s):  
Mikael Bjursell ◽  
Xiufeng Xu ◽  
Therése Admyre ◽  
Gerhard Böttcher ◽  
Sofia Lundin ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Glucose Control ◽  
Beneficial Effects ◽  
Diet Induced Obesity

scholarly journals GLP2: an underestimated signal for improving glycaemic control and insulin sensitivity

2016 ◽  
Vol 229 (2) ◽  
pp. R57-R66 ◽  
Author(s):  
Antonella Amato ◽  
Sara Baldassano ◽  
Flavia Mulè
Keyword(s):  
Glucose Metabolism ◽  
Current Knowledge ◽  
Postprandial Glucose ◽  
Hepatic Insulin Resistance ◽  
Recent Experimental Data ◽  
Protective Effects ◽  
Beneficial Effects ◽  
Diet Induced Obesity ◽  
Discrete Population ◽  
Mucosal Morphology

Glucagon-like peptide 2 (GLP2) is a proglucagon-derived peptide produced by intestinal enteroendocrine L-cells and by a discrete population of neurons in the brainstem, which projects mainly to the hypothalamus. The main biological actions of GLP2 are related to the regulation of energy absorption and maintenance of mucosal morphology, function and integrity of the intestine; however, recent experimental data suggest that GLP2 exerts beneficial effects on glucose metabolism, especially in conditions related to increased uptake of energy, such as obesity, at least in the animal model. Indeed, mice lacking GLP2 receptor selectively in hypothalamic neurons that express proopiomelanocortin show impaired postprandial glucose tolerance and hepatic insulin resistance (by increased gluconeogenesis). Moreover, GLP2 acts as a beneficial factor for glucose metabolism in mice with high-fat diet-induced obesity. Thus, the aim of this review is to update and summarize current knowledge about the role of GLP2 in the control of glucose homeostasis and to discuss how this molecule could exert protective effects against the onset of related obesity type 2 diabetes.

scholarly journals Distinct Effects of Calorie Restriction and Resveratrol on Diet-Induced Obesity and Fatty Liver Formation

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Eveliina Tauriainen ◽  
Mira Luostarinen ◽  
Essi Martonen ◽  
Piet Finckenberg ◽  
Miia Kovalainen ◽  
...  
Keyword(s):  
Physical Activity ◽  
Fatty Liver ◽  
Calorie Restriction ◽  
High Fat Diet ◽  
Adipose Tissue Inflammation ◽  
High Fat ◽  
Beneficial Effects ◽  
Diet Induced Obesity ◽  
Ad Libitum ◽  
Metabolic Performance

The potential of resveratrol to mimic beneficial effects of calorie restriction (CR) was investigated. We compared the effects of both CR (70% ofad libitumenergy intake) or resveratrol (2 g/kg or 4 g/kg food) on high-fat diet-induced obesity and fatty liver formation in C57Bl/6J mice, and we examined their effects on calorimetry, metabolic performance, and the expressions of inflammatory genes and SIRT proteins. We found that resveratrol with 4 g/kg dose partially prevented hepatic steatosis and hepatocyte ballooning and induced skeletal muscle SIRT1 and SIRT4 expression while other examined parameter were unaffected by resveratrol. In contrast, CR provided superior protection against diet-induced obesity and fatty liver formation as compared to resveratrol, and the effects were associated with increased physical activity and ameliorated adipose tissue inflammation. CR increased expressions of SIRT3 in metabolically important tissues, suggesting that the beneficial effects of CR are mediated, at least in part, via SIRT3-dependent pathways.

scholarly journals Angiotensin 1–7 stimulates brown adipose tissue and reduces diet-induced obesity

2018 ◽  
Vol 314 (2) ◽  
pp. E131-E138 ◽  
Author(s):  
Hidechika Morimoto ◽  
Jun Mori ◽  
Hisakazu Nakajima ◽  
Yasuhiro Kawabe ◽  
Yusuke Tsuma ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Renin Angiotensin System ◽  
Hormone Sensitive Lipase ◽  
Brown Adipocyte ◽  
Metabolic Complications ◽  
Subcutaneous White Adipose Tissue ◽  
Beneficial Effects ◽  
Diet Induced Obesity ◽  
Brown Adipose

The renin-angiotensin system is a key regulator of metabolism with beneficial effects of the angiotensin 1–7 (Ang 1–7) peptide. We hypothesized that the antiobesity effect of Ang 1–7 was related to the stimulation of brown adipose tissue (BAT). We administered Ang 1–7 (0.54 mg kg−1 day−1) for 28 days via implanted micro-osmotic pumps to mice with high-fat diet (HFD)-induced obesity. Ang 1–7 treatment reduced body weight, upregulated thermogenesis, and ameliorated impaired glucose homeostasis without affecting food consumption. Furthermore, Ang 1–7 treatment enlarged BAT and the increased expression of UCP1, PRDM16, and prohibitin. Alterations in PRDM16 expression correlated with increased AMPK and phosphorylation of mTOR. Ang 1–7 treatment elevated thermogenesis in subcutaneous white adipose tissue without altering UCP1 expression. These changes occurred in the context of decreased lipid accumulation in BAT from HFD-fed mice, preserved insulin signaling concomitant with phosphorylation of hormone-sensitive lipase and decreased expression of perilipin. These data suggest that Ang 1–7 induces brown adipocyte differentiation leading to upregulation of thermogenesis and improved metabolic profile in diet-induced obesity. Enhancing Ang 1–7 action represents a promising therapy to increase BAT and to reduce the metabolic complications associated with diet-induced obesity.

scholarly journals Beneficial effects of tea catechins on diet-induced obesity: stimulation of lipid catabolism in the liver

2002 ◽  
Vol 26 (11) ◽  
pp. 1459-1464 ◽  
Author(s):  
T Murase ◽  
A Nagasawa ◽  
J Suzuki ◽  
T Hase ◽  
I Tokimitsu
Keyword(s):  
Tea Catechins ◽  
Beneficial Effects ◽  
Lipid Catabolism ◽  
Diet Induced Obesity ◽  
Stimulation Of

scholarly journals The Resin fromProtium heptaphyllumPrevents High-Fat Diet-Induced Obesity in Mice: Scientific Evidence and Potential Mechanisms

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Karine Maria Martins Bezerra Carvalho ◽  
José Delano Barreto Marinho Filho ◽  
Tiago Sousa de Melo ◽  
Ana Jérsia Araújo ◽  
Josiane da Silva Quetz ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Scientific Evidence ◽  
Net Energy ◽  
High Fat ◽  
Beneficial Effects ◽  
Proinflammatory Mediators ◽  
Glucose And Lipid Metabolism ◽  
Diet Induced Obesity ◽  
Obesity In Mice

Herbal compounds rich in triterpenes are well known to regulate glucose and lipid metabolism and to have beneficial effects on metabolic disorders. The present study investigated the antiobesity properties of resin fromProtium heptaphyllum(RPH) and the possible mechanisms in mice fed a high-fat diet (HFD) for 15 weeks. Mice treated with RPH showed decreases in body weight, net energy intake, abdominal fat accumulation, plasma glucose, amylase, lipase, triglycerides, and total cholesterol relative to their respective controls, which were RPH unfed. Additionally, RPH treatment, while significantly elevating the plasma level of ghrelin hormone, decreased the levels of insulin, leptin, and resistin. Besides, HFD-induced increases in plasma levels of proinflammatory mediators TNF-α, IL-6, and MCP-1 were significantly lowered by RPH. Furthermore,in vitrostudies revealed that RPH could significantly inhibit the lipid accumulation in 3T3-L1 adipocytes (measured by Oil-Red O staining) at concentrations up to 50 μg/mL. These findings suggest that the antiobese potential of RPH is largely due to its modulatory effects on various hormonal and enzymatic secretions related to fat and carbohydrate metabolism and to the regulation of obesity-associated inflammation.

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