Photoluminescent folic acid functionalized biocompatible and stimuli-responsive nanostructured polymer brushes for targeted and controlled delivery of doxorubicin

AbstractWe investigated the interplay between different mechanisms of the lateral and vertical segregation in the synthesized via “grafting from” approach symmetric A/B (where A and B are poly(styrene-co-2,3,4,5,6-pentafluorostyrene) and poly(methylmethacrylate), respectively) polymer brushes upon exposure to different solvents. We used X-ray photoemission electron spectroscopy and microscopy (X-PEEM), AFM, water contact angle measurements, and oxygen plasma etching to study morphology of the brushes. The ripple morphology after toluene (nonselective solvent) revealed elongated lamellar-like domains of A and B polymers alternating across the surface. The dimple-A morphology consisting of round clusters of the polymer A was observed after acetone (selective solvent for B). The top layer was enriched with the polymer B showing that the brush underwent both the lateral and vertical phase segregation. A qualitative agreement with predictions of SCF theory was found.

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Multi-Stimuli-Responsive Mesoporous Membranes and Effect of Molecular Architecture on Thermo- and pH-Responsive Behavior of the grafted Block Copolymer brushes

10.26434/chemrxiv.7037699 ◽

2019 ◽

Author(s):

Yanchun Tang ◽

Kohzo Ito ◽

Hideaki Yokoyama

Keyword(s):

Polymer Brushes ◽

Diblock Copolymers ◽

Neutron Reflectivity ◽

Molecular Architecture ◽

Stimuli Responsive ◽

Responsive Polymer ◽

The Matrix ◽

Stable Part ◽

Copolymer Brushes ◽

Mesoporous Membranes

In this study, we prepared ultrafiltration membranes with a decoupled responses of filtration property to temperature and pH. The membrane preparation method was developed based on our previous work. We utilized methanol-supercritical carbon dioxide (methanol-scCO2) selective swelling method to introduce nanopores to block copolymers containing poly(diethylene glycol) methyl ether methacrylate (PMEO2MA), poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA) and polystyrene (PS) blocks. Formation of the mesoporous barrier layer with PS being the mechanically stable part of the matrix was driven by selective swelling of the PMEO2MA-b-PDMAEMA domains. Due to the selective swelling of PMEO2MA or PDMAEMA domains to introduce pores, the interior of the pores are covered with PMEO2MA or PDMAEMA blocks after pore formation. The PMEO2MA-b-PDMAEMA polymer brushes are naturally attached on the pore walls and worked as functional gates. PMEO2MA is a non-toxic, neutral thermo-responsive polymer with LCST at 26 ᴼC. PDMAEMA is a typical weak polyelectrolyte with pKa value at 7.0-7.5 and also a thermo-responsive polymer revealed a LCST of 20-80 °C in aqueous solution. Therefore, these membranes were expected to have multi dimensions as function of the combination of temperature and pH. Moreover, to understand the detail of the temperature and pH depended conformation transitions of PMEO2MA-b-PDMAEMA brushes, those diblock copolymers were end-tethered on flat substrates and analyzed via neutron reflectivity (NR).

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Stimuli-Responsive Y-Shaped Polymer Brushes Based on Junction-Point-Reactive Block Copolymers

Advanced Materials ◽

10.1002/adma.201202105 ◽

2012 ◽

Vol 24 (41) ◽

pp. 5559-5563 ◽

Cited By ~ 31

Author(s):

Christoph Tonhauser ◽

Ali A. Golriz ◽

Christian Moers ◽

Rebecca Klein ◽

Hans-Jürgen Butt ◽

...

Keyword(s):

Block Copolymers ◽

Polymer Brushes ◽

Junction Point ◽

Stimuli Responsive

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External Stimuli-Responsive Nanoparticles for Spatially and Temporary Controlled Delivery of CRISPR-Cas Genome Editors

Biomaterials Science ◽

10.1039/d1bm00558h ◽

2021 ◽

Author(s):

Ruosen Xie ◽

Yuyuan Wang ◽

Shaoqin Gong

Keyword(s):

Genome Editing ◽

Genetic Diseases ◽

Delivery Systems ◽

Controlled Delivery ◽

Stimuli Responsive ◽

New Therapies ◽

External Stimuli

The CRISPR–Cas9 system is a powerful tool for genome editing, which can potentially lead to new therapies for genetic diseases. Up to date, various viral and non-viral delivery systems have...

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Conformation Study of Dual Stimuli-Responsive Core-Shell Diblock Polymer Brushes

Polymers ◽

10.3390/polym10101084 ◽

2018 ◽

Vol 10 (10) ◽

pp. 1084

Author(s):

Kaimin Chen ◽

Lan Cao ◽

Ying Zhang ◽

Kai Li ◽

Xue Qin ◽

...

Keyword(s):

Polymer Brushes ◽

Core Shell ◽

Stimuli Responsive ◽

Research Topics ◽

Design And Synthesis ◽

Mild Conditions ◽

The Core ◽

Responsive Polymer ◽

Stimuli Responsive Polymer ◽

Shed Light

Stimuli-responsive nanoparticles are among the most popular research topics. In this study, two types of core-shell (polystyrene with a photoiniferter (PSV) as the core and diblock as the shell) polymer brushes (PSV@PNIPA-b-PAA and PSV@PAA-b-PNIPA) were designed and prepared using surface-initiated photoiniferter-mediated polymerization (SI-PIMP). Moreover, their pH- and temperature-stimuli responses were explored by dynamic light scattering (DLS) and turbidimeter under various conditions. The results showed that the conformational change was determined on the basis of the competition among electrostatic repulsion, hydrophobic interaction, hydrogen bonding, and steric hindrance, which was also confirmed by protein adsorption experiments. These results are not only helpful for the design and synthesis of stimuli-responsive polymer brushes but also shed light on controlled protein immobilization under mild conditions.

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Thermoswitchable Janus Gold Nanoparticles with Stimuli-Responsive Hydrophilic Polymer Brushes

Langmuir ◽

10.1021/acs.langmuir.6b00562 ◽

2016 ◽

Vol 32 (17) ◽

pp. 4297-4304 ◽

Cited By ~ 13

Author(s):

Xiaoqin Niu ◽

Fen Ran ◽

Limei Chen ◽

Gabriella Jia-En Lu ◽

Peiguang Hu ◽

...

Keyword(s):

Gold Nanoparticles ◽

Polymer Brushes ◽

Hydrophilic Polymer ◽

Stimuli Responsive

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Effect of Structure of Polymers Grafted from Graphene Oxide on the Compatibility of Particles with a Silicone-Based Environment and the Stimuli-Responsive Capabilities of Their Composites

Nanomaterials ◽

10.3390/nano10030591 ◽

2020 ◽

Vol 10 (3) ◽

pp. 591 ◽

Cited By ~ 2

Author(s):

Monika Zygo ◽

Miroslav Mrlik ◽

Marketa Ilcikova ◽

Martina Hrabalikova ◽

Josef Osicka ◽

...

Keyword(s):

Molecular Weight ◽

Graphene Oxide ◽

Radical Polymerization ◽

Polymer Brushes ◽

Silicone Oil ◽

Polymer Chains ◽

Butyl Methacrylate ◽

Raman Shift ◽

Stimuli Responsive ◽

Grafted Polymer

This study reports the utilization of controlled radical polymerization as a tool for controlling the stimuli-responsive capabilities of graphene oxide (GO) based hybrid systems. Various polymer brushes with controlled molecular weight and narrow molecular weight distribution were grafted from the GO surface by surface-initiated atom transfer radical polymerization (SI-ATRP). The modification of GO with poly(n-butyl methacrylate) (PBMA), poly(glycidyl methacrylate) (PGMA), poly(trimethylsilyloxyethyl methacrylate) (PHEMATMS) and poly(methyl methacrylate) (PMMA) was confirmed by thermogravimetric analysis (TGA) coupled with online Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS). Various grafting densities of GO-based materials were investigated, and conductivity was elucidated using a four-point probe method. Raman shift and XPS were used to confirm the reduction of surface properties of the GO particles during SI-ATRP. The contact angle measurements indicated the changes in the compatibility of GOs with silicone oil, depending on the structure of the grafted polymer chains. The compatibility of the GOs with poly(dimethylsiloxane) was also investigated using steady shear rheology. The tunability of the electrorheological, as well as the photo-actuation capability, was investigated. It was shown that in addition to the modification of conductivity, the dipole moment of the pendant groups of the grafted polymer chains also plays an important role in the electrorheological (ER) performance. The compatibility of the particles with the polymer matrix, and thus proper particles dispersibility, is the most important factor for the photo-actuation efficiency. The plasticizing effect of the GO-polymer hybrid filler also has a crucial impact on the matrix stiffness and thus the ability to reversibly respond to the external light stimulation.

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