Unpredictable adverse effects of herbal products

2022 ◽  
Vol 159 ◽  
pp. 112762
Author(s):  
Nurşen Başaran ◽  
Duygu Paslı ◽  
A. Ahmet Başaran
Keyword(s):  
Adverse Effects ◽  
Herbal Products

Herbal Products for Common Auto-Inflammatory Disorders - Novel Approaches

2018 ◽  
Vol 21 (3) ◽  
pp. 161-174 ◽  
Author(s):  
Shanoo Suroowan ◽  
Fawzi Mahomoodally
Keyword(s):  
Adverse Effects ◽  
Chronic Conditions ◽  
Herbal Medicines ◽  
Review Article ◽  
Herbal Products ◽  
Inflammatory Disorders ◽  
Treatment Regimens ◽  
Synthetic Agents ◽  
Unique Approach ◽  
Novel Approaches

Background: Common auto-inflammatory disorders (CAIDs) constitute a wide array of ailments ranging from acute allergies to chronic conditions. Globally, CAIDs remain one of the leading causes of disability and morbidity. Despite playing a leading therapeutic role, the vast profusion of anti-inflammatory synthetic agents have not been able to fully resolve a panoply of CAIDs. Additionally, contemporary synthetic therapy approaches remain bounded by a wide array of limitations essentially being adverse effects and unaffordable costs. In this advent, the use of herbal products provides an interesting avenue to explore in view of developing such treatment regimens. Objective: This review article endeavors to highlight potential herbal products and isolated phytochemicals which can be of benefit in the prophylaxis, management, and treatment alongside avoiding the relapse of CAIDs. Conclusion: This review article has highlighted that herbals, herbal products, and isolated metabolites hold a huge potential in the prophylaxis, management, and treatment of CAIDs. Herbals can act on various targets involved in the pathogenesis of inflammatory disorders. In addition, novel approaches for the management of CAIDs are numerous. Indeed, nanoparticles loaded with phytochemicals have been developed to specifically target the colon for IBD treatment. In silico approaches using herbals also offer unlimited avenues to decipher new pharmacophores. Investigating the potential of polyherbal formulations is another unique approach which can be investigated. Given the inefficacy of conventional medicines, the concomitant use of conventional and herbal medicines can also be explored.

scholarly journals An Introduction to Pharmacotherapy for Inborn Errors of Metabolism

2018 ◽  
Vol 23 (6) ◽  
pp. 432-446
Author(s):  
Aaron A. Harthan
Keyword(s):  
Adverse Effects ◽  
Inborn Errors Of Metabolism ◽  
Single Case ◽  
Case Reports ◽  
Review Article ◽  
Metabolic Process ◽  
Inborn Errors ◽  
Herbal Products ◽  
Disease States ◽  
Treatment Plans

Inborn errors of metabolism comprise a wide array of diseases and complications in the pediatric patient. The rarity of these disorders limits the ability to conduct and review robust literature regarding the disease states, mechanisms of dysfunction, treatments, and outcomes. Often, treatment plans will be based on the pathophysiology associated with the disorder and theoretical agents that may be involved in the metabolic process. Medication therapies usually consist of natural or herbal products. Established efficacious pediatric doses for these products are difficult to find in tertiary resources, and adverse effects are routinely limited to single case reports. This review article attempts to summarize some of the more common inborn errors of metabolism in a manner that is applicable to pharmacists who will provide care for these patients.

Herbal Products and the Liver: A Review of Adverse Effects and Mechanisms

2015 ◽  
Vol 148 (3) ◽  
pp. 517-532.e3 ◽  
Author(s):  
Leonard B. Seeff ◽  
Herbert L. Bonkovsky ◽  
Victor J. Navarro ◽  
Guqi Wang
Keyword(s):  
Adverse Effects ◽  
Herbal Products

scholarly journals Herbal Products for Treatment of Burn Wounds

2020 ◽  
Vol 41 (3) ◽  
pp. 457-465
Author(s):  
Anna Herman ◽  
Andrzej P Herman
Keyword(s):  
Wound Healing ◽  
Adverse Effects ◽  
Current Knowledge ◽  
Herbal Therapy ◽  
Burn Wound ◽  
Herbal Products ◽  
Burn Wound Healing ◽  
Preclinical And Clinical Studies ◽  
Antioxidant Mechanisms ◽  
Wound Healing Activity

Abstract The purpose of this review is to summarize the current knowledge acquired during preclinical and clinical studies regarding topically used herbal products with burn wound-healing activity. Moreover, antimicrobial, anti-inflammatory, and antioxidant mechanisms of their action as well as adverse effects of herbal therapy will be also described.

scholarly journals Herbal Medicines—Are They Effective and Safe during Pregnancy?

Pharmaceutics ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 171
Author(s):  
Beata Sarecka-Hujar ◽  
Beata Szulc-Musioł
Keyword(s):  
Adverse Effects ◽  
Herbal Medicines ◽  
Echinacea Purpurea ◽  
Herbal Remedies ◽  
Efficacy And Safety ◽  
High Quality ◽  
Herbal Products ◽  
Morning Sickness ◽  
Active Substances ◽  
In Pregnancy

Since the teratogenicity of Thalidomide has been proven, herbal products are more commonly used in pregnancy to not only relieve morning sickness but also to fight infections. These products are frequently considered as natural and therefore harmless. However, herbs contain a number of active substances that, when used during pregnancy, can affect the development of the fetus. Often, pregnant women do not consult the usage of herbal medicines with a physician. The access to these products is easy and treatment of certain ailments with the use of herbs is common in many countries. The aim of the present literature review was to discuss available data regarding the efficacy and safety of cranberry, chamomile, Echinacea purpurea, garlic, ginger, Ginkgo biloba, and peppermint, which are used to counteract the most common ailments during pregnancy, i.e., infections and pregnancy-related ailments (e.g., nausea and vomiting, dizziness, and headache). Analysis of available data showed that ginger is one of the most extensively analyzed herbal remedies. The dose of ginger below 1000 mg per day may help to relief hypereremesis gravidarum, and such an amount of ginger did not increase frequency of adverse effects for either woman or developing fetus. Data regarding other herbs are most often heterogeneous and give conflicting results with no clear conclusions. However, all herbal products should be used with a special caution in pregnancy. Further high-quality human studies should be determined to confirm the safe doses of herbal products which could be used by pregnant or breast-feeding women.

scholarly journals Acute Liver Failure Caused by ‘Fat Burners’ and Dietary Supplements: A Case Report and Literature Review

2011 ◽  
Vol 25 (3) ◽  
pp. 157-160 ◽  
Author(s):  
Y Radha Krishna ◽  
V Mittal ◽  
P Grewal ◽  
MI Fiel ◽  
T Schiano
Keyword(s):  
Adverse Effects ◽  
Dietary Supplements ◽  
Green Tea ◽  
Histopathological Examination ◽  
Present Report ◽  
Healthy Woman ◽  
Usnic Acid ◽  
Herbal Remedies ◽  
Herbal Extracts ◽  
Herbal Products

Globally, people are struggling with obesity. Many effective, non-conventional methods of weight reduction, such as herbal and natural dietary supplements, are increasingly being sought. Fat burners are believed to raise metabolism, burn more calories and hasten fat loss. Despite patient perceptions that herbal remedies are free of adverse effects, some supplements are associated with severe hepatotoxicity. The present report describes a young healthy woman who presented with fulminant hepatic failure requiring emergent liver transplantation caused by a dietary supplement and fat burner containing usnic acid, green tea and guggul tree extracts. Thorough investigation, including histopathological examination, revealed no other cause of hepatotoxicity. The present case adds to the increasing number of reports of hepatotoxicity associated with dietary supplements containing usnic acid, and highlights that herbal extracts from green tea or guggul tree may not be free of adverse effects. Until these products are more closely regulated and their advertising better scrutinized, physicians and patients should become more familiar with herbal products that are commonly used as weight loss supplements and recognize those that are potentially harmful.

Use of Herbals as Galactagogues

2012 ◽  
Vol 25 (2) ◽  
pp. 222-231 ◽  
Author(s):  
Antonia Zapantis ◽  
Jennifer G. Steinberg ◽  
Lea Schilit
Keyword(s):  
Clinical Trials ◽  
Adverse Effects ◽  
Milk Production ◽  
Clinical Evidence ◽  
Reference Lists ◽  
Milk Thistle ◽  
Postpartum Women ◽  
Milk Supply ◽  
Herbal Products

With a substantial number of women using herbal products to augment their milk production, this article will review available literature illustrating efficacy and adverse effects of using these products. Embase, PubMed, and EBSCO (all databases) were searched from inception to June 2011 using terms such as “galactagogue,” “galactogogue,” “herbal,” and “botanical” and the search was subsequently narrowed to specific herbals by name. Additional articles were obtained from article reference lists. Supplemental information was obtained with Natural Standard. All abstracts retrieved were evaluated for relevance and germane articles were included. Numerous lactation-stimulating herbals have been identified in the literature with varying degrees of evidence, mostly anecdotal. Use of torbangun, milk thistle, and fenugreek may correlate with increased milk supply. Evidence regarding adverse effects, pharmacodynamic properties, and pharmacokinetic effects remains scarce. Despite the fact that postpartum women may turn to herbal galactagogues, scant clinical evidence exists to justify their effectiveness. Further clinical trials are needed in order to substantiate these findings.

scholarly journals Awareness on the possible adverse effects of Garcinia cambogia: A scientific approach

2020 ◽  
Vol 19 (4) ◽  
pp. 120-133
Author(s):  
James H. Zothantluanga ◽  
Hannah S. Lalnunpuii ◽  
Hans Raj Bhat ◽  
Anshul Shakya
Keyword(s):  
Adverse Effects ◽  
Web Of Science ◽  
Safety Issue ◽  
Herbal Product ◽  
Pharmaceutical Drugs ◽  
Herbal Products ◽  
Garcinia Cambogia ◽  
Therapeutic Value ◽  
The Family ◽  
Scientific Approach

The modern popular ideology is that plant-based products do not have adverse effects. Hence, people are fond of using herbal products of their choice to treat their own ailments or anyone else. As majority of the population are not aware of herbal toxicity concept, the use of formulated single or combined medicinal and/or nutritional plant extracts or isolated compounds to treat chronic diseases are increasingly popular due to the widespread concerns regarding the adverse effects of pharmaceutical drugs. Awareness from the scientific community to bring society to its senses regarding the safety issue of a herbal product is rare. Garcinia gummi-gutta (more popularly known by the synonym Garcinia cambogia in commercial preparations), belonging to the family of Clusiaceae (alt. Guttiferae) is a popularly consumed weight-loss nutraceutical. This review aims to highlight the possible adverse effects of G. cambogia. For the said purpose, 147 articles were collected from PubMed, Web of Science and Google scholar. Literature review revealed a plethora of beneficial actions. Investigational outcomes and clinical evidences hint the possible adverse effects likely to be linked with the use of G. cambogia. However, the use of G. cambogia as an anti-obesity agent is advisable as long as the therapeutic value outweighs the adverse effect.

Anaphylactic Reaction to a Dietary Supplement Containing Willow Bark

2003 ◽  
Vol 37 (6) ◽  
pp. 832-835 ◽  
Author(s):  
Joseph I Boullata ◽  
Patrick J McDonnell ◽  
Cynthia D Oliva
Keyword(s):  
Weight Loss ◽  
Adverse Effects ◽  
Dietary Supplements ◽  
Dietary Supplement ◽  
Anaphylactic Reaction ◽  
Medication History ◽  
Herbal Products ◽  
Initial Symptoms ◽  
History Of ◽  
Willow Bark

OBJECTIVE: To report a case of anaphylaxis resulting from the use of a willow bark–containing dietary supplement in a patient with a history of an aspirin allergy. CASE SUMMARY: A 25-year-old white woman presented to the emergency department of a community teaching hospital with anaphylaxis requiring epinephrine, diphenhydramine, methylprednisolone, and volume resuscitation to which she responded favorably. Medication history revealed that she had ingested 2 capsules of Stacker 2 (NVE Pharmaceuticals, Newton, NJ), a dietary supplement promoted for weight loss, prior to experiencing her initial symptoms. Among other active ingredients, this product contains willow bark. Of significance is that this patient also reported a history of allergy to acetylsalicylic acid. No other causes for anaphylaxis were identified. She continued to receive routine supportive care and the remaining hospital course was uncomplicated. DISCUSSION: Dietary supplements, including herbal products, are used by many individuals who consider them to be inherently safe despite limited regulatory oversight by the Food and Drug Administration. While there may be value to specific botanical ingredients, a potential for adverse effects also exists. The popular product consumed by our patient is used for weight loss and contains willow bark, a source of salicylates. Based on the Naranjo probability scale, it is probable that this case of anaphylaxis was due to this dietary supplement. CONCLUSIONS: The use of any willow bark–containing dietary supplement may present a risk of anaphylactic reaction to patients with a history of allergy to salicylates. Clinicians need to recognize the potential for adverse effects from dietary supplements.

Survey of Preoperative Patients' Use of Herbal Products and Other Selected Dietary Supplements

2002 ◽  
Vol 37 (12) ◽  
pp. 1301-1306 ◽  
Author(s):  
Tricia A. Meyer ◽  
Clinton E. Baisden ◽  
Charles R. Roberson ◽  
David F. Gloyna ◽  
Mohammad H. Rajab ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Dietary Supplements ◽  
Surgical Procedures ◽  
Demographic Data ◽  
Surgical Patients ◽  
Herbal Products ◽  
Saw Palmetto ◽  
Anesthetic Drugs ◽  
Assessment Unit ◽  
Orthopedic Patients

Purpose This study was designed to determine the prevalence of herbal and selected dietary product use among preoperative patients. Methods A questionnaire listing 26 herbal/dietary supplements was given to 979 preoperative patients in the anesthesia assessment unit. Subjects were asked to indicate the amounts and durations of products taken. Demographic data and proposed surgical procedures were noted. Results One hundred and seventy surgical patients (17.4%) reported taking herbal or dietary supplements. Neurosurgical, gynecological, and orthopedic surgical patients reported the highest incidences of use at 21%, 21%, and 20%, respectively. Of patients taking these agents, 34.7% took only one product, 23.5% took two products, 11.2% took three products, and 10.6% took four or more products. The most commonly used herbals, in descending order of frequency, were ginkgo, garlic, ginseng, St. John's wort, and echinacea. Glucosamine, chondroitin, and chromium were the surveyed dietary supplements most widely used. More than 40 herbs were taken occasionally. The median age of users and nonusers was 62 years. Orthopedic patients took glucosamine and chondroitin most commonly, ophthalmic patients took ginkgo most commonly, and urology patients took saw palmetto most commonly. Conclusion The adverse effects of herbals and dietary products during surgical procedures and the interactions between these products and anesthetic drugs warrant further research. The use of herbal or dietary supplements may indicate alteration of patients' perioperative regimens.

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