scholarly journals DNA fragmentation in brighter sperm predicts male fertility independently from age and semen parameters

2015 ◽  
Vol 104 (3) ◽  
pp. 582-590.e4 ◽  
Author(s):  
Monica Muratori ◽  
Sara Marchiani ◽  
Lara Tamburrino ◽  
Marta Cambi ◽  
Francesco Lotti ◽  
...  
Keyword(s):  
Dna Fragmentation ◽  
Male Fertility ◽  
Semen Parameters

scholarly journals Is there a connection with basic sperm parameters and age?

2020 ◽  
Vol 13 (4) ◽  
pp. 58-64
Author(s):  
A.I. Ryzhkov ◽  
◽  
I.S. Shormanov ◽  
S.Yu. Sokolova ◽  
◽  
...  
Keyword(s):  
Dna Fragmentation ◽  
Male Fertility ◽  
Reproductive Technologies ◽  
Semen Parameters ◽  
Sperm Dna Fragmentation ◽  
Who Guidelines ◽  
Negative Relation ◽  
Sperm Analysis ◽  
Mobile Forms ◽  
Sperm Dna

Introduction. TStandard sperm examination, performed according to WHO guidelines, remains the main method of assessment of male fertility. At the same time, this research method has a number of significant limitations, including a low predictive value regarding the outcomes of assisted reproductive technologies (ART) programs and the outcome of naturally occurring pregnancies. The limitations of standard sperm examination dictate the need for additional methods for assessing male fertility. The most promising and widely used test is the assessment of the level of sperm DNA fragmentation. Aim. To evaluate the associations between the levels of sperm DNA fragmentation and the age of the patients along with the following parameters used as a part of standard sperm analysis: semen volume, total number of spermatozoa, percentages of progressively-mobile, non-progressively-mobile and immobile forms, percentages of morphologically normal forms and the forms bearing head defects within the structure of total number of morphological anomalies, as well as semen leukocyte count. Materials and methods. Study materials were the examination results from 121 males aged from 21 to 53 years old (mean age 32.7±4.5 years old), undergoing an examination within the Clinical Institution «Mother and Child – Yaroslavl» during a time period from January 2019 until April 2020. Standard sperm analysis procedures were carried out according to latest edition of WHO Guidelines (2010). The determinations of germ cell DNA fragmentation levels were performed using the TUNEL method. Results. The test results have revealed a weak negative relation between the sperm DNA fragmentation (%) and the percentage of progressively-mobile forms (%) – r = -0.26 (p <0.01). The correlation of sperm DNA fragmentation with age and other parameters was considered statistically insignificant. The second stage of the analysis have demonstrated that the increased degree sperm DNA fragmentation is 1.8-fold more often found in the patients having signs of astenozoospermia (23.6%) comparing to the patients showing normal degree of spermatozoa mobility (13.1%), (p <0.05). Conclusions. The level of sperm DNA fragmentation correlates with the percentage of progressively-mobile forms of spermatozoa (negative relation) and no correlations were found with other semen parameters and with the age. The rates of increased levels of sperm DNA fragmentation are 1.8-fold more often found in astenozoospermia patients comparing to the patients showing normal degrees of spermatozoa mobility.

scholarly journals Chronic Inflammation Impairs Male Fertility—A Case-Control Study in Ulcerative Colitis Patients

2021 ◽  
Vol 10 (7) ◽  
pp. 1460
Author(s):  
Artur Wdowiak ◽  
Mariusz Gujski ◽  
Iwona Bojar ◽  
Dorota Raczkiewicz ◽  
Joanna Bartosińska ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Dna Fragmentation ◽  
Male Fertility ◽  
Sperm Quality ◽  
Sperm Count ◽  
Microbial Pathogens ◽  
Semen Parameters ◽  
Control Group ◽  
Study Group ◽  
Healthy Males

Recent evidence indicates that a systemic state of inflammation may exert a negative effect on male fertility. The aim of this study is to evaluate sperm quality parameters in male patients with ulcerative colitis (UC). Between December 2019 and December 2020 semen analyses are performed in 50 patients with UC in clinical remission. The control group consists of 50 healthy volunteers. Total sperm count, sperm count, percentage of morphologically normal spermatozoa, viability, and progressive motility, are significantly lower in the study group than in healthy males (p < 0.001). The DNA fragmentation index (DFI) and oxidation-reduction potential (ORP) are significantly higher in the study group (28.9% and 1.55% on average, respectively) than in healthy males (14.6% and 0.79% on average, respectively). Bacteriospermia is more clearly observed in the study group (p = 0.037), and the most frequent pathogen is Enterococcus faecalis. The DFI and ORP are significantly higher in bacteria carriers, compared to males without microbial pathogens from both the study and control groups (p < 0.001). To conclude, UC patients have worse basic sperm parameters compared to their healthy counterparts. Deterioration of semen parameters, as well as an intensified DNA fragmentation could be a result of oxidative stress intensification.

scholarly journals Selective serotonin reuptake inhibitors and spermatogenesis

2021 ◽  
Vol 9 (2) ◽  
pp. 74-79
Author(s):  
M. N. Korshunov ◽  
E. S. Korshunova ◽  
Yu. V. Kastrikin ◽  
S. P. Darenkov
Keyword(s):  
Dna Fragmentation ◽  
Male Fertility ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Sperm Concentration ◽  
Semen Parameters ◽  
Sperm Dna Fragmentation ◽  
Normal Morphology ◽  
Sperm Dna ◽  
Semen Volume ◽  
The Mean

Introduction. According to the WHO data, depression is a common disease among women and men of reproductive age. One line of the correction of depressive disorders is selective serotonin reuptake inhibitors (SSRIs). The ingestions have shown that using SSRIs harms sperm quality. The literature date of evaluation of male fertility after discontinuation of antidepressants is quite limited.Purpose of the study. To evaluate the influence of Fluoxetine intake on semen parameters, sperm DNA fragmentation and hormonal status.Materials and methods. Twenty-five men (mean age - 35.2 ± 4.5 yo) with depression were included in the study. Fluoxetine (20 mg per day) was prescribed to all the patients for 12 wk. Semen parameters, sperm DNA fragmentation, sex hormones levels were measured before-after treatment and 3 mo behind discontinuation.Results. After 12 weeks of the treatment the mean semen volume decreased from 3.1 ± 0.7 to 2.9 ± 0.7 ml (p = 0.638), sperm concentration - from 39.4 ± 18.5 to 34.3 ± 16.8 mln/ml (p = 0.384), sperm motility decreased from 41.7 ± 7.6 to 35.5 ± 7.8% (p < 0.05), the mean percent of normal morphology form - from с 12.7 ± 2.8 to 10.7 ± 2.2% (p < 0.001). Sperm DNA fragmentation increased 16.2 ± 4.9 to 22.2 ± 4.3% (p < 0.001). The mean semen volume, sperm concentration, motility, percentage of normal morphology increased and reverted to the normal levels after 3 mounts of drug discontinuation. Sperm DNA fragmentation index decreased, and it had the values less than before the treatment that positively correlated with the reduction of depression's symptoms. It was not significant dynamics in hormonal parameters before and after the therapy.Conclusion. Using fluoxetine has a reversible negative effect on male fertility. It is important to inform the patients about the temporary side effects of SSRIs in fatherhood planning cases.

scholarly journals Metabolic Syndrome and Reproduction

2021 ◽  
Vol 22 (4) ◽  
pp. 1988
Author(s):  
Francesco Lotti ◽  
Sara Marchiani ◽  
Giovanni Corona ◽  
Mario Maggi
Keyword(s):  
Metabolic Syndrome ◽  
Male Fertility ◽  
English Language ◽  
Negative Impact ◽  
Reproductive Potential ◽  
Underlying Mechanism ◽  
Semen Parameters ◽  
Preclinical Studies ◽  
Medline Search ◽  
High Prevalence

Metabolic syndrome (MetS) and infertility are two afflictions with a high prevalence in the general population. MetS is a global health problem increasing worldwide, while infertility affects up to 12% of men. Despite the high prevalence of these conditions, the possible impact of MetS on male fertility has been investigated by a few authors only in the last decade. In addition, underlying mechanism(s) connecting the two conditions have been investigated in few preclinical studies. The aim of this review is to summarize and critically discuss available clinical and preclinical studies on the role of MetS (and its treatment) in male fertility. An extensive Medline search was performed identifying studies in the English language. While several studies support an association between MetS and hypogonadism, contrasting results have been reported on the relationship between MetS and semen parameters/male infertility, and the available studies considered heterogeneous MetS definitions and populations. So far, only two meta-analyses in clinical and preclinical studies, respectively, evaluated this topic, reporting a negative association between MetS and sperm parameters, testosterone and FSH levels, advocating, however, larger prospective investigations. In conclusion, a possible negative impact of MetS on male reproductive potential was reported; however, larger studies are needed.

scholarly journals Obesity Appears to Impact Male Fertility by Degrading Overall Semen Quality Rather than Individual Semen Parameters

2014 ◽  
Vol 04 (15) ◽  
pp. 917-923
Author(s):  
Joseph Petty ◽  
Sami Jabara ◽  
Samuel Prien ◽  
Lindsay Penrose
Keyword(s):  
Male Fertility ◽  
Semen Quality ◽  
Semen Parameters

scholarly journals Male Fertility and Reduction in Semen Parameters: A Single Tertiary-Care Center Experience

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
D. Milardi ◽  
G. Grande ◽  
D. Sacchini ◽  
A. L. Astorri ◽  
G. Pompa ◽  
...  
Keyword(s):  
Reference Values ◽  
Male Fertility ◽  
Ethical Issues ◽  
Semen Analysis ◽  
Care Center ◽  
Tertiary Care ◽  
Healthcare Services ◽  
University Hospital ◽  
Semen Parameters ◽  
Spontaneous Conception

Background. Infertility is both a clinical and a public problem, affecting the life of the couple, the healthcare services, and social environment. Standard semen analysis is the surrogate measure of male fertility in clinical practice.Objective. To provide information about the relationship between semen parameters and spontaneous conception.Methods. We evaluated retrospectively 453 pregnancies that occurred among 2935 infertile couples evaluated at an infertility clinic of a tertiary-care university hospital, between 2004 and 2009.Results. Normal semen analysis was present only in 158 patients; 295 subfertile patients showed alterations in at least one seminal parameter. A reduction in all seminal parameters was observed in 41 patients. Etiological causes of male infertility were identified in 314 patients.Conclusion. Our data highlights the possibility of a spontaneous conception with semen parameters below WHO reference values. Therefore, we support the importance of defining reference values on a population of fertile men. Finally, we analyzed the related ethical issues.

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