scholarly journals Exploring expressive and functional capacities of knitted textiles exposed to wind influence

2021 ◽  
Author(s):  
Erica Hörteborn ◽  
Malgorzata A. Zboinska
Keyword(s):  
Wind Influence ◽  
Functional Capacities

Effects of Increased Dietary Protein and Energy on Composition and Functional Capacities of Blood Mononuclear Cells from Vaccinated, Neonatal Calves

2005 ◽  
Vol 75 (5) ◽  
pp. 357-368 ◽  
Author(s):  
Foote ◽  
Nonnecke† ◽  
Waters ◽  
Palmer ◽  
Beitz ◽  
...  
Keyword(s):  
Weight Gain ◽  
B Cell ◽  
Dietary Protein ◽  
Crude Protein ◽  
Interleukin 2 ◽  
Milk Replacer ◽  
Standard Diet ◽  
Gamma Delta ◽  
Ifn Gamma ◽  
Functional Capacities

Effects of increased protein and energy provided by an intensified milk replacer on the antigen-specific, cell-mediated immune response of the neonatal calf were examined. Calves were fed a standard (0.45 kg/day of a 20% crude protein, 20% fat milk replacer; n = 11) or intensified (1.14 kg/day of a 28% crude protein, 20% fat milk replacer; n = 11) diet from 0 to 6 weeks of age. All calves were vaccinated with Mycobacterium bovis bacillus Calmette-Guerin (BCG) at 1 week of age. The daily weight gain of intensified-diet calves (0.62 kg/day) was greater than the weight gain of standard-diet calves (0.29 kg/day). Liver, kidney, heart, thymus, and subcervical lymph nodes from intensified-diet calves were heavier than the same organs from standard-diet calves. Flow cytometric analysis of peripheral blood mononuclear cell (PBMC) populations indicated that CD4+ cells, gamma delta TCR+ cells, and monocyte percentages, although unaffected by diet during the first 5 weeks of the study, were higher in intensified-diet calves at week 6. The decline in gamma deltad TCR+ cell percentages and increase in B cell percentages with increasing age seen in all calves are characteristic of the maturing immune system of the calf. CD8+ T cell or B cell percentages were not affected by diet. In intensified-diet calves, percentages of CD4+ expressing interleukin-2 receptor increased and percentages of gamma delta TCR+ cells expressing interleukin-2 receptor decreased with time. The same populations in standard-diet calves did not change with time. Percentages of CD4+ and CD8+ T cells, and B cells expressing MHC class II antigen, were unaffected by diet or age. Although mitogen-induced interferon (IFN)-gamma and nitric oxide (NO) secretion increased with age for all calves, PBMC from intensified-diet calves produced less IFN-gamma and more NO than did cells from standard-diet calves at week 6 of the study. Antigen-induced secretion of IFN-gamma and NO also increased with age but was unaffected by diet. Antigen-elicited delayed-type hypersensitivity was unaffected by diet, suggesting increased dietary protein and energy did not alter adaptive immunity in vivo. Overall, these results suggest that feeding calves a commercially available, intensified milk replacer affects minimally the composition and functional capacities of PBMC populations. Additional research is necessary to determine whether these subtle effects influence the calf’s susceptibility to infectious disease.

scholarly journals Pravastatin Promotes Endothelial Colony-Forming Cell Function, Angiogenic Signaling and Protein Expression In Vitro

2021 ◽  
Vol 10 (2) ◽  
pp. 183
Author(s):  
Nadia Meyer ◽  
Lars Brodowski ◽  
Katja Richter ◽  
Constantin S. von Kaisenberg ◽  
Bianca Schröder-Heurich ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Growth Factor ◽  
Endothelial Dysfunction ◽  
Protein Expression ◽  
Tube Formation ◽  
In Vitro Assays ◽  
Heme Oxygenase 1 ◽  
Expression Levels ◽  
Functional Capacities

Endothelial dysfunction is a primary feature of several cardiovascular diseases. Endothelial colony-forming cells (ECFCs) represent a highly proliferative subtype of endothelial progenitor cells (EPCs), which are involved in neovascularization and vascular repair. Statins are known to improve the outcome of cardiovascular diseases via pleiotropic effects. We hypothesized that treatment with the 3-hydroxy-3-methyl-glutaryl–coenzyme A (HMG-CoA) reductase inhibitor pravastatin increases ECFCs’ functional capacities and regulates the expression of proteins which modulate endothelial health in a favourable manner. Umbilical cord blood derived ECFCs were incubated with different concentrations of pravastatin with or without mevalonate, a key intermediate in cholesterol synthesis. Functional capacities such as migration, proliferation and tube formation were addressed in corresponding in vitro assays. mRNA and protein levels or phosphorylation of protein kinase B (AKT), endothelial nitric oxide synthase (eNOS), heme oxygenase-1 (HO-1), vascular endothelial growth factor A (VEGF-A), placental growth factor (PlGF), soluble fms-like tyrosine kinase-1 (sFlt-1) and endoglin (Eng) were analyzed by real time PCR or immunoblot, respectively. Proliferation, migration and tube formation of ECFCs were enhanced after pravastatin treatment, and AKT- and eNOS-phosphorylation were augmented. Further, expression levels of HO-1, VEGF-A and PlGF were increased, whereas expression levels of sFlt-1 and Eng were decreased. Pravastatin induced effects were reversible by the addition of mevalonate. Pravastatin induces beneficial effects on ECFC function, angiogenic signaling and protein expression. These effects may contribute to understand the pleiotropic function of statins as well as to provide a promising option to improve ECFCs’ condition in cell therapy in order to ameliorate endothelial dysfunction.

scholarly journals Conducting experimental investigations of wind influence on high-rise constructions

2018 ◽  
Vol 33 ◽  
pp. 02067 ◽  
Author(s):  
Olga I. Poddaeva ◽  
Anastasia N. Fedosova ◽  
Pavel S. Churin ◽  
Julia S. Gribach
Keyword(s):  
Aerodynamic Drag ◽  
Experimental Investigations ◽  
Building Structures ◽  
High Rise ◽  
Aerodynamic Pressure ◽  
Stage Of Development ◽  
Wind Influence ◽  
Under Construction ◽  
Building Designs ◽  
The Impact

The design of buildings with a height of more than 100 meters is accompanied by strict control in determining the external loads and the subsequent calculation of building structures, which is due to the uniqueness of these facilities. An important factor, the impact of which must be carefully studied at the stage of development of project documentation, is the wind. This work is devoted to the problem of studying the wind impact on buildings above 100 meters. In the article the technique of carrying out of experimental researches of wind influence on high-rise buildings and constructions, developed in the Educational-research-and-production laboratory on aerodynamic and aeroacoustic tests of building designs of NRU MGSU is presented. The publication contains a description of the main stages of the implementation of wind tunnel tests. The article presents the approbation of the methodology, based on the presented algorithm, on the example of a high-rise building under construction. This paper reflects the key requirements that are established at different stages of performing wind impact studies, as well as the results obtained, including the average values of the aerodynamic pressure coefficients, total forces and aerodynamic drag coefficients. Based on the results of the work, conclusions are presented.

In VitroEffects of 3′-Azido-3′-Deoxythymidine (AZT) On Normal Human Polymorphonuclear Cell and Monocyte-Macrophage Functional Capacities

1996 ◽  
Vol 18 (2) ◽  
pp. 161-178 ◽  
Author(s):  
C. de Simone ◽  
A. B. Maffione ◽  
R. Calvello ◽  
C. Nacci ◽  
G. Sciannameo ◽  
...  
Keyword(s):  
Polymorphonuclear Cell ◽  
Normal Human ◽  
Functional Capacities

Expressivism, Psychic Health, and the First-Person Stance

2018 ◽  
Vol 32 (3) ◽  
pp. 351-373 ◽  
Author(s):  
Adam Leite
Keyword(s):  
Psychological Health ◽  
First Person ◽  
Important Phenomenon ◽  
Subjective Perspective ◽  
Clinically Significant ◽  
Functional Capacities ◽  
Philosophical Questions

This article addresses the psychotherapeutically important phenomenon of relating first-personally to one's own emotion, belief, desire, or other attitude. The fundamental theoretical challenge is to understand how one can relate to one's attitudes as one's attitudes without occupying a position that is alienated from them. Philosophical questions in this area are significantly illuminated by considering certain clinically manifested vicissitudes and pathologies of the first-person. The article interprets the first-person relation in terms of a complex set of functional capacities: the capacity to occupy the subjective perspective of the attitude as conscious subject; the capacity to both self-ascribe the attitude and articulate its content, in ways that are expressive manifestations of the attitude; and various capacities involved in relating to one's state as an attitude. The resultant conception of the first-person stance accommodates a range of clinically significant phenomena and suggests a multidimensional specification of one key aspect of psychological health.

Oxygen and the upper limits to animal design and performance.

1998 ◽  
Vol 201 (8) ◽  
pp. 1065-1072 ◽  
Author(s):  
R K Suarez
Keyword(s):  
Energy Metabolism ◽  
Surface Area ◽  
Body Mass ◽  
Current Evidence ◽  
Tracheal System ◽  
Flying Insects ◽  
Upper Limit ◽  
O2 Transport ◽  
Upper Limits ◽  
Functional Capacities

Mass-specific rates of aerobic metabolism VO2/Mb) scale in inverse proportion to body mass (Mb). Thus, small hummingbirds display the highest VO2/Mb known among vertebrates. Among all animals, higher VO2/Mb values are known only in flying insects. The high body-mass-specific rates of metabolism seen in hummingbirds are made possible by high lung O2 diffusing capacities, cardiac outputs, ratios of capillary surface area to muscle fiber surface area, mitochondrial volume densities, cristae surface densities and concentrations of enzymes involved in energy metabolism. Current evidence from control analyses of O2 transport through the respiratory and cardiovascular systems and of metabolic fluxes through pathways of energy metabolism indicates shared control of maximum flux rates among multiple steps (i.e. the absence of single rate-limiting steps). This supports the suggestion that functional capacities at each step in linear pathways or processes are matched to each other, and provides an explanation for why the up-regulation of functional capacities has occurred at virtually all steps in the evolution of the smallest vertebrate homeotherms. Flying insects make use of a tracheal system for O2 transport and, like hummingbirds, possess a highly up-regulated biochemical machinery for substrate oxidation. Studies of hummingbirds and honeybees reveal closer matches between biochemical flux capacities and maximum physiological flux rates than in animals capable of lower maximum VO2/Mb. It is proposed that the upper limits to functional capacities set the upper limit to VO2/Mb. This upper limit to aerobic metabolic rate may contribute, along with other factors, towards establishing the lower limit to vertebrate homeotherm size.

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