A hydrophobic deep eutectic solvents-based integrated method for efficient and green extraction and recovery of natural products from Rosmarinus officinalis leaves, Ginkgo biloba leaves and Salvia miltiorrhiza roots

2021 ◽  
pp. 130282
Author(s):  
Tong Wang ◽  
Qing Wang ◽  
Qing Guo ◽  
Ping Li ◽  
Hua Yang
Keyword(s):  
Natural Products ◽  
Ginkgo Biloba ◽  
Salvia Miltiorrhiza ◽  
Deep Eutectic Solvents ◽  
Rosmarinus Officinalis ◽  
Green Extraction ◽  
Integrated Method

Determination of phenolic acids in Prunella vulgaris L.: a safe and green extraction method using alcohol-based deep eutectic solvents

2015 ◽  
Vol 7 (21) ◽  
pp. 9354-9364 ◽  
Author(s):  
Bohou Xia ◽  
Dong Yan ◽  
Yubing Bai ◽  
Jiachi Xie ◽  
Yi Cao ◽  
...  
Keyword(s):  
Natural Products ◽  
Phenolic Acids ◽  
Extraction Method ◽  
Deep Eutectic Solvents ◽  
Prunella Vulgaris ◽  
Green Extraction

The extraction of natural products with available green and safe solvents is rather limited.

scholarly journals Green Extraction of Phenolic Acids from Artemisia argyi Leaves by Tailor-Made Ternary Deep Eutectic Solvents

Molecules ◽  
2019 ◽  
Vol 24 (15) ◽  
pp. 2842 ◽  
Author(s):  
Li Duan ◽  
Chenmeng Zhang ◽  
Chenjing Zhang ◽  
Zijing Xue ◽  
Yuguang Zheng ◽  
...  
Keyword(s):  
Natural Products ◽  
Water Content ◽  
Organic Solvents ◽  
Phenolic Acids ◽  
Extraction Method ◽  
Deep Eutectic Solvents ◽  
Bioactive Constituents ◽  
Green Extraction ◽  
Caffeoylquinic Acid ◽  
Artemisia Argyi

The Artemisia argyi leaf (AL) has been used as a traditional medicine and food supplement in China and other Asian countries for hundreds of years. Phytochemical studies disclosed that AL contains various bioactive constituents. Among bioactive constituents, phenolic acids have been recognized as the main active compounds in AL. To the best of our knowledge, no research has been focused on extraction method for the bioactive phenolic acids from AL. Nowadays, deep eutectic solvents (DESs) are emerging as a new type of green and sustainable solvent for efficient extraction of bioactive compounds from natural products. In the present study, an environmentally friendly extraction method based on DESs was established to extract bioactive phenolic acids from ALs. Diverse tailor-made solvents, including binary and ternary DESs, were explored for simultaneous extraction of four phenolic acids (3-caffeoylquinic acid, 3,4-di-O-caffeoylquinic acid, 3,5-di-O-caffeoylquinic acid, and 4,5-di-O-caffeoylquinic acid) from AL. The results indicated that the ternary DES composed of a 2:1:2 molar ratio of choline chloride, malic acid, and urea showed enhanced extraction yields for phenolic acids compared with conventional organic solvents and other DESs. Subsequently, the extraction parameters for the four phenolic acids by selected tailor-made DESs, including liquid–solid ratios, water content (%) in the DESs, and extraction time, were optimized using response surface methodology and the optimal extraction conditions were: extraction time, 23.5 min; liquid–solid ratio, 57.5 mL/g (mL of DES/g dry weight of plant material); water content, 54%. The research indicated that DESs were efficient and sustainable green extraction solvents for extraction of bioactive phenolic acids from natural products. Compared to the conventional organic solvents, the DESs have a great potential as possible alternatives to those organic solvents in health-related areas such as food and pharmaceuticals.

Efficient removal of ginkgolic acids from Ginkgo biloba leaves crude extract by using hydrophobic deep eutectic solvents

2021 ◽  
Vol 166 ◽  
pp. 113462
Author(s):  
Qihui Dong ◽  
Jun Cao ◽  
Rong Wu ◽  
Tingting Shi ◽  
Wen Zhang ◽  
...  
Keyword(s):  
Ginkgo Biloba ◽  
Crude Extract ◽  
Deep Eutectic Solvents ◽  
Efficient Removal ◽  
Ginkgolic Acids

Cardio-Protection by Ginkgo biloba Extract 50 in Rats with Acute Myocardial Infarction is Related to Na+–Ca2+ Exchanger

2013 ◽  
Vol 41 (04) ◽  
pp. 789-800 ◽  
Author(s):  
Ai-Hua Liu ◽  
Yi-Min Bao ◽  
Xing-Yu Wang ◽  
Zhi-Xiong Zhang
Keyword(s):  
Myocardial Infarction ◽  
At Risk ◽  
Ginkgo Biloba ◽  
Myocardial Function ◽  
Contractile Function ◽  
Salvia Miltiorrhiza ◽  
Ginkgo Biloba Extract ◽  
Area At Risk ◽  
Ischemia Group ◽  
Cardio Protection

Ginkgo biloba has been used for medical purposes for centuries in traditional Chinese medicine. Ginkgo biloba extract 50 (GBE50) is a new standardized GBE product that matches the standardized German product as EGb761. This paper is aimed at studying the cardio-protection effects of GBE50 Salvia miltiorrhiza on myocardial function, area at risk, myocardial ultra-structure, and expression of calcium handling proteins in rat ischemic myocardium. Myocardium ischemia was induced by the left anterior descending (LAD) coronary artery occlusion and myocardial function was recorded by a transducer advanced into the left ventricle on a computer system. In vitro myocardial infarction was measured by 2,3,5-triphenyltetrazolium chloride (TTC) and Evans blue staining of heart sections. Morphological change was evaluated by electric microscopy and Western blotting was used for protein expression. Hemodynamic experiments in vivo showed that postischemic cardiac contractile function was reduced in ischemic rats. Salvia miltiorrhiza (7.5 g/kg/d×7) and Ginkgo biloba extract 50 (GBE50) (100 mg/kg/d×7) improved post-schemic cardiac diastolic dysfunction while not affecting the systolic function. In hearts of GBE50 group and Salvia miltiorrhiza (SM) group, the area at risk was significantly reduced and myocardial structure was better-preserved. Moreover, Na +– Ca 2+ exchanger (NCX) expression increase and sarcoplasmic reticulum Ca 2+– ATPase 2 (SERCA2), LTCC, and ryanodine receptor 2 (RyR2) expression decreases were smaller than those in ischemia group. There was a significant difference between the GBE50 and ischemia group in NCX expression. GBE50 could improve recovery in contractile function and prevent myocardium from ischemia damage, which may be caused by attenuating the abnormal expression of NCX.

Tailor-made hydrophobic deep eutectic solvents for cleaner extraction of polyprenyl acetates from Ginkgo biloba leaves

2017 ◽  
Vol 152 ◽  
pp. 399-405 ◽  
Author(s):  
Jun Cao ◽  
Meng Yang ◽  
Fuliang Cao ◽  
Jiahong Wang ◽  
Erzheng Su
Keyword(s):  
Ginkgo Biloba ◽  
Deep Eutectic Solvents

scholarly journals Water an Eco-Friendly Crossroad in Green Extraction: An Overview

2019 ◽  
Vol 13 (1) ◽  
pp. 155-162
Author(s):  
Dasha Mihaylova ◽  
Anna Lante
Keyword(s):  
Natural Products ◽  
Extraction Methods ◽  
Green Solvent ◽  
Green Extraction ◽  
Finite Resource ◽  
Ancient Times ◽  
Effective Use

In this review, the function of water and the increasing role of water as a green solvent and co-extractant based on its application in ancient times and the need of environmental thinking have been discussed. A brief summary of various extraction methods for natural products, the application of conventional and innovative processes, based on water and future insights and perspectives considering water as an eco-friendly crossroad in green extraction have been reported. Taking into account also the issue of wastewater, this paper calls for-more effective use of water as a finite resource.

Cosmo-RS-Assisted Solvent Screening for Green Extraction of Natural Products

2018 ◽  
pp. 117-138 ◽  
Author(s):  
Anne-Gaëlle Sicaire ◽  
Aurore Filly ◽  
Maryline Vian ◽  
Anne-Sylvie Fabiano-Tixier ◽  
Farid Chemat
Keyword(s):  
Natural Products ◽  
Green Extraction

scholarly journals Highly Efficient Extraction Procedures Based on Natural Deep Eutectic Solvents or Ionic Liquids for Determination of 20-Hydroxyecdysone in Spinach

Molecules ◽  
2020 ◽  
Vol 25 (20) ◽  
pp. 4736
Author(s):  
Sylwia Bajkacz ◽  
Kornelia Rusin ◽  
Anna Wolny ◽  
Jakub Adamek ◽  
Karol Erfurt ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Extraction Procedure ◽  
Deep Eutectic Solvents ◽  
Molar Ratio ◽  
Green Extraction ◽  
Natural Deep Eutectic Solvents ◽  
Efficient Extraction ◽  
Solid Liquid ◽  
Extraction Agent

A novel, efficient extraction procedure based on natural deep eutectic solvents (NADES) and ionic liquids (ILs) for determination of 20-hydroxyecdysone (20-E) in spinach has been developed. NADES, the first green extraction agent, with different hydrogen bond donors and acceptors are screened in order to determine extraction efficiencies. NADES consisting of lactic acid and levulinic acid at a molar ratio of 1:1 exhibits the highest yields. ILs, the second green extraction agent, with various cations and anions are also investigated, where [TEA] [OAc]·AcOH, χAcOH = 0.75 displays the highest recovery. Moreover, NADES-SLE and IL-SLE (SLE, solid-liquid extraction) parameters are investigated. Using the obtained optimized method, the recoveries of the target compound in spinach are above 93% and 88% for NADES-SLE and IL-SLE procedure, respectively. The methods display good linearity within the range of 0.5–30 μg/g and LODs of 0.17 µg/g. The proposed NADES-SLE-UHPLC-UV and IL-SLE-UHPLC-UV procedures can be applied to the analysis of 20-E in real spinach samples, making it a potentially promising technique for food matrix. The main advantage of this study is the superior efficiency of the new, green extraction solvents, which results in a significant reduction of extraction time and solvents as compared to those in the literature.

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