Steric stabilization of phycobiliprotein loaded liposome through polyethylene glycol adsorbed cellulose nanocrystals and their impact on the gastrointestinal tract

2020 ◽  
Vol 98 ◽  
pp. 105252 ◽  
Author(s):  
Avinash Singh Patel ◽  
SuriyaPrakaash Lakshmibalasubramaniam ◽  
Balunkeswar Nayak
Keyword(s):  
Polyethylene Glycol ◽  
Gastrointestinal Tract ◽  
Cellulose Nanocrystals ◽  
Steric Stabilization

scholarly journals Complications and hospital stay after endoscopic retrieval of drug baggies in body stuffers: an observational prospective study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mahtab Shabani ◽  
Marzieh Kefayati ◽  
Hossein Hassanian-Moghaddam ◽  
Nasim Zamani ◽  
Rebecca McDonald
Keyword(s):  
Polyethylene Glycol ◽  
Gastrointestinal Tract ◽  
Conservative Treatment ◽  
Prospective Study ◽  
Hospital Stay ◽  
Safe Alternative ◽  
Conservative Group ◽  
Observational Prospective Study ◽  
Endoscopic Retrieval ◽  
Upper Gastrointestinal

AbstractBody stuffers routinely receive conservative treatment, i.e. administration of the laxative polyethylene glycol for the passage of ingested drug baggies and observation. Endoscopic baggie removal may offer a safe alternative that could result in shorter hospitalization. We aimed to compare complications, hospital stay, and final outcome in body stuffers assigned to endoscopy versus conservative treatment. This is an observational prospective study of body stuffers presenting to a clinical toxicology center in Tehran (Iran) in 2016–2019, irrespective of the drug ingested. Eligible patients had baggies in their upper gastrointestinal tract and presented without severe poisoning. Patients received either endoscopy or conservative treatment, and clinical outcomes were compared between the groups. A total of 69 patients were enrolled, with a median age of 29 years (range 18–64), among whom 1 was female (2%). Eighteen and 51 patients were endoscopically and conservatively managed, respectively. Drugs most commonly ingested were heroin in endoscopy patients (8/18 cases; 44%) and methamphetamine in the conservative group (28/51 cases; 55%). Endoscopy patients had a shorter hospital stay (median 1.5 vs. 2 days, P = 0.018). In the conservative group, one patient died, and the rate of complications was significantly higher, with more patients experiencing side effects (OR = 1.4, 95% CI = 1.2, 1.7) and requiring intubation (OR = 1.3, 95% CI = 1.1, 1.5). Endoscopic retrieval was associated with fewer complications and shorter hospitalization. Endoscopy may be a safe treatment for body stuffers without severe poisoning on presentation.

scholarly journals Oral lavage with polyethylene glycol reduces microbial colonization in the gastrointestinal tract of broilers

2002 ◽  
Vol 81 (4) ◽  
pp. 585-589 ◽  
Author(s):  
A. Farhat ◽  
C.W. Maddox ◽  
M.E. Edwards ◽  
M.H. Costell ◽  
J.A. Hadley ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Gastrointestinal Tract ◽  
Microbial Colonization

scholarly journals Iso-osmolar hyponatremia from polyethylene glycol

2020 ◽  
Author(s):  
Bryan M Tucker ◽  
James L Pirkle ◽  
Erinda Stefi ◽  
David Sheikh-Hamad ◽  
Thomas DuBose
Keyword(s):  
Differential Diagnosis ◽  
Polyethylene Glycol ◽  
Gastrointestinal Tract ◽  
Patient Care ◽  
Clinical Setting ◽  
Laboratory Data ◽  
Accurate Diagnosis ◽  
Therapeutic Interventions ◽  
Pathophysiological Mechanisms

Abstract Understanding and applying pathophysiological concepts to patient care is an important skill for physicians in the clinical setting. Here, we present a case that demonstrates how the application of common physiological concepts relating to the widely accepted hyponatremia algorithm led to an accurate diagnosis of hyponatremia. This case documents iso-osmolar hyponatremia caused by orally administered polyethylene glycol absorption in the gastrointestinal tract. Herein, we discuss the workup and differential diagnosis for iso-osmolar hyponatremia in juxtaposition with the pathophysiological mechanisms unique to this case. We discuss these pathophysiological mechanisms based on the patients’ laboratory data and responses to therapeutic interventions.

scholarly journals Effect of GNPs on the Piezoresistive, Electrical and Mechanical Properties of PHA and PLA Films

Fibers ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 86
Author(s):  
Gonzalo Mármol ◽  
Usha Kiran Sanivada ◽  
Raul Fangueiro
Keyword(s):  
Mechanical Properties ◽  
Electrical Conductivity ◽  
Polyethylene Glycol ◽  
Polylactic Acid ◽  
Cellulose Nanocrystals ◽  
Graphene Nanoplatelets ◽  
Gauge Factor ◽  
Solvent Casting ◽  
Nanoparticle Distribution ◽  
Primary Focus

Sustainability has become the primary focus for researchers lately. Biopolymers such as polyhydroxyalkanoate (PHA) and polylactic acid (PLA) are biocompatible and biodegradable. Introducing piezoresistive response in the films produced by PLA and PHA by adding nanoparticles can be interesting. Hence, a study was performed to evaluate the mechanical, electrical and piezoresistive response of films made from PHA and PLA. The films were produced by solvent casting, and they were reinforced with graphene nanoplatelets (GNPs) at different nanoparticle concentrations (from 0.15 to 15 wt.%). Moreover, cellulose nanocrystals (CNC) as reinforcing elements and polyethylene glycol (PEG) as plasticizers were added. After the assessment of the nanoparticle distribution, the films were subjected to tests such as tensile, electrical conductivity and piezoresistive response. The dispersion was found to be good in PLA films and there exist some agglomerations in PHA films. The results suggested that the incorporation of GNPs enhanced the mechanical properties until 0.75 wt.% and they reduced thereon. The addition of 1% CNCs and 20% PEG in 15 wt.% GNPs’ tensile values deteriorated further. The PHA films showed better electrical conductivity compared to the PLA films for the same GNPs wt.%. Gauge factor (GF) values of 6.30 and 4.31 were obtained for PHA and PLA, respectively.

scholarly journals EFFECT OF CHRONIC RENAL DYSFUNCTION ON THE PERMEABILITY OF THE COLON TO WATER AND ELECTROLYTES: EXPERIMENTAL STUDY IN RATS

2019 ◽  
Vol 32 (4) ◽  
Author(s):  
Elionai Gomes FREIRE ◽  
José Cirlânio Sousa ALBUQUERQUE ◽  
Israel Pinto LEAL ◽  
Nayara Alves SOUSA ◽  
José Ronaldo Vasconcelos da GRAÇA
Keyword(s):  
Experimental Study ◽  
Renal Failure ◽  
Polyethylene Glycol ◽  
Gastrointestinal Tract ◽  
Wistar Rats ◽  
The Other ◽  
Male Wistar Rats ◽  
Progression Of Renal Failure ◽  
Colonic Secretion ◽  
Secretory Capacity

ABSTRACT Background: Renal insufficiency is a disease that affects several organs by provoking hypervolemia and uremia. The disease reaches more than 500 million people worldwide and few studies bring their influence on the gastrointestinal tract. Aim: To evaluate the influence of 5/6 nephrectomy-induced hypervolemia on colonic permeability to water and electrolytes. Method: Sixty male Wistar rats weighing between 280-300 g were divided into three groups: 3, 7 and 14 days after nephrectomy, each one having a false-operated/control and partially nephrectomized. For colonic permeability they were submitted to colonic perfusion with a solution of Tyroad containing phenolphthalein. Differences among the concentrations of Na+, K+ and Cl- were used to calculate the rate of colonic permeability for the electrolytes. Phenolphthalein concentrations were used to evaluate the rate of secretion and water absorption. Results: The colonic secretion of water and electrolytes occurred expressively in the group seven days after nephrectomy. Hemodynamic and biochemical assessments determined the progression of renal failure in all three groups and polyethylene glycol was shown to be effective in reversing the secretory capacity of the colon. Conclusion: Hypervolemia established after 7 days post-nephrectomy 5/6 caused marked colonic secretion for water and electrolytes. The organism presents progressive colonic secretion as the blood volume increases; on the other hand, polyethylene glycol was able to revert this secretory framework of the colon to water and electrolytes by reversing the hypervolemia.

Enhanced Heat Conduction in Cellulose Nanocrystals Grafting Polyethylene Glycol as Solid-Solid Phase Change Materials

2012 ◽  
Vol 557-559 ◽  
pp. 563-566 ◽  
Author(s):  
Yan Nan Liu ◽  
Hou Yong Yu ◽  
Zong Yi Qin ◽  
Long Chen
Keyword(s):  
Polyethylene Glycol ◽  
Phase Change ◽  
Cellulose Nanocrystals ◽  
Thermal Conduction ◽  
Phase Change Materials ◽  
Solid Phase ◽  
Scanning Calorimetry ◽  
Thermal Delay ◽  
Change Material ◽  
Molecular Skeleton

Green copolymers as phase change material were prepared by grafting polyethylene glycol(PEG) onto a rigid molecular skeleton of cellulose nanocrystals (CNs), and their thermal properties were studied by thermal delay method and differential scanning calorimetry. The influences of the CNs on the thermal conductivity behavior and thermal energy storage capacity of the copolymers were evaluated. As expected, a great enhancement on thermal conduction can be achieved by introducing CNs.

Sign in / Sign up

Export Citation Format

Share Document