scholarly journals Nuclear geyser model of the origin of life: Driving force to promote the synthesis of building blocks of life

2017 ◽  
Vol 8 (2) ◽  
pp. 275-298 ◽  
Author(s):  
Toshikazu Ebisuzaki ◽  
Shigenori Maruyama
Keyword(s):  
Origin Of Life ◽  
Driving Force ◽  
Building Blocks ◽  
The Origin Of Life

Photochemical Evolution of Interstellar/Precometary Organic Material

1997 ◽  
Vol 161 ◽  
pp. 23-47 ◽  
Author(s):  
Louis J. Allamandola ◽  
Max P. Bernstein ◽  
Scott A. Sandford
Keyword(s):  
Origin Of Life ◽  
Building Blocks ◽  
Complex Species ◽  
Infrared Observations ◽  
Interstellar Ice ◽  
Polycyclic Aromatic ◽  
Ultraviolet Photolysis ◽  
The Origin Of Life ◽  
Simple Molecules ◽  
Complex Organic

AbstractInfrared observations, combined with realistic laboratory simulations, have revolutionized our understanding of interstellar ice and dust, the building blocks of comets. Since comets are thought to be a major source of the volatiles on the primative earth, their organic inventory is of central importance to questions concerning the origin of life. Ices in molecular clouds contain the very simple molecules H2O, CH3OH, CO, CO2, CH4, H2, and probably some NH3and H2CO, as well as more complex species including nitriles, ketones, and esters. The evidence for these, as well as carbonrich materials such as polycyclic aromatic hydrocarbons (PAHs), microdiamonds, and amorphous carbon is briefly reviewed. This is followed by a detailed summary of interstellar/precometary ice photochemical evolution based on laboratory studies of realistic polar ice analogs. Ultraviolet photolysis of these ices produces H2, H2CO, CO2, CO, CH4, HCO, and the moderately complex organic molecules: CH3CH2OH (ethanol), HC(= O)NH2(formamide), CH3C(= O)NH2(acetamide), R-CN (nitriles), and hexamethylenetetramine (HMT, C6H12N4), as well as more complex species including polyoxymethylene and related species (POMs), amides, and ketones. The ready formation of these organic species from simple starting mixtures, the ice chemistry that ensues when these ices are mildly warmed, plus the observation that the more complex refractory photoproducts show lipid-like behavior and readily self organize into droplets upon exposure to liquid water suggest that comets may have played an important role in the origin of life.

General discussion after session V

1988 ◽  
Vol 325 (1587) ◽  
pp. 611-618 ◽  
Keyword(s):  
Origin Of Life ◽  
Time Perspective ◽  
Applied Mathematics ◽  
Building Blocks ◽  
Living Systems ◽  
Organic Chemical ◽  
General Terms ◽  
The Earth ◽  
The Origin Of Life ◽  
Emergence Of Life

N. C. Wickramasinghe ( Department of Applied Mathematics and Astronomy, University College, Cardiff, U. K. ). The question of the origin of life is, of course, one of the most important scientific questions and it is also one of the most difficult. One is inevitably faced here with a situation where there are very few empirical facts of direct relevance and perhaps no facts relating to the actual transition from organic material to material that can even remotely be described as living. The time perspective of events that relate to this problem has already been presented by Dr Chang. Uncertainty still persists as to the actual first moment of the origin or the emergence of life on the Earth. At some time between 3800 and 3300 Ma BP the first microscopic living systems seem to have emerged. There is a definite moment in time corresponding to a sudden appearance of cellular-type living systems. Now, traditionally the evolution of carbonaceous compounds which led to the emergence of life on Earth could be divided into three principal steps and I shall just remind you what those steps are. The first step is the production of chemical building blocks that lead to the origin of the organic molecules necessary as a prerequisite for the evolution of life. Step two can be described in general terms as prebiotic evolution, the arrangement of these chemical units into some kind of sequence of precursor systems that come almost up to life but not quite; and then stage three is the early biological evolution which actually effects the transition from proto-cellular organic-type forms into truly cellular living systems. The transition is from organic chemistry, prebiotic chemistry to biochemistry. Those are the three principal stages that have been defined by traditional workers in the field, the people who, as Dr Chang said, have had the courage to make these queries and attempt to answer them. Ever since the classic experiments where organic materials were synthesized in the laboratory a few decades back, it was thought that the first step, the production of organic chemical units, is important for the origin of life on the Earth, and that this had to take place in some location on the Earth itself.

scholarly journals An optimal degree of physical and chemical heterogeneity for the origin of life?

2011 ◽  
Vol 366 (1580) ◽  
pp. 2894-2901 ◽  
Author(s):  
Jack W. Szostak
Keyword(s):  
Nucleic Acid ◽  
Origin Of Life ◽  
Self Assembly ◽  
Building Blocks ◽  
Reaction Products ◽  
Amphiphilic Molecules ◽  
Essential Components ◽  
The Origin Of Life ◽  
Chemical Inputs ◽  
Physical And Chemical

The accumulation of pure, concentrated chemical building blocks, from which the essential components of protocells could be assembled, has long been viewed as a necessary, but extremely difficult step on the pathway to the origin of life. However, recent experiments have shown that moderately increasing the complexity of a set of chemical inputs can in some cases lead to a dramatic simplification of the resulting reaction products. Similarly, model protocell membranes composed of certain mixtures of amphiphilic molecules have superior physical properties than membranes composed of single amphiphiles. Moreover, membrane self-assembly under simple and natural conditions gives rise to heterogeneous mixtures of large multi-lamellar vesicles, which are predisposed to a robust pathway of growth and division that simpler and more homogeneous small unilamellar vesicles cannot undergo. Might a similar relaxation of the constraints on building block purity and homogeneity actually facilitate the difficult process of nucleic acid replication? Several arguments suggest that mixtures of monomers and short oligonucleotides may enable the chemical copying of polynucleotides of sufficient length and sequence complexity to allow for the emergence of the first nucleic acid catalysts. The question of the origin of life may become less daunting once the constraints of overly well-defined laboratory experiments are appropriately relaxed.

scholarly journals Search for water and life's building blocks in the universe: A summary

2015 ◽  
Vol 11 (A29B) ◽  
pp. 436-440
Author(s):  
Edwin A. Bergin
Keyword(s):  
Origin Of Life ◽  
Radioactive Decay ◽  
Building Blocks ◽  
The Origin Of Life ◽  
The Right ◽  
The Universe

AbstractWater and organics need to be supplied to terrestrial worlds like our own to provide the essential compounds required for the origin of life. These molecules form initially during the earliest stages of stellar birth, are supplied by collapse to the planet-forming disk predominantly as ice, and may undergo significant processing during this collapse and within large planetesimals that are heated via radioactive decay. Water and organic carriers can be quite volatile, thus their survival as ices within rocks is not preordained. In this focus meeting our goal is to bring together astronomers, cosmochemists, planetary scientists, chemical physicists, and spectroscopists who each explore individual aspects of this problem. In this summary we discuss some of the main themes that appeared in the meeting. Ultimately, cross-field collaboration is needed to provide greater understanding of the likelihood that terrestrial worlds form with these key compounds readily available on their surfaces – and are hence habitable if present at the right distance from the star.

The first step from molecules to life: Formation of large random molecules acting as micro-environments

2020 ◽  
Author(s):  
Saibal Mitra
Keyword(s):  
Molecular Biology ◽  
Origin Of Life ◽  
Ultraviolet Irradiation ◽  
Building Blocks ◽  
Percolation Process ◽  
Von Neumann ◽  
Percolation Clusters ◽  
Period 2 ◽  
Interstellar Ice ◽  
The Origin Of Life

<p>The mathematician John von Neumann, through his work on universal constructors, discovered<br />a generalized version of the central dogma of molecular biology biology in the 1940s, long  <br />before the biological version had been discovered. While his discovery played no role in the  <br />development of molecular biology, we may benefit from a similar mathematical approach to find  <br />clues on the origin of life. This then involves addressing those problems in the field that  <br />do not depend on the details of organic chemistry. We can then consider a general set of  <br />models that describe machines capable of self-maintenance and self-replication formulated in  <br />terms of a set of building blocks and their interactions. </p> <p>The analogue of the origin of life problem is then to explain how one can get to such  <br />machines starting from a set of only building blocks. A fundamental obstacle one then faces  <br />is the limit on the complexity of low fidelity replicating systems, preventing building  <br />blocks from getting assembled randomly into low fidelity machines which can then improve due  <br />to natural selection [1]. A generic way out of this problem is for the entire ecosystem of  <br />machines to have been encapsulated in a micro-structure with fixed inner surface features  <br />that would have boosted the fidelity [2]. Such micro-structures could have formed as a result  <br />of the random assembly of building blocks, leading to so-called percolation clusters [2].</p> <p>This then leads us to consider how in the real world a percolation process involving the  <br />random assembly of organic molecules can be realized. A well studied process in the  <br />literature is the assembly of organic compounds in ice grains due to UV radiation and heating  <br />events [3,4,5]. This same process will also lead to the percolation process if it proceeds  <br />for a sufficiently long period [2].</p> <p>In this talk I will discuss the percolation process in more detail than has been done in [2],  <br />explaining how it leads to the necessary symmetry breakings such as the origin of chiral  <br />molecules needed to explain the origin of life.   </p> <p> </p> <p>[1] Eigen, M., 1971. Self-organization of matter and the evolution of biological  <br />macromolecules. Naturwissenschaften 58, 465-523.</p> <p>[2] Mitra, S., 2019. Percolation clusters of organics in interstellar ice grains as the  <br />incubators of life, Progress in Biophysics and Molecular Biology 149, 33-38.</p> <p>[3] Ciesla, F., and Sandford.,S., 2012. Organic Synthesis via Irradiation and Warming of Ice  <br />Grains in the Solar Nebula. Science 336, 452-454.</p> <p>[4] Muñoz Caro, G., et al., 2002. Amino acids from ultraviolet irradiation of interstellar ice  <br />analogues. Nature 416, 403-406.</p> <p>[5]  Meinert, C,., et al., 2016. Ribose and related sugars from ultraviolet irradiation of  <br />interstellar ice analogs. Science 352, 208-212.</p>

scholarly journals The Origin of Life on Earth and the Design of Alternative Life Forms

2017 ◽  
Vol 01 (02) ◽  
pp. 121-131 ◽  
Author(s):  
Jack W. Szostak
Keyword(s):  
Nucleic Acids ◽  
Origin Of Life ◽  
Artificial Life ◽  
Building Blocks ◽  
Life Forms ◽  
Chemical Energy ◽  
Synthetic Chemistry ◽  
Broad Scope ◽  
The Origin Of Life ◽  
Life On Earth

To understand the origin of life on Earth, and to evaluate the potential for life on exoplanets, we must understand the pathways that lead from chemistry to biology. Recent experiments suggest that a chemically rich environment that provides the building blocks of membranes, nucleic acids and peptides, along with sources of chemical energy, could result in the emergence of replicating, evolving cells. The broad scope of synthetic chemistry suggests that it may be possible to design and construct artificial life forms based upon a very different biochemistry than that of existing biology.

scholarly journals Geochemistry and the Origin of Life: From Extraterrestrial Processes, Chemical Evolution on Earth, Fossilized Life’s Records, to Natures of the Extant Life

Life ◽  
2018 ◽  
Vol 8 (4) ◽  
pp. 39 ◽  
Author(s):  
Satoru Nakashima ◽  
Yoko Kebukawa ◽  
Norio Kitadai ◽  
Motoko Igisu ◽  
Natsuki Matsuoka
Keyword(s):  
Origin Of Life ◽  
Chemical Evolution ◽  
Building Blocks ◽  
Spectroscopic Studies ◽  
Research Progress ◽  
Complex Nature ◽  
Water Molecules ◽  
Evolution Of Life ◽  
The Origin Of Life ◽  
Emergence Of Life

In 2001, the first author (S.N.) led the publication of a book entitled “Geochemistry and the origin of life” in collaboration with Dr. Andre Brack aiming to figure out geo- and astro-chemical processes essential for the emergence of life. Since then, a great number of research progress has been achieved in the relevant topics from our group and others, ranging from the extraterrestrial inputs of life’s building blocks, the chemical evolution on Earth with the aid of mineral catalysts, to the fossilized records of ancient microorganisms. Here, in addition to summarizing these findings for the origin and early evolution of life, we propose a new hypothesis for the generation and co-evolution of photosynthesis with the redox and photochemical conditions on the Earth’s surface. Besides these bottom-up approaches, we introduce an experimental study on the role of water molecules in the life’s function, focusing on the transition from live, dormant, and dead states through dehydration/hydration. Further spectroscopic studies on the hydrogen bonding behaviors of water molecules in living cells will provide important clues to solve the complex nature of life.

scholarly journals Towards open-ended evolution in self-replicating molecular systems

2017 ◽  
Vol 13 ◽  
pp. 1189-1203 ◽  
Author(s):  
Herman Duim ◽  
Sijbren Otto
Keyword(s):  
Origin Of Life ◽  
De Novo ◽  
Building Blocks ◽  
Full Understanding ◽  
Molecular Systems ◽  
Form Of Life ◽  
Recent Advances ◽  
Molecular Building Blocks ◽  
Minimal Form ◽  
The Origin Of Life

In this review we discuss systems of self-replicating molecules in the context of the origin of life and the synthesis of de novo life. One of the important aspects of life is the ability to reproduce and evolve continuously. In this review we consider some of the prerequisites for obtaining unbounded evolution of self-replicating molecules and describe some recent advances in this field. While evolution experiments involving self-replicating molecules have shown promising results, true open-ended evolution has not been realized so far. A full understanding of the requirements for open-ended evolution would provide a better understanding of how life could have emerged from molecular building blocks and what is needed to create a minimal form of life in the laboratory.

The Driving Force in Organic Evolution and a Theory of the Origin of Life

Ecology ◽  
1929 ◽  
Vol 10 (2) ◽  
pp. 167-176 ◽  
Author(s):  
F. H. Pike
Keyword(s):  
Origin Of Life ◽  
Driving Force ◽  
Organic Evolution ◽  
The Origin Of Life

Looking to the Rocks: Molecular Clues to the Origin of Life

2008 ◽  
Author(s):  
Susan M. Gaines ◽  
Geoffrey Eglinton ◽  
Jürgen Rullkötter
Keyword(s):  
Origin Of Life ◽  
Organic Compounds ◽  
High Pressures ◽  
Biological Evolution ◽  
Building Blocks ◽  
Apparent Paradox ◽  
Living Things ◽  
The Origin Of Life ◽  
Living Organisms ◽  
Prebiotic Earth

When Geoff started analyzing leaf waxes, he hadn’t consciously been looking for compounds in living organisms that are likely to survive in sediments, attacking his Derbyshire question from its other end, as is now a standard ploy in biomarker studies. But when he returned from the Canaries in 1961, it began to dawn on him that this was, in fact, what he had done. It also became apparent that he was not alone in his curiosity about the fate of organic compounds in things like rocks and tars. In fact, he had some very good company. Two prominent Nobel chemists gave talks in Glasgow that year, both posing fundamental questions about the stuff of life. And both, Geoff found, shared his maverick interest in the organic chemistry of rocks and oils. Sir Robert Robinson sought to resolve the apparent paradox of petroleum, which appeared to have formed from the buried detritus of plants and algae that had been subjected to high pressures and temperatures, and yet also contained organic compounds that were quite different from any known in plants and algae. And Melvin Calvin, who had discovered how CO2 is converted to organic molecules in photosynthesis, talked about the origin of life. Experiments done in the past decade had given new meaning to such questions, by showing that simple organic chemicals could form spontaneously under conditions similar to those that were likely to have prevailed on the early, prebiotic earth. The mystery of life’s origin suddenly seemed approachable, and discussions had shifted from the purely theoretical and philosophical toward the empirical, and from the paleontological to the chemical. On the contemporary earth, life has something of a monopoly on making organic compounds. But if amino acids and sugars, the basic building blocks of living things, were produced by other than living things on the early earth, before the advent of life, then one could imagine the world before photosynthesis, before bacterial chemosynthesis. One could imagine some form of chemical evolution that predated Darwin’s biological evolution and launched the simplest, most primitive of bacteria. And one could look to the oldest rocks for evidence.

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