scholarly journals Pulmonary toxicity and gene expression changes after short-term inhalation exposure to surface-modified copper oxide nanoparticles

NanoImpact ◽  
2021 ◽  
pp. 100313
Author(s):  
Ilse Gosens ◽  
Pedro M. Costa ◽  
Magnus Olsson ◽  
Vicki Stone ◽  
Anna L. Costa ◽  
...  
Keyword(s):  
Gene Expression ◽  
Copper Oxide ◽  
Pulmonary Toxicity ◽  
Inhalation Exposure ◽  
Copper Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Short Term ◽  
Surface Modified

Effect of copper oxide nanoparticles on gene expression of NMDA receptor

2021 ◽  
Vol 29 (6) ◽  
pp. 60-66
Author(s):  
Ivan Andreevich Sitnikov ◽  
Daria Ramilevna Shaikhova ◽  
Anna Mikhailovna Amromina ◽  
Marina Petrovna Sutunkova ◽  
Yuliya Vladimirovna Ryabova ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nmda Receptor ◽  
Copper Oxide ◽  
Clinical Manifestations ◽  
Copper Oxide Nanoparticles ◽  
Control Group ◽  
Oxide Nanoparticles ◽  
Genes Encoding ◽  
Effect Of Copper

Introduction. Copper plays an important role in the metabolism of the brain, but particles of copper, in the nanometer range, exhibit neurotoxic properties and cause malfunctioning of brain cells. Material and methods. For 6 weeks, 3 times a week, the animals were injected with a suspension of NPs of copper oxide. The determination of the expression of the genes GRIN1, GRIN2a, and GRIN2b, encoding the proteins GluN1, GluN2a, and GluN2b, respectively, was carried out by real-time PCR with probes. Results. A statistically significant decrease in the expression level of genes encoding NMDA receptor proteins was determined when exposed to 0.5 mg/ml CuO nanoparticles (ΔCt(GRIN1) = 0.813; ΔCt(GRIN2A) = 3.477; ΔCt(GRIN2B) = 1.37) in comparison with control group (ΔCt(GRIN1) = 6.301; ΔCt(GRIN2A) = 7.823; ΔCt(GRIN2B) = 4.747). Conclusion. Evaluation of gene expression of the NMDA receptor may be present in a genetic marker to determine the toxic effect of copper oxide nanoparticles; however, further studies are needed, including behavioral tests to confirm the clinical manifestations of neurodegenerative disorders.

Short-term exposure to low concentrations of copper oxide nanoparticles can negatively impact the ecological performance of a cosmopolitan freshwater fungus

2019 ◽  
Vol 21 (12) ◽  
pp. 2001-2007 ◽  
Author(s):  
Sahadevan Seena ◽  
Santosh Kumar
Keyword(s):  
Copper Oxide ◽  
Copper Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Short Term ◽  
Ecological Processes ◽  
Cuo Nps ◽  
Ecological Performance ◽  
Low Concentrations ◽  
Short Term Exposure ◽  
Freshwater Fungus

Short term exposure to very low concentrations of CuO NPs can have an impact on freshwater ecological processes.

scholarly journals Various antibacterial mechanisms of biosynthesized copper oxide nanoparticles against soilborneRalstonia solanacearum

RSC Advances ◽  
2019 ◽  
Vol 9 (7) ◽  
pp. 3788-3799 ◽  
Author(s):  
Juanni Chen ◽  
Shuyu Mao ◽  
Zhifeng Xu ◽  
Wei Ding
Keyword(s):  
Gene Expression ◽  
Copper Oxide ◽  
Bacterial Wilt ◽  
Ralstonia Solanacearum ◽  
Biofilm Formation ◽  
Cell Metabolism ◽  
Copper Oxide Nanoparticles ◽  
Oxide Nanoparticles

Green synthesized CuONPs disturb cell metabolism, biofilm formation, physical motility and gene expression inRalstonia solanacearum, thereby effectively controlling bacterial wilt.

scholarly journals Enhanced Antimould Action of Surface Modified Copper Oxide Nanoparticles with Phenylboronic Acid Surface Functionality

Biomimetics ◽  
2021 ◽  
Vol 6 (1) ◽  
pp. 19
Author(s):  
Patricia Henry ◽  
Ahmed F. Halbus ◽  
Zahraa H. Athab ◽  
Vesselin N. Paunov
Keyword(s):  
Copper Oxide ◽  
Phenylboronic Acid ◽  
Crop Protection ◽  
Active Agent ◽  
Copper Oxide Nanoparticles ◽  
Environmental Benefits ◽  
Oxide Nanoparticles ◽  
Covalent Bonds ◽  
Surface Modified ◽  
The Impact

Antimould agents are widely used in different applications, such as specialty paints, building materials, wood preservation and crop protection. However, many antimould agents can be toxic to the environment. This work aims to evaluate the application of copper oxide nanoparticles (CuONPs) surface modified with boronic acid (BA) terminal groups as antimould agents. We developed CuONPs grafted with (3-glycidyloxypropyl) trimethoxysilane (GLYMO), coupled with 4-hydroxyphenylboronic acid (4-HPBA), which provided a strong boost of their action as antimould agents. We studied the antimould action of the 4-HPBA-functionalized CuONPs against two mould species: Aspergillus niger (A. niger) and Penicillium chrysogenum (P. chrysogenum). The cis-diol groups of polysaccharides expressed on the mould cell walls can form reversible covalent bonds with the BA groups attached on the CuONPs surface. This allowed them to bind strongly to the mould surface, resulting in a very substantial boost of their antimould activity, which is not based on electrostatic adhesion, as in the case of bare CuONPs. The impact of these BA-surface functionalized nanoparticles was studied by measuring the growth of the mould colonies versus time. The BA-functionalized CuONPs showed significant antimould action, compared to the untreated mould sample at the same conditions and period of time. These results can be applied for the development of more efficient antimould treatments at a lower concentration of active agent with potentially substantial economic and environmental benefits.

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