scholarly journals Stability analysis of non-Newtonian blood flow conveying hybrid magnetic nanoparticles as target drug delivery in presence of inclined magnetic field and thermal radiation: Application to therapy of cancer

2021 ◽  
pp. 100800
Author(s):  
Cedric Gervais Njingang Ketchate ◽  
Pascalin Tiam Kapen ◽  
Didier Fokwa ◽  
Ghislain Tchuen
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Blood Flow ◽  
Stability Analysis ◽  
Magnetic Nanoparticles ◽  
Thermal Radiation ◽  
Inclined Magnetic Field ◽  
Target Drug Delivery ◽  
Target Drug

scholarly journals Pharmaceutical Applications of Iron-Oxide Magnetic Nanoparticles

2019 ◽  
Vol 5 (3) ◽  
pp. 50 ◽  
Author(s):  
Marcos Luciano Bruschi ◽  
Lucas de Alcântara Sica de Toledo
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Covalent Attachment ◽  
Conceptual Information ◽  
Target Drug Delivery ◽  
Advantages And Disadvantages ◽  
Target Drug ◽  
Pharmaceutical Applications ◽  
Iron Oxide Magnetic Nanoparticles

Advances of nanotechnology led to the development of nanoparticulate systems with many advantages due to their unique physicochemical properties. The use of iron-oxide magnetic nanoparticles (IOMNPs) in pharmaceutical areas increased in the last few decades. This article reviews the conceptual information about iron oxides, magnetic nanoparticles, methods of IOMNP synthesis, properties useful for pharmaceutical applications, advantages and disadvantages, strategies for nanoparticle assemblies, and uses in the production of drug delivery, hyperthermia, theranostics, photodynamic therapy, and as an antimicrobial. The encapsulation, coating, or dispersion of IOMNPs with biocompatible material(s) can avoid the aggregation, biodegradation, and alterations from the original state and also enable entrapping the bioactive agent on the particle via adsorption or covalent attachment. IOMNPs show great potential for target drug delivery, improving the therapy as a consequence of a higher drug effect using lower concentrations, thus reducing side effects and toxicity. Different methodologies allow IOMNP synthesis, resulting in different structures, sizes, dispersions, and surface modifications. These advantages support their utilization in pharmaceutical applications, and getting suitable drug release control on the target tissues could be beneficial in several clinical situations, such as infections, inflammations, and cancer. However, more toxicological clinical investigations about IOMNPs are necessary.

A Novel Remote Controllable Drug Delivery System Triggered by Heating From Magnetic Nanoparticles

2009 ◽  
Author(s):  
Xiaoliang Wang ◽  
Hongchen Gu ◽  
Xinyuan Zhu
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Drug Targeting ◽  
New Technology ◽  
Modern Medicine ◽  
Target Drug Delivery ◽  
Target Drug ◽  
Long Time ◽  
Magnetic Filed ◽  
Core Issues

Target drug delivery is one of the core issues in modern medicine. Although both thermo-sensitive and magnetic drug vehicles have been developed for this purpose, reliable drug targeting is yet to achieve, because it’s hard to control local temperature in body for thermo-sensitive drugs, and it’s also difficult to control the colloidal sizes of magnetic vehicles to meet the requirements for both long-time circulation and magnetic responsibility. Here we present a new technology to solve these two problems. The drug (taxel) was combined with hyper-branched thermo-sensitive polymer and magnetic nanoparticles. Magnetic responsibility of the complex can be remotely controlled by applying an alternating magnetic field. The untreated complexes were stable in dispersion, while after exposing to the alternating magnetic filed for 5 minutes, the complexes were destabilized and deposited from dispersion quickly. Unlike the commonly used water bath, the technology present here can heat up the drug vehicles remotely from outside, which must have great potentials in the applications of magnetic or thermo-sensitive drug delivery.

Linear stability analysis of non-Newtonian blood flow with magnetic nanoparticles: application to controlled drug delivery

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Pascalin Tiam Kapen ◽  
Cédric Gervais Njingang Ketchate ◽  
Didier Fokwa ◽  
Ghislain Tchuen
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Stability Analysis ◽  
Magnetic Nanoparticles ◽  
Linear Stability ◽  
Linear Stability Analysis ◽  
Controlled Drug Delivery ◽  
Darcy Number ◽  
Content Type ◽  
The Stability

Purpose For this purpose, a linear stability analysis based on the Navier–Stokes and Maxwell equations is made leading to an eigenvalue differential equation of the modified Orr–Sommerfeld type which is solved numerically by the spectral collocation method based on Chebyshev polynomials. Unlike previous studies, blood is considered as a non-Newtonian fluid. The effects of various parameters such as volume fraction of nanoparticles, Casson parameter, Darcy number, Hartmann number on flow stability were examined and presented. This paper aims to investigate a linear stability analysis of non-Newtonian blood flow with magnetic nanoparticles with an application to controlled drug delivery. Design/methodology/approach Targeted delivery of therapeutic agents such as stem cells and drugs using magnetic nanoparticles with the help of external magnetic fields is an emerging treatment modality for many diseases. To this end, controlling the movement of nanoparticles in the human body is of great importance. This study investigates controlled drug delivery by using magnetic nanoparticles in a porous artery under the influence of a magnetic field. Findings It was found the following: the Casson parameter affects the stability of the flow by amplifying the amplitude of the disturbance which reflects its destabilizing effect. It emerges from this study that the taking into account of the non-Newtonian character is essential in the modeling of such a system, and that the results can be very different from those obtained by supposing that the blood is a Newtonian fluid. The presence of iron oxide nanoparticles in the blood increases the inertia of the fluid, which dampens the disturbances. The Strouhal number has a stabilizing effect on the flow which makes it possible to say that the oscillating circulation mechanisms dampen the disturbances. The Darcy number affects the stability of the flow and has a stabilizing effect, which makes it possible to increase the contact surface between the nanoparticles and the fluid allowing very high heat transfer rates to be obtained. It also emerges from this study that the presence of the porosity prevents the sedimentation of the nanoparticles. By studying the effect of the magnetic field on the stability of the flow, it is observed that the Hartmann number keeps the flow completely stable. This allows saying that the magnetic field makes the dissipations very important because the kinetic energy of the electrically conductive ferrofluid is absorbed by the Lorentz force. Originality/value The originality of this paper resides on the application of the linear stability analysis for controlled drug delivery.

scholarly journals Impact of Thermal Radiation and Heat Source on MHD Blood Flow with an Inclined Magnetic Field in Treating Tumor and Low Blood

2020 ◽  
pp. 77-87
Author(s):  
Ekakitie Omamoke ◽  
Emeka Amos ◽  
Efere Jatari
Keyword(s):  
Magnetic Field ◽  
Differential Equation ◽  
Blood Flow ◽  
Heat Source ◽  
Thermal Radiation ◽  
Inclined Magnetic Field ◽  
Mixed Effect ◽  
Dimensional Variable ◽  
The Impact ◽  
The Magnetic Field

In this paper, we will be analyzing the impact of thermal radiation and heat source on blood flow past a horizontal channel that is permeable with an applied magnetic field that is inclined at variable angles. The non-linear higher partial differential equation which is the governing equation is transformed to ordinary differential equations using non-dimensional variable to non-dimensional equations that is then solved analytically with the application of required boundary conditions for the blood flow and temperature equations which is a function of y and t. Parameters that are varied shows an effect on the blood flow and temperature profile with the presentation of results shown graphically and results clearly discussed. Observations from the research shows that when the thermal radiation increases, there will be a mixed effect in the flow of blood, increase in the magnetic field on the artery shows an increase in flow of blood while the blood flow reduces and the temperature of the blood increases when the heat source is increased. Other parameters also shows an effect on the flow of the blood.

Phase-change material filled hollow magnetic nanoparticles for cancer therapy and dual modal bioimaging

Nanoscale ◽  
2015 ◽  
Vol 7 (19) ◽  
pp. 9004-9012 ◽  
Author(s):  
Jinghua Li ◽  
Yan Hu ◽  
Yanhua Hou ◽  
Xinkun Shen ◽  
Gaoqiang Xu ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Cancer Therapy ◽  
Phase Change ◽  
Phase Change Material ◽  
Alternating Magnetic Field ◽  
Change Material

An alternating magnetic field triggered nanocarrier for drug delivery is fabricated for dual modal imaging-guided thermo-chemo cancer therapy.

scholarly journals Biodegradable Magnetic Nanocomposite Spheres Fabrication by O∕O Emulsion∕Solvent Evaporation Technique for Drug Delivery Purposes

2008 ◽  
Vol 2 (2) ◽  
Author(s):  
R. Asmatulu ◽  
A. Fakhari
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Uv Light ◽  
Solvent Evaporation ◽  
Ferrous Chloride ◽  
Strong Base ◽  
Nanocomposite Particles ◽  
Pump Speed ◽  
Evaporation Technique

Drug targeting systems are important research areas for many diseases treatments (e.g., cancer, nerve damage, heart and artery, diabetic, eye and other medical treatments). Currently, magnetic field, electric field, ultrasound, temperature, UV light and∕or mechanical force systems are considered more for research and development. Magnetic targeted drug delivery system is usually preferred because targeted systems improve the therapeutic index of drug molecules by minimizing the toxic side effects on healthy cells and tissues. In this study, magnetic nanoparticles (∼10nm) were prepared by a chemical coprecipitation of ferric and ferrous chloride salts in the presence of a strong base (ammonium hydroxide) and used for a drug delivery purposes. An oil-in-oil emulsion∕solvent evaporation technique was chosen for the synthesis of nanocomposite spheres. Percentages of magnetic nanoparticles (%5, %10, %20 and%30) and poly(D,L-lactide-co-glycolide) were combined together to produce nanocomposite particles with diameters of 500nmto1.2micronmeter. The effect of particle concentrations on nanocomposite particle size and distribution and morphology were investigated by using scanning electron microscopy (SEM) and laser light scattering (LLS). Additionally, external magnetic fields with various magnet distance, magnetic field, pump speed and solid contents were applied to the nanocomposite particles in a liquid media to find out the effect of variables for the targeting of drug carrying nanocomposite spheres.

scholarly journals Synthesis, Characterization, and Evaluation of a Novel Amphiphilic Polymer RGD-PEG-Chol for Target Drug Delivery System

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Shi Zeng ◽  
Fengbo Wu ◽  
Bo Li ◽  
Xiangrong Song ◽  
Yu Zheng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Large Scale ◽  
Film Formation ◽  
Low Cost ◽  
Amphiphilic Polymer ◽  
Target Drug Delivery ◽  
H Nmr ◽  
Target Drug

An amphiphilic polymer RGD-PEG-Chol which can be produced in large scale at a very low cost has been synthesized successfully. The synthesized intermediates and final products were characterized and confirmed by1H nuclear magnetic resonance spectrum (1H NMR) and Fourier transform infrared spectrum (FT-IR). The paclitaxel- (PTX-) loaded liposomes based on RGD-PEG-Chol were then prepared by film formation method. The liposomes had a size within 100 nm and significantly enhanced the cytotoxicity of paclitaxel to B16F10 cell as demonstrated by MTT test (IC50= 0.079 μg/mL of RGD-modified PTX-loaded liposomes compared to 9.57 μg/mL of free PTX). Flow cytometry analysis revealed that the cellular uptake of coumarin encapsulated in the RGD-PEG-Chol modified liposome was increased for HUVEC cells. This work provides a reasonable, facile, and economic approach to prepare peptide-modified liposome materials with controllable performances and the obtained linear RGD-modified PTX-loaded liposomes might be attractive as a drug delivery system.

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