scholarly journals Pharmaceutical Applications of Iron-Oxide Magnetic Nanoparticles

2019 ◽  
Vol 5 (3) ◽  
pp. 50 ◽  
Author(s):  
Marcos Luciano Bruschi ◽  
Lucas de Alcântara Sica de Toledo
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Covalent Attachment ◽  
Conceptual Information ◽  
Target Drug Delivery ◽  
Advantages And Disadvantages ◽  
Target Drug ◽  
Pharmaceutical Applications ◽  
Iron Oxide Magnetic Nanoparticles

Advances of nanotechnology led to the development of nanoparticulate systems with many advantages due to their unique physicochemical properties. The use of iron-oxide magnetic nanoparticles (IOMNPs) in pharmaceutical areas increased in the last few decades. This article reviews the conceptual information about iron oxides, magnetic nanoparticles, methods of IOMNP synthesis, properties useful for pharmaceutical applications, advantages and disadvantages, strategies for nanoparticle assemblies, and uses in the production of drug delivery, hyperthermia, theranostics, photodynamic therapy, and as an antimicrobial. The encapsulation, coating, or dispersion of IOMNPs with biocompatible material(s) can avoid the aggregation, biodegradation, and alterations from the original state and also enable entrapping the bioactive agent on the particle via adsorption or covalent attachment. IOMNPs show great potential for target drug delivery, improving the therapy as a consequence of a higher drug effect using lower concentrations, thus reducing side effects and toxicity. Different methodologies allow IOMNP synthesis, resulting in different structures, sizes, dispersions, and surface modifications. These advantages support their utilization in pharmaceutical applications, and getting suitable drug release control on the target tissues could be beneficial in several clinical situations, such as infections, inflammations, and cancer. However, more toxicological clinical investigations about IOMNPs are necessary.

scholarly journals Potential Toxicity of Iron Oxide Magnetic Nanoparticles: A Review

Molecules ◽  
2020 ◽  
Vol 25 (14) ◽  
pp. 3159 ◽  
Author(s):  
Nemi Malhotra ◽  
Jiann-Shing Lee ◽  
Rhenz Alfred D. Liman ◽  
Johnsy Margotte S. Ruallo ◽  
Oliver B. Villaflores ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Cell Lines ◽  
Current Knowledge ◽  
Volume Ratio ◽  
The Body ◽  
Toxic Effects ◽  
Iron Oxide Magnetic Nanoparticles

The noteworthy intensification in the development of nanotechnology has led to the development of various types of nanoparticles. The diverse applications of these nanoparticles make them desirable candidate for areas such as drug delivery, coasmetics, medicine, electronics, and contrast agents for magnetic resonance imaging (MRI) and so on. Iron oxide magnetic nanoparticles are a branch of nanoparticles which is specifically being considered as a contrast agent for MRI as well as targeted drug delivery vehicles, angiogenic therapy and chemotherapy as small size gives them advantage to travel intravascular or intracavity actively for drug delivery. Besides the mentioned advantages, the toxicity of the iron oxide magnetic nanoparticles is still less explored. For in vivo applications magnetic nanoparticles should be nontoxic and compatible with the body fluids. These particles tend to degrade in the body hence there is a need to understand the toxicity of the particles as whole and degraded products interacting within the body. Some nanoparticles have demonstrated toxic effects such inflammation, ulceration, and decreases in growth rate, decline in viability and triggering of neurobehavioral alterations in plants and cell lines as well as in animal models. The cause of nanoparticles’ toxicity is attributed to their specific characteristics of great surface to volume ratio, chemical composition, size, and dosage, retention in body, immunogenicity, organ specific toxicity, breakdown and elimination from the body. In the current review paper, we aim to sum up the current knowledge on the toxic effects of different magnetic nanoparticles on cell lines, marine organisms and rodents. We believe that the comprehensive data can provide significant study parameters and recent developments in the field. Thereafter, collecting profound knowledge on the background of the subject matter, will contribute to drive research in this field in a new sustainable direction.

A Novel Remote Controllable Drug Delivery System Triggered by Heating From Magnetic Nanoparticles

2009 ◽  
Author(s):  
Xiaoliang Wang ◽  
Hongchen Gu ◽  
Xinyuan Zhu
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Drug Targeting ◽  
New Technology ◽  
Modern Medicine ◽  
Target Drug Delivery ◽  
Target Drug ◽  
Long Time ◽  
Magnetic Filed ◽  
Core Issues

Target drug delivery is one of the core issues in modern medicine. Although both thermo-sensitive and magnetic drug vehicles have been developed for this purpose, reliable drug targeting is yet to achieve, because it’s hard to control local temperature in body for thermo-sensitive drugs, and it’s also difficult to control the colloidal sizes of magnetic vehicles to meet the requirements for both long-time circulation and magnetic responsibility. Here we present a new technology to solve these two problems. The drug (taxel) was combined with hyper-branched thermo-sensitive polymer and magnetic nanoparticles. Magnetic responsibility of the complex can be remotely controlled by applying an alternating magnetic field. The untreated complexes were stable in dispersion, while after exposing to the alternating magnetic filed for 5 minutes, the complexes were destabilized and deposited from dispersion quickly. Unlike the commonly used water bath, the technology present here can heat up the drug vehicles remotely from outside, which must have great potentials in the applications of magnetic or thermo-sensitive drug delivery.

scholarly journals Synthesis and Characterization of Coated Iron Oxide Nanoparticles Produced for Drug Delivery in Viscoelastic Solution

2020 ◽  
Vol 71 (4) ◽  
pp. 145-154 ◽  
Author(s):  
Iulian Antoniac ◽  
Alexandru Cernea ◽  
Cristian Petcu ◽  
Dan Laptoiu ◽  
Diana Tabaras ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
The Body ◽  
Osteoarthritis Of The Knee ◽  
Layer By Layer ◽  
Area Of Interest ◽  
Physico Chemical ◽  
Iron Oxide Magnetic Nanoparticles

Drug delivery systems enable transportation of drugs in the body, controlling the time, rate or place of the release rendering them ideal for local treatments. When treating joint diseases such as osteoarthritis of the knee the therapeutically substances are given intra-particularly. Magnetic nanoparticles are used so that the solution containing the treatment can be easily directed from the outside with the help of magnets allowing the drug to reach the maximum concentration at the area of interest. Functionalization of nanoparticles is necessary to obtain viscoelastic solutions with optimal physico-chemical and medical properties. This paper presents a superior method of delivering intraarticular hyaluronic acid using iron oxide magnetic nanoparticles (Fe2O3) which were embedded in tetramethylammonium hydroxide (TMOH) and coated using a layer-by-layer technique with hyaluronic acid and inulin. TMOH was chosen for a better dispersion of nanoparticles in the viscoelastic solution, eliminating the risk of agglomerations, hyaluronic acid and inulin being used for medical purposes.

Carboxymethyl starch-coated iron oxide magnetic nanoparticles: a potential drug delivery system for isoniazid

2015 ◽  
Vol 24 (10) ◽  
pp. 815-828 ◽  
Author(s):  
Chinmayee Saikia ◽  
Anowar Hussain ◽  
Anand Ramteke ◽  
Hemanta K. Sharma ◽  
Pritam Deb ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Potential Drug ◽  
Carboxymethyl Starch ◽  
Iron Oxide Magnetic Nanoparticles

Preparation and physical characterization of cobalt iron oxide magnetic nanoparticles loaded polyvinyl alcohol

2021 ◽  
pp. 089270572098557
Author(s):  
M Abu-Abdeen ◽  
O Saber ◽  
E Mousa
Keyword(s):  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Polyvinyl Alcohol ◽  
Saturation Magnetization ◽  
Polymer Films ◽  
Magnetic Hysteresis ◽  
Thermal Method ◽  
Cobalt Iron Oxide ◽  
Cobalt Iron ◽  
Iron Oxide Magnetic Nanoparticles

A solvent thermal method which depends on a thermal process under critical temperature and pressure was used to prepare cobalt iron oxide magnetic nanoparticles with a molar ratio 2. The prepared particles were in the form of nanoparticles with diameter ranging from 5 to 10 nm and with amorphous structure. Magnetic hysteresis behavior with saturation magnetization 36.31 emu/g and coercivity 4 Oe were observed for the nanoparticles. Polyvinyl alcohol was loaded with different concentrations of cobalt iron oxide nanoparticles using casting technique. Hysteresis loops for the polymer films were observed and both the saturation magnetization and coercivity were increased from 0.36 to 16.03 emu/g and 115 to 293 Oe for samples containing 5 and 20 wt% of nanoparticles, respectively. The elastic modulus of films was increased from 2.7 to 4.9 GPa for unloaded and loaded samples with 20 wt%, respectively. The storage modulus of the polymer films was found to obey the percolation behavior.

Fe3O4 Magnetic Nanoparticles: Characterization and Performance Exemplified by the Degradation of Methylene Blue in the Presence of Persulfate

2016 ◽  
Vol 19 (1) ◽  
Author(s):  
Chang-Mao Hung ◽  
Chiu-Wen Chen ◽  
Yu-Zhe Jhuang ◽  
Cheng-Di Dong
Keyword(s):  
Methylene Blue ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Fe3o4 Magnetic Nanoparticles ◽  
Iron Oxide Magnetic Nanoparticles ◽  
Nanoparticles Characterization ◽  
And Performance

AbstractIn this study, the oxidation of methylene blue (MB) over iron oxide magnetic nanoparticles (Fe

Application of Immobilized Fungi Phanerochaete chrysosporium in Removal of Heavy-Metals from Wastewater

2013 ◽  
Vol 779-780 ◽  
pp. 1674-1677 ◽  
Author(s):  
Dan Lian Huang ◽  
Guang Ming Zeng ◽  
Piao Xu ◽  
Cui Lai ◽  
Mei Hua Zhao ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Phanerochaete Chrysosporium ◽  
High Efficiency ◽  
Metal Removal ◽  
Heavy Metal Removal ◽  
Removal Of Heavy Metals ◽  
Iron Oxide Magnetic Nanoparticles ◽  
Ca Alginate

Immobilized microbe technologies are expected to be effectively used in wastewater treatment. Removal of heavy-metals from wastewater by immobilized Phanerochaete chrysosporium (Pc) with Ca-alginate and iron oxide magnetic nanoparticles (MNPs) was studied. The results showed that a biosorbent as Pc immobilized by Ca-alginate and iron oxide magnetic nanoparticles was successfully developed. And the iron oxide magnetic nanoparticles played an important role in the increase of biosorption capacity of Pc. Energy dispersive spectrometer (EDS) analysis confirmed that metal ions adsorbed to the surface of the biosorbents were partly transmitted to the interior of biosorbents, mainly embedded with iron oxide nanoparticles and Ca-alginate. Moreover, it was found that MNPs-Ca-alginate immobilized Pc showed a good affinity to various heavy metals, such as Pb(II), Zn(II), Cd(II) or Mg(II) and so on. The results proved the high efficiency of the biosorbents for heavy-metal removal and its potential application in the treatment of metal-containing wastewater.

scholarly journals Synthesis, Characterization, and Evaluation of a Novel Amphiphilic Polymer RGD-PEG-Chol for Target Drug Delivery System

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Shi Zeng ◽  
Fengbo Wu ◽  
Bo Li ◽  
Xiangrong Song ◽  
Yu Zheng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Large Scale ◽  
Film Formation ◽  
Low Cost ◽  
Amphiphilic Polymer ◽  
Target Drug Delivery ◽  
H Nmr ◽  
Target Drug

An amphiphilic polymer RGD-PEG-Chol which can be produced in large scale at a very low cost has been synthesized successfully. The synthesized intermediates and final products were characterized and confirmed by1H nuclear magnetic resonance spectrum (1H NMR) and Fourier transform infrared spectrum (FT-IR). The paclitaxel- (PTX-) loaded liposomes based on RGD-PEG-Chol were then prepared by film formation method. The liposomes had a size within 100 nm and significantly enhanced the cytotoxicity of paclitaxel to B16F10 cell as demonstrated by MTT test (IC50= 0.079 μg/mL of RGD-modified PTX-loaded liposomes compared to 9.57 μg/mL of free PTX). Flow cytometry analysis revealed that the cellular uptake of coumarin encapsulated in the RGD-PEG-Chol modified liposome was increased for HUVEC cells. This work provides a reasonable, facile, and economic approach to prepare peptide-modified liposome materials with controllable performances and the obtained linear RGD-modified PTX-loaded liposomes might be attractive as a drug delivery system.

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