Serial in vivo brain imaging following experimental TBI in the rat: Documenting the long-term dynamic changes in brain structure and function

Injury ◽  
2010 ◽  
Vol 41 ◽  
pp. S41-S42
Author(s):  
T. O’Brien
Keyword(s):  
Brain Imaging ◽  
Brain Structure ◽  
Structure And Function ◽  
Dynamic Changes ◽  
Brain Structure And Function ◽  
And Function

scholarly journals Brain structure of perinatally HIV-infected patients on long-term treatment

2019 ◽  
Vol 9 (5) ◽  
pp. 433-442 ◽  
Author(s):  
Malon Van den Hof ◽  
Anne Marleen ter Haar ◽  
Matthan W.A. Caan ◽  
Rene Spijker ◽  
Johanna H. van der Lee ◽  
...  
Keyword(s):  
Brain Structure ◽  
Diffusion Tensor ◽  
Structure And Function ◽  
Resonance Spectroscopy ◽  
Cross Sectional ◽  
Long Term Treatment ◽  
Brain Structure And Function ◽  
And Function ◽  
Hiv Negative

ObjectiveWe aim to give an overview of the available evidence on brain structure and function in PHIV-infected patients (PHIV+) using long-term combination antiretroviral therapy (cART) and how differences change over time.MethodsWe conducted an electronic search using MEDLINE, Embase, and PsycINFO. We used the following selection criteria: cohort and cross-sectional studies that reported on brain imaging differences between PHIV+ of all ages who used cART for at least six months before neuroimaging and HIV-negative controls. Two reviewers independently selected studies, performed data extraction, and assessed quality of studies.ResultsAfter screening 1500 abstracts and 343 full-text articles, we identified 19 eligible articles. All included studies had a cross-sectional design and used MRI with different modalities: structural MRI (n = 7), diffusion tensor imaging (DTI) (n = 6), magnetic resonance spectroscopy (n = 5), arterial spin labeling (n = 1), and resting-state functional neuroimaging (n = 1). Studies showed considerable methodological limitations and heterogeneity, preventing us to perform meta-analyses. DTI data on white matter microstructure suggested poorer directional diffusion in cART-treated PHIV+ compared with controls. Other modalities were inconclusive.ConclusionEvidence may suggest brain structure and function differences in the population of PHIV+ on long-term cART compared with the HIV-negative population. Because of a small study population, and considerable heterogeneity and methodological limitations, the extent of brain structure and function differences on neuroimaging between groups remains unknown.

scholarly journals Relative Function: Nuclear Brain Imaging in United States Courts

2011 ◽  
Vol 39 (4) ◽  
pp. 567-593 ◽  
Author(s):  
Susan E. Rushing ◽  
Daniel D. Langleben
Keyword(s):  
Brain Imaging ◽  
Functional Imaging ◽  
Brain Structure ◽  
Neuropsychological Testing ◽  
Photon Emission ◽  
Structure And Function ◽  
Emission Computed Tomography ◽  
Brain Structure And Function ◽  
And Function ◽  
The Brain

Neuropsychological testing—medical imaging of the brain structure and function—allows the expert to inform the court on the brain structure and function of the forensic examinee. Supported by extensive clinical use, neuropsychological testing and structural imaging in the form of computerized tomography and structural magnetic resonance imaging have achieved general acceptance in court. However, functional imaging such as functional MRI and nuclear medicine techniques, such as positron emission tomography (PET), have faced more admissibility challenges. While functional imaging is becoming an increasingly important tool in assessing neuropsychiatric illness, we surmise that evidentiary challenges are largely related to the phase of trial in which the nuclear study is offered as evidence. This article will review the basic science of functional nuclear imaging including PET and single photon emission computed tomography. We will then review cases where admissibility of these techniques has been challenged and consider whether and how nuclear brain imaging can influence the outcome of the trial.

scholarly journals Genome-wide association studies of brain structure and function in the UK Biobank

2017 ◽  
Author(s):  
Lloyd T. Elliott ◽  
Kevin Sharp ◽  
Fidel Alfaro-Almagro ◽  
Sinan Shi ◽  
Karla Miller ◽  
...  
Keyword(s):  
Brain Imaging ◽  
Brain Structure ◽  
Association Studies ◽  
Structure And Function ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Uk Biobank ◽  
Genome Wide ◽  
Brain Structure And Function ◽  
And Function

SummaryThe genetic basis of brain structure and function is largely unknown. We carried out genome-wide association studies of 3,144 distinct functional and structural brain imaging derived phenotypes in UK Biobank (discovery dataset 8,428 subjects). We show that many of these phenotypes are heritable. We identify 148 clusters of SNP-imaging associations with lead SNPs that replicate at p<0.05, when we would expect 21 to replicate by chance. Notable significant and interpretable associations include: iron transport and storage genes, related to changes in T2* in subcortical regions; extracellular matrix and the epidermal growth factor genes, associated with white matter micro-structure and lesion volume; genes regulating mid-line axon guidance development associated with pontine crossing tract organisation; and overall 17 genes involved in development, pathway signalling and plasticity. Our results provide new insight into the genetic architecture of the brain with relevance to complex neurological and psychiatric disorders, as well as brain development and aging. The full set of results is available on the interactive Oxford Brain Imaging Genetics (BIG) web browser.

Cognitive Neuroscience Approaches to Personality Disorders

2018 ◽  
Author(s):  
Andrew Poppe ◽  
Angus W. MacDonald III
Keyword(s):  
Personality Disorders ◽  
Cognitive Neuroscience ◽  
Brain Structure ◽  
Molecular Genetic ◽  
Structure And Function ◽  
Neural Processes ◽  
Brain Structure And Function ◽  
And Function ◽  
And Behavior

This chapter describes a cognitive neuroscience approach to understanding the psychological and neural processes that underlie personality and behavior. It explicates the utility of the cognitive neuroscience approach and the fundamental principles of the methods and how to interpret the findings. The chapter reviews the different neuroimaging tools and approaches that can be used to investigate brain structure and function. In doing so, it provides detailed information about what each method measures and how issues to consider when evaluating these measurements and their functional significance. The chapter provides the reader an appreciation of how understanding brain structure and function in vivo can serve as a bridge between molecular/genetic and symptom-based data to enrich the pathophysiology of personality disorders.

scholarly journals Brain Structure and Function of Chronic Low Back Pain Patients on Long-Term Opioid Analgesic Treatment: A Preliminary Study

2021 ◽  
Vol 17 ◽  
pp. 174480692199093
Author(s):  
Kyle Murray ◽  
Yezhe Lin ◽  
Meena M Makary ◽  
Peter G Whang ◽  
Paul Geha
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Chronic Low Back Pain ◽  
Brain Structure ◽  
Structure And Function ◽  
Low Back ◽  
Brain Structure And Function ◽  
And Function ◽  
Pain Patients

Chronic low back pain (CLBP) is often treated with opioid analgesics (OA), a class of medications associated with a significant risk of misuse. However, little is known about how treatment with OA affect the brain in chronic pain patients. Gaining this knowledge is a necessary first step towards understanding OA associated analgesia and elucidating long-term risk of OA misuse. Here we study CLBP patients chronically medicated with opioids without any evidence of misuse and compare them to CLBP patients not on opioids and to healthy controls using structural and functional brain imaging. CLBP patients medicated with OA showed loss of volume in the nucleus accumbens and thalamus, and an overall significant decrease in signal to noise ratio in their sub-cortical areas. Power spectral density analysis (PSD) of frequency content in the accumbens’ resting state activity revealed that both medicated and unmedicated patients showed loss of PSD within the slow-5 frequency band (0.01–0.027 Hz) while only CLBP patients on OA showed additional density loss within the slow-4 frequency band (0.027–0.073 Hz). We conclude that chronic treatment with OA is associated with altered brain structure and function within sensory limbic areas.

Imaging treatment changes in chronic patients and confounding factors

2011 ◽  
Vol 26 (S2) ◽  
pp. 2154-2154
Author(s):  
J.-L. Martinot ◽  
E. Artiges ◽  
C. Leroy ◽  
M.-L. Paillère Martinot ◽  
S. Mana ◽  
...  
Keyword(s):  
Basal Ganglia ◽  
Mental Disorders ◽  
Brain Imaging ◽  
Brain Structure ◽  
Structure And Function ◽  
Imaging Studies ◽  
Chronic Patients ◽  
Optimal Drug ◽  
Brain Structure And Function ◽  
And Function

1/In juvenile patients, a cross-sectional ALE meta-analysis of both brain structure and function regional deviations in 270 articles allowed to cluster the diagnosed disorders into three sets with respectively marked affective, cognitive, and psychomotor phenomenology. The group with affective phenomenology was characterized by abnormalities of the frontal-limbic regions; the group with “cognition deficits” (incl. schizophrenia) mainly related to cortex abnormalities; and the psychomotor condition was associated with abnormalities in the basal ganglia. Therefore, early regional brain abnormalities might interact with the analysis of subsequent treatments effects in MR studies of brain structure and function of chronic mental disorders. 2/In chronic patients, brain imaging studies of antipsychotic drugs using dopamine receptor radioligands &PET scanner have consistently demonstrated the prevalence of their dose-dependent action in basal ganglia. This information has led to theoretical windows for optimal drug dosage. Recent measures of the dopamine transporter in chronic antipsychotic treatment, or in chronic use of drugs of addiction (e.g. tobacco, cannabis) suggest opposite changes of the adioligand uptake in both conditions. Therefore, control for the associated confounding addictions is required for in vivo analysis of antipsychotic action on the dopamine regulation in cortex and subcortical regions. 3/In treatment-resistant patients, MR & PET imaging studies have detected deviations of both brain structure and function, therefore suggesting biomarker of treatment response. 4/Conclusion: stage of illness, addictions, multimodal imaging, should be considered as covariates for brain imaging determinations of treatment effects in patients with chronic mental disorders.

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