9.1 MATERNAL PERSONALITY TRAITS MODERATE ADHD TREATMENT RESPONSE IN THE MULTIMODAL TREATMENT STUDY OF ADHD (MTA)

2019 ◽  
Vol 58 (10) ◽  
pp. S312-S313
Author(s):  
Guillermo Perez Algorta
Keyword(s):  
Personality Traits ◽  
Treatment Response ◽  
Multimodal Treatment ◽  
Maternal Personality ◽  
Adhd Treatment

scholarly journals Maternal personality traits moderate treatment response in the Multimodal Treatment Study of attention-deficit/hyperactivity disorder

2019 ◽  
Vol 29 (11) ◽  
pp. 1513-1524
Author(s):  
Guillermo Perez Algorta ◽  
Heather A. MacPherson ◽  
L. Eugene Arnold ◽  
Stephen P. Hinshaw ◽  
Lily Hechtman ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Personality Traits ◽  
Attention Deficit ◽  
Multimodal Treatment ◽  
Behavioral Treatment ◽  
Latent Class ◽  
Personality Profiles ◽  
Children With Adhd ◽  
Hyperactivity Disorder ◽  
Maternal Personality

AbstractSome mothers of children with attention-deficit/hyperactivity disorder (ADHD) present with maladaptive personality profiles (high neuroticism, low conscientiousness). The moderating effect of maternal personality traits on treatment outcomes for childhood ADHD has not been examined. We evaluate whether maternal neuroticism and conscientiousness moderated response in the Multimodal Treatment Study of Children with ADHD. This is one of the first studies of this type. In a randomized controlled trial (RCT), 579 children aged 7–10 (M = 8.5); 19.7% female; 60.8% White with combined-type ADHD were randomly assigned to systematic medication management (MedMgt) alone, comprehensive multicomponent behavioral treatment (Beh), their combination (Comb), or community comparison treatment-as-usual (CC). Latent class analysis and linear mixed effects models included 437 children whose biological mothers completed the NEO Five-Factor Inventory at baseline. A 3-class solution demonstrated best fit for the NEO: MN&MC = moderate neuroticism and conscientiousness (n = 284); HN&LC = high neuroticism, low conscientiousness (n = 83); LN&HC = low neuroticism, high conscientiousness (n = 70). Per parent-reported symptoms, children of mothers with HN&LC, but not LN&HC, had a significantly better response to Beh than to CC; children of mothers with MN&MC and LN&HC, but not HN&LC, responded better to Comb&MedMgt than to Beh&CC. Per teacher-reported symptoms, children of mothers with HN&LC, but not LN&HC, responded significantly better to Comb than to MedMgt. Children of mothers with high neuroticism and low conscientiousness benefited more from behavioral treatments (Beh vs. CC; Comb vs. MedMgt) than other children. Evaluation of maternal personality may aid in treatment selection for children with ADHD, though additional research on this topic is needed.

scholarly journals Maternal ADHD Symptoms, Personality, and Parenting Stress: Differences Between Mothers of Children With ADHD and Mothers of Comparison Children

2014 ◽  
Vol 22 (13) ◽  
pp. 1266-1277 ◽  
Author(s):  
Guillermo Perez Algorta ◽  
Carolyn A. Kragh ◽  
L. Eugene Arnold ◽  
Brooke S. G. Molina ◽  
Stephen P. Hinshaw ◽  
...  
Keyword(s):  
Personality Traits ◽  
Parenting Stress ◽  
Multimodal Treatment ◽  
Comparison Group ◽  
Adhd Symptoms ◽  
Children With Adhd ◽  
Biological Mothers ◽  
Maternal Personality ◽  
Normative Comparison ◽  
Maternal Adhd

Objective: Mothers raising a child with ADHD can experience high parenting stress. We evaluated if mothers’ personality traits and own ADHD symptoms could also affect parenting stress. Method: 430 biological mothers from the Multimodal Treatment Study of Children with ADHD (MTA mothers) and 237 of a local normative comparison group (LNCG mothers) were evaluated at baseline. Interactions were tested between mothers’ group and maternal personality/ADHD symptoms related to parenting stress. Results: Compared to LNCG, MTA mothers had higher parenting stress, self-reported ADHD, neuroticism, and lower conscientiousness and agreeableness. When personality and ADHD were evaluated together, ADHD symptoms interacted with mothers’ group: high maternal ADHD was positively associated with parenting stress for LNCG but not MTA mothers. Conclusion: Personality traits or ADHD characteristics do not appear operative for the high parenting stress of mothers of a child with ADHD. However, high maternal ADHD or low conscientiousness are associated with stress levels similar to raising a child with ADHD.

Role of the norepinephrine transporter polymorphisms in atomoxetine treatment: From response to side effects in children with ADHD

2021 ◽  
pp. 026988112110152
Author(s):  
Melike Kevser Gul ◽  
Elif Funda Sener ◽  
Muge Gulcihan Onal ◽  
Esra Demirci
Keyword(s):  
Side Effects ◽  
Treatment Response ◽  
Large Population ◽  
Norepinephrine Transporter ◽  
Response To Treatment ◽  
Nucleotide Polymorphisms ◽  
Children With Adhd ◽  
Real Time Quantitative Pcr ◽  
Treatment Side Effects ◽  
Adhd Treatment

Objective: Atomoxetine (ATX), one of the most commonly used drugs after stimulants in attention deficit hyperactivity disorder (ADHD) treatment, is an inhibitor of the norepinephrine transporter ( NET/SLC6A2), which is also associated with the etiology of ADHD. In this study, we aimed to investigate the effect of NET gene polymorphisms on response to ATX treatment and to find the answers to the questions about whether there is a relationship between the severity of the disorder and the observed side effects in children with ADHD. Method: About 100 children with ADHD and 80 healthy controls (HCs) were included in this study. The dose of ATX was started at 0.5 mg/kg/day and titrated at 1.2 mg/kg/day. Response to treatment of 78 patients was evaluated 2 months after the beginning of the treatment. After whole blood samples were obtained, DNAs were isolated, and samples were stored at −80°C. Two single-nucleotide polymorphisms (SNPs) (rs12708954 and rs3785143) were analyzed by real-time quantitative PCR (qRT-PCR). Results: The patients with both rs12708954 and rs3785143 heterozygous genotype had better treatment response and more side effects than patients with wild type. There was not found any association between any of the investigated NET polymorphisms and ADHD severity. Conclusion: It was, however, found that the NET rs12708954 and rs3785143 genotypes affect the treatment response to ATX in our study; thus, further studies with a large population are needed to understand the effects of NET polymorphisms on treatment, side effects, and also the severity of ADHD.

P.3.02 Personality traits as predictors of treatment response in patient with affective disorder

2004 ◽  
Vol 14 ◽  
pp. S47-S48
Author(s):  
S. Linotte ◽  
P. Oswald ◽  
I. Massat ◽  
D. Souery ◽  
S. Kasper ◽  
...  
Keyword(s):  
Personality Traits ◽  
Treatment Response ◽  
Affective Disorder

scholarly journals Maternal personality traits, antenatal depressive symptoms and the postpartum mother–infant relationship: a prospective observational study

2019 ◽  
Vol 55 (5) ◽  
pp. 621-634 ◽  
Author(s):  
Selina Nath ◽  
Rebecca M. Pearson ◽  
Paul Moran ◽  
Susan Pawlby ◽  
Emma Molyneaux ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Personality Traits ◽  
Early Pregnancy ◽  
Maternal Sensitivity ◽  
Depression Scale ◽  
Older Children ◽  
Maternal Personality ◽  
Antenatal Depressive Symptoms ◽  
Postpartum Bonding ◽  
The Impact

Abstract Purpose Maternal depression has been associated with bonding difficulties and lower maternal sensitivity in observed mother–infant interactions. However, little research has examined the impact of disordered personality traits in mothers on these outcomes. We investigated the association between disordered personality traits in mothers measured during pregnancy and postnatal (a) self-reported bonding with infant; (b) observational mother–infant interactions. Methods Five hundred fifty-six women were recruited during early pregnancy and subsequently followed up at mid-pregnancy (approximately 28 weeks’ gestation) and when infants were aged approximately 3 months (n = 459). During early pregnancy, data were collected on disordered personality traits (using the Standardised Assessment of Personality Abbreviated Scale) and depressive symptoms (using the Edinburgh Postnatal Depression Scale). At 3 months postpartum, self-reported perceived bonding (using the Postpartum Bonding Questionnaire) were collected. A sub-sample of women additionally provided observational mother–infant interaction data (n = 206) (coded using the Child–Adult Relationship Experimental Index). Results Higher disordered personality traits was not associated with maternal perceptions of bonding impairment, but was associated with reduced maternal sensitivity during observational mother–infant interactions [adjusted for age, education, having older children, substance misuse prior to pregnancy, infant sex and gestational age: coefficient = − 0.28, 95% CI = − 0.56 to − 0.00, p < 0.05]. After adjusting for depressive symptoms, the association was attenuated [coefficient = − 0.19, 95% CI = − 0.48 to 0.11, p = 0.217]. Conclusions Mothers with disordered personality traits did not perceive themselves as having bonding impairments with their infants but were less sensitive during observed interactions, though depressive symptoms attenuated this relationship. Both depression and disordered personality traits need to be addressed to optimize mother–infant interactions.

“Anybody's child”: severe disorders of mother-to-infant bonding

1997 ◽  
Vol 171 (2) ◽  
pp. 175-181 ◽  
Author(s):  
R. Channi Kumar
Keyword(s):  
Mental Illness ◽  
Personality Traits ◽  
Severe Pain ◽  
Direct Evidence ◽  
Catastrophic Failure ◽  
Maternal Bonding ◽  
Childhood Experiences ◽  
Maternal Personality ◽  
First Child ◽  
Child Factors

BackgroundThis paper describes severe, disorders of maternal affection and behaviour and suggests that there is an early process of mother-to-infant bonding which can go seriously wrong.MethodForty-four self-selected women who had suffered from at least one episode of postnatal mental illness described an unexpected and often catastrophic failure to love one or more of their babies.ResultsThese women reported absent affection, sometimes hate, rejection, neglect or impulses to harm, in relation to at least one of their children. These feelings often began immediately or very shortly after the birth, and with one exception, were specific to one child; such characteristics are best encapsulated by the term ‘maternal bonding disorder’. Twenty-nine of the women were multiparae; first-borns were not significantly more likely to be the focus for such feelings. There was no direct evidence of predisposing maternal personality traits or previous experiences. Postnatal mental illness and recalled severe pain during labour were significantly associated with such disorders which, in their severe forms, did not occur in the absence of postnatal mental illness.ConclusionsThe nature of the link between postnatal mental illness and disorders of maternal bonding remains unclear. Because, in multiparae, the disorder often ‘missed’ the first child, factors such as maternal personality traits or early childhood experiences cannot be regarded as sufficient causes.

Are Maternal Personality Traits an Etiological Factor in Adolescents with Functional Chest Pain?

2021 ◽  
Author(s):  
Fatih Hilmi Çetin ◽  
Serkan Fazlı Çelik ◽  
Merve Çıkılı Uytun ◽  
Zehra Babadağı
Keyword(s):  
Chest Pain ◽  
Personality Traits ◽  
Etiological Factor ◽  
Maternal Personality

scholarly journals Temperament, character and personality disorders as predictors of response to interpersonal psychotherapy and cognitive-behavioural therapy for depression

2007 ◽  
Vol 190 (6) ◽  
pp. 503-508 ◽  
Author(s):  
Peter R. Joyce ◽  
Janice M. McKenzie ◽  
Janet D. Carter ◽  
Alma M. Rae ◽  
Suzanne E. Luty ◽  
...  
Keyword(s):  
Personality Disorder ◽  
Personality Traits ◽  
Treatment Response ◽  
Cognitive Behavioural Therapy ◽  
Randomised Trial ◽  
Interpersonal Psychotherapy ◽  
Behavioural Therapy ◽  
Patient Treatment ◽  
Comparable Efficacy ◽  
Cognitive Behavioural

BackgroundInterpersonal psychotherapy and cognitive–behavioural therapy are widely accepted as effective treatments for major depression. There is little evidence on how personality disorder or personality traits affect treatment response.AimsTo determine whether personality disorder or traits have an adverse impact on treatment response to interpersonal psychotherapy or cognitive–behavioural therapy in people receiving out-patient treatment for depression.MethodThe study was a randomised trial in a university-based clinical research unit for out-patients with depression.ResultsPersonality disorder did not adversely affect treatment response for patients with depression randomised to cognitive–behavioural therapy Conversely, personality disorder did adversely affect treatment response for patients randomised to interpersonal psychotherapy.ConclusionsDespite the two therapies having comparable efficacy in patients with depression, response to interpersonal psychotherapy (but not cognitive–behavioural therapy) is affected by personality traits. This could suggest the two therapies are indicated for different patients or that they work by different mechanisms.

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