Protective effects of a new active complex with vitamin C nanospheres against UV-induced imbalanced biomarkers of skin aging

The newly found SARS-CoV-2 has led to the pandemic of COVID-19, which has caused respiratory distress syndrome and even death worldwide. This has become a global public health crisis. Unfortunately, elders and subjects with comorbidities have high mortality rates. One main feature of COVID-19 is the cytokine storm, which can cause damage in cells and tissues including the kidneys. Here, we reviewed the current literature on renal impairments in patients with COVID-19 and analyzed the possible etiology and mechanisms. In addition, we investigated the potential use of vitamin C for the prevention of renal injury in those patients. It appears that vitamin C could be helpful to improve the outcomes of patients with COVID-19. Lastly, we discussed the possible protective effects of vitamin C on renal functions in COVID-19 patients with existing kidney conditions.

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PROTECTIVE EFFECTS OF VITAMIN C AGAINST CISPLATIN-INDUCED NEPHROTOXICITY AND LIPID PEROXIDATION IN ADULT RATS: A DOSE-DEPENDENT STUDY

Pharmacological Research ◽

10.1006/phrs.1999.0600 ◽

2000 ◽

Vol 41 (4) ◽

pp. 405-411 ◽

Cited By ~ 143

Author(s):

LUSÂNIA M. GREGGI ANTUNES ◽

JOANA D'ARC C. DARIN ◽

MARIA DE LOURDES P. BIANCHI

Keyword(s):

Lipid Peroxidation ◽

Vitamin C ◽

Protective Effects ◽

Adult Rats ◽

Dose Dependent

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Protective effects of Vitamin C on cisplatin nephrotoxicity

Archives of Pharmacal Research ◽

10.1007/bf02978240 ◽

1994 ◽

Vol 17 (1) ◽

pp. 11-16 ◽

Cited By ~ 1

Author(s):

Se-Young Choung ◽

Jae-Myeong Kong

Keyword(s):

Vitamin C ◽

Protective Effects ◽

Cisplatin Nephrotoxicity

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Protective role of vitamins A, C, and E against the genotoxic damage induced by aflatoxin B1 in cultured human lymphocytes

Toxicology and Industrial Health ◽

10.1177/0748233709106068 ◽

2009 ◽

Vol 25 (3) ◽

pp. 183-188 ◽

Cited By ~ 12

Author(s):

L Alpsoy ◽

G Agar ◽

M Ikbal

Keyword(s):

Vitamin A ◽

Vitamin C ◽

Human Lymphocytes ◽

Mutagenic Effect ◽

Treated Group ◽

Protective Role ◽

Effective Concentration ◽

Dependent Manner ◽

Protective Effects ◽

Aflatoxin B

In this study, we aimed to evaluate the effect of vitamins A, C, and E against aflatoxin B1 (AFB1) on blood cultures in relation to induction of sister chromatid exchange (SCE). The results indicated genotoxic and mutagenic damage in cultured human lymphocytes exposed to AFB1. The results showed that 5 μM concentration of AFB1 increased SCE. When vitamins A, C, and E were added to AFB1, the frequency of SCE decreased. These results suggest that vitamins A, C, and E could effectively inhibit AFB1-induced SCE, which may partially responsible for its mutagenic effect of AFB1. Besides, the protective effect of vitamins A, C, and E against AFB1 was increased in a dose-dependent manner (i.e., as the doses increased, their protective effects also increased). There was a significant decrease in the SCE frequency in AFB1-treated group compared with the groups receiving AFB1 and also vitamins A, C, and E. The most effective concentration was 100 microM vitamin C, and the lowest effective concentration was 0.5 microM vitamin A. Vitamin C has the most effective concentration of 100 μM, and vitamin A has the lowest effective concentration of 0.5 μM. The order of the decreasing effect of the SCE frequency of vitamins was as follows: vitamin C > vitamin E > vitamin A.

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Effect of vitamin C supplementation on hematological parameters in smokeless tobacco chewers

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v12i3.4819 ◽

2021 ◽

Vol 12 (3) ◽

pp. 2088-2094

Author(s):

Jaywant S. Thorat ◽

Anand G. Joshi ◽

Kanchan C. Wingkar

Keyword(s):

Platelet Count ◽

Vitamin C ◽

Smokeless Tobacco ◽

Hematological Parameters ◽

Protective Effects ◽

Baseline Study ◽

Vitamin C Supplementation ◽

Baseline Values ◽

Wbc Count ◽

Rbc Count

The present study was aimed to evaluate the effect of Vitamin C (VC) supplementation on hematological parameters in Smokeless Tobacco (ST) chewers. A total of 338 subjects aged between 31 to 60 years (168 ST chewers and 170 ST non-chewers) participated in the present study. ST chewers were further divided into 3 subgroups with respect to ST chewing duration in years. Subjects of both the groups were examined at the baseline study and after 45 days of supplementation of 1 g of Vitamin C (VC) for hematological parameters. WBC count (p=0.04), granulocytes % (p=0.0007), HCT (p=0.01) and MCV (p=0.04) were significantly increased whereas, monocytes % (p=0.002) and platelet count (p<0.0001) were significantly decreased in ST chewers as compared to controls. After supplementation of VC, WBC count (p<0.001) and granulocytes % (p<0.0001) were significantly decreased and lymphocytes % (p=0.008), monocytes % (p<0.0001), RBC count (p=0.01) and Hb content (p=0.006) were significantly increased in ST chewers as compared to their baseline values. In conclusion, the use of ST had deleterious effects on hematological parameters; however, supplementation of 1 g of VC showed protective effects on hematological parameters.

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Protective Effects of Garlic Extract and Vitamin C Against Cypermethrin Reproductive Toxicity in Male Rats

Research Journal of Veterinary Sciences ◽

10.3923/rjvs.2008.1.15 ◽

2008 ◽

pp. 1-15 ◽

Cited By ~ 4

Author(s):

M.E. Assayed

Keyword(s):

Vitamin C ◽

Reproductive Toxicity ◽

Garlic Extract ◽

Male Rats ◽

Protective Effects

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Protective Effects of Unsaponifiable Matter from Perilla Seed Meal on UVB-induced Damages and the Underlying Mechanisms in Human Skin Fibroblasts

Antioxidants ◽

10.3390/antiox8120644 ◽

2019 ◽

Vol 8 (12) ◽

pp. 644 ◽

Cited By ~ 4

Author(s):

Hana Lee ◽

Jeehye Sung ◽

Younghwa Kim ◽

Heon Sang Jeong ◽

Junsoo Lee

Keyword(s):

Unsaponifiable Matter ◽

Transforming Growth Factor Beta ◽

Collagen Synthesis ◽

Transforming Growth Factor ◽

Skin Aging ◽

Seed Meal ◽

Activator Protein 1 ◽

Protective Effects ◽

Uvb Exposure ◽

Perilla Seed

Unsaponifiable matter (USM) from perilla seed meal contains numerous phytochemicals, including tocopherols, phytosterols, squalene, and policosanols, that exhibit antioxidant and health-promoting properties. In this study, the protective effects of USM on UVB-induced skin aging were investigated in Hs68 cells. UVB irradiation decreased cell viability by 26% compared to the control. However, USM blocked UVB-induced cytotoxicity. Moreover, USM treatment significantly decreased the UVB-induced production of reactive oxygen species and attenuated the UVB-induced production and mRNA expression of matrix metalloproteinases (MMPs) by inhibiting the phosphorylation of mitogen-activated protein kinases and activator protein 1 (AP-1). Furthermore, UVB exposure led to a 49.4% reduction in collagen synthesis. However, USM treatment restored collagen synthesis through upregulation of the transforming growth factor beta (TGF-β)/Smad2/3 pathways. These data indicate that USM regulates the production of MMPs and collagen by modulation of the TGF-β/Smad pathway and AP-1 activity, suggesting that USM may be a useful anti-photoaging ingredient.

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