16311 Protective effects of an active complex against unbalanced biomarkers induced by infrared-A radiation, blue light, and heavy metals: An integral approach of skin aging

2020 ◽  
Vol 83 (6) ◽  
pp. AB175
Author(s):  
Liliana Torloni ◽  
Lara Facó ◽  
Erida Magaton ◽  
Samara Eberlin ◽  
Ana Lúcia Alves Tabarini Pinheiro
Keyword(s):  
Heavy Metals ◽  
Blue Light ◽  
Skin Aging ◽  
Integral Approach ◽  
Protective Effects ◽  
Active Complex

scholarly journals Protective Effects of Unsaponifiable Matter from Perilla Seed Meal on UVB-induced Damages and the Underlying Mechanisms in Human Skin Fibroblasts

Antioxidants ◽  
2019 ◽  
Vol 8 (12) ◽  
pp. 644 ◽  
Author(s):  
Hana Lee ◽  
Jeehye Sung ◽  
Younghwa Kim ◽  
Heon Sang Jeong ◽  
Junsoo Lee
Keyword(s):  
Unsaponifiable Matter ◽  
Transforming Growth Factor Beta ◽  
Collagen Synthesis ◽  
Transforming Growth Factor ◽  
Skin Aging ◽  
Seed Meal ◽  
Activator Protein 1 ◽  
Protective Effects ◽  
Uvb Exposure ◽  
Perilla Seed

Unsaponifiable matter (USM) from perilla seed meal contains numerous phytochemicals, including tocopherols, phytosterols, squalene, and policosanols, that exhibit antioxidant and health-promoting properties. In this study, the protective effects of USM on UVB-induced skin aging were investigated in Hs68 cells. UVB irradiation decreased cell viability by 26% compared to the control. However, USM blocked UVB-induced cytotoxicity. Moreover, USM treatment significantly decreased the UVB-induced production of reactive oxygen species and attenuated the UVB-induced production and mRNA expression of matrix metalloproteinases (MMPs) by inhibiting the phosphorylation of mitogen-activated protein kinases and activator protein 1 (AP-1). Furthermore, UVB exposure led to a 49.4% reduction in collagen synthesis. However, USM treatment restored collagen synthesis through upregulation of the transforming growth factor beta (TGF-β)/Smad2/3 pathways. These data indicate that USM regulates the production of MMPs and collagen by modulation of the TGF-β/Smad pathway and AP-1 activity, suggesting that USM may be a useful anti-photoaging ingredient.

scholarly journals Oligomeric Procyanidin Nanoliposomes Prevent Melanogenesis and UV Radiation-Induced Skin Epithelial Cell (HFF-1) Damage

Molecules ◽  
2020 ◽  
Vol 25 (6) ◽  
pp. 1458 ◽  
Author(s):  
Yashu Chen ◽  
Fenghong Huang ◽  
David Julian McClements ◽  
Bijun Xie ◽  
Zhida Sun ◽  
...  
Keyword(s):  
Protective Effect ◽  
Fibroblast Cell ◽  
Skin Aging ◽  
Ultraviolet B ◽  
Protective Effects ◽  
Protection Mechanism ◽  
Uva Irradiation ◽  
Culture Model ◽  
Radiation Induced ◽  
Human Foreskin Fibroblast Cell

The potential protective effect of nanoliposomes loaded with lotus seedpod oligomeric procyanidin (LSOPC) against melanogenesis and skin damaging was investigated. Fluorescence spectroscopy showed that, after encapsulation, the LSOPC-nanoliposomes still possessed strong inhibitory effects against melanogenesis, reducing the activity of both monophenolase and diphenolase. Molecular docking indicated that LSOPC could generate intense interactive configuration with tyrosinase through arene–H, arene–arene, and hydrophobic interaction. An ultraviolet radiated cell-culture model (human foreskin fibroblast cell (HFF-1)) was used to determine the protective effects of the LSOPC-nanoliposomes against skin aging and damage. Results showed that LSOPC-nanoliposomes exerted the highest protective effects against both ultraviolet B (UVB) and ultraviolet A (UVA) irradiation groups compared with non-encapsulated LSOPC and a control (vitamin C). Superoxide dismutase (SOD) and malonaldehyde (MDA) assays demonstrated the protection mechanism may be related to the anti-photooxidation activity of the procyanidin. Furthermore, a hydroxyproline assay suggested that the LSOPC-nanoliposomes had a strong protective effect against collagen degradation and/or synthesis after UVA irradiation.

Protective effects of soft acrylic yellow filter against blue light-induced retinal damage in rats

2006 ◽  
Vol 83 (6) ◽  
pp. 1493-1504 ◽  
Author(s):  
Masaki Tanito ◽  
Sachiko Kaidzu ◽  
Robert E. Anderson
Keyword(s):  
Blue Light ◽  
Retinal Damage ◽  
Protective Effects ◽  
Yellow Filter

scholarly journals Quercetin Directly Targets JAK2 and PKCδ and Prevents UV-Induced Photoaging in Human Skin

2019 ◽  
Vol 20 (21) ◽  
pp. 5262 ◽  
Author(s):  
Shin ◽  
Lee ◽  
Hong ◽  
Lim ◽  
Byun
Keyword(s):  
Protein Kinase ◽  
Human Skin ◽  
Fruits And Vegetables ◽  
Molecular Mechanisms ◽  
Skin Aging ◽  
Janus Kinase ◽  
Activator Protein 1 ◽  
Protective Effects ◽  
Matrix Metalloproteinase 1 ◽  
Extracellular Signal

Quercetin is a naturally occurring polyphenol present in various fruits and vegetables. The bioactive properties of quercetin include anti-oxidative, anti-cancer, anti-inflammatory, and anti-diabetic effects. However, the effect of quercetin on skin aging and the direct molecular targets responsible have remained largely unknown. Herein, we investigated the protective effect of quercetin against UV-mediated skin aging and the molecular mechanisms responsible. Treatment with quercetin suppressed UV-induced matrix metalloproteinase-1 (MMP-1) and cyclooxygenase-2 (COX-2) expression and prevented UV-mediated collagen degradation in human skin tissues. Quercetin exerted potent inhibitory effects towards UV-induced activator protein-1 (AP-1) and nuclear factor-kappa B (NF-κB) activity. Further examination of the upstream signaling pathways revealed that quercetin can attenuate UV-mediated phosphorylation of extracellular signal-regulated kinase (ERK), c-Jun N terminal kinases (JNK), protein kinase B (Akt), and signal transducer and activator of transcription 3 (STAT3). Kinase assays using purified protein demonstrated that quercetin can directly inhibit protein kinase C delta (PKCδ) and Janus kinase 2 (JAK2) kinase activity. Quercetin was observed to bind to PKCδ and JAK2 in pull-down assays. These findings suggest that quercetin can directly target PKCδ and JAK2 in the skin to elicit protective effects against UV-mediated skin aging and inflammation. Our results highlight the potential use of quercetin as a natural agent for anti-skin aging applications.

scholarly journals The protective role of propolis against multi heavy metals-induced oxidative stress-hepato-renal damage in the male of albino rats

2021 ◽  
Author(s):  
Ayman Ahmed Bassiouny El-Amawy ◽  
Samir Attia Mohammed Zaahkouk ◽  
Hesham Gamal Abdel Rasheed ◽  
Bassem Elsayed Elaraby Mohammed
Keyword(s):  
Heavy Metals ◽  
Oral Administration ◽  
Antioxidant Defense System ◽  
Protective Role ◽  
Albino Rats ◽  
Protective Effects ◽  
Toxic Heavy Metals ◽  
Propolis Extract ◽  
Liver And Kidney

Abstract The study was designed to clarify the hepato-renal protective effects of propolis extract against heavy metals-induced toxicity via oral administration to the males of albino rats. Lead (Pb), Nickel (Ni), Cadmium (Cd), and Antimony (Sb) are toxic heavy metals have the ability to produce reactive radicals in the biological systems causing public and animals health hazards through disrupting balances between pro-oxidant and antioxidant defense system, resulting in excessive reactive oxygen species (ROS) production. The most commonly affected organs are liver and kidney. Propolis is a natural product with different shapes and resinous substance collected by honey bees, it attenuates many diseases damage due to its anti-oxidative action and its potentiality to minimize the deleterious effects of free radicals on tissues. The concentrations of Pb, Cd, Ni and Sb as well as the activities of antioxidants endogenous enzymes including; glutathione peroxidase (Gpx), glutathione reductase (GR), catalase (CAT), and superoxide dismutase (SOD) were all determined in the tissues of liver and kidney; while aspartate transaminase (ASAT), alanine transaminase (ALAT), total protein (TP), urea and createnine, were measured in the serum of experimental rats beside histopathologicl examination in the tissues of liver and kidney. The oral administration of propolis provided a significantly therapeutic role against multi-metals-induced hepato-renal toxicity with relative improving to histopathological changes because of its scavenging and chelating properties as concluded from the present investigation.

scholarly journals (−)-Loliolide Isolated from Sargassum horneri Abate UVB-Induced Oxidative Damage in Human Dermal Fibroblasts and Subside ECM Degradation

Marine Drugs ◽  
2021 ◽  
Vol 19 (8) ◽  
pp. 435
Author(s):  
Ilekuttige Priyan Shanura Fernando ◽  
Soo-Jin Heo ◽  
Mawalle Kankanamge Hasitha Madhawa Dias ◽  
Dissanayaka Mudiyanselage Dinesh Madusanka ◽  
Eui-Jeong Han ◽  
...  
Keyword(s):  
Inflammatory Responses ◽  
Skin Aging ◽  
Dermal Fibroblasts ◽  
Sargassum Horneri ◽  
Mitogen Activated Protein Kinase ◽  
Ros Generation ◽  
Protective Effects ◽  
Human Dermal Fibroblasts ◽  
Mitogen Activated Protein ◽  
Uvb Exposure

Ultraviolet (UV) B exposure is a prominent cause of skin aging and a contemporary subject of interest. The effects are progressing through the generation of reactive oxygen species (ROS) that alter cell signaling pathways related to inflammatory responses. The present study evaluates the protective effects of (7aR)-6-hydroxy-4,4,7a-trimethyl-6,7-dihydro-5H-1-benzofuran-2-one (HTT) isolated from the edible brown algae Sargassum horneri against UVB protective effects in human dermal fibroblasts (HDFs). HTT treatment dose-dependently suppressed intracellular ROS generation in HDFs with an IC50 of 62.43 ± 3.22 µM. HTT abated UVB-induced mitochondrial hyperpolarization and apoptotic body formation. Furthermore, UVB-induced activation of key nuclear factor (NF)-κB and mitogen-activated protein kinase signaling proteins were suppressed in HTT treated cells while downregulating pro-inflammatory cytokines (interleukin-1β, 6, 8, 33 and tumor necrosis factor-α). Moreover, HTT treatment downregulated matrix metalloproteinase1, 2, 3, 8, 9 and 13 that was further confirmed by the inhibition of collagenase and elastase activity. The evidence implies that HTT delivers protective effects against premature skin aging caused by UVB exposure via suppressing inflammatory responses and degradation of extracellular matrix (ECM) components. Extensive research in this regard will raise perspectives for using HTT as an ingredient in UV protective ointments.

scholarly journals Inhibition of the MAPK Signaling Pathway by Red Rice Extract in UVB-irradiated Human Skin Fibroblasts

2016 ◽  
Vol 11 (12) ◽  
pp. 1934578X1601101 ◽  
Author(s):  
Pornngarm Limtrakul ◽  
Supachai Yodkeeree ◽  
Wanisa Punfa ◽  
Jatupol Srisomboon
Keyword(s):  
Signaling Pathway ◽  
Human Fibroblasts ◽  
Radical Scavenging ◽  
Biological Properties ◽  
Mapk Signaling ◽  
Skin Aging ◽  
Mapk Signaling Pathway ◽  
Protective Effects ◽  
Red Rice ◽  
Anti Oxidant

Red rice has demonstrated several biological properties including anti-oxidant and anti-inflammation properties. However, the anti-photoaging activity has not yet been investigated. The aim of this study relates to the photo-protective effects of red rice extract (RRE) on UVB-induced skin aging. RRE was prepared and the active compounds and anti-oxidant activity were determined. The cytotoxicity of fibroblasts and secretions of IL-6 and IL-8 were evaluated. The effects of RRE on collagen and hyaluronic acid (HA) synthesis from fibroblasts were evaluated. Then, the collagenase and MMP-2 activity was determined. The effect of RRE on UV-induced MMP-1, nuclear factor kappa B (NF-κB), activator protein-1 (AP-1) and phosphorylation of MAPK protein expression was determined by western blot analysis. The RRE exerted a free radical scavenging property. RRE significantly increased collagen and HA synthesis in UVB-irradiated human fibroblasts. Moreover, RRE significantly inhibited UVB induced MMP-1 expression, MMP-2 and collagenase activity. Upon UVB irradiation, mitogen activated protein kinases (MAPKs) is activated and this pathway stimulates the expression of interleukin-6 and-8 (IL-6 and-8). Our results show that RRE decreases UVB-induced IL-6 and -8 production and the phosphorylation of c-Jun NH2-terminal kinase (JNK) and the p38 MAPK signaling process. In addition, RRE reduced UVB-induced activation of NF-κB and AP-1. RRE could suppress UV-induced inflammation and skin aging via the inhibition of the MAPK signaling pathway leading to the decrease of NF-κB and AP-1 activation resulting in a decrease in ECM degradation and an increase in ECM synthesis.

Sign in / Sign up

Export Citation Format

Share Document