Distributions of C-Reactive Protein and its Association With Metabolic Syndrome in Middle-Aged and Older Chinese People

Context: Age-related declines in testosterone and IGF-I are associated with deposition of visceral fat, a component of the metabolic syndrome (MES). Objective: Testosterone and IGF-I may interact with familial disposition to diabetes mellitus to increase the association with MES. Design: We conducted a cross-sectional cohort study. Setting: The study was conducted in a university teaching hospital. Subjects: Study subjects included 179 middle-aged men with a family history of diabetes (FH) (aged 39.1 ± 8.1 yr) and 128 men without FH (aged 43.8 ± 8.5 yr). Main Outcome Measures: Clinical characteristics, frequency of MES using the World Health Organization criteria with Asian definitions of obesity (body mass index ≥ 25 kg/m2), and serum levels of total testosterone, IGF-I, and high-sensitive C-reactive protein (hs-CRP) were measured. Results: Men with FH had higher frequency of MES than those without FH [39.1 vs. 23.4% (P = 0.004)]. On multivariate analysis, smoking (former and current smokers), low total testosterone, and IGF-I but elevated hs-CRP levels explained 35% of the MES variance in men with FH. The frequency of MES increased with declining tertiles of total testosterone and IGF-I but increasing tertiles of hs-CRP. After adjustment for age and smoking history, subjects with all three risk factors had a 13-fold increase in risk association with MES compared with those without hormonal and inflammatory risk factors. These risk associations were not found in men without FH in whom only smoking (ex and current) and low total testosterone level were independent predictors for MES, which explained 14% of the variance. Conclusions: Clustering of FH, hormonal abnormalities, and high hs-CRP is associated with MES in Chinese middle-aged men.

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Serum C-Reactive Protein and Risk of Cardiovascular Events in Middle-Aged and Older Chinese Population

The American Journal of Cardiology ◽

10.1016/j.amjcard.2009.02.028 ◽

2009 ◽

Vol 103 (12) ◽

pp. 1727-1731 ◽

Cited By ~ 16

Author(s):

Shan Jiang ◽

Yuqian Bao ◽

Xuhong Hou ◽

Qichen Fang ◽

Chen Wang ◽

...

Keyword(s):

Chinese Population ◽

Cardiovascular Events ◽

C Reactive Protein ◽

Middle Aged ◽

Reactive Protein ◽

Older Chinese

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Predictive value of asymmetric dimethylarginine and C-reactive protein for the risk of developing metabolic syndrome in middle-aged men

IJC Metabolic & Endocrine ◽

10.1016/j.ijcme.2014.10.001 ◽

2014 ◽

Vol 5 ◽

pp. 42-47 ◽

Cited By ~ 2

Author(s):

Toshiaki Otsuka ◽

Yasuhiro Nishiyama ◽

Yuko Kachi ◽

Katsuhito Kato ◽

Hirofumi Inagaki ◽

...

Keyword(s):

Metabolic Syndrome ◽

Predictive Value ◽

Asymmetric Dimethylarginine ◽

C Reactive Protein ◽

Middle Aged ◽

Reactive Protein

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Comparison between C-reactive protein and adipocyte fatty acid-binding protein as a component of metabolic syndrome in middle-aged women

Clinical Biochemistry ◽

10.1016/j.clinbiochem.2010.12.002 ◽

2011 ◽

Vol 44 (4) ◽

pp. 304-306 ◽

Cited By ~ 7

Author(s):

Anna Stefanska ◽

Grazyna Sypniewska ◽

Beata Blaszkiewicz ◽

Irena Ponikowska ◽

Malgorzata Cwiklinska-Jurkowska

Keyword(s):

Metabolic Syndrome ◽

Fatty Acid ◽

Fatty Acid Binding Protein ◽

Binding Protein ◽

C Reactive Protein ◽

Middle Aged ◽

Fatty Acid Binding ◽

Reactive Protein ◽

Acid Binding Protein

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Effects of Aerobic and Resistance Exercise on Insulin Resistance, C-reactive Protein, and Physical Fitness in Middle-aged Women with Metabolic Syndrome

The Official Journal of the Korean Academy of Kinesiology ◽

10.15758/jkak.2013.15.2.81 ◽

2013 ◽

Vol 15 (2) ◽

pp. 81-91

Author(s):

김종휴 ◽

강설중 ◽

노종철

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

Physical Fitness ◽

Resistance Exercise ◽

C Reactive Protein ◽

Middle Aged ◽

Reactive Protein

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Association between epicardial adipose tissue, high-sensitivity C-reactive protein and myocardial dysfunction in middle-aged men with suspected metabolic syndrome

Cardiovascular Diabetology ◽

10.1186/s12933-018-0735-7 ◽

2018 ◽

Vol 17 (1) ◽

Cited By ~ 11

Author(s):

Dong-Hyuk Cho ◽

Hyung Joon Joo ◽

Mi-Na Kim ◽

Do-Sun Lim ◽

Wan Joo Shim ◽

...

Keyword(s):

Metabolic Syndrome ◽

Adipose Tissue ◽

Epicardial Adipose Tissue ◽

Myocardial Dysfunction ◽

High Sensitivity ◽

C Reactive Protein ◽

Middle Aged ◽

Reactive Protein

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Reduced High-Molecular-Weight Adiponectin and Elevated High-Sensitivity C-Reactive Protein Are Synergistic Risk Factors for Metabolic Syndrome in a Large-Scale Middle-Aged to Elderly Population: the Shimanami Health Promoting Program Study

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2007-0397 ◽

2008 ◽

Vol 93 (3) ◽

pp. 715-722 ◽

Cited By ~ 34

Author(s):

Yasuharu Tabara ◽

Haruhiko Osawa ◽

Ryuichi Kawamoto ◽

Rieko Tachibana-Iimori ◽

Miyuki Yamamoto ◽

...

Keyword(s):

Metabolic Syndrome ◽

Molecular Weight ◽

High Molecular Weight ◽

Metabolic Disorders ◽

High Sensitivity ◽

Community Dwelling ◽

C Reactive Protein ◽

Middle Aged ◽

Reactive Protein ◽

Hmw Adiponectin

Abstract Objective: In Western countries, one of the most important modifiable targets for the prevention of cardiovascular diseases is metabolic syndrome. Adiponectin is an adipose tissue-specific plasma protein that inversely associates with metabolic syndrome. Among several molecular isoforms, high-molecular-weight (HMW) complex is considered the active form. Increased serum high-sensitivity C-reactive protein (hsCRP) concentration also associates with metabolic syndrome, and adiponectin could modulate plasma C-reactive protein levels. Here, through cross-sectional investigation, we investigated whether reduced HMW adiponectin and increased hsCRP levels in plasma are synergistically associated with metabolic syndrome. Measurement of HMW complex of adiponectin is one of the novelties of this study. Design: We analyzed 1845 community-dwelling middle-aged to elderly subjects (62 ± 13 yr). Plasma HMW adiponectin levels were measured by ELISA. Clinical parameters were obtained from the subjects’ personal health records, evaluated at their annual medical check-up. Results: Each component of metabolic syndrome, except for raised blood pressure, showed significantly lower plasma HMW adiponectin concentrations for both men and women (P < 0.001). In contrast, plasma hsCRP levels were significantly higher in subjects with metabolic disorders (P < 0.001). After adjusting for other confounding factors, HMW adiponectin [log normalized, odds ratio 0.084 (95% confidence interval 0.050–0.142), P < 0.001] and hsCRP [3.009 (2.175–4.163), P < 0.001] were identified as independent determinants of metabolic syndrome. In addition to the direct associations, we also observed a synergistic effect between these two molecules (F = 11.8, P < 0.001). Conclusions: Reduced HMW adiponectin and elevated hsCRP are synergistically associated with the accumulation of metabolic disorders. The combination of these markers would be useful for identifying at-risk populations.

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c-Reactive protein and the metabolic syndrome in older Chinese: Guangzhou Biobank Cohort Study

Atherosclerosis ◽

10.1016/j.atherosclerosis.2006.08.061 ◽

2007 ◽

Vol 194 (2) ◽

pp. 483-489 ◽

Cited By ~ 18

Author(s):

X.Q. Lao ◽

G. Neil Thomas ◽

C.Q. Jiang ◽

W.S. Zhang ◽

P. Yin ◽

...

Keyword(s):

Metabolic Syndrome ◽

Cohort Study ◽

C Reactive Protein ◽

Reactive Protein ◽

The Metabolic Syndrome ◽

Older Chinese

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Abstract T P161: Asymmetric Dimethylarginine, C-reactive Protein, and the Risk of Developing Metabolic Syndrome in Middle-Aged Men

Stroke ◽

10.1161/str.46.suppl_1.tp161 ◽

2015 ◽

Vol 46 (suppl_1) ◽

Author(s):

Yasuhiro Nishiyama ◽

Toshiaki Otsuka ◽

Masayuki Ueda ◽

Kazumi Kimura

Keyword(s):

Metabolic Syndrome ◽

Asymmetric Dimethylarginine ◽

Serum Levels ◽

Cox Proportional Hazards Model ◽

New Combination ◽

C Reactive Protein ◽

Middle Aged ◽

Reactive Protein ◽

The Metabolic Syndrome ◽

Hs Crp

BACKGROUND: The metabolic syndrome has known as an independent risk factor of stroke. We have recently shown that the measurement of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, may be useful for identifying individuals with a high risk of stroke among Japanese population. We aimed to examine whether serum levels of ADMA and a high-sensitivity C-reactive protein (hs-CRP) are associated with the risk of developing metabolic syndrome in middle-aged men. METHODS: In this longitudinal study, serum ADMA and hs-CRP levels were measured in Japanese men without metabolic syndrome, which was diagnosed according to the currently accepted unified criteria. The subjects were followed-up for a maximum of four years to determine new-onset metabolic syndrome. A Cox proportional hazards model with adjusting for potential confounders was applied to determine the hazard ratio (HR) for developing metabolic syndrome according to serum levels of ADMA and hs-CRP, considered either alone or in combination. RESULTS: Of the 848 subjects (mean age, 43 ± 6 years), 100 subjects developed metabolic syndrome. High ADMA levels (≥ 0.45μmol/L) alone did not show a significant HR for developing metabolic syndrome, while high hs-CRP levels (≥ 0.3 mg/L) did (HR 1.82, 95% CI 1.17-2.83). The combination of high levels of both hs-CRP and ADMA had a high HR (2.32, 95% CI 1.30-4.14) as compared to low levels of both markers. In contrast, the HR was not significant in the combination of high hs-CRP and low ADMA levels, as well as low hs-CRP and high ADMA levels. CONCLUSIONS: Serum hs-CRP, but not ADMA, levels were associated with the risk of metabolic syndrome. Furthermore, the combination of high ADMA and high CRP levels increased the risk of metabolic syndrome. Hence, further studies are needed, but measuring the new combination of two markers may potentiate the predictive value for developing cardiovascular diseases including stroke.

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