The relationship of dispositional compassion for others with depressive symptoms over a 15-year prospective follow-up

The study was designed to demonstrate the relationship of free fatty acids (FFAs) and eicosanoids levels with the severity of depressive symptoms in stroke. The ischemic stroke patients (n = 74) were included in the prospective study. The risk of depression was evaluated by the Beck Depression Inventory-II (BDI-II) 7 days and 6 months after the stroke onset. FFAs and inflammatory metabolites were determined by gas chromatography and liquid chromatography. In the acute phase of stroke, BDI-II and FFAs inversely correlated with C13:0 tridecanoic acid, C15:1 cis-10-pentadecanoid acid, C17:1 cis-10- heptadecanoid acid, C18:0 stearic acid, C20:3n6 eicosatrienoic acid, C22:1cis13 docosenoic acid and C22:6n3 docosahexaenoic acid (DHA). DHA level was significantly lower in patients with low vs. high BDI-II score. In the follow-up examination, BDI-II score directly correlated with C16:0 palmitic acid. The changes in BDI-II score during 6-month observation inversely correlated with lipoxin A4 and protectin D1, and directly correlated with 5-oxo-ETE. Importantly, the severity of depressive symptoms was associated with n3 PUFA level. Diet-derived FFAs were observed to potentially affect the inflammatory pathways in pathogenesis of depression in stroke and reduced DHA levels can attenuate depressive symptoms in stroke patients.

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A Decade of Disparities in Diabetes Technology Use and HbA1c in Pediatric Type 1 Diabetes: A Trans-Atlantic Comparison

10.2337/figshare.12808301 ◽

2020 ◽

Author(s):

Ananta Addala ◽

Marie Auzanneau ◽

Kellee Miller ◽

Werner Maier ◽

Nicole Foster ◽

...

Keyword(s):

Type 1 Diabetes ◽

Technology Use ◽

Hemoglobin A1c ◽

Diabetes Technology ◽

Design And Methods ◽

Relationship Of ◽

The Relationship ◽

Pediatric Type 1 Diabetes

Objective: As diabetes technology use in youth increases worldwide, inequalities in access may exacerbate disparities in hemoglobin A1c (HbA1c). We hypothesized an increasing gap in diabetes technology use by socioeconomic status (SES) would be associated with increased HbA1c disparities. Research Design and Methods: Participants aged <18 years with diabetes duration ≥1 year in the Type 1 Diabetes Exchange (T1DX, US, n=16,457) and Diabetes Prospective Follow-up (DPV, Germany, n=39,836) registries were categorized into lowest (Q1) to highest (Q5) SES quintiles. Multiple regression analyses compared the relationship of SES quintiles with diabetes technology use and HbA1c from 2010-2012 and 2016-2018. Results: HbA1c was higher in participants with lower SES (in 2010-2012 & 2016-2018, respectively: 8.0% & 7.8% in Q1 and 7.6% & 7.5% in Q5 for DPV; and 9.0% & 9.3% in Q1 and 7.8% & 8.0% in Q5 for T1DX). For DPV, the association between SES and HbA1c did not change between the two time periods, whereas for T1DX, disparities in HbA1c by SES increased significantly (p<0.001). After adjusting for technology use, results for DPV did not change whereas the increase in T1DX was no longer significant. Conclusions: Although causal conclusions cannot be drawn, diabetes technology use is lowest and HbA1c is highest in those of the lowest SES quintile in the T1DX and this difference for HbA1c broadened in the last decade. Associations of SES with technology use and HbA1c were weaker in the DPV registry.

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The Relationship of Psychiatric Symptoms with Performance-Based and Self-Reported Cognitive Function After Ischemic Stroke

Journal of the International Neuropsychological Society ◽

10.1017/s1355617721000187 ◽

2021 ◽

pp. 1-13

Author(s):

Elisabeth Kliem ◽

Elise Gjestad ◽

Truls Ryum ◽

Alexander Olsen ◽

Bente Thommessen ◽

...

Keyword(s):

Ischemic Stroke ◽

Executive Function ◽

Depressive Symptoms ◽

Cognitive Function ◽

Psychiatric Symptoms ◽

Post Stroke ◽

Cognitive Difficulties ◽

Memory And Attention ◽

Relationship Of ◽

The Relationship

Abstract Objective: Findings on the relationship of psychiatric symptoms with performance-based and self-reported cognitive function post-stroke are inconclusive. We aimed to (1) study the relation of depression and anxiety to performance-based cognitive function and (2) explore a broader spectrum of psychiatric symptoms and their association with performance-based versus self-reported cognitive function. Method: Individuals with supratentorial ischemic stroke performed neuropsychological examination 3 months after stroke. For primary analyses, composite scores for memory and attention/executive function were calculated based on selected neuropsychological tests, and the Hospital Anxiety and Depression Scale (HADS) was used. Psychiatric symptoms and self-reported cognitive function for secondary aims were assessed using the Symptom-Checklist-90 – Revised (SCL-90-R). Results: In a sample of 86 patients [mean (M) age: 64.6 ± 9.2; Mini-Mental State Examination (MMSE), 3–7 days post-stroke: M = 28.4 ± 1.7; National Institutes of Health Stroke Scale (NIHSS) after 3 months: M = 0.7 ± 1.6] depressive symptoms (HADS) were associated with poorer memory performance after controlling for age, sex, and education (p ≤ .01). In a subsample (n = 41; Age: M = 65.7 ± 8.1; MMSE: M = 28.4 ± 1.8; NIHSS: M = 1.0 ± 1.9), symptoms of phobic anxiety (SCL-90-R) were associated with poorer performance-based memory and attention/executive function, and symptoms of anxiety (SCL-90-R) with lower attention/executive function. Higher levels of self-reported cognitive difficulties were associated with higher scores in all psychiatric domains (p ≤ .05). Conclusion: Even in relatively well-functioning stroke patients, depressive symptoms are associated with poorer memory. The results also suggest that various psychiatric symptoms are more related to self-reported rather than to performance-based cognitive function. Screening for self-reported cognitive difficulties may not only help to identify patients with cognitive impairment, but also those who need psychological treatment.

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Investigation of the Correlation between Postherpetic Itch and Neuropathic Pain over Time

Pain Research and Management ◽

10.1155/2018/9305126 ◽

2018 ◽

Vol 2018 ◽

pp. 1-6 ◽

Cited By ~ 4

Author(s):

Rie Ishikawa ◽

Masako Iseki ◽

Rie Koga ◽

Eiichi Inada

Keyword(s):

Neuropathic Pain ◽

Herpes Zoster ◽

Pain Intensity ◽

Visual Analog Scale ◽

Analog Scale ◽

Paindetect Questionnaire ◽

Relationship Of ◽

The Relationship ◽

Over Time

Postherpetic itch (PHI), or herpes zoster itch, is an intractable and poorly understood disease. We targeted 94 herpes zoster patients to investigate their pain and itch intensities at three separate stages of the condition (acute, subacute, and chronic). We used painDETECT questionnaire (PDQ) scores to investigate the correlation between PHI and neuropathic pain. Seventy-six patients were able to complete follow-up surveys. The prevalence of PHI was 47/76 (62%), 28/76 (37%), and 34/76 (45%) at the acute, subacute, and chronic stages, respectively. PHI manifestation times and patterns varied. We investigated the relationship of PHI with neuropathic pain using the visual analog scale (VAS), which is a measure of pain intensity, and the PDQ, which is a questionnaire used to evaluate the elements of neuropathic pain. The VAS and PDQ scores did not differ significantly between PHI-positive and PHI-negative patients. A large neuropathic component was not found for herpes zoster itch, suggesting that neuropathic pain treatments may not able to adequately control the itch. Accordingly, we suggest that a more PHI-focused therapy is required to address this condition.

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The Relationship of Left Ventricular Trabeculation to Ventricular Function and Structure Over a 9.5-Year Follow-Up

Journal of the American College of Cardiology ◽

10.1016/j.jacc.2014.08.035 ◽

2014 ◽

Vol 64 (19) ◽

pp. 1971-1980 ◽

Cited By ~ 105

Author(s):

Filip Zemrak ◽

Mark A. Ahlman ◽

Gabriella Captur ◽

Saidi A. Mohiddin ◽

Nadine Kawel-Boehm ◽

...

Keyword(s):

Ventricular Function ◽

Left Ventricular ◽

Relationship Of ◽

The Relationship

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Influence of uric acid on the correlation between waist circumference and triglyceride glucose index: an analysis from CHARLS

Lipids in Health and Disease ◽

10.1186/s12944-021-01474-0 ◽

2021 ◽

Vol 20 (1) ◽

Author(s):

Jia Zheng ◽

Min Jiang ◽

Yanxia Xie

Keyword(s):

Uric Acid ◽

Waist Circumference ◽

Mediation Effects ◽

Panel Model ◽

Triglyceride Glucose Index ◽

Study Population ◽

Relationship Of ◽

The Relationship ◽

Longitudinal Relationships

Abstract Background Waist circumference (WC) and uric acid (UA) are significantly related. Still, their temporal sequence and how the sequence works on future risk of triglyceride glucose (TyG) are unknown, especially in the Chinese population. Methods Cross-lagged panel model was used to analyze the reciprocal, longitudinal relationships among a set of interrelated variables. The mediation model was constructed to test the effect of the relationship between WC and UA on TyG. Results A total of 5727 subjects were enrolled in our study population, of which 53.5% were women, and the mean age was 59.0 (standard deviation, 8.62) years. After adjusting for traditional confounding factors, the results showed that a higher level of baseline WC was significantly associated with a higher level of follow-up UA (β = 0.003, P = 0.031) and follow-up TyG (β = 0.003, P < 0.001);. Simultaneously, there was no statistical association between the level of baseline UA and the level of follow-up WC (β = − 0.009, P = 0.951). The mediation effects of UA on WC-TyG were estimated to be 18.1% in adults, and 36.2% in women. Conclusions The current study demonstrated that higher baseline level of WC probably preceded UA’ level in general population. In addition, UA mediated the relationship of WC to TyG, especially in females. And the possible mechanism would require further clarification.

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The Relationship of Frequency of Follow-Up Visits to Asthma Outcomes in Patients with Moderate Persistent Asthma

Journal of Asthma ◽

10.1081/jas-120017206 ◽

2003 ◽

Vol 40 (1) ◽

pp. 49-53 ◽

Cited By ~ 14

Author(s):

Michael Schatz ◽

Eva Rodriguez ◽

Reuben Falkoff ◽

Robert S. Zeiger

Keyword(s):

Persistent Asthma ◽

Asthma Outcomes ◽

Relationship Of ◽

The Relationship ◽

Moderate Persistent Asthma

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Prediction of Reproductive Success in Multiparous First Service Dairy Cows by Parameters from In-Line Sensors

Agriculture ◽

10.3390/agriculture11040334 ◽

2021 ◽

Vol 11 (4) ◽

pp. 334

Author(s):

Ramūnas Antanaitis ◽

Vida Juozaitienė ◽

Dovilė Malašauskienė ◽

Mindaugas Televičius ◽

Mingaudas Urbutis ◽

...

Keyword(s):

Electrical Conductivity ◽

Blood Parameters ◽

Negative Energy ◽

Hydroxybutyric Acid ◽

Pregnancy Status ◽

Group A ◽

Biochemical Indices ◽

Relationship Of ◽

The Relationship

The aim of the current study was to evaluate the relationship of different parameters from an automatic milking system (AMS) with the pregnancy status of multiparous cows at first service and to assess the accuracy of such a follow-up with regard to blood parameters. Before the insemination of cows, blood samples for measuring biochemical indices were taken from the coccygeal vessels and the concentrations of blood serum albumin (ALB), cortisol, non-esterified fatty acids (NEFA) and the activities of aspartate aminotransferase (AST) and gamma glutamyltransferase (GGT) were determined. From oestrus day to seven days after oestrus, the following parameters were registered: milk yield (MY), electric milk conductivity, lactate dehydrogenase (LDH) and β-hydroxybutyric acid (BHB). The pregnancy status was evaluated using ultrasound “Easy scan” 30–35 days after insemination. Cows were grouped by reproductive status: PG− (non-pregnant; n = 48) and PG+ (pregnant; n = 44). The BHB level in PG− cows was 1.2 times higher (p < 0.005). The electrical conductivity of milk was statistically significantly higher in all quarters of PG− cows (1.07 times) than of PG+ cows (p < 0.05). The arithmetic mean of blood GGT was 1.61 times higher in PG− cows and the NEFA value 1.23 times higher (p < 0.05) compared with the PG+ group. The liver function was affected, the average ALB of PG− cows was 1.19 times lower (p < 0.05) and the AST activity was 1.16 times lower (p < 0.05) compared with PG+ cows. The non-pregnant group had a negative energy balance demonstrated by high in-line milk BHB and high blood NEFA concentrations. We found a greater number of cows with cortisol >0.0.75 mg/dL in the non-pregnant group. A higher milk electrical conductivity in the non-pregnant cows pointed towards a greater risk of mastitis while higher GGT activities together with lower albumin concentrations indicated that the cows were more affected by oxidative stress.

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The relationship of severe health disorders with bone loss, grip strength, and mobility in postmenopausal women – a 15-year follow-up study

Disability and Rehabilitation ◽

10.3109/09638288.2015.1103789 ◽

2015 ◽

Vol 38 (14) ◽

pp. 1407-1414

Author(s):

Juha Suuronen ◽

Samu Sjöblom ◽

Risto Honkanen ◽

Heli Koivumaa-Honkanen ◽

Heikki Kröger ◽

...

Keyword(s):

Bone Loss ◽

Grip Strength ◽

Postmenopausal Women ◽

Follow Up Study ◽

Health Disorders ◽

Relationship Of ◽

The Relationship

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Frequency of post-traumatic osteoarthritis in dogs after repair of a humeral condylar fracture

Veterinary and Comparative Orthopaedics and Traumatology ◽

10.1055/s-0038-1632755 ◽

2003 ◽

Vol 16 (01) ◽

pp. 01-05 ◽

Cited By ~ 18

Author(s):

M. F. Besancon ◽

M. G. Conzemius ◽

K. G. Miles ◽

A. S. Kapatkin ◽

W. T. N. Culp ◽

...

Keyword(s):

Fracture Repair ◽

Fracture Reduction ◽

Vertical Force ◽

Condylar Fracture ◽

Limb Function ◽

Anatomic Reduction ◽

Post Traumatic ◽

Relationship Of ◽

The Relationship

SummaryThe frequency of post-traumatic osteoarthritis (PTO) in the dog after repair of a humeral condylar fracture (HCF) and the relationship of fracture reduction to outcome is unknown. The objectives of this study were to determine the frequency of PTO in dogs after HCF repair and to determine the relationship between fracture reduction, limb function and follow-up osteoarthrosis (OA) score. All dogs were evaluated by physical and radiographic examinations and dogs with unilateral fracture repair were also examined by force platform gait analysis. Initial and follow-up radiographs were scored for reduction and evidence of osteoarthrosis using previously published grading scales. This study evaluated 15 fractures in 13 dogs with a mean follow-up time of 43 months. Osteoarthrosis developed or progressed radiographically in all elbows. Peak vertical force (PVF) was significantly reduced (p <0.01) in the affected limb, however vertical impulse (VI) did not differ (p = 0.12) when compared to the opposite normal limb. Pain-free range of motion was reduced in flexion (p <0.01), but not in extension (p = 0.98) when compared to the normal limb. Fracture reduction score did not correlate with follow-up OA score (p = 0.07), PVF (p = 0.40), VI (p = 0.72), flexion (p =0.50), or extension (p = 0.62). Due to the high incidence of PTO, owners should be warned of the possibility of declining limb function over time despite near anatomic reduction.

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