scholarly journals The impact of city epidemics on rural labor market: The Korean Middle East Respiratory Syndrome case

2017 ◽  
Vol 43 ◽  
pp. 30-40 ◽  
Author(s):  
Ayoung Lee ◽  
Joonmo Cho
2018 ◽  
Vol 4 (2) ◽  
pp. 27 ◽  
Author(s):  
Younglee Kim ◽  
Eunju Seo ◽  
Youngseon Seo ◽  
Vivien Dee ◽  
Eunhee Hong

Background: The unprecedented nationwide outbreak of the Middle East Respiratory Syndrome Coronavarius (MERS-CoV) from June to July in 2015 took the Korean healthcare system unexpectedly and created physical and psychological stress and trauma to Registered Nurses unprepared to deal with the viral outbreak.Purpose: We investigated the effects of Middle East Respiratory Syndrome Coronavirus (MERS-CoV), post-traumatic stress disorder (PTSD) and burnout among Korean registered nurses (RNs).Methods: A descriptive cross sectional design using a self-administered survey of a convenience sample of 112 Korean RNs. The Impact of Event Scale-Revised-Korean version (IES-R-K) for PTSD and the Maslach Burnout Inventory-Human Services Survey (MBI-HSS) for burnout were utilized.Results: Overall prevalence for symptoms of PTSD was 50.0%. PTSD was significantly correlated to burnout (r = .480, p = .000), especially two burnout subscales, emotional exhaustion (r = .533, p = .000), and depersonalization (r = .497, p = .000).Conclusions: Future anticipatory guidance and management of traumatic outbreak or disaster should be considered for nurses’ mental health. Public health and safety at the national level must address quality health outcomes for both patients and healthcare professionals alike.


2017 ◽  
Vol 91 (23) ◽  
Author(s):  
Courtney M. Daczkowski ◽  
Octavia Y. Goodwin ◽  
John V. Dzimianski ◽  
Jonathan J. Farhat ◽  
Scott D. Pegan

ABSTRACT Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging human pathogen that is the causative agent for Middle East respiratory syndrome (MERS). With MERS outbreaks resulting in over 35% fatalities and now spread to 27 countries, MERS-CoV poses a significant ongoing threat to global human health. As part of its viral genome, MERS-CoV encodes a papain-like protease (PLpro) that has been observed to act as a deubiquitinase and deISGylase to antagonize type I interferon (IFN-I) immune pathways. This activity is in addition to its viral polypeptide cleavage function. Although the overall impact of MERS-CoV PLpro function is observed to be essential, difficulty has been encountered in delineating the importance of its separate functions, particularly its deISGylase activity. As a result, the interface of MERS-CoV and human interferon-stimulated gene product 15 (hISG15) was probed with isothermal calorimetry, which suggests that the C-terminal domain of hISG15 is principally responsible for interactions. Subsequently, the structure of MERS-CoV PLpro was solved to 2.4 Å in complex with the C-terminal domain of hISG15. Utilizing this structural information, mutants were generated that lacked appreciable deISGylase activity but retained wild-type deubiquitinase and peptide cleavage activities. Hence, this provides a new platform for understanding viral deISGylase activity within MERS-CoV and other CoVs. IMPORTANCE Coronaviruses, such as Middle East respiratory syndrome coronavirus (MERS-CoV), encode a papain-like protease (PLpro) that possesses the ability to antagonize interferon immune pathways through the removal of ubiquitin and interferon-stimulated gene product 15 (ISG15) from target proteins. The lack of CoV proteases with attenuated deISGylase activity has been a key obstacle in delineating the impact between deubiquitinase and deISGylase activities on viral host evasion and pathogenesis. Here, biophysical techniques revealed that MERS-CoV PLpro chiefly engages human ISG15 through its C-terminal domain. The first structure of MERS-CoV PLpro in complex with this domain exposed the interface between these two entities. Employing these structural insights, mutations were employed to selectively remove deISGylase activity with no appreciable impact on its other deubiquitinase and peptide cleavage biochemical properties. Excitingly, this study introduces a new tool to probe the pathogenesis of MERS-CoV and related viruses through the removal of viral deISGylase activity.


2020 ◽  
pp. 76-85
Author(s):  
Benhur Şirvan Çetin

After Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and the Middle East Respiratory Syndrome Coronavirus (MERS-CoV), SARS-CoV-2 is the newest member of the family of coronaviruses that are pathogenic to humans. The disease which occurs with SARS-CoV-2 is called coronavirus disease 2019 (COVID-19). COVID-19 was first described in December 2019 and has caused millions of people to get sick and hundreds of thousands of deaths over the past year. In this review, the epidemiology, diagnosis, clinical and aboratory features, radiological findings, treatment, and management of the disease are all reviewed from a pediatrician’s perspective. Post-infectious complications, the impact of COVID-19 on global child health, and vaccine developments were also discussed in this review.


2017 ◽  
Vol 74 (5) ◽  
pp. 521-523 ◽  
Author(s):  
Sarah H. Alfaraj ◽  
Jaffar A. Al-Tawfiq ◽  
Nojoom A. Alzahrani ◽  
Talal A. Altwaijri ◽  
Ziad A. Memish

Ekonomika APK ◽  
2021 ◽  
Vol 318 (4) ◽  
pp. 51-67
Author(s):  
Oleksii Mohylnyi ◽  
Nataliia Patyka ◽  
Olena Hryschenko

The purpose of the article is to assess the impact of restrictive quarantine measures in 2020-2021 related to the spread of the COVID-19 pandemic on the rural labor market, the level of employment and the extent of rural poverty. Research methods. The basis for the study were general scientific and economic methods, creative heritage of the classical political economy founders, publications of Ukrainian scientists on the impact of quarantine restrictions related to the spread of the COVID-19 pandemic, on social and labor relations in rural areas, regulations, data from the State Statistics Service of Ukraine and the State Employment Service, Internet resources and other sources. The monographic approach was used in the analysis of the employment rate dynamics of the rural population, changes in the labor market and the scale of poverty caused by the lockdowns introduction in 2020-2021. Normative and positive approaches are used to highlight the labor potential of rural areas and opportunities for its implementation in a pandemic. A number of abstract-logical techniques allowed formulating intermediate and final conclusions and proposals. Research results. The phenomenon of the category "labor" as a process of conscious and purposeful activity on the transformation of natural and economic factors of production in order to meet human needs is considered. The institutional preconditions of spatial differences in the concentration of jobs in rural and urban areas and the deepening of inequality in their development are highlighted. Changes caused by a number of restrictions on economic activity in order to prevent the spread of the COVID-19 pandemic in Ukraine are analyzed, in the field of the rural population employment by age groups, employment status, unemployment among working-age people, the number of employees who received unemployment status, as well as the workload per vacancy registered with the State Employment Service, the dynamics of its provision of services to rural residents. Public opinion that in the employment and rural labor market due to non-compliance with quarantine restrictions on economic activity, technological features of agricultural production and lower density, the rural population suffers less from quarantine measures is refuted. As a result of the introduction of two all-Ukrainian lockdowns in 2020–2021, the number of employed rural population decreased by 361 thousand people, or by 7%, of them employed - by 198 thousand and self-employed - by 153 thousand. The unemployment rate for this period also increased by 1.7 percentage points, or 11.5%. In April-May 2021, almost 120,000 workers received the status of unemployed dismissed from agricultural, forestry and fisheries enterprises, or one in five of the total in the economy. In addition, the number of applicants for one vacancy in rural areas has doubled, while reducing the financial capacity of the State Employment Service, especially with regard to the implementation of active forms of employment recovery. An integral consequence of quarantine restrictions was the spread of poverty among the rural population and the further social exclusion of people with unprotected self-employment. Scientific novelty. Methodological approaches to assessing the negative impact of quarantine restrictions related to the spread of the COVID-19 pandemic on rural employment, the rural labor market and the well-being of rural households have been further developed. Practical significance. The results of the impact of quarantine restrictions on employment and the rural labor market in 2020-2021 may be taken into account when developing measures to support micro and small businesses and self-employed agricultural workers in extreme conditions of society, such as a pandemic. Tabl.: 3. Figs.: 5. Refs.: 35.


PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e9783
Author(s):  
Khalid Hussain Al-Ahmadi ◽  
Mohammed Hussain Alahmadi ◽  
Ali Saeed Al-Zahrani ◽  
Maged Gomaa Hemida

About 83% of laboratory-confirmed Middle East respiratory syndrome coronavirus (MERS-CoV) cases have emerged from Saudi Arabia, which has the highest overall mortality rate worldwide. This retrospective study assesses the impact of spatial/patient characteristics for 14-and 45-day MERS-CoV mortality using 2012–2019 data reported across Saudi regions and provinces. The Kaplan–Meier estimator was employed to estimate MERS-CoV survival rates, Cox proportional-hazards (CPH) models were applied to estimate hazard ratios (HRs) for 14-and 45-day mortality predictors, and univariate local spatial autocorrelation and multivariate spatial clustering analyses were used to assess the spatial correlation. The 14-day, 45-day and overall mortality rates (with estimated survival rates) were 25.52% (70.20%), 32.35% (57.70%) and 37.30% (56.50%), respectively, with no significant rate variations between Saudi regions and provinces. Nationally, the CPH multivariate model identified that being elderly (age ≥ 61), being a non-healthcare worker (non-HCW), and having an underlying comorbidity were significantly related to 14-day mortality (HR = 2.10, 10.12 and 4.11, respectively; p < 0.0001). The 45-day mortality model identified similar risk factors but with an additional factor: patients aged 41–60 (HR = 1.44; p < 0.0001). Risk factors similar to those in the national model were observed in the Central, East and West regions and Riyadh, Makkah, Eastern, Madinah and Qassim provinces but with varying HRs. Spatial clusters of MERS-CoV mortality in the provinces were identified based on the risk factors (r2 = 0.85–0.97): Riyadh (Cluster 1), Eastern, Makkah and Qassim (Cluster 2), and other provinces in the north and south of the country (Cluster 3). The estimated HRs for the 14-and 45-day mortality varied spatially by province. For 45-day mortality, the highest HRs were found in Makkah (age ≥ 61 and non-HCWs), Riyadh (comorbidity) and Madinah (age 41–60). Coming from Makkah (HR = 1.30 and 1.27) or Qassim province (HR = 1.77 and 1.70) was independently related to higher 14-and 45-day mortality, respectively. MERS-CoV patient survival could be improved by implementing appropriate interventions for the elderly, those with comorbidities and non-HCW patients.


2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Emma G. Gardner ◽  
David Kelton ◽  
Zvonimir Poljak ◽  
Maria Van Kerkhove ◽  
Sophie von Dobschuetz ◽  
...  

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