Estimation of 24-hour sodium, potassium and albumin excretion from spot urine samples in a national representative survey of hypertension (PHYSA)

2014 ◽  
Vol 8 (4) ◽  
pp. e83
Author(s):  
Jorge Polonia ◽  
Luis Martins ◽  
Fernando Pinto ◽  
Jose Nazare
Keyword(s):  
Urine Samples ◽  
Representative Survey ◽  
Sodium Potassium ◽  
Spot Urine ◽  
Albumin Excretion ◽  
National Representative Survey

scholarly journals Effect of storage duration and analyte concentration on measurement of neutral pH clinical chemistry urine analytes

2021 ◽  
Vol 9 (10) ◽  
pp. 3022
Author(s):  
Chapal Debnath ◽  
Niral Savaliya
Keyword(s):  
Clinical Chemistry ◽  
Control Sample ◽  
Urine Samples ◽  
Internal Quality ◽  
Analyte Concentration ◽  
Storage Duration ◽  
Sodium Potassium ◽  
Spot Urine ◽  
Almost All ◽  
Hospital Wards

Background: The aim of the study was focused very keenly in measuring the changes in concentration of sodium, potassium and creatinine in urine, stored for 60 days effect of urinary storage duration of clinical chemistry analytes. This study determined whether patient urine samples can be used for day to day urine quality control.Methods: Spot urine samples were collected from left over samples from the admitted patients in various hospital wards. The samples are kept which its pH was unaltered or unspiked and was aliquoted and deep fridged immediately. These aliquots were melted at an incubator temperature of 86 ºC and was analyzed in the analyzer for 60 days and data were collected for checking variations.Results: With the strenous and continious monitoring from the side of the researchers, the researchers had throughly analysed and found that in both the sets almost all of those analysed urine test of pH 5 and analytes remained very much stable for a period of 60 days which could be used for running daily internal quality controls.Conclusions: Patient urine can be used as internal quality control sample for at least 60 days for sodium, potassium and creatinine. During the 60 days period, there is no appreciable degradation of any of the two sets of samples for sodium, potassium and creatinine measurements.

P3.23 URINARY ALBUMIN EXCRETION FROM SPOT URINE SAMPLES PREDICT ALL-CAUSE AND STROKE MORTALITY IN AFRICANS

2013 ◽  
Vol 7 (3-4) ◽  
pp. 132
Author(s):  
R. Schutte ◽  
A.E. Schutte ◽  
H.W. Huisman ◽  
J.M. van Rooyen ◽  
C.M.T. Fourie ◽  
...  
Keyword(s):  
Urinary Albumin Excretion ◽  
Urinary Albumin ◽  
Urine Samples ◽  
Stroke Mortality ◽  
Spot Urine ◽  
Albumin Excretion

scholarly journals Urinary Albumin Excretion From Spot Urine Samples Predict All-Cause and Stroke Mortality in Africans

2014 ◽  
Vol 27 (6) ◽  
pp. 811-818 ◽  
Author(s):  
Rudolph Schutte ◽  
Roland E. Schmieder ◽  
Hugo W. Huisman ◽  
Wayne Smith ◽  
Johannes M. van Rooyen ◽  
...  
Keyword(s):  
Urinary Albumin Excretion ◽  
Urinary Albumin ◽  
Urine Samples ◽  
Stroke Mortality ◽  
Spot Urine ◽  
Albumin Excretion

scholarly journals Biochemical Assessment of Renal and Liver Function among Preeclamptics in Lagos Metropolis

2018 ◽  
Vol 2018 ◽  
pp. 1-6
Author(s):  
Oloruntoba Ayodele Ekun ◽  
Oluwatumininu Mary Olawumi ◽  
Christian Chigozie Makwe ◽  
Nkeiruka Ogochukwu Ogidi
Keyword(s):  
Uric Acid ◽  
Liver Function ◽  
Total Protein ◽  
Venous Blood ◽  
Urine Samples ◽  
Plasma Sodium ◽  
Cross Sectional ◽  
Blood Samples ◽  
Spot Urine ◽  
Specific Syndrome

Objectives. Preeclampsia is a pregnancy specific syndrome. Studies have shown that preeclampsia has multiorgan dysfunction effects. This study evaluated biomarkers of renal and liver function among preeclamptic Nigerian women. Study Design. This was a cross-sectional study conducted among 49 preeclamptic women and 50 normotensive healthy pregnant women. Method. The baseline data comprising age, gestational age, and blood pressure were obtained. Venous blood and spot urine samples were collected from each participant. Plasma obtained from blood samples taken into lithium heparinized vacutainer bottles was assayed for electrolytes, urea, creatinine, total protein, albumin, and uric acid, while sera samples from blood samples taken into serum separation tube- (SST-) gel vacutainer were assayed for aspartate transaminase and alanine transaminase using ion selective electrode technique and Cobas autoanalyzer. Spot urine samples were assayed for protein and creatinine using Pyrogallol’s reagent and Jaffe’s methods, respectively. Microalbuminuria (protein/creatinine ratio) was generated from spot urine protein and creatinine data. Result. The plasma sodium, total protein, and albumin in preeclamptic group were significantly decreased (p<0.05) when compared with control. There was statistically significant increase (p<0.05) in microalbuminuria, plasma potassium, urea, creatinine, uric acid levels, serum AST, and ALT activities in preeclamptic group. A positive association (p<0.05) between alanine aminotransferase and biomarkers of renal function was observed. Conclusion. Preeclampsia has deleterious effects on renal and liver function as shown by alteration of these parameters.

scholarly journals Estimation of 24-Hour Sodium Excretion from Spot Urine Samples

2010 ◽  
Vol 12 (3) ◽  
pp. 174-180 ◽  
Author(s):  
Samuel J. Mann ◽  
Linda M. Gerber
Keyword(s):  
Sodium Excretion ◽  
Urine Samples ◽  
Spot Urine

Purine derivatives in spot urine samples and plasma of sheep: a possible index of microbial protein supply

1993 ◽  
Vol 1993 ◽  
pp. 5-5 ◽  
Author(s):  
X. B. Chen ◽  
Adriana T. Mejia ◽  
D. J. Kyle ◽  
E. R. Ørskov
Keyword(s):  
Urinary Excretion ◽  
Feed Intake ◽  
Urine Samples ◽  
Plasma Samples ◽  
Microbial Protein ◽  
Purine Derivatives ◽  
Feeding Regime ◽  
Spot Urine ◽  
Alternative Index ◽  
Protein Supply

In ruminants, daily urinary excretion of purine derivatives (PD) reflects the absorption of microbial purines and can be used as an index of microbial protein supply (Chen, Ørskov and Hovell, 1991). The application could be extended to farm conditions if measurements based on spot urine samples or plasma could serve as an alternative index. The objective of this study was to examine whether PD concentrations in spot urine or plasma samples vary diurnally during a given feeding regime and if they reflect differences in daily PD excretion induced by varying feed intake.

scholarly journals Best Albuminuria Measurement to Predict Cardiovascular and Renal Events

2016 ◽  
Vol 43 (5) ◽  
pp. 383-388 ◽  
Author(s):  
Lucie Bauer ◽  
Insa E. Emrich ◽  
John W. Pickering ◽  
Kathrin Untersteller ◽  
Franziska Sandermann ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Cardiovascular Events ◽  
Albumin Excretion Rate ◽  
Primary Analysis ◽  
Home Study ◽  
Spot Urine ◽  
Albumin Excretion ◽  
Net Reclassification Improvement ◽  
Kdigo Guidelines

Background: Kidney Disease Improving Global Outcomes (KDIGO) guidelines encourage clinicians to estimate 24-hour albuminuria as albumin to creatinine ratio (ACR) from spot urine samples. However, ACR underestimates 24-hour albumin excretion in muscular individuals. Equations that adjust ACR for surrogates of muscle mass to yield an estimated albumin excretion rate (eAER) were developed. We hypothesised that eAER is a better predictor of cardiovascular and renal outcomes than ACR. Methods: We determined ACR and eAER among 443 patients with chronic kidney disease G2-G4 recruited into the CARE FOR HOMe study. Patients were classified into KDIGO albuminuria categories, and followed for cardiovascular and renal events. The primary analysis was the net reclassification improvement (NRI) for those with and without events within 3 years of follow-up. Results: Eighty five patients experienced cardiovascular events during 3 years of follow-up, 13 of whom were reclassified to a more advanced albuminuria category, and 1 patient to a less advanced category by eAER compared to ACR (NRIevent: 14.1% (95% CI 5.8-22.4)). Among 358 patients without a cardiovascular event, 17 patients were reclassified to a more advanced albuminuria category, and 2 patients to a less advanced category by eAER (NRIno event: -4.2%, 95% CI -8.5 to -1.8). Sixty patients went through renal events, and 383 patients had event-free 3-year follow-up. NRIevent was 6.7% (95% CI -1.2 to 14.5), and NRIno event was -6.0% (95% CI -10.6 to 3.4) for renal events. Conclusion: Compared to ACR albuminuria categories, eAER categories are better associated with future cardiovascular events, but not with renal events.

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