scholarly journals Controlled drug release for tissue engineering

2015 ◽  
Vol 219 ◽  
pp. 119-128 ◽  
Author(s):  
Kunal J. Rambhia ◽  
Peter X. Ma
Keyword(s):  
Tissue Engineering ◽  
Drug Release ◽  
Controlled Drug Release

Biomedical applications of polymers 2001 - 2002

e-Polymers ◽  
2003 ◽  
Vol 3 (1) ◽  
Author(s):  
Joseph Jagur-Grodzinski
Keyword(s):  
Tissue Engineering ◽  
Gene Therapy ◽  
Gene Delivery ◽  
Drug Release ◽  
Wound Dressing ◽  
Biomedical Applications ◽  
Bone Repair ◽  
Controlled Drug Release ◽  
Artificial Organs ◽  
Drug And Gene Delivery

Abstract Papers published during 2001 - 2002 on the synthesis and preparation of polymers and polymer-based devices and their applications are reviewed. Polymers for drug and gene delivery, gene therapy, controlled drug release, conjugation with peptides, proteins, and nucleotides, tissue engineering, bone repair and regeneration, coatings, wound dressing, artificial skin and other artificial organs are discussed.

Instant hydrogel formation of terpyridine-based complexes triggered by DNA via non-covalent interaction

Nanoscale ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 4044-4052 ◽  
Author(s):  
Lijun Geng ◽  
Xudong Yu ◽  
Yajuan Li ◽  
Yanqiu Wang ◽  
Yongquan Wu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Covalent Interaction ◽  
Wide Range ◽  
Hydrogel Formation ◽  
Potential Use

Biomolecule-based hydrogels have potential use in a wide range of applications such as controlled drug release, tissue engineering, and biofabrication.

Reducing the Risk in Controlled Drug Release by Using Tannic Acid in Liposomal Formulations

2018 ◽  
Vol 68 (12) ◽  
pp. 2925-2918
Author(s):  
Gabriela Cioca ◽  
Maricel Agop ◽  
Marcel Popa ◽  
Simona Bungau ◽  
Irina Butuc
Keyword(s):  
Drug Release ◽  
Tannic Acid ◽  
Release Rate ◽  
Controlled Drug Release ◽  
Toxicity Threshold ◽  
Release System ◽  
Liposomal Formulations ◽  
Cross Linker ◽  
Natural Cross

One of the main challenges in designing a release system is the possibility to control the release rate in order to maintain it at a constant value below a defined limit, to avoid exceeding the toxicity threshold. We propose a method of overcoming this difficulty by introducing the drug into liposomes, prior to its inclusion in the hydrogel. Furthermore, a natural cross linker (as is tannic acid) is used, instead of the toxic cross linkers commonly used, thus reducing the toxicity of the release system as a whole.

Nanostructured Ketorolac-Tromethamine/MCF: Synthesis, Characterization and Application in Drug Release System

2018 ◽  
Vol 14 (5) ◽  
pp. 432-439 ◽  
Author(s):  
Juliana M. Juarez ◽  
Jorgelina Cussa ◽  
Marcos B. Gomez Costa ◽  
Oscar A. Anunziata
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Controlled Drug Release ◽  
Delivery Systems ◽  
The Body ◽  
Fickian Diffusion ◽  
Ketorolac Tromethamine

Background: Controlled drug delivery systems can maintain the concentration of drugs in the exact sites of the body within the optimum range and below the toxicity threshold, improving therapeutic efficacy and reducing toxicity. Mesostructured Cellular Foam (MCF) material is a new promising host for drug delivery systems due to high biocompatibility, in vivo biodegradability and low toxicity. Methods: Ketorolac-Tromethamine/MCF composite was synthesized. The material synthesis and loading of ketorolac-tromethamine into MCF pores were successful as shown by XRD, FTIR, TGA, TEM and textural analyses. Results: We obtained promising results for controlled drug release using the novel MCF material. The application of these materials in KETO release is innovative, achieving an initial high release rate and then maintaining a constant rate at high times. This allows keeping drug concentration within the range of therapeutic efficacy, being highly applicable for the treatment of diseases that need a rapid response. The release of KETO/MCF was compared with other containers of KETO (KETO/SBA-15) and commercial tablets. Conclusion: The best model to fit experimental data was Ritger-Peppas equation. Other models used in this work could not properly explain the controlled drug release of this material. The predominant release of KETO from MCF was non-Fickian diffusion.

Sign in / Sign up

Export Citation Format

Share Document