Effect of drug incorporation and polymer properties on the characteristics of electrospun nanofibers for drug delivery

2022 ◽  
pp. 103112
Author(s):  
Madeline B. Gelb ◽  
Ashish Punia ◽  
Shari Sellers ◽  
Parul Kadakia ◽  
James Ormes ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Electrospun Nanofibers ◽  
Polymer Properties ◽  
Drug Incorporation

An insight on electrospun-nanofibers-inspired modern drug delivery system in the treatment of deadly cancers

RSC Advances ◽  
2015 ◽  
Vol 5 (71) ◽  
pp. 57984-58004 ◽  
Author(s):  
A. Balaji ◽  
M. V. Vellayappan ◽  
A. A. John ◽  
A. P. Subramanian ◽  
S. K. Jaganathan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Electrospun Nanofibers ◽  
Modern Drug ◽  
Drug Incorporation ◽  
Insight Into

This review gives an insight into the process of electrospinning, its essential parameters, the types of drug incorporation and the works reported on common dreadful cancers.

scholarly journals Influence of bulk incorporation of FDAc and PTX on polymer properties

2017 ◽  
Vol 3 (2) ◽  
pp. 691-694
Author(s):  
Michael Teske ◽  
Katharina Wulf ◽  
Daniela Arbeiter ◽  
Thomas Eickner ◽  
Klaus-Peter Schmitz ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polymer Surface ◽  
Physicochemical Characterization ◽  
Spray Coating ◽  
High Increase ◽  
Polymer Properties ◽  
Wide Range ◽  
Tunable Mechanical Properties ◽  
Drug Incorporation ◽  
Additional Coupling

AbstractIn the last decades PLLA-based copolymers have been among the most attractive polymeric candidates used to fabricate devices for drug delivery and stent applications in the cardiovascular system. PLLA is biocompatible and biodegradable, exhibits a wide range of erosion times and has tunable mechanical properties. Therefore, the influence of drug incorporation on the physicochemical properties of biodegradable PLLA copolymers were examined in this study using Fluorescein diacetate (FDAc) and Paclitaxel (PTX). A percental amount of these drugs (17.5 %) were incorporated into poly(L-lactide-co-glycolide) (P(LLA-co-GA)) and poly(L-lactide-co-ε-caprolactone) (P(LLA-co-CL)) made via spray coating. The polymer surface properties, such as surface morphology and hydrophilicity were also examined and remained rather unchanged for both polymers after drug loadings. Furthermore, also the contact angle changed rather marginally. However, both polymers have already different thermal properties without the drug embedded, especially the glass transition temperature (TG) is for P(LLA-co-CL) under 37°C and for P(LLA-co-GA) considerable above with around 66°C. An rather high increase in TG achieved by addition of FDAc or PTX, crucial influences the drug release profiles for P(LLA-co-CL) in contrast to P(LLA-co-GA). Besides these results preliminarily experiments of additional coupling of other drugs on the polymer surface were performed and we obtained an influence of FDAc or PTX. The drug incorporation and physicochemical characterization data obtained in this study is relevant in optimizing the incorporation or coupling of further drugs on the polymer surface and delivery properties of these potential multi drug delivery coatings.

scholarly journals Recent Advances in Fiber–Hydrogel Composites for Wound Healing and Drug Delivery Systems

Antibiotics ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 248
Author(s):  
Marta O. Teixeira ◽  
Joana C. Antunes ◽  
Helena P. Felgueiras
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Mechanical Stability ◽  
Fiber Spinning ◽  
Comprehensive Overview ◽  
Triggered Drug Release ◽  
Medicinal Properties ◽  
Hydrogel Composites ◽  
Drug Incorporation ◽  
Stimuli Sensitive

In the last decades, much research has been done to fasten wound healing and target-direct drug delivery. Hydrogel-based scaffolds have been a recurrent solution in both cases, with some reaching already the market, even though their mechanical stability remains a challenge. To overcome this limitation, reinforcement of hydrogels with fibers has been explored. The structural resemblance of fiber–hydrogel composites to natural tissues has been a driving force for the optimization and exploration of these systems in biomedicine. Indeed, the combination of hydrogel-forming techniques and fiber spinning approaches has been crucial in the development of scaffolding systems with improved mechanical strength and medicinal properties. In this review, a comprehensive overview of the recently developed fiber–hydrogel composite strategies for wound healing and drug delivery is provided. The methodologies employed in fiber and hydrogel formation are also highlighted, together with the most compatible polymer combinations, as well as drug incorporation approaches creating stimuli-sensitive and triggered drug release towards an enhanced host response.

scholarly journals Fast Dissolving Electrospun Nanofibers Fabricated from Jelly Fig Polysaccharide/Pullulan for Drug Delivery Applications

Polymers ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 241
Author(s):  
Thangavel Ponrasu ◽  
Bei-Hsin Chen ◽  
Tzung-Han Chou ◽  
Jia-Jiuan Wu ◽  
Yu-Shen Cheng
Keyword(s):  
Drug Delivery ◽  
Water Vapor Permeability ◽  
Electrospun Nanofibers ◽  
Average Diameter ◽  
Xrd Analysis ◽  
Water Soluble ◽  
Vapor Permeability ◽  
Uv Spectrum ◽  
Sem Images ◽  
Triton X

The fast-dissolving drug delivery systems (FDDDSs) are developed as nanofibers using food-grade water-soluble hydrophilic biopolymers that can disintegrate fast in the oral cavity and deliver drugs. Jelly fig polysaccharide (JFP) and pullulan were blended to prepare fast-dissolving nanofiber by electrospinning. The continuous and uniform nanofibers were produced from the solution of 1% (w/w) JFP, 12% (w/w) pullulan, and 1 wt% Triton X-305. The SEM images confirmed that the prepared nanofibers exhibited uniform morphology with an average diameter of 144 ± 19 nm. The inclusion of JFP in pullulan was confirmed by TGA and FTIR studies. XRD analysis revealed that the increased crystallinity of JFP/pullulan nanofiber was observed due to the formation of intermolecular hydrogen bonds. The tensile strength and water vapor permeability of the JFP/pullulan nanofiber membrane were also enhanced considerably compared to pullulan nanofiber. The JFP/pullulan nanofibers loaded with hydrophobic model drugs like ampicillin and dexamethasone were rapidly dissolved in water within 60 s and release the encapsulants dispersive into the surrounding. The antibacterial activity, fast disintegration properties of the JFP/pullulan nanofiber were also confirmed by the zone of inhibition and UV spectrum studies. Hence, JFP/pullulan nanofibers could be a promising carrier to encapsulate hydrophobic drugs for fast-dissolving/disintegrating delivery applications.

Electrospun nanofibers comprising of silk fibroin/gelatin for drug delivery applications: Thyme essential oil and doxycycline monohydrate release study

2018 ◽  
Vol 106 (4) ◽  
pp. 1092-1103 ◽  
Author(s):  
Masoud Dadras Chomachayi ◽  
Atefeh Solouk ◽  
Somaye Akbari ◽  
Davoud Sadeghi ◽  
Fereshteh Mirahmadi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Essential Oil ◽  
Silk Fibroin ◽  
Electrospun Nanofibers ◽  
Thyme Essential Oil ◽  
Release Study ◽  
Drug Delivery Applications

scholarly journals A Summary of Electrospun Nanofibers as Drug Delivery System: Drugs Loaded and Biopolymers Used as Matrices

2018 ◽  
Vol 15 (10) ◽  
pp. 1360-1374 ◽  
Author(s):  
Erick José Torres-Martinez ◽  
José Manuel Cornejo Bravo ◽  
Aracely Serrano Medina ◽  
Graciela Lizeth Pérez González ◽  
Luis Jesús Villarreal Gómez
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Electrospun Nanofibers

ChemInform Abstract: Electrosprayed Nanoparticles and Electrospun Nanofibers Based on Natural Materials: Applications in Tissue Regeneration, Drug Delivery and Pharmaceuticals

ChemInform ◽  
2015 ◽  
Vol 46 (15) ◽  
pp. no-no
Author(s):  
Radhakrishnan Sridhar ◽  
Rajamani Lakshminarayanan ◽  
Kalaipriya Madhaiyan ◽  
Veluchamy Amutha Barathi ◽  
Keith Hsiu Chin Lim ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Regeneration ◽  
Electrospun Nanofibers ◽  
Natural Materials

Polymer nanofibers for biomedical applications: advances by electrospinning

2021 ◽  
Vol 04 ◽  
Author(s):  
Anna L.M.M. Toledo ◽  
Talita N. da Silva ◽  
Arianne C. dos S. Vaucher ◽  
Arthur H. V. Miranda ◽  
Gabriela C. C. Silva de Miranda ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
New Technologies ◽  
Low Cost ◽  
Electrospun Nanofibers ◽  
Delivery Systems ◽  
Electrospun Fibers ◽  
Sustained Delivery ◽  
Biomedical Devices ◽  
Ultrathin Fibers

Background: The demand for novel biomaterials has been exponentially rising in the last years as well as the searching for new technologies able to produce more efficient products in both drug delivery systems and regenerative medicine. Objective: The technique that can pretty well encompass the needs for novel and high-end materials with a relatively low-cost and easy operation is the electrospinning of polymer solutions. Methods: Electrospinning usually produces ultrathin fibers that can be applied in a myriad of biomedical devices including sustained delivery systems for drugs, proteins, biomolecules, hormones, etc that can be applied in a broad spectrum of applications, from transdermal patches to cancer-related drugs. Results: Electrospun fibers can be produced to mimic certain tissues of the human body, being an option to create new scaffolds for implants with several advantages. Conclusions: In this review, we aimed to encompass the use of electrospun fibers in the field of biomedical devices, more specifically in the use of electrospun nanofibers applications toward the production of drug delivery systems and scaffolds for tissue regeneration.

Vesicular Drug Delivery Systems

2017 ◽  
pp. 121-147
Author(s):  
Preeti Khulbe
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Colloidal Dispersions ◽  
Polyphenolic Compounds ◽  
Future Prospects ◽  
Lipid Complex ◽  
Research Experiences ◽  
Drug Molecules ◽  
Pass Through ◽  
Drug Incorporation

Pharmacosomes are the colloidal dispersions of drugs covalently bound to lipids and may exist as ultrafine vesicular, micellar or hexagonal aggregates, depending on the chemical structure of the drug lipid complex. The term pharmacosomes is explicitly used to describe the zwitterion, amphiphilic stoichiometric complexes of polyphenolic compounds with phospholipids. The system is formed by linking a drug (pharmakon) to a carrier (soma), they are called pharmacosomes. Pharmacosomes can pass through biomembranes efficiently and possess advantages over the use of other vesicular systems such as transferosomes liposomes and noisome. Pharmacososmes are design to avoid the unusual problems associated with the liposomal entrapment of polar drug molecules like low drug incorporation, leakage and solubility. This chapter includes the basic introduction, applications, method of preparation, characterisation, advantages, some research experiences and future prospects of pharmacosomes.

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