scholarly journals Fast Dissolving Electrospun Nanofibers Fabricated from Jelly Fig Polysaccharide/Pullulan for Drug Delivery Applications

Polymers ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 241
Author(s):  
Thangavel Ponrasu ◽  
Bei-Hsin Chen ◽  
Tzung-Han Chou ◽  
Jia-Jiuan Wu ◽  
Yu-Shen Cheng
Keyword(s):  
Drug Delivery ◽  
Water Vapor Permeability ◽  
Electrospun Nanofibers ◽  
Average Diameter ◽  
Xrd Analysis ◽  
Water Soluble ◽  
Vapor Permeability ◽  
Uv Spectrum ◽  
Sem Images ◽  
Triton X

The fast-dissolving drug delivery systems (FDDDSs) are developed as nanofibers using food-grade water-soluble hydrophilic biopolymers that can disintegrate fast in the oral cavity and deliver drugs. Jelly fig polysaccharide (JFP) and pullulan were blended to prepare fast-dissolving nanofiber by electrospinning. The continuous and uniform nanofibers were produced from the solution of 1% (w/w) JFP, 12% (w/w) pullulan, and 1 wt% Triton X-305. The SEM images confirmed that the prepared nanofibers exhibited uniform morphology with an average diameter of 144 ± 19 nm. The inclusion of JFP in pullulan was confirmed by TGA and FTIR studies. XRD analysis revealed that the increased crystallinity of JFP/pullulan nanofiber was observed due to the formation of intermolecular hydrogen bonds. The tensile strength and water vapor permeability of the JFP/pullulan nanofiber membrane were also enhanced considerably compared to pullulan nanofiber. The JFP/pullulan nanofibers loaded with hydrophobic model drugs like ampicillin and dexamethasone were rapidly dissolved in water within 60 s and release the encapsulants dispersive into the surrounding. The antibacterial activity, fast disintegration properties of the JFP/pullulan nanofiber were also confirmed by the zone of inhibition and UV spectrum studies. Hence, JFP/pullulan nanofibers could be a promising carrier to encapsulate hydrophobic drugs for fast-dissolving/disintegrating delivery applications.

scholarly journals The Effect of Extraction Conditions on the Barrier and Mechanical Properties of Kefiran Films

Coatings ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 602
Author(s):  
Carmen Rodica Pop ◽  
Teodora Emilia Coldea ◽  
Liana Claudia Salanţă ◽  
Alina Lăcrămioara Nistor ◽  
Andrei Borşa ◽  
...  
Keyword(s):  
Water Vapor ◽  
Conformational Changes ◽  
Water Vapor Permeability ◽  
Edible Films ◽  
Film Structure ◽  
Water Soluble ◽  
Vapor Permeability ◽  
Water Molecules ◽  
Compact Structure ◽  
Technology Applications

Kefiran is an exopolysaccharide classified as a heteropolysaccharide comprising glucose and galactose in equimolar quantities, and it is classified as a water-soluble glucogalactan. This work aimed to investigate the effect of different extraction conditions of kefiran on the structural and physical properties of the edible films obtained. Fourier-transform infrared spectroscopy and scanning electron microscopy were performed, together with a determinations of moisture content, solubility, water vapor permeability and degree of swelling. The kefiran films presented values of the water vapor permeability between 0.93 and 4.38 × 10−11 g/m.s.Pa. These results can be attributed to the development of a more compact structure, where glycerol had no power to increase the free volume and the water vapor diffusion through their structure. The possible conformational changes in the kefiran film structure, due to the interspersing of the plasticizers and water molecules that they absorb, could be the reason for producing flexible kefiran films in the case of using glycerol as a plasticizer at 7.5% w/w. Moreover, it was observed that the extraction conditions are a significant factor in the properties of these films and their food technology applications.

scholarly journals Variasi Jarak Antar Layer Bentonit Pada Pembuatan Nanokomposit Pla-Bentonit Sebagai Kemasan Makanan

2020 ◽  
Vol 8 (1) ◽  
pp. 57-65
Author(s):  
Vita Wonoputri ◽  
Natasha Emanuella ◽  
Evelyn Angelica ◽  
Johnner Sitompul
Keyword(s):  
Food Packaging ◽  
Water Vapor Permeability ◽  
Xrd Analysis ◽  
Basal Spacing ◽  
Vapor Permeability ◽  
X Ray Diffraction ◽  
X Ray ◽  
The Matrix ◽  
Treatment Data ◽  
Octadecyl Amine

In this study, bentonite was used as a filler in the synthesis of polylactic acid (PLA) nanocomposite. The mechanical property of PLA-Bentonite nanocomposite was treated using two different surfactants, namely octadecyl amine (ODA) and trimethyl stearyl ammonium chloride (TSC) at two different concentration (20 mmol and 40 mmol). The treatments of ODA and TSC in the matrix with regards to the basal spacing of bentonite stacks  measured by X-Ray Diffraction (XRD) analysis. The results showed a significant increase in basal spacing was obtained when TSC 40 was applied for treatment. Data of Fourier Transform Infrared Spectroscopy (FTIR) suggested that this increase was caused by the incorporation of surfactant into the bentonite stacks. Most of the PLA-Bentonite nanocomposite can form intercalation structure, while a sample containing TSC 40 formed exfoliation structure. This exfoliation structure resulted in a film with the best tensile strength and water vapor permeability compared to the others. The film containing TSC 40 showed the lowest reduction in water activity, almost similar to the bread sample wrapped using conventional plastic. The bread wrapped with TSC 40 film was not grown by fungi as opposed to the conventional plastic, showing the potential of the nanocomposite film as food packaging.

Fabrication and Characterization of Cellulose Acetate Ultrafine Fiber Containing Silver Nanoparticles by Electrospinning

2011 ◽  
Vol 337 ◽  
pp. 116-119 ◽  
Author(s):  
Dong Mei Zhao ◽  
Qing Mao Feng ◽  
Li Li Lv ◽  
Jian Li
Keyword(s):  
Electron Microscopy ◽  
Silver Nanoparticles ◽  
Cellulose Acetate ◽  
Average Diameter ◽  
Xrd Analysis ◽  
Water Soluble ◽  
Ag Nps ◽  
Ultrafine Fibers ◽  
Transmission Electron ◽  
Electrospinning Method

Silver nanoparticles (Ag NPs)/cellulose acetate (CA) composite ultrafine fibers were successfully prepared by the electrospinning method. Water-soluble Ag NPs were directly mixed into CA polymer fibers to form organic–inorganic composite ultrafine fibers. The optical property of Ag NPs was measured by ultraviolet-visble spectrometer (UV-vis). The presence and identification of crystalline of Ag NPs were confirmed by XRD analysis. Transmission electron microscopy (TEM) images showed that silver nanoparticles (Ag NPs) with an average diameter of 5–15 nm were obtained and were well distributed in the CA ultrafine fibers. The morphologies of the as-prepared electrospun Ag NPs/CA composite ultrafine fibers were characterized by scanning electron microscopy (SEM) and TEM. The composition of fibers was characterized by FTIR spectrometer.

scholarly journals Inkjet Printable and Self-Curable Disperse Dyes/P(St-BA-MAA) Nanosphere Inks for Both Hydrophilic and Hydrophobic Fabrics

Polymers ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1402 ◽  
Author(s):  
Yawei Song ◽  
Kuanjun Fang ◽  
Yanfei Ren ◽  
Zhiyuan Tang ◽  
Rongqing Wang ◽  
...  
Keyword(s):  
Fiber Surface ◽  
Spherical Shape ◽  
Average Diameter ◽  
Film Coating ◽  
Water Soluble ◽  
Disperse Dyes ◽  
Scanning Calorimetry ◽  
Sem Images ◽  
Long Term Stability ◽  
Dsc Measurements

Low-water-soluble disperse dyes possess a broad color gamut and good durability, but they need chemical or physical modification before being used in inks and can only be applied to several kinds of hydrophobic fabrics. In this work, disperse dyes/P(St-BA-MAA) nanospheres (known as DPN) absorbed by sodium nitrilotriacetate (known as NTA@DPN) were prepared and applied into ink formulations, which exhibited high dye fixation, long-term stability and self-curable ability without addition of any binder. Transmission electron microscopy (TEM) images showed the nanospheres have homogeneous core-shell spherical shape and the average diameter increased by 20.6 nm after coloration. X-ray diffraction (XRD), Fourier transform infrared spectrum (FTIR), and differential scanning calorimetry (DSC) measurements illustrated the interaction between dyes and nanospheres and indicated that the colored nanospheres contained both dye molecules and crystalline dyes. The Zeta potential and particle size measurements demonstrated that the dispersion stability was improved when sodium nitrilotriacetate (NTA) was absorbed onto DPN. The rheological behavior of the NTA@DPN inks was Newtonian and desired droplet formation was achieved at the viscosity of 4.23 mPa·s. Both hydrophilic cotton and hydrophobic polyester fabrics were cationic modified before used, which had an excellent image quality and desired rubbing fastness after inkjet printing. Scanning electron microscope (SEM) images showed NTA@DPN formed stable deposits on the surface of modified fibers and could self-cure to form continuous film coating on the fiber surface after being baked at 150 °C without addition of any binder.

Electrospun Polyvinylpyrrolidone (PVP) Nanofiber Mats Loaded by Garcinia mangostana L. Extracts

2016 ◽  
Vol 880 ◽  
pp. 11-14 ◽  
Author(s):  
Ida Sriyanti ◽  
Dhewa Edikresnha ◽  
Muhammad Miftahul Munir ◽  
Heni Rachmawati ◽  
Khairurrijal
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Composite Nanofibers ◽  
Precursor Solution ◽  
Average Diameter ◽  
Delivery Systems ◽  
Garcinia Mangostana ◽  
Sem Images ◽  
Electrospinning Method ◽  
Nanofiber Mats

Composite nanofibers of polyvinylpyrrolidone (PVP) and Garcinia mangostana L. extract (GME) have been synthesized through electrospinning method for application in drug delivery systems. The precursor solution of 10 mL PVP 10% w/w and GME 2% w/w was then electrospun collected at the rotating collector at the following optimum parameters: a voltage of 15 kV, a collector-nozzle distance of 12 cm, and a flow rate of 1 mL/hour. SEM images showed that the average diameters were 476 nm and 690 nm for the PVP and PVP-GME composite nanofibers, respectively. To some degree, the addition of GME into PVP nanofibers increased the average diameter size of nanofibers. Moreover, the release studies, it was shown that 80% of the GME was released within 30 minutes. Therefore, the PVP-GME composite nanofibers can be applied as the drug delivery systems.

scholarly journals Correlation between Structures and Antioxidant Activities of Polyvinylpyrrolidone/Garcinia mangostana L. Extract Composite Nanofiber Mats Prepared Using Electrospinning

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Ida Sriyanti ◽  
Dhewa Edikresnha ◽  
Annisa Rahma ◽  
Muhammad Miftahul Munir ◽  
Heni Rachmawati ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Surface Area ◽  
Intermolecular Interactions ◽  
Antioxidant Activities ◽  
High Surface ◽  
Water Soluble ◽  
Garcinia Mangostana ◽  
Sem Images ◽  
Composite Nanofiber ◽  
Nanofiber Mats

Nanofiber mats of polyvinyl(pyrrolidone) (PVP) with Garcinia mangostana extract (GME) as the encapsulated drug have been developed using electrospinning. SEM images of all electrospun PVP/GME composite nanofiber mats showed that they had similar and smooth morphology, no beads, and spindle shape. Its average diameter decreased and its surface area therefore increased with the decrease of its PVP concentration. The benefit of high surface area is obvious in drug delivery systems for poorly water-soluble drugs. Their FTIR spectra indicated that PVP and GME interacted intermolecularly via hydrogen bonds in the composite nanofiber mats. A conformational change in the C-H chain of PVP occurred in the composite nanofiber mats due to the intermolecular interactions. Their XRD patterns confirmed that they were amorphous because of amorphization during electrospinning. The XRD analyses also strengthened the FTIR studies; namely, GME and PVP formed intermolecular interactions in the electrospun composite nanofiber mats. As a result, GME as the encapsulated drug was molecularly dispersed in the electrospun PVP nanofiber matrix that functioned as a drug delivery system. From the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, the composite nanofiber mats exhibited very high antioxidant activities despite having been exposed to high voltage during electrospinning. Therefore, they are potential antioxidant products for food and pharmaceutics.

Effect of DMDHEU treatment on properties of bacterial cellulose material

2021 ◽  
pp. 004051752199235
Author(s):  
Florentina Sederavičiūtė ◽  
Jurgita Domskienė ◽  
Lina Jurgelionytė ◽  
Audronė Sankauskaite ◽  
Dushan Kimmer
Keyword(s):  
Water Absorption ◽  
Bacterial Cellulose ◽  
Three Dimensional ◽  
Water Vapor Permeability ◽  
Barrier Properties ◽  
Absorption Capacity ◽  
Vapor Permeability ◽  
Crosslinking Reaction ◽  
Sem Images ◽  
Cellulose Material

The aim of this study was to estimate the influence of purification and treatment with textile finishing agent procedures on structural, mechanical, and water barrier properties of bacterial cellulose (BC) in order to predict the end-use properties. Kombucha fungus generated by Komagataeibacter xylinus species, formerly known as Gluconacetobacter xylinus, was used to produce the BC material. The BC was purified with 0.5% sodium hydroxide (NaOH) solution and treated with 5%, 10%, and 20% concentration of N, N-dimethylol 4,5-dihydroxy-ethylene urea (DMDHEU). By Fourier transform spectroscopy (FTIR) and X-ray diffractometer (XRD) was estimated, that the purification with a weak alkali solution was effective to remove amorphous matter of the BC material. Scanning electron microscope (SEM) images demonstrated the BC structure, similar to a non-woven textile fabric with clearly visible three-dimensional networks of fine cellulose fibers. After the purification process, the BC material tensile strength increased by 52%; however, the strain decreased by 93%. BC material after treatment with 20% DMDHEU regained deformability and tensile properties analogous to untreated samples. Water vapor permeability (WVP) values increased and water absorption capacity (WAC) decreased in BC material with increasing DMDHEU concentration. According to the FTIR results, the crosslinking reaction of DMDHEU and adjacent BC molecules was proved. The treatment with DMDHEU restores the amorphous properties of BC material, and therefore blocks water absorption, and the decrease in the water absorption parameter might be determined.

scholarly journals Electrospun nanofibers: A nanotechnological approach for drug delivery and dissolution optimization in poorly water-soluble drugs

ADMET & DMPK ◽  
2020 ◽  
Author(s):  
Luis Castillo-Henríquez ◽  
Rolando Vargas-Zúñiga ◽  
Jorge Pacheco-Molina ◽  
Jose Vega-Baudrit
Keyword(s):  
Drug Delivery ◽  
High Surface ◽  
High Surface Area ◽  
Electrospun Nanofibers ◽  
Water Soluble ◽  
Poorly Water Soluble Drugs ◽  
Small Pore ◽  
Water Soluble Drugs ◽  
Poorly Water Soluble ◽  
Surface Morphologies

<p class="ADMETabstracttext">Electrospinning is a novel and sophisticated technique for the production of nanofibers with high surface area, extreme porous structure, small pore size, and surface morphologies that make them suitable for biomedical and bioengineering applications, which can provide solutions to current drug delivery issues of poorly water-soluble drugs. Electrospun nanofibers can be obtained through different methods asides from the conventional one, such as coaxial, multi-jet, side by side, emulsion, and melt electrospinning. In general, the application of an electric potential to a polymer solution causes a charged liquid jet that moves downfield to an oppositely charged collector, where the nanofibers are deposited. Plenty of polymers that differ in their origin, degradation character and water affinity are used during the process. Physicochemical properties of the drug, polymer(s), and solvent systems need to be addressed to guarantee successful manufacturing. Therefore, this review summarizes the recent progress in electrospun nanofibers for their use as a nanotechnological tool for dissolution optimization and drug delivery systems for poorly water-soluble drugs.</p>

A New Approach for the Preparation of Bleached Shellac for Pharmaceutical Application: Solid Method

2012 ◽  
Vol 506 ◽  
pp. 250-253 ◽  
Author(s):  
S. Saengsod ◽  
S. Limmatvapirat ◽  
Manee Luangtana-Anan
Keyword(s):  
Fruits And Vegetables ◽  
Color Change ◽  
Raw Materials ◽  
Water Vapor Permeability ◽  
Acid Value ◽  
Consumer Products ◽  
Water Soluble ◽  
Vapor Permeability ◽  
Pharmaceutical Industries ◽  
Bleached Shellac

With increased awareness about the environment, raw materials from petroleum based synthetics and the "green" quotient of consumer products have developed, shellac or shellac modified resins have gained importance due to their unique nontoxic and hypoallergenic properties. Shellac is water soluble, biologically degradable and has film forming, excellent adhesion, hardness, high gloss and superior in electrical properties. Shellac or shellac modified resins are also compatible with other resins and can be cross linked making them a wider applications. Shellac is abundant in Thailand, China and India, which produced from lac insects, Laccifer Lacca. The resinous secretion can be purified to become shellac. The main structure of shellac consists of polyesters and single esters that have hydroxyl and carboxyl groups [1, . Shellac was first used as a wood polish for music instruments and furniture and later for uses in spar varnishes with antifouling properties for ship paints, phonographic records, wood and wallpaper paints, printing inks, resins for electrical applications and floor polishes. Currently, new applications for using are such as child-safe paints and inks and the coating of fruits and vegetables, food and confectionary, pills, tablets and vitamins in the pharmaceutical industries. Bleached shellac has been widely used in pharmaceutical and cosmetics instead of native shellac due to the whiteness. However, conventional method for bleached shellac used many solvents [3, . Therefore, the aim of this study was to explore a new technique in order to avoid the use of organic solvent prior to the process of bleaching. The comparison was made between bleaching by the conventional and the new methods. The studied properties were acid value, viscosity, color change, water vapor permeability, chemical structure and powder x-ray diffraction.

Fabrication of a Novel Electrospun Polyacrylonitrile/Giant Ball {Mo132} Composite Nanofibrous Mats in Adsorption of 2-CEES

2019 ◽  
Vol 3 (2) ◽  
pp. 130-138
Author(s):  
Reza Haddad ◽  
Mehdi Dusti Telgerd ◽  
Hojjatalla Hadi ◽  
Mohammad Sadeghinia
Keyword(s):  
Room Temperature ◽  
Composite Nanofibers ◽  
Sulfur Mustard ◽  
Electrospun Nanofibers ◽  
Average Diameter ◽  
Heterogeneous Structure ◽  
Adsorption Ability ◽  
Sem Images ◽  
Electrospinning Technique ◽  
Good Ability

Background: Polyacrylonitrile/Mo132 composite nanofibers mats was synthesized by an electrospinning technique using PAN and giant ball nano-polyoxomolybdateMo132. The nanocluster Mo132 was mixed with PAN solution and then electrospun to produce bead-free nanofibers. The aim of this study is to evaluate the adsorption ability of electrospun composite nanofibers against sulfur mustard stimulants and assess the possibility of using the electrospun nanofibers as protective membranes in chemical masks and warfare clothing. Adsorption of sulfur mustard stimulants was investigated on the surface of PAN nanofibers embedded with keplerate nano-polyoxomolybdate. Methods: In order to study the 2-CEES adsorption ability, the prepared PAN/Mo132 nanofibers composite was further prepared and exposed to 2-CEES solution. The surface morphology and other properties of the PAN/Mo132 nanofibers composite were characterized by various techniques, including SEM, TEM, FT-IR, UV-Vis. SEM images which showed that the average diameter of the fibers was found to be between 100-120 nm. Results: The adsorption efficiency of PAN/Mo132 composite in adsorption of 2-CEES was obtained 89% after 7h at room temperature. The results showed that composite nanofibers PAN/Mo132 will have a good ability as protective clothing and chemical masks against chemical warfare agents. Conclusion: PAN/Mo132 nanofibers were prepared by electrospinning method. The leaching of Mo132 from the nanofibers was not observed, meaning that the catalyst had excellent stability and could be used as a heterogeneous structure against the adsorption of sulfur mustard stimulant at room temperature. This composite nanofibers membrane exhibited good performance to adsorb 2-CEES in comparison with pure PAN. The adsorption rate of 2-CEES increases with increasing the amount of Mo132 embedded in the PAN nanofibers.

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