A review of Penthorum chinense Pursh for hepatoprotection: Traditional use, phytochemistry, pharmacology, toxicology and clinical trials

2020 ◽  
Vol 251 ◽  
pp. 112569 ◽  
Author(s):  
Anqi Wang ◽  
Mingxing Li ◽  
Huimin Huang ◽  
Zhangang Xiao ◽  
Jing Shen ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Traditional Use ◽  
Penthorum Chinense Pursh ◽  
Penthorum Chinense

Kaempferol from Penthorum chinense Pursh suppresses HMGB1/TLR4/NF-κB signaling and NLRP3 inflammasome activation in acetaminophen-induced hepatotoxicity

2020 ◽  
Vol 11 (9) ◽  
pp. 7925-7934
Author(s):  
Yi-Chao Du ◽  
Li Lai ◽  
Hao Zhang ◽  
Fu-Rui Zhong ◽  
Huan-Li Cheng ◽  
...  
Keyword(s):  
Nlrp3 Inflammasome ◽  
Inflammasome Activation ◽  
Nlrp3 Inflammasome Activation ◽  
Penthorum Chinense Pursh ◽  
Penthorum Chinense

In this study, kaempferol (KA) ameliorates APAP-induced hepatotoxicity by activating HO-1/NQO1 and inhibiting HMGB1/TLR4/NF-κB signaling and NLRP3 inflammasome activation.

scholarly journals Enzymatic Extraction, Purification, and Characterization of Polysaccharides from Penthorum chinense Pursh: Natural Antioxidant and Anti-Inflammatory

2018 ◽  
Vol 2018 ◽  
pp. 1-13 ◽  
Author(s):  
Li-mei Lin ◽  
Ling-jia Zhao ◽  
Jing Deng ◽  
Su-hui Xiong ◽  
Jie Tang ◽  
...  
Keyword(s):  
Radical Scavenging ◽  
Steepest Ascent ◽  
Penthorum Chinense Pursh ◽  
Ft Ir ◽  
Experimental Yield ◽  
Burman Design ◽  
Anti Inflammatory ◽  
Penthorum Chinense ◽  
Optimized Conditions ◽  
Plackett Burman Design

Penthorum chinense Pursh (PCP) is a kind of functional food or medicine for liver protection. In the present work, Plackett-Burman design, steepest ascent method, and response surface methodology (RSM) were employed to obtain maximum total sugar yield. The experimental yield of 6.91% indicated a close agreement with the predicted yield of 7.00% of the model under optimized conditions. The major polysaccharide fraction (PCPP-1a) from PCPP was purified and identified as acidic polysaccharides with a high content of uronic acid (FT-IR, UV, HPGPC). PCPP had similar monosaccharide profile with PCPP-1a but was rich in galacturonic acid (HPLC). Both of PCPP and PCPP-1a possessed strong hydroxyl radical scavenging, DPPH radical scavenging, and Fe2+ chelating activities. Moreover, they were revealed to show strong anti-inflammatory activities by inhibiting NO, TNF-α, and IL-1β release compared to LPS treatment in RAW264.7 cells. These data suggest that the polysaccharides from PCP could be potential natural products for treating ROS and inflammatory-related diseases.

Informed consent in phase I clinical trials: Implications for trends in design.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e14077-e14077
Author(s):  
Paul Henry Frankel ◽  
Susan G. Groshen
Keyword(s):  
Clinical Trials ◽  
Informed Consent ◽  
Phase I ◽  
Dose Finding ◽  
Institutional Review Boards ◽  
Severe Toxicity ◽  
Phase I Clinical Trials ◽  
Traditional Use ◽  
Phase I Studies ◽  
Definition Of

e14077 Background: Informed Consent (IC) is a critical aspect of human subjects protection. Institutional Review Boards are tasked with insuring proper IC as one aspect of protecting participants in clinical trials. Phase I trials in oncology present special issues with IC, as often neither the risks nor the benefits are well-known. This has resulted in carefully worded IC templates for Phase I studies based on the traditional use of dose-finding designs that are geared towards finding the “Maximum Tolerated Dose (MTD)”. As the definition of this term varies by study, the implication for patient risk and informed consent are rarely discussed. Methods: We reviewed Phase I designs to present options for improving the informed consent process for Phase I oncology trials. Results: Phase I studies have seen an increase in designs based on work from the early 1990s seeking a dose that results in a targeted percent of patients experiencing a “Dose Limiting Toxicity (DLT)” to define the MTD. The most common definition of a DLT is a treatment-related toxicity that results in a particularly concerning severe toxicity (grade 3 or higher) in the first cycle of therapy and the most common rate targeted (in designs that define toxicity as a goal) is 25%. In that setting, while lower doses may have a lower likelihood of DLT, higher doses or the expansion cohort are likely to have a 25% chance of DLT if the target is pursued. This information is rarely quantitatively communicated in the informed consent. Conclusions: IRBs and investigators should consider communicating through informed consent the quantitative summary of goals of the study and related risk. For example, transparency suggests conveying when the goal (target) of the study is to find the dose where there is a one in four chance of experiencing a severe adverse event in the first cycle.

scholarly journals Antioxidant and Hepatoprotective Effect of Penthorum chinense Pursh Extract against t-BHP-Induced Liver Damage in L02 Cells

Molecules ◽  
2015 ◽  
Vol 20 (4) ◽  
pp. 6443-6453 ◽  
Author(s):  
Yangyang Hu ◽  
Shengpeng Wang ◽  
Anqi Wang ◽  
Ligen Lin ◽  
Meiwan Chen ◽  
...  
Keyword(s):  
Liver Damage ◽  
Hepatoprotective Effect ◽  
Penthorum Chinense Pursh ◽  
Penthorum Chinense ◽  
L02 Cells

The hepatoprotective effect of aqueous extracts of Penthorum chinense Pursh against acute alcohol-induced liver injury is associated with ameliorating hepatic steatosis and reducing oxidative stress

2015 ◽  
Vol 6 (5) ◽  
pp. 1510-1517 ◽  
Author(s):  
Yi-Wei Cao ◽  
Yun Jiang ◽  
Da-Yong Zhang ◽  
Xiao-Jing Zhang ◽  
Yuan-Jia Hu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Injury ◽  
Hepatic Steatosis ◽  
Folk Medicine ◽  
Hepatoprotective Effect ◽  
Aqueous Extracts ◽  
Health Food ◽  
Penthorum Chinense Pursh ◽  
Penthorum Chinense

Aqueous extracts ofPenthorum chinensePursh, a health food and folk medicine, protects against acute alcohol-induced liver injury.

New phenolic glycosides isolated from Penthorum chinense Pursh

2015 ◽  
Vol 11 ◽  
pp. 163-167 ◽  
Author(s):  
Doudou Huang ◽  
Yun Jiang ◽  
Wansheng Chen ◽  
Fengyan Yao ◽  
Dan Xue ◽  
...  
Keyword(s):  
Phenolic Glycosides ◽  
Penthorum Chinense Pursh ◽  
Penthorum Chinense

scholarly journals Characterization of the anti-Staphylococcus aureus fraction from Penthorum chinense Pursh stems

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Bin Ding ◽  
Qinchao Ding ◽  
Shun Zhang ◽  
Zhuo Jin ◽  
Zhaolei Wang ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Penthorum Chinense Pursh ◽  
Penthorum Chinense

Traditional Chinese Herbal Medicine Penthorum chinense Pursh: A Phytochemical and Pharmacological Review

2015 ◽  
Vol 43 (04) ◽  
pp. 601-620 ◽  
Author(s):  
Anqi Wang ◽  
Ligen Lin ◽  
Yitao Wang
Keyword(s):  
Herbal Medicine ◽  
Hepatitis B ◽  
Current Knowledge ◽  
Bile Secretion ◽  
Protective Effects ◽  
Traditional Chinese Herbal Medicine ◽  
Wide Range ◽  
Key Enzyme ◽  
Penthorum Chinense Pursh ◽  
Penthorum Chinense

Penthorum chinense Pursh (Ganhuangcao), a traditional Chinese medicine, is used for the prevention and treatment of liver diseases, including hepatitis B, hepatitis C, and alcoholic liver damage. A wide range of investigations have been carried out on this herbal medicine from pharmacognosy to pharmaceuticals, as well as pharmacology. The extract of P. chinense was reported to have significant liver protective effects through anti-oxidation, reduction of key enzyme levels, inhibition of hepatitis B virus DNA replication, and promotion of bile secretion. Based on the current knowledge, flavonoids and phenols are considered to be responsible for P. chinense's bioactivities. The main purpose of this review is to provide comprehensive and up-to-date knowledge of the phytochemical and pharmacological studies performed on P. chinense during the past few decades. Moreover, it intends to provide new insights into the research and development of this herbal medicine.

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