Hyperbranched polymers (HBPs) have been applied in various fields because of its outstanding biodegradability and biocompatibility. At present, there are a variety of methods that are used to fabricate HBPs, such as polycondensation, reactive polymerization and ring-opening polymerization according to reaction mechanism. These methods are all environmental-friendly and high-efficient to generate HBPs, and are valuable for industrialization. In this work, we conclude some common methods of HBPs fabrication and make the comparison between them to analyze their advantages and disadvantages, which contribute in how to improve the synthesis process in the future research.