scholarly journals Self-emulsifying drug delivery system of black seed oil with improved hypotriglyceridemic effect and enhanced hepatoprotective function

2021 ◽  
Vol 78 ◽  
pp. 104391
Author(s):  
Shimul Halder ◽  
Amena Islam ◽  
Md. Abdul Muhit ◽  
Manik Chandra Shill ◽  
Syed Shabbir Haider
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Seed Oil ◽  
Black Seed ◽  
Hypotriglyceridemic Effect ◽  
Black Seed Oil

scholarly journals Development of self nanoemulsifying drug delivery system for black seed oil (Nigella sativa L.)

2020 ◽  
Vol 1469 ◽  
pp. 012022
Author(s):  
S E Priani ◽  
S S Maulidina ◽  
F Darusman ◽  
L Purwanti ◽  
D Mulyanti
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Seed Oil ◽  
Nigella Sativa ◽  
Black Seed ◽  
Black Seed Oil

scholarly journals Development Liquid and Solid Self Microemulsifying Drug Delivery System (L-SMEDDS and S-SMEDDS) Containing Black Seed Oil (Nigella sativa L.)

2020 ◽  
pp. 7-13
Author(s):  
Sani Ega Priani ◽  
Septiani Siti Maulidina ◽  
Fitrianti Darusman
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Seed Oil ◽  
Nigella Sativa ◽  
Spherical Shape ◽  
Black Seed ◽  
Globule Size ◽  
System L ◽  
Black Seed Oil

Aims: The aims of this research were to develop and characterize liquid and solid micro emulsifying drug delivery system (L-SMEDDS and S-SMEDDS) containing black seed oil.  Study Design: Experimental Research Design (laboratory). Place and Duration of Study: The study was conducted at research laboratory of pharmacy department UNISBA, between August 2018- August 2019. Methodology: The optimization of L-SMEDDS was carried out using various comparison of oil, surfactant, and cosurfactant. All formulations were evaluated for percent transmittance, emulsification time, dispersibility, robustness, and thermodynamic stability. The best formula of L-SMEDSS was evaluated for globule size distribution and converted to S-SMEDDS by spray drying method using aerosil 200 as adsorbent. S-SMEDDS were evaluated for organoleptic, flowability, compressibility, emulsification time, dispersibility, robustness and surface morphology. Results: The best formula of L-SMEDDS contains tween 80 as a surfactant and PEG 400 as cosurfactant (2:1) with a ratio of oil and Smix (2:8). The L-SMEDDS preparation meets the requirement of percent transmittance (95.77%), emulsification time (37.67 seconds), grade A of dispersibility, stable of robustness and thermodynamics study with the average of globule size was 231 nm. S-SMEDDS preparation meets the requirement of the moisture content, flowability, emulsification time, and stable on robustness testing with a spherical shape. Conclusion: L-SMEDDS and S-SMEDDS of black seed oil have been developed and have good physical characteristics and stability.

Neem seed oil and gum arabic-based oil-in-water emulsions as potential ocular drug delivery system

2019 ◽  
Vol 41 (13) ◽  
pp. 1911-1924 ◽  
Author(s):  
Dilshad Quereshi ◽  
Somali Dhal ◽  
Debasis Das ◽  
Biswaranjan Mohanty ◽  
Arfat Anis ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Seed Oil ◽  
Gum Arabic ◽  
Ocular Drug Delivery ◽  
Neem Seed ◽  
Oil In Water ◽  
Neem Seed Oil

scholarly journals Bioactive Self-Nanoemulsifying Drug Delivery Systems (Bio-SNEDDS) for Combined Oral Delivery of Curcumin and Piperine

Molecules ◽  
2020 ◽  
Vol 25 (7) ◽  
pp. 1703 ◽  
Author(s):  
Mohsin Kazi ◽  
Ahmad A. Shahba ◽  
Saad Alrashoud ◽  
Majed Alwadei ◽  
Abdelrahman Y. Sherif ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Droplet Size ◽  
Health Care Professionals ◽  
Seed Oil ◽  
Amorphous State ◽  
In Vitro Dissolution ◽  
Size Analysis ◽  
Black Seed ◽  
Natural Oils ◽  
Black Seed Oil

Background: Bioactive oils of natural origin have gained huge interests from health care professionals and patients. Objective: To design a bioactive self-nanoemulsifying drug delivery system (Bio-SNEDDS) comprising curcumin (CUR) and piperine (PP) by incorporating bioactive natural oils in the formulation. Methods: The self-emulsifying properties of apricot, avocado, black seed and Zanthoxylum rhetsa seed oils were screened within various SNEDDS formulations. Each liquid SNEDDS formulation was loaded with both CUR and PP. The optimal liquid SNEDDS were solidified using Aeroperl® and Neusilin® at 1:1 w/w ratio. Liquid and solid SNEDDS were characterized by droplet size analysis, equilibrium solubility, scanning electron microscopy, X-ray powder diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy. In-vitro dissolution studies were performed to evaluate the efficiency of CUR and PP release from solid Bio-SNEDDS. Results: The liquid SNEDDS comprised of black seed oil exhibited excellent self-emulsification performance, low droplet size along with transparent appearance. The inclusion of the cosolvent Transcutol P improved the solubilization capacity of both CUR and PP. The liquid SNEDDS were efficiently solidified using the two adsorbents and presented the drugs within amorphous state. In particular, SNEDDS comprised of black seed oil/Imwitor988/Transcutol P/Cremophor RH40 (20/20/10/50) and when solidified with Neusilin showed enhanced CUR and PP release (up to 60% and 77%, respectively). In addition, this formulation efficiently delivers the highly bioactive black seed oil to the patient. Conclusions: The optimized Bio-SNEDDS comprising black seed oil showed outstanding self-emulsification characteristics along with enhanced CUR/PP dissolution upon solidification.

scholarly journals Pomegranate Seed Oil Exerts Synergistic Effects with trans-Resveratrol in a Self-nanoemulsifying Drug Delivery System

2015 ◽  
Vol 38 (10) ◽  
pp. 1658-1662 ◽  
Author(s):  
Lu-yang Lu ◽  
Yuan Liu ◽  
Zhi-feng Zhang ◽  
Xiao-jun Gou ◽  
Jun-hao Jiang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Seed Oil ◽  
Synergistic Effects ◽  
Pomegranate Seed Oil ◽  
Pomegranate Seed

scholarly journals Development of 3D-Printed, Liquisolid and Directly Compressed Glimepiride Tablets, Loaded with Black Seed Oil Self-Nanoemulsifying Drug Delivery System: In Vitro and In Vivo Characterization

2022 ◽  
Vol 15 (1) ◽  
pp. 68
Author(s):  
Tarek A. Ahmed ◽  
Hanadi A. Alotaibi ◽  
Waleed S. Alharbi ◽  
Martin K. Safo ◽  
Khalid M. El-Say
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Seed Oil ◽  
Three Dimensional ◽  
Three Dimensional Printing ◽  
Black Seed Oil ◽  
Compression Characteristics ◽  
Dimensional Printing

Glimepiride is characterized by an inconsistent dissolution and absorption profile due to its limited aqueous solubility. The aim of this study was to develop glimepiride tablets using three different manufacturing techniques, as well as to study their quality attributes and pharmacokinetics behavior. Black seed oil based self-nanoemulsifying drug delivery system (SNEDDS) formulation was developed and characterized. Glimepiride liquisolid and directly compressed tablets were prepared and their pre-compression and post-compression characteristics were evaluated. Semi-solid pastes loaded with SNEDDS were prepared and used to develop three-dimensional printing tablets utilizing the extrusion technique. In vivo comparative pharmacokinetics study was conducted on Male Wistar rats using a single dose one-period parallel design. The developed SNEDDS formulation showed a particle size of 45.607 ± 4.404 nm, and a glimepiride solubility of 25.002 ± 0.273 mg/mL. All the studied tablet formulations showed acceptable pre-compression and post-compression characteristics and a difference in their in vitro drug release behavior. The surface of the liquisolid and directly compressed tablets was smooth and non-porous, while the three-dimensional printing tablets showed a few porous surfaces. The inner structure of the liquisolid tablets showed some cracks and voids between the incorporated tablet ingredients while that of the three-dimensional printing tablets displayed some tortuosity and a gel porous-like structure. Most of the computed pharmacokinetic parameters improved with the liquisolid and three-dimensional printed tablets. The relative bioavailabilities of the three-dimensional printed and liquisolid tablets compared to commercial product were 121.68% and 113.86%, respectively. Therefore, the liquisolid and three-dimensional printed tablets are promising techniques for modifying glimepiride release and improving in vivo performance but more clinical investigations are required.

Hexosomes based on cholesterol and phosphatidylcholine: a new drug delivery system for curcumin release

Planta Medica ◽  
2015 ◽  
Vol 81 (16) ◽  
Author(s):  
AR Bilia ◽  
G Capecchi ◽  
MC Salvatici ◽  
B Isacchi ◽  
MC Bergonzi
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
New Drug
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