Clinical characteristics and predictive factors for mortality in coryneform bacteria bloodstream infection in hematological patients

2017 ◽  
Vol 23 (3) ◽  
pp. 148-153 ◽  
Author(s):  
Shun-ichi Kimura ◽  
Ayumi Gomyo ◽  
Jin Hayakawa ◽  
Yu Akahoshi ◽  
Naonori Harada ◽  
...  
Keyword(s):  
Bloodstream Infection ◽  
Predictive Factors ◽  
Clinical Characteristics ◽  
Coryneform Bacteria ◽  
Hematological Patients

Predictive Factors for the Development of Central Line–Associated Bloodstream Infection Due to Gram-Negative Bacteria in Intensive Care Unit Patients After Surgery

2008 ◽  
Vol 29 (1) ◽  
pp. 51-56 ◽  
Author(s):  
Pranavi V. Sreeramoju ◽  
Jocelyn Tolentino ◽  
Sylvia Garcia-Houchins ◽  
Stephen G. Weber
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Bloodstream Infection ◽  
Predictive Factors ◽  
Tertiary Care ◽  
Central Line ◽  
Gram Negative Bacteria ◽  
Gram Positive ◽  
Gram Negative ◽  
Gram Positive Bacteria

Objectives.To examine the relative proportions of central line-associated bloodstream infection (BSI) due to gram-negative bacteria and due to gram-positive bacteria among patients who had undergone surgery and patients who had not. The study also evaluated clinical predictive factors and unadjusted outcomes associated with central line-associated BSI caused by gram-negative bacteria in the postoperative period.Design.Observational, case-control study based on a retrospective review of medical records.Setting.University of Chicago Medical Center, a 500-bed tertiary care center located on Chicago's south side.Patients.Adult intensive care unit (ICU) patients who developed central line-associated BSI.Results.There were a total of 142 adult patients who met the Centers for Disease Control and Prevention National Nosocomial Infection Surveillance System definition for central line-associated BSI. Of those, 66 patients (46.5%) had infections due to gram-positive bacteria, 49 patients (34.5%) had infections due to gram-negative bacteria, 23 patients (16.2%) had infections due to yeast, and 4 patients (2.8%) had mixed infections. Patients who underwent surgery were more likely to develop central line-associated BSI due to gram-negative bacteria within 28 days of the surgery, compared with patients who had not had surgery recently (57.6% vs 27.3%; P = .002). On multivariable logistic regression analysis, diabetes mellitus (adjusted odds ratio [OR], 4.6 [95% CI, 1.2-18.1]; P = .03) and the presence of hypotension at the time of the first blood culture positive for a pathogen (adjusted OR, 9.8 [95% CI, 2.5-39.1]; P = .001 ) were found to be independently predictive of central line-associated BSI caused by gram-negative bacteria. Unadjusted outcomes were not different in the group with BSI due to gram-negative pathogens, compared to the group with BSI due to gram-positive pathogens.Conclusions.Clinicians caring for critically ill patients after surgery should be especially concerned about the possibility of central line-associated BSI caused by gram-negative pathogens. The presence of diabetes and hypotension appear to be significant associated factors.

scholarly journals Clinical characteristics of peripheral venous catheter-associated gram-negative bloodstream infection among patients with malignancy

PLoS ONE ◽  
2020 ◽  
Vol 15 (1) ◽  
pp. e0228396
Author(s):  
Toshiharu Sasaki ◽  
Sohei Harada ◽  
Shungo Yamamoto ◽  
Daisuke Ohkushi ◽  
Brian Hayama ◽  
...  
Keyword(s):  
Bloodstream Infection ◽  
Clinical Characteristics ◽  
Venous Catheter ◽  
Gram Negative ◽  
Peripheral Venous Catheter

scholarly journals Polymicrobial Bloodstream Infection in Neonates: Microbiology, Clinical Characteristics, and Risk Factors

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e83082 ◽  
Author(s):  
Ming-Horng Tsai ◽  
Shih-Ming Chu ◽  
Jen-Fu Hsu ◽  
Reyin Lien ◽  
Hsuan-Rong Huang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bloodstream Infection ◽  
Clinical Characteristics

scholarly journals Clinical Characteristics and Prognostic Factors of Posterior Segment Intraocular Foreign Body: Canadian Experience from a Tertiary University Hospital in Quebec

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Jean-Philippe Rozon ◽  
Guillaume Lavertu ◽  
Mélanie Hébert ◽  
Eunice You ◽  
Serge Bourgault ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Foreign Body ◽  
Regression Model ◽  
Predictive Factors ◽  
Clinical Characteristics ◽  
Logistic Regression Model ◽  
Visual Outcome ◽  
Posterior Segment ◽  
Multiple Logistic Regression ◽  
Multiple Logistic Regression Model

Purpose. To identify predictive factors for visual outcomes of patients presenting with a posterior segment intraocular foreign body (IOFB). Methods. A retrospective chart review was performed for all consecutive patients operated for posterior segment IOFB removal between January 2009 and December 2018. Data were collected for patient demographics, clinical characteristics at presentation, IOFB characteristics, surgical procedures, and postoperative outcomes. A multiple logistic regression model was built for poor final visual acuity (VA) as an outcome (defined as final VA 50 letters or worse [Snellen equivalent: 20/100]). Results. Fifty-four patients were included in our study. Ninety-three percent of patients were men, with a mean age of 40.4 ± 12.6 years. Metallic IOFB comprised 88% of cases with a mean ± standard deviation (SD) size of 5.31 ± 4.62 mm. VA improved in 70% of patients after IOFB removal. Predictive factors for poor VA outcome included poor baseline VA, larger IOFB size, high number of additional diagnoses, an anterior chamber extraction, a second intervention, the use of C3F8 or silicone tamponade, and the presence of vitreous hemorrhage, hyphema, and iris damage. Predictive factors for a better visual outcome included first intention intraocular lens (IOL) implantation and the use of air tamponade. In the multiple logistic regression model, both baseline VA ( p  = 0.009) and number of additional complications ( p  = 0.01) were independent risk factors for a poor final VA. Conclusions. A high number of concomitant complications and poor baseline VA following posterior segment IOFB were significant predictive factors of poor visual outcome.

scholarly journals Clinical characteristics and drug sensitivity analysis of bloodstream infection caused by Klebsiella pneumoniae in the north of Henan province

2021 ◽  
Author(s):  
Yanchao Wang ◽  
Shanmei Wang ◽  
Wenjuan Wang ◽  
Youhua Yuan ◽  
Junzheng Yang
Keyword(s):  
Drug Resistance ◽  
Antibiotic Resistance ◽  
Klebsiella Pneumoniae ◽  
Bloodstream Infection ◽  
Clinical Characteristics ◽  
Drug Sensitivity ◽  
Resistance Rate ◽  
Henan Province ◽  
The North ◽  
Drug Sensitivity Test

Objectives To analyze clinical characteristics of bloodstream infection caused by Klebsiella pneumoniae and antibiotic resistance of Klebsiella pneumoniae in the north of Henan province, provide the basis for rational selection of antimicrobial drugs. Methods Klebsiella pneumoniae was isolated from 195 patients with bloodstream infection caused by Klebsiella pneumoniae in 2017 in the north of Henan Province, Phoenix100 blood culture and identification system were used for bacterial identification and drug sensitivity test was used for antibiotic resistance detection, and WHONET 5.6 software was used for data analysis of antibiotic resistance and antibiotic sensitivity; the medical history of patients, antibiotic use and laboratory examination results of 195 cases of patients with bloodstream infection caused by Klebsiella pneumoniae were also retrospectively analyzed. Results The patients with bloodstream infection caused by Klebsiella pneumoniae were mainly distributed in ICU, surgical department and Internal medicine department. There were 110 patients with bloodstream infection caused by Klebsiella pneumoniae accompanied with underlying diseases, accounting for 56.41% in 195 patients with bloodstream infection caused by Klebsiella pneumoniae, and 87 (87/110, 77.3%) patients accompanied with hypertension and diabetes. Drug sensitivity test showed that in 195 patients with bloodstream infection caused by Klebsiella pneumoniae, the top three antibiotics of the drug resistance rate of Klebsiella pneumoniae were cefazolin (74%), amoxicillin/clavulanic acid (70.1%), ampicillin /sulbactam (68.5%); the lower three antibiotics of drug resistance rate were imipenem (52%), cefepime (53%) and amikacin (33%); there were 81 strains of Klebsiella pneumoniae produced ESBLs, accounting for 41.53% in 195 strains of Klebsiella pneumoniae. The drug resistance rate of ESBLs positive strains was significantly higher than that of ESBL negative strains. It should be pointed out that the resistance of ESBLs positive strains of Klebsiella pneumoniae to cefazole reached 100%, followed by gentamicin (71.4%), ciprofloxacin (70.4%) and levofloxacin (69.1%); The resistance of ESBLs negative strains to cefazole was 18.2%, followed by gentamicin (3.5%), ciprofloxacin (3.0%) and levofloxacin (19.3%). Conclusions The number of total bacteria isolated from departments with large number of patients is relatively large, and the number of pneumonia patients caused by Klebsiella is also increased; ESBLs positive strains in this hospital are still the main reasons for the drug resistance of Klebsiella pneumoniae, reducing the antibiotics use of cefazol, gentamycin, ciprofloxacin and levofloxacin can effectively reduce the resistance of Klebsiella pneumoniae in the hospital. At the same time, we should pay attention to some contraindications for treating hypertension, diabetes drugs and antibiotics; the clinical staff should pay attention to the timely blood culture test, rational drug use can reduce the emergence of drug-resistant strains and prevent the outbreak of nosocomial infection.

scholarly journals Clinical Characteristics, Treatment Outcomes and Predictive Factors in Optic Neuritis

2018 ◽  
Vol 12 (1) ◽  
pp. 247-255 ◽  
Author(s):  
Linda Hansapinyo ◽  
Chayanee Vivattanaseth
Keyword(s):  
Optic Neuritis ◽  
Treatment Outcomes ◽  
Predictive Factors ◽  
Clinical Characteristics ◽  
Demyelinating Disease ◽  
Univariate Analysis ◽  
Multivariate Logistic Regression Analysis ◽  
Thai Population ◽  
Visual Outcomes ◽  
Clinical Presentations

Background: The causes, clinical presentations and treatment outcomes of optic neuritis are distinct among different populations. Early diagnosis based on clinical presentations plays an important role in treating optic neuritis patients. Objective: The study aimed to determine clinical characteristics, treatment outcomes and predictive factors of treatment outcomes in optic neuritis patients with and without demyelinating disease. Methods: A retrospective descriptive study of optic neuritis patients carried out between January 2009 and December 2016 was done. Univariate analysis and multivariate logistic regression analysis were used to evaluate the predictive factors of treatment outcomes. Results: Among 150 patients with optic neuritis, 58 patients were diagnosed with Neuromyelitis Optica Spectrum Disease (NMOSD), 23 patients were diagnosed with Multiple Sclerosis (MS) and 69 patients were idiopathic. The age at presentation in the NMOSD group was significantly younger than the MS group and the idiopathic group. The female:male ratio was significantly lower in the idiopathic group than in the NMOSD group. The initial Best Corrected Visual Activity (BCVA) of 20/20-20/60 (p = 0.001) and the idiopathic group (p =0.030) was associated with good visual outcomes. Initial BCVA of < 20/200 (p = 0.009) and the NMOSD group (p < 0.001) was associated with poor visual outcomes. Conclusion: NMOSD is a more common cause of optic neuritis than MS in Thai population. Female patients with poor initial VA, poor response to steroids treatment, and presenting recurrent attacks are highly suspicious for NMOSD. Optic neuritis without associated demyelinating disease has a better visual outcome and lower recurrence rate.

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