584 Role of UVB-induced, IL-1 in dermal collagen alteration in murine skin

Excision arthroplasty is an alternative procedure for degenerative arthritis of the trapezium carpal bone that has failed non-surgical treatment. Autologous or heterologous interposition materials are used following excision of the trapezium, but may not prevent first metacarpal-scaphoid joint collapse or subsidence. AlloDerm® is a cadaver-harvested, immunologically inert dermal collagen graft. This report documents the uncomplicated use of AlloDerm® in 13 thumbs of 9 patients who had first carpometacarpal (CMC) joint excision interposition arthroplasty for degenerative arthritis. Joints functioned well after arthroplasty with AlloDerm®. These clinical results compare favorably to results in 6 Silicon implant CMC arthroplasty patients, and 3 autologous dermal graft CMC arthroplasty patients. Future clinical research, on joint stability, the durability of this collagen graft, newer dermal collagen substrates, and prevention of metacarpal subsidence, will determine the ultimate role of AlloDerm® in interposition arthroplasty.

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The integument

10.1093/oso/9780198785552.003.0002 ◽

2017 ◽

Author(s):

Derek Burton ◽

Margaret Burton

Keyword(s):

Seasonal Changes ◽

Neural Control ◽

Epidermal Cells ◽

Hormonal Activity ◽

Fish Skin ◽

Skin Structure ◽

Terrestrial Vertebrates ◽

Boundary Functions ◽

Dermal Collagen

The skin is the boundary between fish and environment and possesses important boundary functions such as protection and camouflage. Fish skin is mucigenic, contrasting with keratinized skin in terrestrial vertebrates. Structurally, there is an outer epidermis, a dermis and an inner hypodermis, the entire mucigenic epidermis remaining alive, with mitotic cells, unlike a keratinized epidermis. A variety of specialized epidermal cells are described, and the role of the ‘bias-sleeve’ orientation of dermal collagen is discussed. Scales, scutes and bony plates have protective roles. The variety of morphological types is considered. Skin colouration has important boundary functions in fish; colour largely depends upon different kinds of chromatophores, mainly dermal, and may change under hormonal or neural control in some species. Seasonal changes may occur in skin structure which can also be affected by captivity. Pollutants such as oil can affect fish skin structure both directly and systemically by influencing hormonal activity.

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Rapamycin Protects Skin Fibroblasts From UVA-Induced Photoaging by Inhibition of p53 and Phosphorylated HSP27

Frontiers in Cell and Developmental Biology ◽

10.3389/fcell.2021.633331 ◽

2021 ◽

Vol 9 ◽

Author(s):

Gen-Long Bai ◽

Ping Wang ◽

Xin Huang ◽

Zi-Yue Wang ◽

Di Cao ◽

...

Keyword(s):

Type I Collagen ◽

Skin Aging ◽

Dermal Fibroblasts ◽

Type I ◽

Aging Effects ◽

Smad Signaling Pathway ◽

Skin Photoaging ◽

Dermal Collagen ◽

Induced Apoptosis

Skin aging caused by UV radiation is called photoaging is characterized by skin roughness and dryness accompanied by a significant reduction of dermal collagen. Rapamycin is a macrolide immunosuppressant which has been shown to exhibit “anti-aging” effects in cells and organisms, however, its roles in the skin photoaging remains unclear. Here, we investigate the role of rapamycin and HSP27, which we have previously identified as an inhibitor of UV-induced apoptosis and senescence in HaCat cells, in a UVA-induced photoaging model of primary human dermal fibroblasts (HDFs). Results from senescence-associated beta-galactosidase (SA-β-gal) staining revealed that rapamycin significantly reduced senescence in UVA-treated HDFs. In addition, treatment with rapamycin significantly increased cell autophagy levels, decreased the expression of p53 and phosphorylated HSP27, and reduced genotoxic and oxidative cellular stress levels in UVA-induced HDFs. Knockdown of HSP27 resulted in a significant increase of MMP-1 and MMP-3 as well as a decrease in type I collagen expression. Rapamycin mitigated these effects by activation of the classical TGF-β/Smad signaling pathway and increasing the transcriptional activity of MAPK/AP-1. Taken together, these results suggest that rapamycin may potentially serve as a preventive and therapeutic agent for UVA-induced photoaging of the skin.

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Influence of aging on the quality of the skin of white women: the role of collagen

Acta Cirurgica Brasileira ◽

10.1590/s0102-86502012001000012 ◽

2012 ◽

Vol 27 (10) ◽

pp. 736-740 ◽

Cited By ~ 15

Author(s):

Eloina do Rocio Valenga Baroni ◽

Maria de Lourdes Pessole Biondo-Simões ◽

André Auersvald ◽

Luiz Augusto Auersvald ◽

Mário Rodrigues Montemor Netto ◽

...

Keyword(s):

White Women ◽

Histological Analysis ◽

Age Groups ◽

Skin Aging ◽

Dermal Collagen ◽

Relationship Of ◽

The Relationship ◽

Total P

PURPOSE: Evaluate the influence of aging on the quality of the skin of white women, analyzing the dermal collagen. METHODS: Pre-auricular flaps were collected for histological and morphometric analysis of 218 white women who underwent spontaneous facial aesthetic plastic surgery. Picrosirius ultrared stain was used for analysis and quantification of collagen in five age groups (<40 years, 40 to 49 years, 50 to 59 years, 60 to 69 years and 70 to 79 years) . RESULTS: Histological analysis showed changes suggestive of skin aging (fragmentation and disorganization of collagen fibers), especially in patients over 60 years. There were no significant changes in the relationship of age with the thickness of the dermis and epidermis, but there was with the percentage of the collagen I, III and total (p<0.001), which decreased with increasing aging. CONCLUSION: There is reduction in collagen with increasing age, and an increase in its degradation, leading to fragmentation of the fibers.

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Skin Photoaging and the Role of Antioxidants in Its Prevention

ISRN Dermatology ◽

10.1155/2013/930164 ◽

2013 ◽

Vol 2013 ◽

pp. 1-11 ◽

Cited By ~ 94

Author(s):

Ruža Pandel ◽

Borut Poljšak ◽

Aleksandar Godic ◽

Raja Dahmane

Keyword(s):

Structural Integrity ◽

Skin Atrophy ◽

Antioxidant Treatment ◽

Surface Receptors ◽

Skin Photoaging ◽

Dermal Collagen ◽

Endogenous Antioxidants ◽

Skin Formation ◽

Skin Phototype

Photoaging of the skin depends primarily on the degree of ultraviolet radiation (UVR) and on an amount of melanin in the skin (skin phototype). In addition to direct or indirect DNA damage, UVR activates cell surface receptors of keratinocytes and fibroblasts in the skin, which leads to a breakdown of collagen in the extracellular matrix and a shutdown of new collagen synthesis. It is hypothesized that dermal collagen breakdown is followed by imperfect repair that yields a deficit in the structural integrity of the skin, formation of a solar scar, and ultimately clinically visible skin atrophy and wrinkles. Many studies confirmed that acute exposure of human skin to UVR leads to oxidation of cellular biomolecules that could be prevented by prior antioxidant treatment and to depletion of endogenous antioxidants. Skin has a network of all major endogenous enzymatic and nonenzymatic protective antioxidants, but their role in protecting cells against oxidative damage generated by UV radiation has not been elucidated. It seems that skin’s antioxidative defence is also influenced by vitamins and nutritive factors and that combination of different antioxidants simultaneously provides synergistic effect.

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Body coloration and mechanisms of colour production in Archelosauria: The case of deirocheline turtles

10.1101/556670 ◽

2019 ◽

Cited By ~ 1

Author(s):

Jindřich Brejcha ◽

José Vicente Bataller ◽

Zuzana Bosáková ◽

Jan Geryk ◽

Martina Havlíková ◽

...

Keyword(s):

Pigment Cell ◽

Complex Trait ◽

Cell Types ◽

Freshwater Turtles ◽

Nano Structure ◽

Body Coloration ◽

Dermal Collagen ◽

Visual Signalling ◽

Pteridine Derivatives

AbstractAnimal body coloration is a complex trait resulting from the interplay of multiple colour-producing mechanisms. Increasing knowledge of the functional role of animal coloration stresses the need to study the proximate causes of colour production. Here we present a description of colour and colour producing mechanisms in two non-avian archelosaurs, the freshwater turtles Trachemys scripta and Pseudemys concinna. We compare reflectance spectra; cellular, ultra-, and nano-structure of colour-producing elements; and carotenoid/pteridine derivatives contents in the two species. In addition to xanthophores and melanocytes, we found abundant iridophores which may play a role in integumental colour production. We also found abundant dermal collagen fibres that may serve as thermoprotection but possibly also play role in colour production. The colour of yellow-red skin patches results from an interplay between carotenoids and pteridine derivatives. The two species differ in the distribution of pigment cell types along the dorsoventral head axis, as well as in the diversity of pigments involved in colour production, which may be related to visual signalling. Our results indicate that archelosaurs share some colour production mechanisms with amphibians and lepidosaurs, but also employ novel mechanisms based on the nano-organization of the extracellular protein matrix that they share with mammals.

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