Dual gate-keeping and reversible on-off switching drug release for anti-cancer therapy with pH- and NIR light-responsive mesoporous silica-coated gold nanorods

2021 ◽  
Author(s):  
Ju Hyang Park ◽  
Kyung Eun Sung ◽  
Ki Hak Kim ◽  
Jong Ryeol Kim ◽  
Jongbok Kim ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Gold Nanorods ◽  
Nir Light ◽  
Anti Cancer ◽  
Dual Gate ◽  
Gate Keeping

scholarly journals Novel concept of the smart NIR-light–controlled drug release of black phosphorus nanostructure for cancer therapy

2018 ◽  
Vol 115 (3) ◽  
pp. 501-506 ◽  
Author(s):  
Meng Qiu ◽  
Dou Wang ◽  
Weiyuan Liang ◽  
Liping Liu ◽  
Yin Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Near Infrared ◽  
Black Phosphorus ◽  
Deep Penetration ◽  
Nir Light

A biodegradable drug delivery system (DDS) is one the most promising therapeutic strategies for cancer therapy. Here, we propose a unique concept of light activation of black phosphorus (BP) at hydrogel nanostructures for cancer therapy. A photosensitizer converts light into heat that softens and melts drug-loaded hydrogel-based nanostructures. Drug release rates can be accurately controlled by light intensity, exposure duration, BP concentration, and hydrogel composition. Owing to sufficiently deep penetration of near-infrared (NIR) light through tissues, our BP-based system shows high therapeutic efficacy for treatment of s.c. cancers. Importantly, our drug delivery system is completely harmless and degradable in vivo. Together, our work proposes a unique concept for precision cancer therapy by external light excitation to release cancer drugs. If these findings are successfully translated into the clinic, millions of patients with cancer will benefit from our work.

Dual targeting hyaluronic acid - RGD mesoporous silica coated gold nanorods for chemo-photothermal cancer therapy

2017 ◽  
Vol 81 ◽  
pp. 261-270 ◽  
Author(s):  
Huimin Zhou ◽  
Haixing Xu ◽  
Xin Li ◽  
Yahui Lv ◽  
Tian Ma ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Gold Nanorods ◽  
Dual Targeting

NIR-responsive carbon-based nanocarriers for switchable on/off drug release and synergistic cancer therapy

2018 ◽  
Vol 6 (47) ◽  
pp. 7794-7799 ◽  
Author(s):  
Rongrong Nie ◽  
Hongji Liu ◽  
Lin Hu ◽  
Xinyu Gu ◽  
Junchao Qian ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Nir Light ◽  
Carbon Based

This communication reports a chitosan-gated carbon-based nanocarrier as a NIR light-switchable drug delivery system for controlled on/off drug release.

scholarly journals An aptamer-targeting photoresponsive drug delivery system using “off–on” graphene oxide wrapped mesoporous silica nanoparticles

Nanoscale ◽  
2015 ◽  
Vol 7 (14) ◽  
pp. 6304-6310 ◽  
Author(s):  
Yuxia Tang ◽  
Hao Hu ◽  
Molly Gu Zhang ◽  
Jibin Song ◽  
Liming Nie ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Cancer Therapy ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
Targeted Cancer Therapy

A photoresponsive drug delivery system was developed for light-mediated drug release and aptamer-targeted cancer therapy.

scholarly journals Fabrication of Photothermo-Responsive Drug-Loaded Nanogel for Synergetic Cancer Therapy

Polymers ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1098 ◽  
Author(s):  
Ray Chang ◽  
Wei-Bor Tsai
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Green Laser ◽  
Cancer Drug ◽  
Cell Mortality ◽  
Anti Cancer ◽  
Temperature Stimulus ◽  
Sodium Copper Chlorophyllin ◽  
532 Nm

Temperature stimulus, easy modulation in comparison to other environmental stimuli, makes thermo-responsive nanocarriers popular in the applications of controlled drug release for cancer therapy. In this study, photosensitive sodium copper chlorophyllin (SCC) was incorporated into thermo-responsive polymeric nanogels consisted of N-isopropylacrylamide and N-(hydroxymethyl)acrylamide. Significant heat was generated from the SCC-containing nanogels under the exposure to 532-nm green laser, and resulted in cell mortality. The thermo-responsive nanogel loaded with 5-FU, an anti-cancer drug, released the drug explosively when exposed to green laser. The combination of hyperthermia and temperature-induced drug release via green laser irradiation greatly enhanced cell mortality to a maximal extent. Such photothermo-responsive nanogel possesses a great potential in anti-cancer treatment.

Fe3O4@mSiO2 core–shell nanocomposite capped with disulfide gatekeepers for enzyme-sensitive controlled release of anti-cancer drugs

2015 ◽  
Vol 3 (6) ◽  
pp. 1010-1019 ◽  
Author(s):  
Chunyu Yang ◽  
Wei Guo ◽  
Liru Cui ◽  
Na An ◽  
Ting Zhang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Cancer Treatment ◽  
Silica Shell ◽  
Core Shell ◽  
Passive Targeting ◽  
Anti Cancer ◽  
Multifunctional Nanocarriers ◽  
Nanoparticle Core

Multifunctional nanocarriers based on the magnetic Fe3O4 nanoparticle core and bis-(3-carboxy-4-hydroxy phenyl) disulfide modified mesoporous silica shell were synthesized for cancer treatment through passive targeting and enzyme-sensitive drug release.

scholarly journals Gold Nanocage-Incorporated Poly(ε-Caprolactone) (PCL) Fibers for Chemophotothermal Synergistic Cancer Therapy

Pharmaceutics ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 60 ◽  
Author(s):  
Ju Park ◽  
Hojun Seo ◽  
Da Kim ◽  
Ji Choi ◽  
Jin Son ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Cancer Therapy ◽  
Drug Release ◽  
Near Infrared ◽  
Hyperthermia Treatment ◽  
Anticancer Efficacy ◽  
Drug Molecules ◽  
Nir Light ◽  
Rapid Release ◽  
Triggered Drug Release

This paper introduces a new fibrous system for synergistic cancer therapy, which consists of gold nanocage (AuNC)-loaded poly(ε-caprolactone) (PCL) fibers with encapsulation of a chemotherapeutic anticancer drug in their core and loading of a phase-changeable fatty acid in their sheath. Under on–off switching of near-infrared (NIR) light irradiation, the excellent photothermal ability and photostability of AuNCs allows repeated, significant heating of the fibers to a temperature available to hyperthermia. Simultaneously, the NIR light-induced heat generation enables the melting out of the loaded fatty acid, leading to a rapid release of the drug molecules from the fibers. The combination of this NIR light-triggered drug release with the repeated hyperthermia treatment exhibits excellent anticancer efficacy.

scholarly journals PREPARATION AND CHARACTERIZATION OF A NEAR-INFRARED LIGHT RESPONSIVE MICROCAPSULE SYSTEM FOR CANCER THERAPY

2014 ◽  
Vol 07 (01) ◽  
pp. 1350037 ◽  
Author(s):  
YINGFENG DI ◽  
SISI CUI ◽  
YUEQING GU
Keyword(s):  
Cancer Therapy ◽  
Gold Nanorods ◽  
Self Assembly ◽  
Near Infrared ◽  
Infrared Light ◽  
Layer By Layer ◽  
Near Infrared Light ◽  
Nir Light ◽  
Alternative Material ◽  
Confocal Fluorescence Imaging

A novel near-infrared light responsive microcapsule system, gold nanorod-covered DOX-loaded hollow CaCO 3 microcapsule ( AuNR -HM-DOX) is developed for cancer therapy. The hollow CaCO 3 microcapsules were prepared based on the self-assembly between chitosan and sodium alginate on CaCO 3 particles via layer-by-layer technique, and then covered with gold nanorods to obtain the microcapsule system. Upon near-infrared (NIR) irradiation, microcapsule with gold nanorods can convert the absorbed NIR light into heat. Meanwhile, doxorubicin (DOX), a chemotherapy drug, is loaded into the microcapsule system via electrostatic adsorption for combined photothermal therapy and chemotherapy. Properties of AuNR -HM-DOX including grain diameter, optical spectra were characterized. Confocal fluorescence imaging was performed to observe the morphology of the capsules and existence of DOX in the core, confirming the successful loading of DOX. The release of DOX from the capsules under continuous NIR irradiation was investigated to evaluate the temperature responsiveness of AuNR -HM-DOX. Results indicate that AuNR -HM-DOX microcapsules possess uniform particle size and high light responsiveness. The combination of chemical and physical therapy of AuNR -HM-DOX features great potential as an adjuvant therapeutic alternative material for combined cancer therapy.

Bioresponsive carbon nano-gated multifunctional mesoporous silica for cancer theranostics

Nanoscale ◽  
2016 ◽  
Vol 8 (8) ◽  
pp. 4537-4546 ◽  
Author(s):  
Rajendra Prasad ◽  
Sandhya Aiyer ◽  
Deepak S. Chauhan ◽  
Rohit Srivastava ◽  
Kaliaperumal Selvaraj
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Theranostic Agent ◽  
Functionalized Mesoporous Silica ◽  
Dual Functional ◽  
Successful Design ◽  
Bio Imaging ◽  
Green Fluorescent ◽  
Cancer Theranostics

A successful design of a novel dual functional green fluorescent CQD functionalized mesoporous silica based nano-theranostic agent for targeted bio-imaging and bio-responsive drug release has been reported. This study proves that the release of a preloaded anticancer drug is triggered by exposure to a tumor like environment which makes it an efficient theranostic system for cancer therapy.

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