scholarly journals ZZEF1 is a Histone Reader and Transcriptional Coregulator of Krüppel-Like Factors

2021 ◽  
Vol 433 (2) ◽  
pp. 166722
Author(s):  
Yucong Yu ◽  
Adam Tencer ◽  
Hongwen Xuan ◽  
Tatiana G. Kutateladze ◽  
Xiaobing Shi
Keyword(s):  
Transcriptional Coregulator

scholarly journals Transcriptional coregualtor NUPR1 maintains tamoxifen resistance in breast cancer cells

2021 ◽  
Vol 12 (2) ◽  
Author(s):  
Lingling Wang ◽  
Jiashen Sun ◽  
Yueyuan Yin ◽  
Yanan Sun ◽  
Jinyi Ma ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Critical Role ◽  
Endocrine Resistance ◽  
Autophagic Flux ◽  
Physical Interaction ◽  
Premature Senescence ◽  
Breast Cancers ◽  
Transcriptional Coregulator

AbstractTo support cellular homeostasis and mitigate chemotherapeutic stress, cancer cells must gain a series of adaptive intracellular processes. Here we identify that NUPR1, a tamoxifen (Tam)-induced transcriptional coregulator, is necessary for the maintenance of Tam resistance through physical interaction with ESR1 in breast cancers. Mechanistically, NUPR1 binds to the promoter regions of several genes involved in autophagy process and drug resistance such as BECN1, GREB1, RAB31, PGR, CYP1B1, and regulates their transcription. In Tam-resistant ESR1 breast cancer cells, NUPR1 depletion results in premature senescence in vitro and tumor suppression in vivo. Moreover, enforced-autophagic flux augments cytoplasmic vacuolization in NUPR1-depleted Tam resistant cells, which facilitates the transition from autophagic survival to premature senescence. Collectively, these findings suggest a critical role for NUPR1 as a transcriptional coregulator in enabling endocrine persistence of breast cancers, thus providing a vulnerable diagnostic and/or therapeutic target for endocrine resistance.

scholarly journals RNA-bound PGC-1α controls gene expression in liquid-like nuclear condensates

2020 ◽  
Author(s):  
Joaquín Pérez-Schindler ◽  
Bastian Kohl ◽  
Konstantin Schneider-Heieck ◽  
Volkan Adak ◽  
Julien Delezie ◽  
...  
Keyword(s):  
Target Genes ◽  
Rna Binding ◽  
Protein Complexes ◽  
Transcriptional Networks ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Central Function ◽  
Skeletal Muscle Wasting ◽  
Active Transcription ◽  
Transcriptional Coregulator

AbstractThe peroxisome-proliferator-activated receptor-γ coactivator-1α (PGC-1α) integrates environmental cues by controlling complex transcriptional networks in various metabolically active tissues. However, it is unclear how a transcriptional coregulator coordinates dynamic biological programs in response to multifaceted stimuli such as endurance training or fasting. Here, we discovered a central function of the poorly understood C-terminal domain (CTD) of PGC-1α to bind RNAs and assemble multi-protein complexes. Surprisingly, in addition to controlling the coupling of transcription and processing of target genes, RNA binding is indispensable for the recruitment of PGC-1α to chromatin into liquid-like nuclear condensates, which compartmentalize and regulate active transcription. These results demonstrate a hitherto unsuspected molecular mechanism by which complexity in the regulation of large transcriptional networks by PGC-1α is achieved. These findings are not only essential for the basic understanding of transcriptional coregulator-driven control of biological programs, but will also help to devise new strategies to modulate these processes in pathological contexts in which PGC-1α function is dysregulated, such as type 2 diabetes, cardiovascular diseases or skeletal muscle wasting.

scholarly journals Muscle Regeneration and Myogenic Differentiation Defects in Mice Lacking TIS7

2004 ◽  
Vol 24 (8) ◽  
pp. 3514-3525 ◽  
Author(s):  
Santhosh K. Vadivelu ◽  
Robert Kurzbauer ◽  
Benjamin Dieplinger ◽  
Margit Zweyer ◽  
Ralf Schafer ◽  
...  
Keyword(s):  
Cell Fate ◽  
Muscle Regeneration ◽  
Skeletal Muscles ◽  
Myogenic Differentiation ◽  
Mouse Development ◽  
Differentiation Potential ◽  
Tetradecanoyl Phorbol Acetate ◽  
Transcriptional Coregulator ◽  
Myogenic Satellite Cells ◽  
Laminin Α2

ABSTRACT The tetradecanoyl phorbol acetate-induced sequence 7 gene (tis7) is regulated during cell fate processes and functions as a transcriptional coregulator. Here, we describe the generation and analysis of mice lacking the tis7 gene. Surprisingly, TIS7 knockout mice show no gross histological abnormalities and are fertile. Disruption of the tis7 gene by homologous recombination delayed muscle regeneration and altered the isometric contractile properties of skeletal muscles after muscle crush damage in TIS7−/− mice. Cultured primary myogenic satellite cells (MSCs) from TIS7−/− mice displayed marked reductions in differentiation potential and fusion index in a strictly cell-autonomous fashion. Loss of TIS7 caused the down-regulation of muscle-specific genes, such as those for MyoD, myogenin, and laminin-α2. Fusion potential in TIS7−/− MSCs could be rescued by TIS7 expression or laminin supplementation. Therefore, TIS7 is not essential for mouse development but plays a novel regulatory role during adult muscle regeneration.

Transcriptional coregulator RIP140: an essential regulator of physiology

2017 ◽  
Vol 58 (3) ◽  
pp. R147-R158 ◽  
Author(s):  
Jaya Nautiyal
Keyword(s):  
Nuclear Receptors ◽  
Physiological Processes ◽  
Reproductive Axis ◽  
Transcriptional Coregulators ◽  
Transcriptional Coregulator ◽  
Gene Regulatory ◽  
Drive Gene ◽  
Regulatory Decisions ◽  
Regulatory Sites

Transcriptional coregulators drive gene regulatory decisions in the transcriptional space. Although transcription factors including all nuclear receptors provide a docking platform for coregulators to bind, these proteins bring enzymatic capabilities to the gene regulatory sites. RIP140 is a transcriptional coregulator essential for several physiological processes, and aberrations in its function may lead to diseased states. Unlike several other coregulators that are known either for their coactivating or corepressing roles, in gene regulation, RIP140 is capable of acting both as a coactivator and a corepressor. The role of RIP140 in female reproductive axis and recent findings of its role in carcinogenesis and adipose biology have been summarised.

scholarly journals A transcriptional coregulator, SPIN·DOC, attenuates the coactivator activity of Spindlin1

2017 ◽  
Vol 292 (51) ◽  
pp. 20808-20817 ◽  
Author(s):  
Narkhyun Bae ◽  
Min Gao ◽  
Xu Li ◽  
Tolkappiyan Premkumar ◽  
Gianluca Sbardella ◽  
...  
Keyword(s):  
Transcriptional Coregulator

scholarly journals De novoand rare inherited mutations implicate the transcriptional coregulator TCF20/SPBP in autism spectrum disorder

2014 ◽  
Vol 51 (11) ◽  
pp. 737-747 ◽  
Author(s):  
Christian Babbs ◽  
Deborah Lloyd ◽  
Alistair T Pagnamenta ◽  
Stephen R F Twigg ◽  
Joanne Green ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Transcriptional Coregulator ◽  
Inherited Mutations

scholarly journals Role of transcriptional coregulator GRIP1 in the anti-inflammatory actions of glucocorticoids

2012 ◽  
Vol 109 (29) ◽  
pp. 11776-11781 ◽  
Author(s):  
Y. Chinenov ◽  
R. Gupte ◽  
J. Dobrovolna ◽  
J. R. Flammer ◽  
B. Liu ◽  
...  
Keyword(s):  
Transcriptional Coregulator ◽  
Anti Inflammatory

scholarly journals Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl−/− mice

Blood ◽  
2008 ◽  
Vol 112 (8) ◽  
pp. 3148-3153 ◽  
Author(s):  
Maria Kauppi ◽  
James M. Murphy ◽  
Carolyn A. de Graaf ◽  
Craig D. Hyland ◽  
Kylie T. Greig ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Protein C ◽  
Lymphoid Cells ◽  
Wild Type ◽  
Gene Encoding ◽  
Mutagenesis Screen ◽  
Transcriptional Regulatory ◽  
Regulatory Complex ◽  
Transcriptional Coregulator ◽  
B Lymphoid

Abstract In an N-nitroso-N-ethylurea (ENU) mutagenesis screen using Mpl−/− mice, we isolated a semidominant suppressor of thrombocytopenia, termed Plt6. The gene mutated in Plt6 mice encodes the transcriptional coregulator p300, and the mutation, a tyrosine to asparagine substitution at amino acid 630 (Y630N), disrupts the interaction between p300 and c-Myb. Mpl−/−p300Plt6/+ mice displayed elevated platelet counts relative to Mpl−/−p300+/+ controls, whereas mice homozygous for the Plt6 mutation produced supraphysiological levels of circulating platelets. On a wild-type genetic background, mice homozygous for the p300Plt6 mutation, or recipients of Mpl+/+p300Plt6/Plt6 bone marrow, also exhibited thrombocytosis as well as deficiencies in B-lymphoid cells. Increased platelet numbers in Plt6 mutant mice were accompanied by significant increases in megakaryocyte progenitor cells within the bone marrow and spleen with concomitantly elevated numbers of megakaryocytes. The expansion of megakaryocytopoiesis and suppression of Mpl−/− thrombocytopenia in Plt6 mutants is highly reminiscent of that observed in mice with mutations affecting the p300 partner protein c-Myb, suggesting an indispensable repressive role for the c-Myb/p300 transcriptional regulatory complex in megakaryocyte develop-ment, the inhibition of which allows substantial thrombopoietin (TPO)–independent platelet production.

scholarly journals Selective autophagic receptor p62 regulates the abundance of transcriptional coregulator ARIP4 during nutrient starvation

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Megumi Tsuchiya ◽  
Shin Isogai ◽  
Hiroaki Taniguchi ◽  
Hidehito Tochio ◽  
Masahiro Shirakawa ◽  
...  
Keyword(s):  
Nutrient Starvation ◽  
Transcriptional Coregulator
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