This paper reports on the flow (centrifugal = radially outward, centripetal = radially inward) through rotating radial orifices with and without preswirl in the flow approaching the orifice in the outer annulus. The aerodynamical behavior of flow through radial rotating holes is different from the one through axial and stationary holes due to the presence of centrifugal and Coriolis forces. To investigate the flow phenomena and the discharge coefficient of these orifices in detail, an existing test rig containing two independently rotating shafts (corotating and counter rotating) was used. To simulate conditions of real gas turbines, where the flow is often influenced by upstream components, various preswirl angles were used in the test rig. Measurements of the flow discharge coefficient in both flow directions through the orifices (centripetal and centrifugal), with and without preswirl generation in the outer annulus, are presented at various flow conditions (pressure ratios across orifices, Mach numbers of approaching flow) and for different geometric parameters (length to diameter ratios, sharp/rounded inlet edges). Flow effects that occur with preswirled flow are clarified. A comparison of the experimental data, for both flow directions, shows a similar behavior of the discharge coefficients with increasing shaft speeds. To supplement the experimental data and to better understand the experimental findings, numerical simulations were performed, which show a good agreement with the experimental results. Furthermore, an optimization model with complete automatic grid generation, computational fluid dynamics (CFD) simulation, and postprocessing, was built to enable large parametric studies, e.g., grid independence of the solutions.