A retrospective study of effect of Terminalia arjuna and evidence based standard therapy on echocardiographic parameters in patients of dilated cardiomyopathy

2013 ◽  
Vol 6 (5) ◽  
pp. 493-498
Author(s):  
G. Bhawani ◽  
Ashutosh Kumar ◽  
K.S.N. Murthy ◽  
Neera Kumari ◽  
Ch. Ganapati Swami
Keyword(s):  
Retrospective Study ◽  
Dilated Cardiomyopathy ◽  
Standard Therapy ◽  
Terminalia Arjuna ◽  
Evidence Based ◽  
Echocardiographic Parameters

Psychosocial Issues of Patients With Implantable Cardioverter Defibrillators

2005 ◽  
Vol 14 (4) ◽  
pp. 294-303 ◽  
Author(s):  
Sandra B. Dunbar
Keyword(s):  
Quality Of Life ◽  
High Risk ◽  
Standard Therapy ◽  
Ventricular Arrhythmias ◽  
Evidence Based ◽  
Psychosocial Issues ◽  
Implantable Cardioverter Defibrillators ◽  
Life Threatening ◽  
Cardioverter Defibrillators

Use of implantable cardioverter defibrillators has become standard therapy for patients at high risk for life-threatening ventricular arrhythmias. Although acceptance of the device is generally high among patients and their families, quality of life and psychosocial issues associated with use of the defibrillators deserve greater attention to improve outcomes. Psychosocial issues, their ramifications, and theory-and evidence-based approaches to improving outcomes are described.

scholarly journals A five year trend analysis of malaria prevalence in Guba district, Benishangul-Gumuz regional state, western Ethiopia: a retrospective study

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Shemsia Alkadir ◽  
Tegenu Gelana ◽  
Araya Gebresilassie
Keyword(s):  
Public Health ◽  
Retrospective Study ◽  
Trend Analysis ◽  
Malaria Control ◽  
Health Centre ◽  
Malaria Prevalence ◽  
Health Concern ◽  
Evidence Based ◽  
Public Health Concern ◽  
Western Ethiopia

Abstract Background In Ethiopia, malaria is a serious public health concern and has great impact on socio-economy. The trend analysis of malaria data from health facilities is useful for understanding its transmission dynamics and implementing evidence-based malaria control strategies. The aim of this study was to determine the trends of malaria infection in Guba district, western Ethiopia. Methods A retrospective study was undertaken at Mankush Health Centre, western Ethiopia. All malaria cases reported from 2014 to 2018 were carefully reviewed from the laboratory record books to determine the trends of malaria morbidity. Data were analyzed using SPSS version 20.0. Results In total, 16,964 malaria suspects were diagnosed using microscopy over the last 5 years, of which 8658 (51.04%) were confirmed positive cases. Plasmodium falciparum, P. vivax, and mixed infection (both species) accounted for 75.2, 24.5 and 0.28% of the cases, respectively. Males patients were more affected (n = 5028, 58.1%) than female ones (n = 3630, 41.9%). Of the total confirmed cases, 60.4% were age group of subjects (≥ 15 years) followed by 22.6% of 5–14 years and 15.9% of under 5 years. High malaria prevalence was observed in spring (September to November) season, while the least was observed in autumn (March to May) with the prevalence of 45.6 and 11.5%, respectively. Conclusions The study demonstrated that malaria is a public health concern, in which P. falciparum is the predominant species followed by P. vivax. Therefore, the district health bureau and other concerned stakeholders should strength evidence-based malaria control and prevention interventions to interrupt disease transmission and eventual reduction malaria of malaria cases in Guba district.

Evaluation of add on effect of carvedilol on standard protocol of digoxin, frusemide and benazepril in the management of dilated cardiomyopathy in dogs

2018 ◽  
Author(s):  
Akhilesh Kumar ◽  
Sahadeb Dey ◽  
Abhishek Chandra Saxena ◽  
Sumit Mahajan
Keyword(s):  
Quality Of Life ◽  
Cardiac Function ◽  
Dilated Cardiomyopathy ◽  
Standard Therapy ◽  
Ace Inhibitor ◽  
Systolic Function ◽  
Serum Levels ◽  
Post Treatment ◽  
Beneficial Effects

This is a prospective, controlled, randomized clinical trial in canine patients with overt Dilated Cardiomyopathy (DCM). We hypothesized that the addition of the third generation beta-blocker carvedilol to the standard treatment of diuretic (furosemide), inotropic support (digoxin) and ACE-inhibitor (benazepril) would have beneficial effects over cardiac function and quality of life (QoL) that would be measurable 90 days post-treatment. 16 dogs diagnosed with overt DCM were recruited. They underwent clinical examination, electrocardiography, echocardiography and neurohormonal profiling (NT-proBNP and NO). Dogs were divided in two groups, receiving standard therapy or standard therapy plus carvedilol and subjected to re-evaluation on 90 days post-treatment. Our results indicated that the addition of carvedilol to the standard therapy improved echocardiographic indices of systolic function (FS and EF), reduced NT-proBNP and NO serum levels and quality of life within the group but did not showed the significant improvement over standard therapy. This suggested that the addition of carvedilol to the standard therapy in canine patients with overt DCM might have beneficial effects in cardiac function and quality of life in the treatment was continued for longer period.

Echocardiographic Parameters in Children with Dilated Cardiomyopathy

2013 ◽  
Vol 24 (2) ◽  
pp. 149-152
Author(s):  
Attia W. A. ◽  
Ibrahim L. A.
Keyword(s):  
Dilated Cardiomyopathy ◽  
Echocardiographic Parameters

scholarly journals A five year trend analysis of malaria prevalence in Guba district, Benishangul-Gumuz Regional State, western Ethiopia: A retrospective study

2020 ◽  
Author(s):  
Shemsia Alkadir ◽  
Tegenu Gelana ◽  
Araya Gebresilassie
Keyword(s):  
Public Health ◽  
Retrospective Study ◽  
Trend Analysis ◽  
Malaria Control ◽  
Health Centre ◽  
Malaria Prevalence ◽  
Health Concern ◽  
Evidence Based ◽  
Public Health Concern ◽  
Western Ethiopia

Abstract Background: In Ethiopia, malaria is a serious public health concern and has great impact on socio-economy. The trend analysis of malaria data from health facilities is useful for understanding its transmission dynamics and implementing evidence-based malaria control strategies. The aim of this study was to determine the trends of malaria infection in Guba district, western Ethiopia. Methods: A retrospective study was undertaken at Mankush Health Centre, western Ethiopia. All malaria cases reported from 2014 to 2018 were carefully reviewed from the laboratory record books to determine the trends of malaria morbidity. Data were analyzed using SPSS version 20.0. Results: In total, 16,964 malaria suspects were diagnosed using microscopy over the last 5 years, of which 8,658 (51.04%) were confirmed positive cases. Plasmodium falciparum , P. vivax , and mixed infection (both species) accounted for 75.2%, 24.5% and 0.28% of the cases, respectively. Males patients were more affected (n=5,028, 58.1%) than female ones (n=3,630, 41.9%). Of the total confirmed cases, 60.4% were age group of subjects (≥ 15 years) followed by 22.6% of 5-14 years and 15.9% of under 5 years. High malaria prevalence was observed in spring (September to November) season, while the least was observed in autumn (March to May) with the prevalence of 45.6% and 11.5%, respectively. Conclusions: The study demonstrated that malaria is a public health concern, in which P. falciparum is the predominant species followed by P . vivax . Therefore, the district health bureau and other concerned stakeholders should strength evidence-based malaria control and prevention interventions to interrupt disease transmission and eventual reduction malaria of malaria cases in Guba district. Key words : Ethiopia, Guba, malaria, prevalence, retrospective

scholarly journals Circulating circRNA as biomarkers for dilated cardiomyopathy etiology

2021 ◽  
Author(s):  
Marina C. Costa ◽  
Maria Calderon-Dominguez ◽  
Alipio Mangas ◽  
Oscar Campuzano ◽  
Georgia Sarquella-Brugada ◽  
...  
Keyword(s):  
Dilated Cardiomyopathy ◽  
Circular Rna ◽  
Circular Rnas ◽  
List Type ◽  
Rt Pcr ◽  
Multicentric Study ◽  
Non Invasive ◽  
The Third ◽  
Diagnostic Potential ◽  
Echocardiographic Parameters

Abstract Dilated cardiomyopathy (DCM) is the third most common cause of heart failure. The multidisciplinary nature of testing — involving genetics, imaging, or cardiovascular techniques — makes its diagnosis challenging. Novel and reliable biomarkers are needed for early identification and tailored personalized management. Peripheral circular RNAs (circRNAs), a leading research topic, remain mostly unexplored in DCM. We aimed to assess whether peripheral circRNAs are expressed differentially among etiology-based DCM. The study was based on a case–control multicentric study. We enrolled 130 subjects: healthy controls (n = 20), idiopathic DCM (n = 30), ischemic DCM (n = 20), and familial DCM patients which included pathogen variants of (i) LMNA gene (n = 30) and (ii) BCL2-associated athanogene 3 (BAG3) gene (n = 30). Differentially expressed circRNAs were analyzed in plasma samples by quantitative RT-PCR and correlated to relevant systolic and diastolic parameters. The pathophysiological implications were explored through bioinformatics tools. Four circRNAs were overexpressed compared to controls: hsa_circ_0003258, hsa_circ_0051238, and hsa_circ_0051239 in LMNA-related DCM and hsa_circ_0089762 in the ischemic DCM cohort. The obtained areas under the curve confirm the discriminative capacity of circRNAs. The circRNAs correlated with some diastolic and systolic echocardiographic parameters with notable diagnostic potential in DCM. Circulating circRNAs may be helpful for the etiology-based diagnosis of DCM as a non-invasive biomarker. Key messages The limitations of cardiac diagnostic imaging and the absence of a robust biomarker reveal the need for a diagnostic tool for dilated cardiomyopathy (DCM). The circular RNA (circRNA) expression pattern is paramount for categorizing the DCM etiologies. Our peripheral circRNAs fingerprint discriminates between various among etiology-based DCM and correlates with some echocardiographic parameters. We provide a potential non-invasive biomarker for the etiology-based diagnosis of LMNA-related DCM and ischemic DCM.

scholarly journals Structural and electrophysiological remodeling interrelation in postinfarction cardiosclerosis and dilated cardiomyopathy

2016 ◽  
Vol 97 (2) ◽  
pp. 173-177
Author(s):  
E S Mazur ◽  
V V Mazur ◽  
Kh A Djaber ◽  
Yu A Orlov
Keyword(s):  
Left Ventricle ◽  
Ejection Fraction ◽  
Right Ventricle ◽  
Dilated Cardiomyopathy ◽  
Myocardial Remodeling ◽  
Terminal Part ◽  
Postinfarction Cardiosclerosis ◽  
Electrophysiological Properties ◽  
Echocardiographic Parameters ◽  
Rms Amplitude

Aim. To study the interrelation of ventricles echocardiographic parameters and signal-averaged electrocardiogram indicators in patients with postinfarction cardiosclerosis and dilated cardiomyopathy.Methods. 28 patients with postinfarction cardiosclerosis (men aged 49 to 71 years) and 29 patients with dilated cardiomyopathy (men aged 24 to 61 years) were examined. All patients underwent echocardiography, by which left ventricle final diastolic and systolic volumes with ejection fraction calculation, right ventricle end diastolic and systolic volumes were determined. According to the signal-averaged electrocardiogram, filtered ventricular complex duration, the ventricular complex with an amplitude of less than 40 mV terminal part duration and signal root-mean-square (rms) amplitude of the ventricular complex last 40 ms were evaluated.Results.. According to the correlation analysis, increase in left ventricle end-diastolic and systolic volumes and decrease in its ejection fraction, as well as an increase in right ventricle end-diastolic and systolic volumes were associated with an increase in the filtered ventricular complex duration and the ventricular complex with an amplitude of less than 40 mV terminal part duration in patients with postinfarction cardiosclerosis. The left ventricle volumes increase and ejection fraction reduction were also associated with the signal rms amplitude of the ventricular complex last 40 ms reduction in patients with postinfarction cardiosclerosis. Similar interrelation was not found in patients with dilated cardiomyopathy.Conclusion. In patients with postinfarction cardiosclerosis cavities dilation and reduced systolic ventricular function are accompanied by the myocardium electrophysiological properties deterioration; in patients with dilated cardiomyopathy interrelation between structural and electrophysiological indicators of myocardial remodeling was not found.

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