Impaired adipogenesis in adipose tissue associated with hepatic lipid deposition induced by chronic inflammation in mice with chew diet

The article presents a modern view of obesity as a chronic inflammation of adipose tissue. Obesity is accompanied by metabolic changes in lipid, protein, carbohydrate, mineral metabolism and disorders in the hormonal function of adipose tissue as an endo- and paracrine organ. At the moment, there are searched the biochemical markers of metabolic disorders of obesity. The obesity-related factors (hyperglycemia, increased lipid levels, insulin resistance, chronic inflammation, hyperleptinemia, endothelial dysfunction, impaired respiratory function of mitochondria, minerals and microelements deficiency) form and increase oxidative stress making it an integral component of the pathogenesis of obesity and possible complications. Given the important role of Q10 coenzyme in antioxidant tissue protection, the authors discuss the relationship of obesity and metabolic disorders to the endogenous levels of Q10 coenzyme and its possible use for pharmacological correction.

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Adipose tissue remodeling and chronic inflammation in obesity visualized by in vivo molecular imaging method

Journal of Biorheology ◽

10.1007/s12573-010-0020-1 ◽

2010 ◽

Vol 24 (1) ◽

pp. 11-15 ◽

Cited By ~ 2

Author(s):

Satoshi Nishimura ◽

Mika Nagasaki

Keyword(s):

Adipose Tissue ◽

Molecular Imaging ◽

Chronic Inflammation ◽

Tissue Remodeling ◽

Imaging Method ◽

Adipose Tissue Remodeling

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Anti-Obesity Effects of Collagen Peptide Derived from Skate (Raja kenojei) Skin Through Regulation of Lipid Metabolism

Marine Drugs ◽

10.3390/md16090306 ◽

2018 ◽

Vol 16 (9) ◽

pp. 306 ◽

Cited By ~ 14

Author(s):

Minji Woo ◽

Yeong Song ◽

Keon-Hee Kang ◽

Jeong Noh

Keyword(s):

Body Weight ◽

Adipose Tissue ◽

Fatty Acid ◽

Lipid Metabolism ◽

Protein Expression ◽

The Body ◽

Chow Diet ◽

Dependent Manner ◽

Hepatic Lipid ◽

Collagen Peptide

This study investigated the anti-obesity effects of collagen peptide derived from skate skin on lipid metabolism in high-fat diet (HFD)-fed mice. All C57BL6/J male mice were fed a HFD with 60% kcal fat except for mice in the normal group which were fed a chow diet. The collagen-fed groups received collagen peptide (1050 Da) orally (100, 200, or 300 mg/kg body weight per day) by gavage, whereas the normal and control groups were given water (n = 9 per group). The body weight gain and visceral adipose tissue weight were lower in the collagen-fed groups than in the control group (p < 0.05). Plasma and hepatic lipid levels were significantly reduced by downregulating the hepatic protein expression levels for fatty acid synthesis (sterol regulatory element binding protein-1 (SREBP-1), fatty acid synthase (FAS), and acetyl-CoA carboxylase (ACC)) and cholesterol synthesis (SREBP-2 and 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)) and upregulating those for β-oxidation (peroxisome proliferator-activated receptor alpha (PPAR-α) and carnitine palmitoyltransferase 1 (CPT1)) and synthesis of bile acid (cytochrome P450 family 7 subfamily A member 1 (CYP7A1)) (p < 0.05). In the collagen-fed groups, the hepatic protein expression level of phosphorylated 5′ adenosine monophosphate-activated protein kinase (p-AMPK) and plasma adiponectin levels were higher, and the leptin level was lower (p < 0.05). Histological analysis revealed that collagen treatment suppressed hepatic lipid accumulation and reduced the lipid droplet size in the adipose tissue. These effects were increased in a dose-dependent manner. The findings indicated that skate collagen peptide has anti-obesity effects through suppression of fat accumulation and regulation of lipid metabolism.

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Acute-phase responses and adipocytokines

Oxford Textbook of Rheumatology ◽

10.1093/med/9780199642489.003.0058_update_001 ◽

2013 ◽

pp. 424-430

Author(s):

Elena Neumann ◽

Klaus Frommer ◽

Ulf Müller-Ladner

Keyword(s):

Adipose Tissue ◽

Immune System ◽

Chronic Inflammation ◽

Acute Phase ◽

Rheumatic Diseases ◽

Innate Immune System ◽

Current Knowledge ◽

Cell Types ◽

Bioactive Substances ◽

Different Cell Types

Adipokines, also called adipocytokines, are highly bioactive substances mainly expressed by adipose tissue. In addition to adipocytes, different cell types resident in various tissues produce adipokines under pathophysiological conditions. Adipokines include a growing number of pluripotent molecules such as adiponectin, resistin, leptin, and visfatin. Since distinct effects of adipokines on inflammation have been described, their influence on the (innate) immune system has been investigated in rheumatology, gastroenterology, and endocrinology. This review gives an overview on the current knowledge about the influence which adipokines have on the immune system and chronic inflammation in rheumatic diseases.

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