scholarly journals Adipose Tissue Deficiency and Chronic Inflammation in Diabetic Goto-Kakizaki Rats

PLoS ONE ◽  
2011 ◽  
Vol 6 (2) ◽  
pp. e17386 ◽  
Author(s):  
Bai Xue ◽  
Siddharth Sukumaran ◽  
Jing Nie ◽  
William J. Jusko ◽  
Debra C. DuBois ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Chronic Inflammation

scholarly journals Metabolic markers and oxidative stress in children’s obesity pathogenesis

2020 ◽  
Vol 65 (1) ◽  
pp. 22-29
Author(s):  
O. V. Povarova ◽  
E. A. Gorodetskaya ◽  
E. I. Kalenikova ◽  
O. S. Medvedev
Keyword(s):  
Oxidative Stress ◽  
Adipose Tissue ◽  
Chronic Inflammation ◽  
Metabolic Disorders ◽  
Mineral Metabolism ◽  
Related Factors ◽  
Metabolic Markers ◽  
Hormonal Function ◽  
The Moment ◽  
Relationship Of

The article presents a modern view of obesity as a chronic inflammation of adipose tissue. Obesity is accompanied by metabolic changes in lipid, protein, carbohydrate, mineral metabolism and disorders in the hormonal function of adipose tissue as an endo- and paracrine organ. At the moment, there are searched the biochemical markers of metabolic disorders of obesity. The obesity-related factors (hyperglycemia, increased lipid levels, insulin resistance, chronic inflammation, hyperleptinemia, endothelial dysfunction, impaired respiratory function of mitochondria, minerals and microelements deficiency) form and increase oxidative stress making it an integral component of the pathogenesis of obesity and possible complications. Given the important role of Q10 coenzyme in antioxidant tissue protection, the authors discuss the relationship of obesity and metabolic disorders to the endogenous levels of Q10 coenzyme and its possible use for pharmacological correction.

Acute-phase responses and adipocytokines

2013 ◽  
pp. 424-430
Author(s):  
Elena Neumann ◽  
Klaus Frommer ◽  
Ulf Müller-Ladner
Keyword(s):  
Adipose Tissue ◽  
Immune System ◽  
Chronic Inflammation ◽  
Acute Phase ◽  
Rheumatic Diseases ◽  
Innate Immune System ◽  
Current Knowledge ◽  
Cell Types ◽  
Bioactive Substances ◽  
Different Cell Types

Adipokines, also called adipocytokines, are highly bioactive substances mainly expressed by adipose tissue. In addition to adipocytes, different cell types resident in various tissues produce adipokines under pathophysiological conditions. Adipokines include a growing number of pluripotent molecules such as adiponectin, resistin, leptin, and visfatin. Since distinct effects of adipokines on inflammation have been described, their influence on the (innate) immune system has been investigated in rheumatology, gastroenterology, and endocrinology. This review gives an overview on the current knowledge about the influence which adipokines have on the immune system and chronic inflammation in rheumatic diseases.

scholarly journals Modeling the Effect of High Calorie Diet on the Interplay between Adipose Tissue, Inflammation, and Diabetes

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
V. Prana ◽  
P. Tieri ◽  
M.C. Palumbo ◽  
E. Mancini ◽  
F. Castiglione
Keyword(s):  
Adipose Tissue ◽  
Chronic Inflammation ◽  
Blood Glucose Concentration ◽  
Caloric Intake ◽  
Direct Consequence ◽  
Calorie Intake ◽  
Human Organism ◽  
Inflammatory State ◽  
Set Up ◽  
High Calorie

Background. Type 2 diabetes (T2D) is a chronic metabolic disease potentially leading to serious widespread tissue damage. Human organism develops T2D when the glucose-insulin control is broken for reasons that are not fully understood but have been demonstrated to be linked to the emergence of a chronic inflammation. Indeed such low-level chronic inflammation affects the pancreatic production of insulin and triggers the development of insulin resistance, eventually leading to an impaired control of the blood glucose concentration. On the contrary, it is well-known that obesity and inflammation are strongly correlated. Aim. In this study, we investigate in silico the effect of overfeeding on the adipose tissue and the consequent set up of an inflammatory state. We model the emergence of the inflammation as the result of adipose mass increase which, in turn, is a direct consequence of a prolonged excess of high calorie intake. Results. The model reproduces the fat accumulation due to excessive caloric intake observed in two clinical studies. Moreover, while showing consistent weight gains over long periods of time, it reveals a drift of the macrophage population toward the proinflammatory phenotype, thus confirming its association with fatness.

Impaired adipogenesis in adipose tissue associated with hepatic lipid deposition induced by chronic inflammation in mice with chew diet

Life Sciences ◽  
2015 ◽  
Vol 137 ◽  
pp. 7-13 ◽  
Author(s):  
Shumin Yang ◽  
Wenlong Zhang ◽  
Qianna Zhen ◽  
Rufei Gao ◽  
Tingting Du ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Chronic Inflammation ◽  
Lipid Deposition ◽  
Hepatic Lipid

scholarly journals HMGB1, an innate alarmin, plays a critical role in chronic inflammation of adipose tissue in obesity

2017 ◽  
Vol 454 ◽  
pp. 103-111 ◽  
Author(s):  
Jing Zhang ◽  
Lei Zhang ◽  
Shu Zhang ◽  
Qilin Yu ◽  
Fei Xiong ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Chronic Inflammation ◽  
Critical Role

scholarly journals Pathophysiological justification of age- and gender-dependent morphological changes in the adipose tissue in rat models of metabolic syndrome

2021 ◽  
Author(s):  
Natalia A. Shutova ◽  
Olha V. Nikolaieva ◽  
Irina Yu. Kuzmina ◽  
Olena O. Pavlova ◽  
Inna O. Sulhdost
Keyword(s):  
Metabolic Syndrome ◽  
Adipose Tissue ◽  
Chronic Inflammation ◽  
Morphological Changes ◽  
Regional Distribution ◽  
Morphological Characteristics ◽  
The Body ◽  
Age And Gender ◽  
White Rats ◽  
And Gender

Introduction: The mechanisms of metabolic syndrome (MS) is one of the urgent issues in medicine. Regional distribution of the adipose tissue should be diagnosed at clinical examination, as the morphometric parameters of the cells of the active adipose tissue components may indicate the metabolic state. Aim: The aim of the study was to evaluate the differences in morphological and histological parameters of the adipose tissue associated with the development of MS in animals of different ages and gender. Material and methods: An experimental study was carried out on 144 WAG/G Sto white rats, divided into three study groups. Group 1 included young immature rats, 3 months old; group 2 consisted of 48 sexually mature rats, aged 5–6 months; group 3 consisted of 48 old rats, 18 months old. Each group was divided into 2 subgroups, control and experimental, and was additionally divided according to gender. Results and discussion: The body mass indices and specific weights of mesenteric, epididymal, retroperitoneal and subcutaneous adipose tissue were determined in rats, as well as morphological characteristics of adipocytes of the adipose tissue. It was shown that histological and morphological changes in the adipose tissue of the animals were age- and gender-dependent, and that obesity is associated with chronic inflammation of the adipose tissue. Conclusions: The results of the study can be used for further determination of possible age and gender differences in the adipose tissue involvement in the development of chronic inflammation, as well as monitoring and correction of adipose tissue dysfunction in MS.

scholarly journals Inflammatory pathways involved in adipose tissue hypertrophy and the effect of Acai (Euterpe oleracea Martius) on the modulation of this process: a review

2020 ◽  
Vol 9 (9) ◽  
pp. e62996813
Author(s):  
Tamires Cássia de Melo Souza ◽  
Gabriel Vitor de Melo Souza ◽  
Ana Carolina Pinheiro Volp
Keyword(s):  
Adipose Tissue ◽  
Chronic Inflammation ◽  
Bioactive Compounds ◽  
Metabolic Diseases ◽  
Sample Size Calculation ◽  
Control Group ◽  
Euterpe Oleracea ◽  
Treatment And Prevention

Adipose tissue plays an important role in chronic inflammation and the presence of bioactive compounds in food has been widely discussed as a means of prevention and treatment of various pathological conditions. The aim of this review is to promote an overview and elucidate pathways involved in the chronic inflammatory process triggered by adipose tissue hypertrophy and to discuss data related to the use of Acai in the modulation of inflammation. Initially, a narrative review was carried out on metabolic and molecular pathways involved in the process of subclinical chronic inflammation (NF-κB, AP-1, cross-talk between macrophages and adipocytes, increased LPS and Nrf2 pathway). Then, an integrative review was carried out on the effect of Acai in processes of chronic subclinical inflammation in humans. The database consulted was PubMed, in which the name of the fruit was crossed with the descriptors "inflammation" and "chronic diseases", prioritizing in vivo and in vitro studies related to the human species, carried out in the last ten years. It was observed that the immunomodulatory effects of Acai are increasingly clear, however, are not enough to classify the fruit as a tool in the treatment and prevention of metabolic diseases. To make possible more comprehensive inferences, it is necessary that future studies include assessment of the bioavailability of the bioactive compounds present, in addition to being performed using more suitable methods, with humans, containing sample size calculation, control group and placebo.

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