scholarly journals Reinforced bioplastic film at different microcrystalline cellulose concentration

2021 ◽  
Author(s):  
Nor Amira Othman ◽  
Fatmawati Adam ◽  
Nur Hidayah Mat Yasin
Keyword(s):  
Microcrystalline Cellulose ◽  
Cellulose Concentration ◽  
Bioplastic Film

scholarly journals Room-temperature dissolution and chemical modification of cellulose in aqueous tetraethylammonium hydroxide–carbamide solutions

Cellulose ◽  
2019 ◽  
Vol 27 (4) ◽  
pp. 1933-1950 ◽  
Author(s):  
Juho Antti Sirviö ◽  
Juha P. Heiskanen
Keyword(s):  
Chemical Modification ◽  
Charge Density ◽  
Microcrystalline Cellulose ◽  
Room Temperature ◽  
Molar Ratio ◽  
Cellulose Modification ◽  
Tetraethylammonium Hydroxide ◽  
Cellulose Concentration

AbstractThe room-temperature dissolution of cellulose in aqueous tetraethylammonium hydroxide (TEAOH) in the presence of carbamides (ureas) was investigated. Without carbamide, 35 wt% TEAOH was able to dissolve cellulose (microcrystalline cellulose) up to 3 wt%, whereas carbamides—such as urea, N-methylurea, N-ethylurea, 1,3-dimethylurea, and imidazolidone—were able to improve the dissolution of cellulose. At 5 wt% cellulose concentration, the highest carbamide contents in the solvent still able to dissolve cellulose within 1 h were 56 and 55 wt% of 1,3-dimethylurea and N-methylurea, respectively. When using urea, up to 15% of cellulose could be dissolved in a solution containing 22 wt% of urea. To demonstrate the possibility of the use of a carbamide-based solvent in cellulose modification, cationic cellulose was produced using glycidyltrimethylammonium chloride (GTAC). At a molar ratio of 1:3 of cellulose and GTAC, all the studied TEAOH–carbamide solvents produce cationic cellulose with higher charge density compared to the reference NaOH–urea solvent.

scholarly journals An Artificial Neural Network Approach to Predict the Effects of Formulation and Process Variables on Prednisone Release from a Multipartite System

Pharmaceutics ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 109 ◽  
Author(s):  
Arthur Manda ◽  
Roderick Walker ◽  
Sandile Khamanga
Keyword(s):  
Dissolution Rate ◽  
Microcrystalline Cellulose ◽  
In Vitro Release ◽  
Process Variables ◽  
Extrusion Speed ◽  
Sodium Starch Glycolate ◽  
Artificial Neural ◽  
Vitro Release ◽  
Cellulose Concentration

The impact of formulation and process variables on the in-vitro release of prednisone from a multiple-unit pellet system was investigated. Box-Behnken Response Surface Methodology (RSM) was used to generate multivariate experiments. The extrusion-spheronization method was used to produce pellets and dissolution studies were performed using United States Pharmacopoeia (USP) Apparatus 2 as described in USP XXIV. Analysis of dissolution test samples was performed using a reversed-phase high-performance liquid chromatography (RP-HPLC) method. Four formulation and process variables viz., microcrystalline cellulose concentration, sodium starch glycolate concentration, spheronization time and extrusion speed were investigated and drug release, aspect ratio and yield were monitored for the trained artificial neural networks (ANN). To achieve accurate prediction, data generated from experimentation were used to train a multi-layer perceptron (MLP) using back propagation (BP) and the Broyden-Fletcher-Goldfarb-Shanno (BFGS) 57 training algorithm until a satisfactory value of root mean square error (RMSE) was observed. The study revealed that the in-vitro release profile of prednisone was significantly impacted by microcrystalline cellulose concentration and sodium starch glycolate concentration. Increasing microcrystalline cellulose concentration retarded dissolution rate whereas increasing sodium starch glycolate concentration improved dissolution rate. Spheronization time and extrusion speed had minimal impact on prednisone release but had a significant impact on extrudate and pellet quality. This work demonstrated that RSM can be successfully used concurrently with ANN for dosage form manufacture to permit the exploration of experimental regions that are omitted when using RSM alone.

scholarly journals Improved properties of keratin-based bioplastic film blended with microcrystalline cellulose: A comparative analysis

2020 ◽  
Vol 32 (1) ◽  
pp. 853-857 ◽  
Author(s):  
Basma Y. Alashwal ◽  
Mohamed Saad Bala ◽  
Arun Gupta ◽  
Swati Sharma ◽  
Puranjan Mishra
Keyword(s):  
Comparative Analysis ◽  
Microcrystalline Cellulose ◽  
Bioplastic Film

Effects of release modifier on Carvedilol release from Kollidon SR based matrix

2012 ◽  
Vol 1 (8) ◽  
pp. 186 ◽  
Author(s):  
Urmi Das ◽  
Mohammad Salim Hossain
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Microcrystalline Cellulose ◽  
Matrix Tablets ◽  
Dissolution Time ◽  
Release Mechanism ◽  
Matrix Tablet ◽  
Weight Variation ◽  
The Matrix ◽  
Tablet Formulations

<p>Sustained release Carvedilol matrix tablets constituting Kollidon SR were developed in this study in an attempt to investigate the effect of release modifiers on the release profile of Carvedilol from matrix. Three matrix tablet formulations were prepared by direct compression of Kollidon SR in combination with release modifier (HPMC and Microcrystalline Cellulose) and magnesium stearate. Tablets containing only Kollidon SR with the active ingredient demonstrated a rapid rate of drug release. Incorporation of HPMC in the matrix tablet prolonged the release of drug but incorporation of Microcrystalline Cellulose showed superimposable release pattern with an initial burst effect as confirmed by mean dissolution time and Higuchi release rate data. After 7 hours of dissolution, Carvedilol release from the matrix systems were 91.42%, 83.41%, from formulation F1 and F2 respectively. Formulation F3 exhibited 100 % release at 4 hours. All the tablet formulations showed acceptable pharmaco-technical properties and complied with the in-house specifications for tablet weight variation, friability, hardness, thickness, and diameter. Prepared tablets also showed sustained release property for carvedilol. The drug release mechanism from the matrix tablets of F1 and F2 was found to be followed by Fickian and F3 by Non-Fickian mechanism.</p><p>DOI: <a href="http://dx.doi.org/10.3329/icpj.v1i8.11095">http://dx.doi.org/10.3329/icpj.v1i8.11095</a></p> <p>International Current Pharmaceutical Journal 2012, 1(8): 186-192</p>

Optimization of Microcrystalline Cellulose PH 101, Lactose, and Kollidon® K 30 To Obtain Co-Processed Excipient Through Spray Drying

2017 ◽  
Vol 7 (2) ◽  
Author(s):  
Kusuma P. ◽  
Syukri Y ◽  
Sholehuddin F. ◽  
Fazzri N. ◽  
Romdhonah . ◽  
...  
Keyword(s):  
Spray Drying ◽  
Microcrystalline Cellulose ◽  
Chemical Change ◽  
Direct Compression ◽  
Flow Properties ◽  
Scanning Calorimetry ◽  
Compression Process ◽  
Infrared Spectrophotometer ◽  
Physical Mixtures ◽  
Spray Dried

The most efficient tablet processing method is direct compression. For this method, the filler-binder can be made by coprocessing via spray drying method. The purpose of this study was to investigate the effect of spray dried co-processing on microcrystalline cellulose (MCC) PH 101, lactose and Kollidon® K 30 as well as to define the optimum proportions. Spray dried MCC PH 101, lactose, and Kollidon® K 30 were varied in 13 different mixture design proportions to obtain compact, free-flowing filler-binder co-processed excipients (CPE). Compactibility and flow properties became the key parameters to determine the optimum proportions of CPE that would be compared to their physical mixtures. The result showed that the optimum proportion of CPE had better compactibility and flow properties than the physical mixtures. The optimum CPE, consisting of only MCC PH 101 and Kollidon® K 30 without lactose, that were characterized using infrared spectrophotometer, differential scanning calorimetry (DSC), X-ray diffraction (XRD), and scanning electron microscope (SEM) indicated no chemical change therein. Therefore, this study showed that spray dried MCC PH 101, lactose and Kollidon® K 30 could be one of the filler-binder alternatives for direct compression process.

β-Cyclodextrin Polymers on Microcrystalline Cellulose as a Granular Media for Organic Micropollutant Removal from Water

2018 ◽  
Author(s):  
Diego Alzate-Sanchez ◽  
Yuhan Ling ◽  
Chenjun Li ◽  
Benjamin Frank ◽  
Reiner Bleher ◽  
...  
Keyword(s):  
Microcrystalline Cellulose ◽  
Continuous Flow ◽  
Granular Media ◽  
Anaerobic Biodegradation ◽  
Thin Coating ◽  
Micropollutant Removal ◽  
Cyclodextrin Polymers ◽  
Flow Experiments ◽  
Aerobic And Anaerobic ◽  
Cellulose Composite

This manuscript describes cyclodextrin polymers formed as a thin coating on microcrystalline cellulose. The resulting polymer/cellulose composite shows promising performance for removing organic pollutants from water and can be packed into columns for continuous-flow experiments. The polymer/cellulose composite also shows excellent resistance to aerobic and anaerobic biodegradation.

Effect of Microcrystalline Cellulose from Banana Stem Fiber on Mechanical Properties and Crystallinity of PLA Composite Films

2011 ◽  
Vol 695 ◽  
pp. 170-173 ◽  
Author(s):  
Voravadee Suchaiya ◽  
Duangdao Aht-Ong
Keyword(s):  
Tensile Strength ◽  
Young’S Modulus ◽  
Microcrystalline Cellulose ◽  
Young's Modulus ◽  
Agricultural Waste ◽  
Composite Films ◽  
Sem Image ◽  
Biocomposite Films ◽  
Twin Screw ◽  
Banana Stem

This work focused on the preparation of the biocomposite films of polylactic acid (PLA) reinforced with microcrystalline cellulose (MCC) prepared from agricultural waste, banana stem fiber, and commercial microcrystalline cellulose, Avicel PH 101. Banana stem microcrystalline cellulose (BS MCC) was prepared by three steps, delignification, bleaching, and acid hydrolysis. PLA and two types of MCC were processed using twin screw extruder and fabricated into film by a compression molding. The mechanical and crystalline behaviors of the biocomopsite films were investigated as a function of type and amount of MCC. The tensile strength and Young’s modulus of PLA composites were increased when concentration of MCC increased. Particularly, banana stem (BS MCC) can enhance tensile strength and Young’s modulus of PLA composites than the commercial MCC (Avicel PH 101) because BS MCC had better dispersion in PLA matrix than Avicel PH 101. This result was confirmed by SEM image of fractured surface of PLA composites. In addition, XRD patterns of BS MCC/PLA composites exhibited higher crystalline peak than that of Avicel PH 101/PLA composites

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